Clinical potential and challenges of spatially profiling tumor-infiltrating lymphocytes in early-stage breast cancer.

Publication Title

PLoS medicine / Public Library of Science

Authors

• David B Page, Providence Cancer Institute, Portland, OR USA; Earle A. Chiles Research Institute, Portland, OR USAFollow
• Michael Simanonok, Earle A. Chiles Research Institute, Portland, OR USA; Center for Cardiovascular Analytics, Research and Data Science (CARDS), Providence Heart Institute, Providence Research Network, Portland, OR USAFollow
• Douglas A Hanes, Earle A. Chiles Research Institute, Portland, OR USAFollow
• Alan Su, Earle A. Chiles Research Institute, Portland, OR USAFollow

Document Type

Article

Publication Date

3-1-2026

Keywords

oregon; portland; chiles; cards; cards publication

Abstract

Digitally automated spatial profiling of immune-tumor cell interactions using multispectral immunofluorescence holds promise as a biomarker to predict outcomes in early-stage breast cancer, but prospective validation and harmonization with existing biomarkers is necessary before clinical adoption.

Area of Special Interest

Cardiovascular (Heart)

Area of Special Interest

Cancer

Area of Special Interest

Women & Children

Specialty/Research Institute

Earle A. Chiles Research Institute

Specialty/Research Institute

Center for Cardiovascular Analytics, Research and Data Science (CARDS)

Specialty/Research Institute

Oncology

DOI

10.1371/journal.pmed.1004979