Metabolic Effects of Diet and Exercise in Patients with Moderate to Severe CKD: A Randomized Clinical Trial.

Publication Title

Journal of the American Society of Nephrology : JASN

Authors

T Alp Ikizler
Cassianne Robinson-Cohen
Charles Ellis
Samuel A E Headley
Katherine Tuttle, Kidney Research Institute and Division of Nephrology, Department of Medicine, University of Washington, Seattle, WashingtonFollow
Richard J Wood
Elizabeth Elspeth Evans
Charles M Milch
Kelsey Anne Moody
Michael Germain
Chutatip Limkunakul
Aihua Bian
Thomas G Stewart
Jonathan Himmelfarb, Kidney Research Institute and Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington

Document Type

Article

Publication Date

1-1-2018

Keywords

Chronic inflammation; chronic kidney disease; diet; exercise; metabolism; oxidative stress

Abstract

CKD is steadily increasing along with obesity worldwide. Furthermore, obesity is a proinflammatory risk factor for progression of CKD and cardiovascular disease. We tested the hypothesis that implementation of caloric restriction and aerobic exercise is feasible and can improve the proinflammatory metabolic milieu in patients with moderate to severe CKD through a pilot, randomized, 2×2 factorial design trial. Of 122 participants consented, 111 were randomized to receive caloric restriction and aerobic exercise, caloric restriction alone, aerobic exercise alone, or usual care. Of those randomized, 42% were women, 25% were diabetic, and 91% were hypertensive; 104 started intervention, and 92 completed the 4-month study. Primary outcomes were a change from baseline in absolute fat mass, body weight, plasma F

Area of Special Interest

Kidney & Diabetes

Specialty/Research Institute

Nephrology