Characteristics of patients with liver tumors deemed ineligible for enrollment on Children's Oncology Group trial AHEP1531: An opportunity to expand inclusion criteria and improve outcome.
Publication Title
Pediatric blood & cancer
Document Type
Article
Publication Date
1-1-2025
Keywords
Humans; Liver Neoplasms; Female; Male; Child; Hepatoblastoma; Child, Preschool; Carcinoma, Hepatocellular; Infant; Patient Selection; Adolescent; Surveys and Questionnaires; Children's Oncology Group; hepatoblastoma; hepatocellular carcinoma; hypoxia; ineligible; pediatric; washington; spokane
Abstract
BACKGROUND: Specific patients with hepatoblastoma (HB) and hepatocellular carcinoma (HCC) do not meet eligibility criteria for Children's Oncology Group (COG) trials, limiting an understanding of how comorbidities affect the outcome. We define such a population for future-focused care improvements.
METHODS: A questionnaire was sent to COG institutional principal investigators to obtain anonymized data regarding patients with a liver tumor diagnosis not enrolled on AHEP1531 due to ineligibility by trial criteria or other reasons (excluding parent/patient preference).
RESULTS: Responses received for 55 patients (38 HB, 4 HCC, and 13 not reported) included 12 excluded from further analysis due to various factors, including lack of additional information. Five patients were eligible but not enrolled due to pandemic-related staffing issues (n = 1) or the best interest of the patient (physician preference, n = 1; risk for poor tolerance of chemotherapy, n = 1; not specified, n = 2). The remaining 38 patients included 1 ineligible due to a prior malignancy, 9 due to performance status, and 4 due to timing requirements. Thirty-five of 38 patients were ineligible due to organ function criteria (pulmonary/oxygen requirement, n = 25; renal, n = 10; liver, n = 4; cardiac, n = 3). Seven patients were ineligible due to two or more organ function criteria. Twenty-five of 38 patients were reported to have a preexisting condition including 4 patients with trisomy 18.
CONCLUSIONS: Patients with HB, and potentially HCC, who are ineligible for COG trials are primarily patients with an oxygen requirement and/or renal insufficiency, often associated with preexisting congenital conditions. Such patients would benefit from future studies to improve outcomes.
Area of Special Interest
Women & Children
Area of Special Interest
Cancer
Area of Special Interest
Digestive Health
Specialty/Research Institute
Pediatrics
Specialty/Research Institute
Oncology
Specialty/Research Institute
Hepatology
DOI
10.1002/pbc.31389
