Immunotherapy for Head and Neck Cancer.
Publication Title
Oral Maxillofac Surg Clin North Am
Document Type
Article
Publication Date
2-1-2019
Keywords
Adoptive T-cell transfer; Checkpoint inhibitor; Head and neck cancer; Immunotherapy; Oncolytic virus; Squamous cell carcinoma
Abstract
The immune system has a vital role in the development, establishment, and progression of head and neck squamous cell carcinoma (HNSCC). Immune evasion of cancer cells leads to progression of HNSCC. An understanding of this mechanism provides the basis for improved therapies and outcomes for patients. Through the tumor's influence on the microenvironment, the immune system can be exploited to promote metastasis, angiogenesis, and growth. This article provides an overview of the interaction between immune infiltrating cells in the tumor microenvironment, and the immunologic principles related to HNSCC. Current immunotherapeutic strategies and emerging results from ongoing clinical trials are presented.
Area of Special Interest
Cancer
Specialty/Research Institute
Oncology
Specialty/Research Institute
Earle A. Chiles Research Institute
