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Submissions from 2020

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760 Trough levels of ipilimumab in serum as a potential predictive biomarker of clinical outcomes for patients with advanced melanoma after treatment with ipilimumab, Yoshinobu Koguchi, Noriko Iwamoto, Takashi Shimada, Shu-Ching Chang, John Cha, Brian D. Piening, Brendan Curti, Walter Urba, and William L. Redmond

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760 Trough levels of ipilimumab in serum as a potential predictive biomarker of clinical outcomes for patients with advanced melanoma after treatment with ipilimumab, Yoshinobu Koguchi, Noriko Iwamoto, Takashi Shimada, Shu-Ching Chang, John Cha, Brian D. Piening, Brian Piening, Brendan Curti, Walter Urba, and William L. Redmond

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Sex-Related Differences in the Long-Term Outcomes of Patients with Femoropopliteal Arterial Disease Treated with the IN.PACT Drug-Coated Balloon in the IN.PACT SFA Randomized Controlled Trial: A Post Hoc Analysis., Maureen P Kohi, Marianne Brodmann, Thomas Zeller, Antonio Micari, Iris Baumgartner, Hong Wang, Bridget Wall, and Mahmood K Razavi

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Cholecystectomy for Biliary Pancreatitis Is Often Not Performed During Index Hospitalization and Is Associated With Worse Outcomes., Divyanshoo R Kohli, Madhav Desai, Kevin F Kennedy, Sravanthi Parasa, and Prateek Sharma

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Patient and Physician Predictors of FFR/iFR Utilization in ACS and SIHD, Payal Kohli, Peiqi Wang, Andrew Wang, Lucy Liu, Ali Weinstein, Jeptha P. Curtis, John A. Spertus, Jonathan P. Piccini, Marty Makary, and Tyler J Gluckman

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The 25 most cited articles on lateral lumbar interbody fusion: short review., Bradley Kolb, Catherine Peterson, Hassan Fadel, Emre Yilmaz, Kwame Waife, R Shane Tubbs, Gary Rajah, Blake Walker, Vicki Diaz, and Marc Moisi

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Adoption of a Strategy of Cerebral Embolic Protection During Transcatheter Aortic Valve Replacement is Associated with Fewer Neurologic Events in a Large Volume Center, EC Korngold, EB Kirker, Robert W. Hodson, Ruyun Jin, Kateri Spinelli, Shih-Ting Chiu, S Verburg, V Kumar, and BM Jones

Transcarotid TAVR: The best alternative, Ethan C Korngold

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Plasma levels of soluble ACE2are associated with sex, Metabolic Syndrome, and its biomarkers in a large cohort, pointing to a possible mechanism for increased severity in COVID-19., Sergey A Kornilov, Isabelle Lucas, Kathleen Jade, Chengzhen L Dai, Jennifer C Lovejoy, and Andrew T Magis

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Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain., Olena Korvatska, Kostantin Kiianitsa, Alexander Ratushny, Mark Matsushita, Neal Beeman, Wei-Ming Chien, Jun-Ichi Satoh, Michael O Dorschner, C Dirk Keene, Theo K Bammler, Thomas D Bird, and Wendy H Raskind

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Embracing the COVID-19 Disruption: Leadership Perspectives on the Future of Acute Care, Theo Koury, Denise Brown, Rick Rawson, Joanne Roberts, and In collaboration with Vituity

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Outcomes of Acute Myocardial Infarction Hospitalizations During the COVID-19 Pandemic, Margaret Krasne, Tyler J Gluckman, Joseph Edward Marine, Roger S. Blumenthal, and Garima Sharma

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Examining Relationships Between Resilience Protective Factors and Moral Distress Among Nursing Students., Lorretta Krautscheid, Laura Mood, Susan M McLennon, Taylor C Mossman, Marie Wagner, and Jessica Wode

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Examining Relationships Between Resilience Protective Factors and Moral Distress Among Nursing Students., Lorretta Krautscheid, Laura Mood, Susan M McLennon, Taylor C Mossman, Marie Wagner, and Jessica Wode

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Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States., Stephanie A. Kujawski, Karen K. Wong, Jennifer P. Collins, Lauren Epstein, Marie E. Killerby, Claire M. Midgley, Glen R. Abedi, Olivia Almendares, Kayla N. Anderson, Vaughn Barry, Karlyn Beer, Isaac Benowitz, Holly M. Biggs, Alison M. Binder, Catherine H. Bozio, Jonathan Bryant-Genevier, Alicia Budd, Jordan Cates, Kevin Chatham-Stephens, Nora Chea, Victoria Chu, Max Cohen, Erin F. Conners, Aaron T. Curns, Vishal Dasari, Patrick Dawson, Matthew Donahue, Lindsey M. Duca, Mathew D. Esona, Leora R. Feldstein, Marc Fischer, Alicia Fry, Romeo R. Galang, Susan I. Gerber, Isaac Ghinai, Cheri Grigg, Aron J. Hall, Jennifer Harcourt, Amber K. Haynes, Michelle Holshue, Jennifer C. Hunter, Max W. Jacobs, Shifaq Kamili, Lindsay Kim, Hannah L. Kirking, Miwako Kobayashi, Ram Koppaka, Yan Li, Stephen Lindstrom, Ruth Link-Gelles, Joana Lively, Xiaoyan Lu, Brian Lynch, Lakshmi Malapati, Mariel Marlow, Nancy McClung, Olivia McGovern, Tristan D. McPherson, Sung-sil Moon, Ruth N. Moro, Janna' Murray, Shannon Novosad, Sara E. Oliver, Clinton R. Paden, Mark A. Pallansch, Manisha Patel, Satich K. Pillai, Talia Pindyck, Ian Pray, Krista Queen, Heather Reese, Brian Rha, Heather Rhodes, Melissa A. Rolfes, Janell A. Routh, Senthilkumar K. Sakthivel, Sarah Scott, Varun Shetty, Bryan Stierman, Azaibi Tamin, Ying Tao, Natalie J. Thornburg, Suxiang Tong, Anna Uehara, Timothy M. Uyeki, Grace Vahey, Jennifer R. Verani, Megan Wallace, Lijuan Wang, John T. Watson, Matthew Westercamp, Brett Whitaker, Rebecca C. Woodruff, Jonathan M. Wortham, Amy Xie, Anna Yousaf, Jing Zhang, N Seema Ahmed, Jennifer O'Shea, William Stoecker, Francisco N. Alvarez, Rachel Bystritsky, Sajan Patel, Sharon Balter, Howard Chiou, Rebecca Fisher, Chelsea Foo, Prabhu Gounder, Jeffrey D. Gunzenhauser, Meredith Haddix, Claire Jarashow, Talar Kamali, Moon Kim, Jan King, Roshan Reporter, Dawn Terashita, Elizabeth Traub, Karri Bartlett, Amanda Kita-Yarbro, Michael A. Ben-Aderet, Jeremy Falk, Oren Friedman, Jonathan Grein, Gary I. Gutkin, Kelly Lo, Gregory Marks, Mitali Mehta, Margie Morgan, Rekha Murthy, Isabel Pedraza, Christopher Shepherd, Ethan A. Smith, Tiffany Wu, Stephanie R. Black, Marielle J. Fricchione, Jennifer E. Layden, Tristan D. McPherson, Massimo Pacilli, Brandon Bonin, Sara Cody, George S. Han, Sarah L. Rudman, Shanon Smith, Elsa Villarino, Catherine M. Brown, Jennifer Lo, Larry Madoff, Hollianne Bruce, Diane Buell, Suzanne Evans, Melissa M. Garcia, Graham Gerrard, Michelle Livingston, Philip Robinson, Regina Sy-Santos, E Matt Charles, Isaac Ghinai, Demian Christiansen, Kiran Joshi, Rachel Rubin, Traci DeSalvo, Thomas Haupt, Rachel Klos, Anna Kocharian, Ian Pray, George Diaz, Keith Erickson, Audrey Meier, Ahmet Tural, Sarah Wilkerson, Suzanne Donovan, Glenn E. Mathisen, Martin Fenstersheib, Lynn Mello, Kathleen Harriman, Cora Hoover, Michelle Holshue, Scott Lindquist, Kenneth K. Komatsu, Susan Robinson, Nichole Quick, Matthew Zahn, Sarah Scott, and Rebecca Sunenshine

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Reply to Barner and Bruno-Murtha., Ravina Kullar, Jerod Nagel, Susan C Bleasdale, Sarah H Sutton, Snezana Naumovski, Cheryl Smith, James E Leggett, Dana Wollins, Chris Busky, and Ellie J C Goldstein

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2020 ACC Expert Consensus Decision Pathway for Anticoagulant and Antiplatelet Therapy in Patients With Atrial Fibrillation or Venous Thromboembolism Undergoing Percutaneous Coronary Intervention or With Atherosclerotic Cardiovascular Disease: A Report of the American College of Cardiology Solution Set Oversight Committee, Dharam J. Kumbhani, Christopher P. Cannon, Craig J. Beavers, Deepak L. Bhatt, Adam Cuker, Tyler J Gluckman, Joseph E. Marine, Roxana Mehran, Steven R. Messe, Nimesh S. Patel, Benjamin E. Peterson, Kenneth Rosenfield, Sarah A. Spinler, and Vinod H. Thourani

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ANG1005, a brain penetrating peptide-drug conjugate, shows activity in patients with breast cancer with leptomeningeal carcinomatosis and recurrent brain metastases., Priya Kumthekar, Shou-Ching Tang, Andrew J Brenner, Santosh Kesari, David E Piccioni, Carey K Anders, Jose A Carrillo, Pavani Chalasani, Peter Kabos, Shannon L Puhalla, Katherine H R Tkaczuk, Agustin Garcia, Manmeet S Ahluwalia, Jeffrey S Wefel, Nehal Lakhani, and Nuhad K Ibrahim

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Perioperative Pain and Addiction Interdisciplinary Network (PAIN): consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users by a modified Delphi process., Karim S Ladha, Alexander McLaren-Blades, Akash Goel, Michael J Buys, Paul Farquhar-Smith, Simon Haroutounian, Yuvaraj Kotteeswaran, Kwesi Kwofie, Bernard Le Foll, Nicholas J Lightfoot, Joel Loiselle, Hamish Mace, Judith Nicholls, Aviva Regev, Leiv Arne Rosseland, Harsha Shanthanna, Avinash Sinha, Ainsley Sutherland, Rob Tanguay, Sherry Yafai, Martha Glenny, Paul Choi, Salima S J Ladak, Timothy Sean Leroux, Ian Kawpeng, Bana Samman, Rajbir Singh, and Hance Clarke

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Collection Management in the Age of Hospital Mergers, Elizabeth Laera, Aidy Weeks, Heather Martin, Jean Gudenas, and Angela Spencer

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Labor and delivery guidance for coronavirus disease 2019., David C. Lagrew and Laurence E Shields

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Guidance for Cardiac Electrophysiology During the Coronavirus (COVID-19) Pandemic from the Heart Rhythm Society COVID-19 Task Force; Electrophysiology Section of the American College of Cardiology; and the Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology, American Heart Association., Dhanunjaya R Lakkireddy, Mina K Chung, Rakesh Gopinathannair, Kristen K Patton, Tyler J Gluckman, Mohit Turagam, Jim Cheung, Parin Patel, Jaun Sotomonte, Rachel Lampert, Janet K Han, Bharath Rajagopalan, Lee Eckhardt, Jose Joglar, Kristin Sandau, Brian Olshansky, Elaine Wan, Peter A Noseworthy, Miguel Leal, Elizabeth Kaufman, Alejandra Gutierrez, Joseph M Marine, Paul J Wang, and Andrea M Russo

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Ineffective esophageal motility is not a contraindication to total fundoplication., Anne-Sophie Laliberte, Brian Louie, Candice L. Wilshire, Alexander S Farivar, Adam J Bograd, and Ralph W Aye

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Daytime sleepiness and functional outcomes after neurological insult., Kristen Marie Lane, Elena Crooks, Gina L. Sprint, and Douglas L Weeks

Impact of a Stroke Transitional Care Navigator at a Comprehensive Stroke Center Poster Presented at the International Stoke Conference, online, D Larsen, A Lesko, and E Baraban

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COVID-19 and cancer: A guide with suggested COVID-19 rule-out criteria to support clinical decision-making., Christopher Larson, Bryan Oronsky, Sharad Goyal, Carolyn Ray, Farah Hedjran, Terese C Hammond, Santosh Kesari, Scott Caroen, Michelle Lybeck, Vaughn E Dobalian, Arnold Oronsky, and Tony Reid

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Motor-sparing nerve blocks for total knee replacement: A scoping review., Sebastián Layera, Julián Aliste, Daniela Bravo, Mohammed Saadawi, Francis V Salinas, and De Q Tran

Coronary Atherosclerosis & Cardiovascular Risk Factors in Subjects with Clonal Hematopoiesis, Michael Layoun

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Virtual education in neurosurgery during the COVID-19 pandemic., Tyler Lazaro, Visish M Srinivasan, Maryam Rahman, Ashok Asthagiri, Garni Barkhoudarian, Lola B Chambless, Peter Kan, Ganesh Rao, Brian V Nahed, and Akash J Patel

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Patterns of Alcohol Use After Early Liver Transplantation for Alcoholic Hepatitis., Brian P Lee, Gene Y Im, John P Rice, Ann Lazar, Ethan Weinberg, Hyosun Han, Haripriya Maddur, R Mark Ghobrial, George Therapondos, Christine Hsu, Oren K Fix, Sheila Eswaran, Kirti Shetty, Jag Chhatwal, Ozden O Dalgic, Neha Jakhete, Constance Mobley, David W Victor, Neil Mehta, Lisanne Dinges, Mary Rinella, Thomas D Schiano, Michael R Lucey, and Norah Terrault

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Phase 1 study of CWP232291 in patients with relapsed or refractory acute myeloid leukemia and myelodysplastic syndrome., Je-Hwan Lee, Stefan Faderl, John M Pagel, Chul Won Jung, Sung-Soo Yoon, Animesh D Pardanani, Pamela S Becker, Howard Lee, Jeongeun Choi, Kyoungjune Lee, Minkyoung Kim, and Jorge E Cortes

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Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease., Min Young Lee, Junghee Lee, Seung Jae Hyeon, Hyesun Cho, Yu Jin Hwang, Jong-Yeon Shin, Ann C McKee, Neil W Kowall, Jong-Il Kim, Thor D Stein, Daehee Hwang, and Hoon Ryu

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Hurricanes, Wildfires, and Now a Pandemic: The Importance of Clinical Leadership, Thomas H. Lee and Amy Compton-Phillips

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Characterizing the cancer-associated microbiome with small RNA sequencing data., Wei-Hao Lee, Kai-Pu Chen, Kai Wang, Hsuan-Cheng Huang, and Hsueh-Fen Juan

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Invited Commentary., Eric J Lehr and John Petersen

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Asymptomatic, but not always benign - new insights into severe mitral regurgitation., Eric J Lehr and O Madalina Petrescu

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Effective therapy or double trouble? Simultaneous ECMO and thrombolysis of acute massive pulmonary embolism., Eric J Lehr and Ming Zhang

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386 Phase I/Ib first-in-human study of HEK-NIZ985, a recombinant IL-15/IL-15Rα heterodimer, alone and in combination with spartalizumab, in adults with advanced and metastatic solid tumors, Rom Leidner, Andrea Wang-Gillam, Sumati Gupta, Robert Wesolowski, Douglas McNeel, Kevin Conlon, Nehal Parikh, Jessica O'Keeffe, Niladri Roy Chowdhury, Xiaoli Wang, Ryan Sullivan, and John Thompson

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386 Phase I/Ib first-in-human study of HEK-NIZ985, a recombinant IL-15/IL-15Rα heterodimer, alone and in combination with spartalizumab, in adults with advanced and metastatic solid tumors, Rom Leidner, Andrea Wang-Gillam, Sumati Gupta, Robert Wesolowski, Douglas McNeel, Kevin Conlon, Nehal Parikh, Jessica O'Keeffe, Niladri Roy Chowdhury, Xiaoli Wang, Ryan Sullivan, and John Thompson

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Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry., Alexander Leitner, Alexandre M J J Bonvin, Christoph H Borchers, Robert J Chalkley, Julia Chamot-Rooke, Colin W Combe, Jürgen Cox, Meng-Qiu Dong, Lutz Fischer, Michael Götze, Fabio C Gozzo, Albert J R Heck, Michael R Hoopmann, Lan Huang, Yasushi Ishihama, Andrew R Jones, Nir Kalisman, Oliver Kohlbacher, Karl Mechtler, Robert L Moritz, Eugen Netz, Petr Novak, Evgeniy Petrotchenko, Andrej Sali, Richard A Scheltema, Carla Schmidt, David Schriemer, Andrea Sinz, Frank Sobott, Florian Stengel, Konstantinos Thalassinos, Henning Urlaub, Rosa Viner, Juan A Vizcaíno, Marc R Wilkins, and Juri Rappsilber

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Recognition to Treatment: The Roles of Emergency Medical Service Providers and Mobile Intensive Care Nurses in Sepsis, Jodee Lejnieks, Cyndie Strader, Linda Chirieleison, Cherry Tanjapatkul, and Ahlam Jadalla

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Academics in Absentia: An Opportunity to Rethink Conferences in the Age of Coronavirus Cancellations., Juan N Lessing, Lauren R Anderson, Nicholas M Mark, Lauren A Maggio, and Steven J Durning

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Clinical trial discrimination of physical function instruments for psoriatic arthritis: A systematic review., Ying-Ying Leung, Richard Holland, Ashish J Mathew, Christine Lindsay, Niti Goel, Alexis Ogdie, Ana-Maria Orbai, Pil Hojgaard, Jeffrey Chau, Laura C Coates, Vibeke Strand, Dafna D Gladman, Robin Christensen, William Tillett, and Philip Mease

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Appraisal of candidate instruments for assessment of the physical function domain in patients with psoriatic arthritis., Ying Ying Leung, Ana-Maria Orbai, Alexis Ogdie, Pil Hojgaard, Richard Holland, Niti Goel, Jeffrey Chau, Laura C Coates, Vibeke Strand, Dafna D Gladman, Philip Mease, Robin Christensen, and William Tillett

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The GRAPPA-OMERACT Working Group: 4 Prioritized Domains for Completing the Core Outcome Measurement Set for Psoriatic Arthritis 2019 Updates., Ying Ying Leung, William Tillett, Ana-Maria Orbai, Alexis Ogdie, Lihi Eder, Laura C Coates, Richard Holland, Anna Antony, Niti Goel, Philip Mease, Vibeke Strand, Oliver FitzGerald, Maarten de Wit, Christine A Lindsay, Kristina Callis Duffin, and Dafna D Gladman

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International consensus definitions of clinical trial outcomes for kidney failure: 2020., Adeera Levin, Rajiv Agarwal, William G Herrington, Hiddo L Heerspink, Johannes F E Mann, Shahnaz Shahinfar, Katherine Tuttle, Jo-Ann Donner, Vivekanand Jha, Masaomi Nangaku, Dick de Zeeuw, Meg J Jardine, Kenneth W Mahaffey, Aliza M Thompson, Mary Beaucage, Kate Chong, Glenda V Roberts, Duane Sunwold, Hans Vorster, Madeleine Warren, Sandrine Damster, Charu Malik, Vlado Perkovic, and participant authors of the International Society of Nephrology’s 1st International Consensus Meeting on Defining Kidney Failure in Clinical Trials

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Radiofrequency Ablation for the Palliative Treatment of Bone Metastases: Outcomes from the Multicenter OsteoCool Tumor Ablation Post-Market Study (OPuS One Study) in 100 Patients., Jason Levy, Thomas Hopkins, Jonathan Morris, Nam D Tran, Elizabeth David, Francesco Massari, Hamed Farid, Alexander Vogel, William G O'Connell, Peter Sunenshine, Robert Dixon, Afshin Gangi, Nicolas von der Höh, and Sandeep Bagla

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Longitudinal analysis reveals transition barriers between dominant ecological states in the gut microbiome., Roie Levy, Andrew T Magis, John C Earls, Ohad Manor, Tomasz Wilmanski, Jennifer Lovejoy, Sean M Gibbons, Gilbert S Omenn, Leroy Hood, and Nathan D Price

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Proceedings of the 2019 Santa Fe Bone Symposium: New Concepts in the Care of Osteoporosis and Rare Bone Diseases., E Michael Lewiecki, John P Bilezikian, Risa Kagan, Deborah Krakow, Michael R McClung, Paul D Miller, Eric T Rush, Christopher R Shuhart, Nelson B Watts, and Elaine W Yu

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Metabolic Dynamics and Prediction of Gestational Age and Time to Delivery in Pregnant Women., Liang Liang, Marie-Louise Hee Rasmussen, Brian D. Piening, Xiaotao Shen, Songjie Chen, Hannes Röst, John K Snyder, Robert Tibshirani, Line Skotte, Norman Cy Lee, Kévin Contrepois, Bjarke Feenstra, Hanyah Zackriah, Michael Snyder, and Mads Melbye

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Response: D-dimer triage for COVID-19., Chenghong Li, Zhenguo Zhai, and Bruce L Davidson

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MEMOTE for standardized genome-scale metabolic model testing., Christian Lieven, Moritz E Beber, Brett G Olivier, Frank T Bergmann, Meric Ataman, Parizad Babaei, Jennifer A Bartell, Lars M Blank, Siddharth Chauhan, Kevin Correia, Christian Diener, Andreas Dräger, Birgitta E Ebert, Janaka N Edirisinghe, José P Faria, Adam M Feist, Georgios Fengos, Ronan M T Fleming, Beatriz García-Jiménez, Vassily Hatzimanikatis, Wout van Helvoirt, Christopher S Henry, Henning Hermjakob, Markus J Herrgård, Ali Kaafarani, Hyun Uk Kim, Zachary King, Steffen Klamt, Edda Klipp, Jasper J Koehorst, Matthias König, Meiyappan Lakshmanan, Dong-Yup Lee, Sang Yup Lee, Sunjae Lee, Nathan E Lewis, Filipe Liu, Hongwu Ma, Daniel Machado, Radhakrishnan Mahadevan, Paulo Maia, Adil Mardinoglu, Gregory L Medlock, Jonathan M Monk, Jens Nielsen, Lars Keld Nielsen, Juan Nogales, Intawat Nookaew, Bernhard O Palsson, Jason A Papin, Kiran R Patil, Mark Poolman, Nathan D Price, Osbaldo Resendis-Antonio, Anne Richelle, Isabel Rocha, Benjamín J Sánchez, Peter J Schaap, Rahuman S Malik Sheriff, Saeed Shoaie, Nikolaus Sonnenschein, Bas Teusink, Paulo Vilaça, Jon Olav Vik, Judith A H Wodke, Joana C Xavier, Qianqian Yuan, Maksim Zakhartsev, and Cheng Zhang

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Publisher Correction: MEMOTE for standardized genome-scale metabolic model testing., Christian Lieven, Moritz E Beber, Brett G Olivier, Frank T Bergmann, Meric Ataman, Parizad Babaei, Jennifer A Bartell, Lars M Blank, Siddharth Chauhan, Kevin Correia, Christian Diener, Andreas Dräger, Birgitta E Ebert, Janaka N Edirisinghe, José P Faria, Adam M Feist, Georgios Fengos, Ronan M T Fleming, Beatriz García-Jiménez, Vassily Hatzimanikatis, Wout van Helvoirt, Christopher S Henry, Henning Hermjakob, Markus J Herrgård, Ali Kaafarani, Hyun Uk Kim, Zachary King, Steffen Klamt, Edda Klipp, Jasper J Koehorst, Matthias König, Meiyappan Lakshmanan, Dong-Yup Lee, Sang Yup Lee, Sunjae Lee, Nathan E Lewis, Filipe Liu, Hongwu Ma, Daniel Machado, Radhakrishnan Mahadevan, Paulo Maia, Adil Mardinoglu, Gregory L Medlock, Jonathan M Monk, Jens Nielsen, Lars Keld Nielsen, Juan Nogales, Intawat Nookaew, Bernhard O Palsson, Jason A Papin, Kiran R Patil, Mark Poolman, Nathan D Price, Osbaldo Resendis-Antonio, Anne Richelle, Isabel Rocha, Benjamín J Sánchez, Peter J Schaap, Rahuman S Malik Sheriff, Saeed Shoaie, Nikolaus Sonnenschein, Bas Teusink, Paulo Vilaça, Jon Olav Vik, Judith A H Wodke, Joana C Xavier, Qianqian Yuan, Maksim Zakhartsev, and Cheng Zhang

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iREAD: a tool for intron retention detection from RNA-seq data., Hong-Dong Li, Cory C Funk, and Nathan D Price

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IsoResolve: Predicting Splice Isoform Functions by Integrating Gene and Isoform-level Features with Domain Adaptation., Hong-Dong Li, Changhuo Yang, Zhimin Zhang, Mengyun Yang, Fang-Xiang Wu, Gilbert S Omenn, and Jianxin Wang

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Abstract 219: Use of Machine Learning Models to Identify Atherosclerotic Cardiovascular Disease Patients at Very High Risk for Future Events in a Multi-state Health Care System, Hsin-Fang Li, Amir Ali, Kateri Spinelli, A Sajja, SS Virani, SS Martin, and Tyler J Gluckman

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Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer., Ling Li, Lisa Hobson, Laura Perry, Bethany Clark, Susan Heavey, Aiman Haider, Ashwin Sridhar, Greg Shaw, John Kelly, Alex Freeman, Ian Wilson, Hayley Whitaker, Elmar Nurmemmedov, Sebastian Oltean, Sean Porazinski, and Michael Ladomery

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A Deep-Learning Algorithm (ECG12Net) for Detecting Hypokalemia and Hyperkalemia by Electrocardiography: Algorithm Development., Chin-Sheng Lin, Chin Lin, Wen-Hui Fang, Chia-Jung Hsu, Sy-Jou Chen, Kuo-Hua Huang, Wei-Shiang Lin, Chien-Sung Tsai, Chih-Chun Kuo, Tom Chau, Stephen Jh Yang, and Shih-Hua Lin

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Nursing Clinical Ladder Program: The Embedded Librarian, Danielle Linden

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Effective Prevention of Proximal Junctional Failure in Adult Spinal Deformity Surgery Requires a Combination of Surgical Implant Prophylaxis and Avoidance of Sagittal Alignment Overcorrection., Breton G Line, Shay Bess, Renaud Lafage, Virgine Lafage, Frank Schwab, Christopher Ames, Han Jo Kim, Michael Kelly, Munish Gupta, Douglas Burton, Robert A Hart, Eric Klineberg, Khaled Kebaish, Richard Hostin, Gregory Mundis, Robert Eastlack, Christopher Shaffrey, and Justin S Smith

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Complications Associated With Ureteroscopic Management of Upper Tract Urothelial Carcinoma., Jennifer M Linehan, Mark Schoenberg, Elyse Seltzer, Kim Thacker, and Angela B Smith

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Mesenchymal stem cells as living anti-inflammatory therapy for COVID-19 related acute respiratory distress syndrome., Feng Lin, Thomas E Ichim, Sandeep Pingle, Lawrence D Jones, Santosh Kesari, and Shashaanka Ashili

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Intracranial Efficacy and Survival With Tucatinib Plus Trastuzumab and Capecitabine for Previously Treated HER2-Positive Breast Cancer With Brain Metastases in the HER2CLIMB Trial., Nancy U Lin, Virginia Borges, Carey Anders, Rashmi K Murthy, Elisavet Paplomata, Erika Hamilton, Sara Hurvitz, Sherene Loi, Alicia Okines, Vandana Abramson, Philippe L Bedard, Mafalda Oliveira, Volkmar Mueller, Amelia Zelnak, Michael P DiGiovanna, Thomas Bachelot, A Jo Chien, Ruth O'Regan, Andrew Wardley, Alison Conlin, David Cameron, Lisa Carey, Giuseppe Curigliano, Karen Gelmon, Sibylle Loibl, JoAl Mayor, Suzanne McGoldrick, Xuebei An, and Eric P Winer

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Prospective Molecular Profiling of Circulating Tumor Cells from Patients with Melanoma Receiving Combinatorial Immunotherapy., Selena Y Lin, Shu-Ching Chang, Stella Lam, Romela Irene Ramos, Kevin Tran, Shuichi Ohe, Matthew P Salomon, Ali Asgar S Bhagat, Chwee Teck Lim, Trevan D Fischer, Leland J Foshag, Christine L Boley, Steven J O'Day, and Dave Hoon

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Sequential Pilot Trials of Aliviado Dementia Care to Inform an Embedded Pragmatic Clinical Trial., Shih-Yin Lin, Catherine E Schneider, Alycia A Bristol, Maureen Clancy, Sara A Sprague, Melissa Aldridge, Tara Cortes, Keith S Goldfeld, Jean S Kutner, Susan L Mitchell, Joseph W Shega, Bei Wu, Carolyn W Zhu, and Abraham A Brody

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Societal Impact of COVID-19, Chris Little and Rhonda Medows

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Predicting breast cancer response to neoadjuvant treatment using multi-feature MRI: results from the I-SPY 2 TRIAL., Wen Li, David C Newitt, Jessica Gibbs, Lisa J Wilmes, Ella F Jones, Vignesh A Arasu, Fredrik Strand, Natsuko Onishi, Alex Anh-Tu Nguyen, John Kornak, Bonnie N Joe, Elissa R Price, Haydee Ojeda-Fournier, Mohammad Eghtedari, Kathryn W Zamora, Stefanie A Woodard, Heidi Umphrey, Wanda Bernreuter, Michael Nelson, An Ly Church, Patrick Bolan, Theresa Kuritza, Kathleen Ward, Kevin Morley, Dulcy Wolverton, Kelly Fountain, Dan Lopez-Paniagua, Lara Hardesty, Kathy Brandt, Elizabeth S McDonald, Mark Rosen, Despina Kontos, Hiroyuki Abe, Deepa Sheth, Erin P Crane, Charlotte Dillis, Pulin Sheth, Linda Hovanessian-Larsen, Dae Hee Bang, Bruce Porter, Karen Y Oh, Neda Jafarian, Alina Tudorica, Bethany L Niell, Jennifer Drukteinis, Mary S Newell, Michael A Cohen, Marina Giurescu, Elise Berman, Constance Lehman, Savannah C Partridge, Kimberly A Fitzpatrick, Marisa H Borders, Wei T Yang, Basak Dogan, Sally Goudreau, Thomas Chenevert, Christina Yau, Angela DeMichele, Don Berry, Laura J Esserman, and Nola M Hylton

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Clinical Characteristics of 46 Pregnant Women with a SARS-CoV-2 Infection in Washington State., Erica M Lokken, Christie L Walker, Shani Delaney, Alisa Kachikis, Nicole M Kretzer, Anne Erickson, Rebecca Resnick, Jeroen Vanderhoeven, Joseph K Hwang, Nena Barnhart, Jasmine Rah, Stephen A Mccartney, Kimberly K Ma, Emily M Huebner, Chad Thomas, Jessica S Sheng, Bettina W Paek, Kristin Retzlaff, Carolyn R Kline, Jeff Munson, Michela Blain, Sylvia M Lacourse, Gail Deutsch, and Kristina Adams Waldorf

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The power of social media: A call for change in professional perspective., Kira Long

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Multicenter validation of association between decline in MRI-PDFF and histologic response in nonalcoholic steatohepatitis., Rohit Loomba, Brent A Neuschwander-Tetri, Arun Sanyal, Naga Chalasani, Anna Mae Diehl, Norah Terrault, Kris Kowdley, Srinivasan Dasarathy, David Kleiner, Cynthia Behling, Joel Lavine, Mark Van Natta, Michael Middleton, James Tonascia, and Claude Sirlin

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Selective Translation of Low Abundance and Upregulated Transcripts in Halobacterium salinarum., Adrián López García de Lomana, Ulrike Kusebauch, Arjun V Raman, Min Pan, Serdar Turkarslan, Alan P R Lorenzetti, Robert L Moritz, and Nitin Baliga

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CT301 - A phase Ib study to evaluate RO7198457, an individualized Neoantigen Specific immunoTherapy (iNeST), in combination with atezolizumab in patients with locally advanced or metastatic solid tumors, Juanita S. Lopez, Ross Camidge, Marco Iafolla, Sylvie Rottey, Martin Schuler, Matthew Hellmann, Ali Balmanoukian, Luc Dirix, Michael Gordon, Ryan Sullivan, Brian S. Henick, Charles Drake, Kit Wong, Patricia LoRusso, Patrick Ott, Lawrence Fong, Aglaia Schiza, Jeffrey Yachnin, Christian Ottensmeier, Fadi Braiteh, Johanna Bendell, Rom Leidner, George Fisher, Guy Jerusalem, Laura Molenaar-Kuijsten, Marcus Schmidt, Scott A. Laurie, Raid Aljumaily, Achim Rittmeyer, Eelke Gort, Ignacio Melero, Lars Mueller, Rachel Sabado, Patrick Twomey, Jack Huang, Manesh Yadav, Jingbin Zhang, Felicitas Mueller, Evelyna Derhovanessian, Ugur Sahin, Ozlem Tureci, and Thomas Powles

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Abstract CT301: A phase Ib study to evaluate RO7198457, an individualized Neoantigen Specific immunoTherapy (iNeST), in combination with atezolizumab in patients with locally advanced or metastatic solid tumors, Juanita S. Lopez, Ross Camidge, Marco Iafolla, Sylvie Rottey, Martin Schuler, Matthew Hellmann, Ani Balmanoukian, Luc Dirix, Michael Gordon, Ryan Sullivan, Bryan S. Henick, Chares Drake, Kit Wong, Patricia LoRusso, Patrick Ott, Lawrence Fong, Aglaia Schiza, Jeffrey Yachnin, Christian Ottensmeier, Fadi Braiteh, Joanna Bendell, Rom Leidner, George Fisher, Guy Jerusalem, Laura Molenaar-Kuijsten, Marcus Schmidt, Scott A. Laurie, Raid Aljumaily, Achim Rittmeyer, Eelke Gort, Ignacio Melero, Lars Mueller, Rachel Sabado, Patrick Twomey, Jack Huang, Manesh Yadav, Jingbin Zhang, Felicitas Mueller, Evelyna Derhovanessian, Ugur Sahin, Ozlem Tureci, and Thomas Powels

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SCAI expert consensus statement on out of hospital cardiac arrest., Amir Lotfi, Lloyd W Klein, Ravi S Hira, Jaya Mallidi, Roxana Mehran, John C Messenger, Duane S Pinto, Michael R Mooney, Tanveer Rab, Demetri Yannopoulos, and Sean van Diepen

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Commentary: Defining low-risk lesions for esophageal preservation informed by resecting the organ., Brian Louie

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Commentary: Toward Minimally Invasive Management of Epiphrenic Diverticula., Brian Louie

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Response to the Comment on "Objective Evidence of Reflux Control After Magnetic Sphincter Augmentation: One Year Results From a Post Approval Study"., Brian Louie, Christy Dunst, and John C Lipham

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Perioperative Anticoagulation Management in Spine Surgery: Initial Findings From the AO Spine Anticoagulation Global Survey., Philip Louie, Garrett Harada, James Harrop, Thomas Mroz, Khalid Al-Saleh, Giovanni Barbanti Brodano, Jens R Chapman, Michael Fehlings, Serena Hu, Yoshiharu Kawaguchi, Michael Mayer, Venugopal Menon, Jong-Beom Park, Sheeraz Qureshi, Shanmuganathan Rajasekaran, Marcelo Valacco, Luiz Vialle, Jeffrey C Wang, Karsten Wiechert, K Daniel Riew, and Dino Samartzis

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154 Marrow-infiltrating lymphocytes (MILs): A novel adoptive immunotherapy for hematological and solid tumors, Eric Lutz, Lakshmi Rudraraju, Elizabeth DeOliveira, Amanda Seiz, Monil Shah, Celine Colmenares, Beverly Dan Fu, Daniela Bota, Collin Brummel, Chad Brenner, Paul Swiecicki, Nicole E. Fredich, David B Page, Eleni Efstatihiou, Ivan Borrello, and Kimberly Noonan

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154 Marrow-infiltrating lymphocytes (MILs): A novel adoptive immunotherapy for hematological and solid tumors, Eric Lutz, Lakshmi Rudraraju, Elizabeth DeOliveira, Amanda Seiz, Monil Shah, Celine Colmenares, Beverly Dan Fu, Daniela Bota, Collin Brummel, Chad Brenner, Paul Swiecicki, Nicole E. Fredich, David B Page, Eleni Efstatihiou, Ivan Borrello, and Kimberly Noonan

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Pregnancy associated breast cancer., Heather MacDonald

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COVID-19 Clinical Guidance For the Cardiovascular Care Team, Thomas M. Maddox, Eric C. Stecker, Biykem Bozkurt, Nathalie DeMichelis, John U. Doherty, Andrew Freeman, Tyler J Gluckman, Dipti Itchhaporia, Andrew P. Miller, Andrea L. Price, Lonny Reisman, Prem Soman, Mohammad Madjid, Scott D. Solomon, and Orly Vardeny

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A synthesis of bacterial and archaeal phenotypic trait data., Joshua S Madin, Daniel A Nielsen, Maria Brbic, Ross Corkrey, David Danko, Kyle Edwards, Martin K M Engqvist, Noah Fierer, Jemma L Geoghegan, Michael Gillings, Nikos C Kyrpides, Elena Litchman, Christopher E Mason, Lisa Moore, Søren L Nielsen, Ian T Paulsen, Nathan D Price, T B K Reddy, Matthew A Richards, Eduardo P C Rocha, Thomas M Schmidt, Heba Shaaban, Maulik Shukla, Fran Supek, Sasha G Tetu, Sara Vieira-Silva, Alice R Wattam, David A Westfall, and Mark Westoby

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Superior Extended Nasal Myocutaneous Island Flap: An Alternative to Forehead Flap Reconstruction of the Nose., Simon Madorsky, Anthony Do, and Orr Meltzer

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Myomucosal Lip Island Flap for Reconstruction of Small to Medium Lower Lip Defects., Simon Madorsky and Orr Meltzer

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Untargeted longitudinal analysis of a wellness cohort identifies markers of metastatic cancer years prior to diagnosis., Andrew T Magis, Noa Rappaport, Matthew P Conomos, Gilbert S Omenn, Jennifer C Lovejoy, Leroy Hood, and Nathan D Price

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Statin Prescription Rates, Adherence, and Associated Clinical Outcomes Among Women with PAD and ICVD., Dhruv Mahtta, Sarah T Ahmed, David J Ramsey, Julia M Akeroyd, Michelle T Lee, Fatima Rodriguez, Erin D Michos, Dipti Itchhaporia, Khurram Nasir, Mahboob Alam, Hani Jneid, Christie M Ballantyne, Laura A Petersen, and Salim S Virani

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Hospital-Level Variation in the Frequency of Cesarean Delivery Among Nulliparous Women Who Undergo Labor Induction., Elliott K Main, Shen-Chih Chang, Yvonne W Cheng, Melissa G Rosenstein, and David C. Lagrew

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Five-Year Outcomes of Transcatheter or Surgical Aortic-Valve Replacement., Raj R Makkar, Vinod H Thourani, Michael J Mack, Susheel K Kodali, Samir Kapadia, John G Webb, Sung-Han Yoon, Alfredo Trento, Lars G Svensson, Howard C Herrmann, Wilson Y Szeto, D Craig Miller, Lowell Satler, David J Cohen, Todd M Dewey, Vasilis Babaliaros, Mathew R Williams, Dean J Kereiakes, Alan Zajarias, Kevin L Greason, Brian K Whisenant, Robert W. Hodson, David L Brown, William F Fearon, Mark J Russo, Philippe Pibarot, Rebecca T Hahn, Wael A Jaber, Erin Rogers, Ke Xu, Jaime Wheeler, Maria C Alu, Craig R Smith, and Martin B Leon

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Lenvatinib (LEN) plus pembrolizumab (PEMBRO) for early-line treatment of advanced/recurrent endometrial cancer (EC)., Vicky Makker, Matthew H Taylor, Carol Aghajanian, Ana Oaknin, James Mier, Allen Lee Cohn, Margarita Romeo, Raquel Bratos, Marcia S. Brose, Christopher DiSimone, Mark Messing, Lea Dutta, Min Ren, Emmett V. Schmidt, Robert Orlowski, Jodi Alicia McKenzie, Kathryn Gillis, and Antonio Casado Herraez

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Lenvatinib Plus Pembrolizumab in Patients With Advanced Endometrial Cancer., Vicky Makker, Matthew H Taylor, Carol Aghajanian, Ana Oaknin, James Mier, Allen L Cohn, Margarita Romeo, Raquel Bratos, Marcia S Brose, Christopher DiSimone, Mark Messing, Daniel E Stepan, Corina E Dutcus, Jane Wu, Emmett V Schmidt, Robert Orlowski, Pallavi Sachdev, Robert Shumaker, and Antonio Casado Herraez

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Response to Letter to the Editor re: Correction About the Nursing Delirium Screening Scale (Nu-DESC) in Response to: "A Study of the Psychometric Properties of the "Stanford Proxy Test for Delirium" (S-PTD): A New Screening Tool for the Detection of Delirium"., Jose R Maldonado, Yelizaveta I Sher, Mario Alberto Benitez-Lopez, Vidushi Savant, Renee Garcia, Andrea Ament, and Earl De Guzman

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PD47-04 SINGLE CELL RNA-SEQUENCING OF FRESH SUPERFICIAL NON-MUSCLE INVASIVE BLADDER CANCER DEMONSTRATES GENE EXPRESSSION PATHWAY DIFFFERENCES BETWEEN HIGH AND LOW GRADE TUMORS, Stanley Malkowiicz, Brian D. Piening, Alexa Dowdell, David Walls, Nik Nair, Baoli Chang, and Brendan Keating

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Tuberculum Sellae Meningiomas in Pregnancy: 3 Cases Treated in the Second Trimester and Literature Review., Regin Jay Mallari, Jai Deep Thakur, Chester Griffiths, Howard Krauss, Amy Eisenberg, Garni Barkhoudarian, and Daniel F Kelly

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Graph-based exploitation of gene ontology using GOxploreR for scrutinizing biological significance., Kalifa Manjang, Shailesh Tripathi, Olli Yli-Harja, Matthias Dehmer, and Frank Emmert-Streib

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Alpha1-Antitrypsin Deficiency: A Cause of Chronic Liver Disease., Vignan Manne and Kris V Kowdley

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Health and disease markers correlate with gut microbiome composition across thousands of people., Ohad Manor, Chengzhen L Dai, Sergey A Kornilov, Brett Smith, Nathan D Price, Jennifer C Lovejoy, Sean M Gibbons, and Andrew T Magis

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A phase I/II study of rovalpituzumab tesirine in delta-like 3-expressing, advanced solid tumors., Aaron Scott Mansfield, David S. Hong, Christine L. Hann, Anna F. Farago, Himisha Beltran, Saiama Naheed Waqar, Andrew Eugene Hendifar, Lowell Brian Anthony, Matthew H Taylor, Alan Haruo Bryce, Scott T. Tagawa, Karl D. Lewis, Jiaxin Niu, Christine H. Chung, James M. Cleary, Michael Rossi, Carrianne Ludwig, Ricardo Valenzuela, Yan Luo, and Rahul Raj Aggarwal

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The Efficacy and Safety of Transversus Abdominis Plane Blocks After Open Cholecystectomy in Low- and Middle-Income Countries., Amtul Mansoor, Stephen Ellwood, Gary Hoffman, Anthony J Scholer, Amy Gore, Dennis Grech, Bradley Patrick, and Ziad Sifri

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Effect of obesity and overweight status on complications and survival after minimally invasive kidney surgery in patients with clinical t2 renal masses., Michele Marchioni, Francesco Berardinelli, Chao Zhang, Giuseppe Simone, Robert Uzzo, Umberto Capitanio, Andrea Minervini, Clayton Lau, Jihad Kaouk, Peter Langestroer, Enrico Checcucci, Nicolò De Luyk, James Robert Porter, Michele Gallucci, Alexander Kutikov, Alessandro Larcher, Andrea Mari, Patrick Sean Kilday, Koon Ho Rha, Giuseppe Quarto, Sisto Perdona, Wesley White, Daniel Eun, Ithaar H Derweesh, Alexandre Mottrie, Uzoma Arnold Anele, Kenneth M Jacobsohn, Francesco Porpiglia, Benjamin Challacombe, Chandru P Sundaram, Riccardo Autorino, Bo Yang, and Luigi Schips