Periocular Rejuvenation with PRF Gel.
Publication Title
Facial plastic surgery : FPS
Document Type
Article
Publication Date
4-28-2026
Keywords
california; pni; santa monica
Abstract
Aim and background: Age-related changes in the periorbital region contribute to tear trough deepening and infraorbital hollowing, which create a fatigued appearance.
Historical aspect: Platelet concentrates have been used for many years for their regenerative capabilities. Platelet-rich fibrin (PRF) Gel has recently been introduced as a natural alternative to hyaluronic acid (HA) fillers for periorbital rejuvenation.
Anatomy: The main cause for periorbital hollowness is volume loss in the fat pads, most specifically the sub-orbicularis oculi fat (SOOF).
Patient selection: PRF Gel is well-suited for patients seeking a conservative approach, especially those with prior HA-related complications or compromised lymphatic drainage.
Techniques: PRF Gel is created by combining denatured albumin (2,600 rpm, 7 minutes) with liquid PRF (1,100 rpm, 5 minutes) in a 3.5:1.5 cc ratio to form an injectable gel.
Postoperative care: Treatment requires minimal downtime and fewer restrictions compared to HA fillers.
Current and future development: Prospective observations show progressive volume improvement with repeated treatments. Refinement of centrifugation and protocols may further enhance clinical outcomes.
Conclusion and clinical relevance: PRF Gel offers a new and autologous treatment to patients who are seeking a more conservative and natural approach to under-eye rejuvenation.
Area of Special Interest
Neurosciences (Brain & Spine)
Specialty/Research Institute
Neurosciences
Specialty/Research Institute
Plastic Surgery
DOI
10.1055/a-2849-8705
