Reduced Likelihood of Hospitalization with the JN.1 or HV.1 SARS-CoV-2 Variants Compared to the EG.5 Variant.
Publication Title
The Journal of infectious diseases
Document Type
Article
Publication Date
7-19-2024
Keywords
washington; spokane; pshmc; swedish; covid-19
Abstract
Within a multi-state viral genomic surveillance program, we evaluated whether proportions of SARS-CoV-2 infections attributed to the JN.1 variant and to XBB-lineage variants (including HV.1 and EG.5) differed between inpatient and outpatient care settings during periods of cocirculation. Both JN.1 and HV.1 were less likely than EG.5 to account for infections among inpatients versus outpatients (aOR=0.60 [95% CI: 0.43-0.84; p=0.003] and aOR=0.35 [95% CI: 0.21-0.58; p<0.001], respectively). JN.1 and HV.1 variants may be associated with a lower risk of severe illness. The severity of COVID-19 may have attenuated as predominant circulating SARS-CoV-2 lineages shifted from EG.5 to HV.1 to JN.1.
Keywords: COVID-19; SARS-CoV-2 variants; genomic surveillance; hospitalization; severity.
Specialty/Research Institute
Hospital Medicine
Specialty/Research Institute
Infectious Diseases
DOI
10.1093/infdis/jiae364
