Sex differences in Spontaneous Coronary Artery Dissection: A Report of the iSCAD Registry

Publication Title

American College of Cardiology Annual Scientific Session and Expo, April 6-8, 2024, Atlanta, GA

Document Type

Abstract

Publication Date

4-2024

Keywords

oregon; cards; cards publication

Abstract

Background

Spontaneous coronary artery dissection (SCAD) is a cause of myocardial infarction which most frequently affects perimenopausal women. To date, there is limited data regarding the characteristics of men who develop SCAD.

Methods

Detailed information regarding demographics, presenting characteristics, precipitating factors, and outcomes in males and females were obtained from the prospective, multicenter iSCAD Registry.

Results

Of 1,252 patients who experienced SCAD enrolled in the iSCAD Registry from 1/2019-9/2023, 80 (6.4%) were males. Mean age did not differ between sexes (females=49.7±10.4, males=50.2±10.3, p=0.792). Females more often reported emotional stress preceding SCAD. Males more often reported physical stress, both isometric and aerobic exertion. There were sex differences in symptoms, with females reporting a higher prevalence of non-chest discomfort, shortness of breath, and nausea/vomiting. Males had lower rates of autoimmune conditions, systemic inflammatory disorder, fibromuscular dysplasia, and migraine. Although in-hospital outcomes did not differ, length of stay was 6.1±19.0 days for females vs 3.8±2.4 days for males (p=0.003).

Conclusion

In a large US SCAD population, females more often reported emotional stress preceding SCAD while males reported physical exertion as a trigger. Females were more likely to present with non-chest discomfort symptoms. In-hospital outcomes were similar between sexes but length of stay was longer for females.

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Footnotes

Oral Contributions

B402

Sunday, April 7, 2024, 10:21 a.m.-10:31 a.m.

Session Title: Highlighted Original Research: Ischemic Heart Disease and the Year in Review

Abstract Category: 22. Ischemic Heart Disease: Clinical Science

Presentation Number: 906-08

Area of Special Interest

Cardiovascular (Heart)

Specialty/Research Institute

Cardiology

DOI

10.1016/S0735-1097(24)03140-1


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