Increased Intracranial Pressure in Myelin-Oligodendrocyte Glycoprotein Antibody-Associated Disease.
Publication Title
The neurologist
Document Type
Article
Publication Date
1-1-2025
Keywords
Humans; Myelin-Oligodendrocyte Glycoprotein; Female; Male; Adult; Intracranial Hypertension; Retrospective Studies; Adolescent; Child; Young Adult; Child, Preschool; Autoantibodies; Optic Neuritis; oregon; portland
Abstract
OBJECTIVES: To assess characteristics of increased intracranial pressure (ICP) in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).
METHODS: This is a multicenter retrospective review of 84 MOGAD cases at the University of Florida, Baylor College of Medicine, the University of California San Diego, and Providence Health and Services, Portland, Oregon, to identify cases with a documented increased opening pressure >25 cm H2O. A literature review was conducted to identify previously reported MOGAD cases with an opening pressure >25 cm H2O.
RESULTS: Of 28 MOGAD cases with available opening pressures, 6 (21.4%) patients (age: 5 to 36 y; 2/6 females) had documented increased ICP with an opening pressure of 26 to 46 cm H2O and optic nerve head edema on funduscopic examination. The increased ICP occurred in the setting of bilateral optic neuritis in all cases. In 5/6 patients, this was the initial presentation of the disorder. Anti-MOG titers were 1:40 (n = 1), 1:100 (n = 4), and 1:1000 (n = 1). In our literature review, we identified 13 additional MOGAD cases with ICP elevations in the setting of meningo-cortical presentations (n = 10), as well as bilateral optic neuritis (n = 3).
CONCLUSIONS: Increased ICP may occur in MOGAD and may be more common in patients with optic neuritis or meningoencephalitis.
Area of Special Interest
Women & Children
Area of Special Interest
Neurosciences (Brain & Spine)
Specialty/Research Institute
Pediatrics
Specialty/Research Institute
Neurosciences
DOI
10.1097/NRL.0000000000000577
