Case Series of Histopathological Findings in Chronic Kidney Disease: Insights From the Kidney Precision Medicine Project.
Publication Title
Kidney Med
Document Type
Article
Publication Date
2-1-2026
Keywords
Chronic kidney disease; diabetes; histopathology; hypertension; kidney biopsy.
Abstract
RATIONALE & OBJECTIVE: The Kidney Precision Medicine Project is obtaining kidney biopsies from people with chronic kidney disease (CKD) and acute kidney injury for comprehensive clinical, histopathological, and molecular characterization. Here, we describe histopathological findings from a subset of kidney biopsies from adults with CKD.
STUDY DESIGN: Descriptive case series of histopathology findings from adjudicated CKD biopsies.
SETTING & PARTICIPANTS: Kidney Precision Medicine Project enrolled adults with CKD and diabetes (DKD) and/or hypertension (HCKD) with persistent eGFR 30-59 mL/min/1.73 m
EXPOSURES: This is a descriptive study without defined exposures.
OUTCOMES: Characterization of glomerular, tubulointerstitial, and vascular histopathological features across CKD biopsies.
ANALYTICAL APPROACH: Continuous variables were summarized as mean (standard deviation) or median (interquartile range); categorial variables were summarized as count (percentage).
RESULTS: Participants' mean age was 59 years, 59% were female. Mean eGFR was 55 mL/min/1.73 m
LIMITATIONS: Small sample size and lack of longitudinal data limit generalizability.
CONCLUSIONS: Kidney biopsies in people with common causes of CKD demonstrate a broad range of histopathology and may have clinical utility. Unsuspected disease processes and unexpected and nonspecific findings precluding a definitive diagnosis are often present.
Area of Special Interest
Kidney & Diabetes
DOI
10.1016/j.xkme.2025.101206
