NTRK fusions and concomitant immune and genomic landscape detected by DNA and RNA comprehensive genomic profiling in a large healthcare system

Publication Title

Front Med (Lausanne)

Authors

• Alexa K Dowdell, Earle A. Chiles Research Institute, Portland, OR, United States.; Providence St. Joseph Health, Portland, OR, United States.Follow
• Thomas R. Ward, Providence St. Joseph Health, Portland, OR, United States.Follow
• Lauren Hamilton, Earle A. Chiles Research Institute, Portland, OR, United States.; Providence St. Joseph Health, Portland, OR, United States.Follow
• Roshanthi Weerasinghe, Providence St. Joseph Health, Portland, OR, United States.Follow
• Erica Schnettler
• Pratheesh Sathyan
• Alison Roos
• Josiah T Wagner, Providence St. Joseph Health, Portland, OR, United States.Follow
• John Welle, Providence St. Joseph Health, Portland, OR, United States.Follow
• Ryan Meng, Earle A. Chiles Research Institute, Portland, OR, United States.; Providence St. Joseph Health, Portland, OR, United States.Follow
• Alexandra Q Bartlett, Earle A. Chiles Research Institute, Portland, OR, United States.; Providence St. Joseph Health, Portland, OR, United States.Follow
• Carlo Bifulco, Earle A. Chiles Research Institute, Portland, OR, United States.; Providence St. Joseph Health, Portland, OR, United States.Follow
• Brian D. Piening, Earle A. Chiles Research Institute, Portland, OR, United States.; Providence St. Joseph Health, Portland, OR, United States.Follow

Document Type

Article

Publication Date

1-1-2026

Keywords

NTRK; actionability; fusion; pan-cancer; real world evidence (RWE).; oregon; chiles; genomics

Abstract

INTRODUCTION: The use of next-generation sequencing (NGS) in clinical investigations has enabled the identification of actionable biomarkers across tumor histologies, paving the way for the development of pan-tumor therapies. Gene fusions involving

METHODS: In this study, we investigated the frequency of

RESULTS: Among 15,128 adult patients, CGP identified 30 pathogenic

DISCUSSION: These findings highlight the value of RNA-based NGS, particularly when used alongside DNA NGS, to provide a comprehensive assessment of

Area of Special Interest

Cancer

Specialty/Research Institute

Oncology

DOI

10.3389/fmed.2026.1764392