Association between class III obesity and overall survival in previously untreated younger patients with acute myeloid leukemia enrolled on SWOG S1203.
Publication Title
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Document Type
Article
Publication Date
7-1-2024
Keywords
washington; swedish; Humans; Leukemia, Myeloid, Acute; Female; Male; Adult; Obesity; Middle Aged; Body Mass Index; Young Adult; Hematopoietic Stem Cell Transplantation; Adolescent; Prognosis; Survival Rate
Abstract
There has been ongoing debate on the association between obesity and outcomes in acute myeloid leukemia (AML). Currently few studies have stratified outcomes by class I obesity, class II obesity, and class III obesity, and a more nuanced understanding is becoming increasingly important with the rising prevalence of obesity. We examined the association between body mass index (BMI) and outcomes in previously untreated AML in younger patients (age =60) enrolled in SWOG S1203 (n = 729). Class III obesity was associated with an increased rate of early death (p = 0.004) and worse overall survival (OS) in multivariate analysis (hazard ratio (HR) 2.48, 95% confidence interval (CI) 1.62-3.80 versus normal weight). Class III obesity was also associated with worse OS after allogeneic hematopoietic cell transplant (HR 2.37, 95% CI 1.24-4.54 versus normal weight). These findings highlight the unique risk of class III obesity in AML, and the importance of further investigation to better characterize this patient population.
Area of Special Interest
Cancer
Area of Special Interest
Digestive Health
Specialty/Research Institute
Gastroenterology
Specialty/Research Institute
Oncology
DOI
10.21203/rs.3.rs-4020184/v1
