Investigating Associations Between Psychological Distress and Changes in Peripheral Blood Monocytes in Patients With CLL/SLL Managed With Active Surveillance.
Publication Title
Cancer Med
Document Type
Article
Publication Date
5-1-2026
Keywords
Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Female; Monocytes; Male; Middle Aged; Aged; Psychological Distress; Watchful Waiting; Stress, Psychological; Killer Cells, Natural; Anxiety; Aged, 80 and over; chronic lymphocytic leukemia (CLL); monocytes; psychological distress.; washington; swedish; swedish cancer
Abstract
Asymptomatic patients with a new diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) are commonly managed by active surveillance as per International Workshop on Chronic Lymphocytic Leukemia (iwCLL) criteria; however, many patients report elevated distress during surveillance. Psychological distress may have biologic implications given that natural killer [NK] cells, T cells, and monocytes are not only sensitive to distress, but also critical in controlling disease progression. Therefore, the objective of this study was to explore associations of distress with immune biomarkers in patients with CLL/SLL being managed by active surveillance. We enrolled 76 participants and assessed perceived stress, anxiety, and depressive symptoms at study entry and every 6 months for up to 2 years during active surveillance. Blood samples were collected at the same time points to assess biomarkers on T cell, NK cell, and monocyte subsets. In multivariable regression analyses, higher levels of perceived stress and anxiety were significantly associated with lower percentages of intermediate monocytes (IM); anxiety was also significantly associated with higher percentages of classical monocytes (CM). In longitudinal analyses, higher stress and anxiety were significantly associated with higher percentages of CM at 12 months. This is one of the first studies to observe that psychological distress is associated with differential patterns of monocyte distribution in patients with CLL/SLL managed with active surveillance.
Area of Special Interest
Cancer
Area of Special Interest
Mental Health
Specialty/Research Institute
Oncology
Specialty/Research Institute
Behavioral Health
DOI
10.1002/cam4.71903
