A foundation model for joint segmentation, detection and recognition of biomedical objects across nine modalities.

Theodore Zhao
Yu Gu
Jianwei Yang
Naoto Usuyama
Ho Hin Lee
Sid Kiblawi
Tristan Naumann
Jianfeng Gao
Angela Crabtree, Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Jacob Abel, Providence Genomics, Portland, OR, USA.
C Moung-Wen, Providence Genomics, Portland, OR, USA.
Brian D. Piening, Providence Genomics, Portland, OR, USA.; Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Carlo Bifulco, Providence Genomics, Portland, OR, USA.; Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Mu Wei
Hoifung Poon
Sheng Wang

Abstract

Biomedical image analysis is fundamental for biomedical discovery. Holistic image analysis comprises interdependent subtasks such as segmentation, detection and recognition, which are tackled separately by traditional approaches. Here, we propose BiomedParse, a biomedical foundation model that can jointly conduct segmentation, detection and recognition across nine imaging modalities. This joint learning improves the accuracy for individual tasks and enables new applications such as segmenting all relevant objects in an image through a textual description. To train BiomedParse, we created a large dataset comprising over 6 million triples of image, segmentation mask and textual description by leveraging natural language labels or descriptions accompanying existing datasets. We showed that BiomedParse outperformed existing methods on image segmentation across nine imaging modalities, with larger improvement on objects with irregular shapes. We further showed that BiomedParse can simultaneously segment and label all objects in an image. In summary, BiomedParse is an all-in-one tool for biomedical image analysis on all major image modalities, paving the path for efficient and accurate image-based biomedical discovery.