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Submissions from 2024

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Safety and real-world dosing of onabotulinumtoxinA for the treatment of adult spasticity: post hoc analysis of the Adult Spasticity International Registry study., Ganesh Bavikatte, Alberto Esquenazi, Michael A Dimyan, Khashayar Dashtipour, Wuwei Feng, Angeli Mayadev, Kristina Fanning, Tiziana Musacchio, Aleksej Zuzek, and Gerard E Francisco

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Diroximel Fumarate in Patients with Relapsing-Remitting Multiple Sclerosis: NEDA-3 After Re-Baselining in the Phase 3 EVOLVE-MS-1 Study., J D Bowen, Jessica Stulc, Samuel F Hunter, Hailu Chen, James B Lewin, Matthew Scaramozza, Ivan Bozin, and Florian Then Bergh

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Letter to the Editor: Terminology of intraneural invasion, perineural invasion and perineural spread., Stepan Capek, R Shane Tubbs, and Robert J Spinner

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Let's Put AI to Really Good Use!, Jens R Chapman, Jeff Wang, and Karsten Wiechert

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Beyond Dogma: The Three E Test for New Technologies., Jens R Chapman, Karsten Wiechert, and Jeffrey C Wang

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In Memoriam: Dr. Takanori Fukushima (1942–2024), Manuel De Jesus Encarnacion Ramirez, Nicola Montemurro, Renat Nurmukhametov, Matias Costa, Alvaro Campero, Miguel Angel Arraez, and Matias Baldoncini

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Hip Osteoarthritis in Patients Undergoing Surgery for Severe Adult Spinal Deformity: Prevalence and Impact on Spine Surgery Outcomes., Bassel G Diebo, Daniel Alsoof, Mariah Balmaceno-Criss, Mohammad Daher, Renaud Lafage, Peter G Passias, Christopher P Ames, Christopher I Shaffrey, Douglas C Burton, Vedat Deviren, Breton G Line, Alex Soroceanu, D Kojo Hamilton, Eric O Klineberg, Gregory M Mundis, Han Jo Kim, Jeffrey L Gum, Justin S Smith, Juan S Uribe, Khaled M Kebaish, Munish C Gupta, Pierce D Nunley, Robert K Eastlack, Richard Hostin, Themistocles S Protopsaltis, Lawrence G Lenke, Robert A Hart, Frank J Schwab, Shay Bess, Virginie Lafage, and Alan H Daniels

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Impact of Self-Reported Loss of Balance and Gait Disturbance on Outcomes following Adult Spinal Deformity Surgery., Bassel G Diebo, Daniel Alsoof, Renaud Lafage, Mohammad Daher, Mariah Balmaceno-Criss, Peter G Passias, Christopher P Ames, Christopher I Shaffrey, Douglas C Burton, Vedat Deviren, Breton G Line, Alex Soroceanu, David Kojo Hamilton, Eric O Klineberg, Gregory M Mundis, Han Jo Kim, Jeffrey L Gum, Justin S Smith, Juan S Uribe, Khaled M Kebaish, Munish C Gupta, Pierce D Nunley, Robert K Eastlack, Richard Hostin, Themistocles S Protopsaltis, Lawrence G Lenke, Robert A Hart, Frank J Schwab, Shay Bess, Virginie Lafage, Alan H Daniels, and ISSG

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Elective Single-Level Primary Anterior Cervical Decompression and Fusion for Degenerative Spondylotic Cervical Myelopathy is Associated With Decreased Resource Utilization Versus Posterior Cervical Decompression and Fusion., Jerry Y Du, Karim Shafi, Collin W Blackburn, Jens R Chapman, Nicholas U Ahn, Randall E Marcus, and Todd J Albert

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Resource Utilization following Anterior Versus Posterior Cervical Decompression and Fusion for Acute Central Cord Syndrome., Jerry Y Du, Karim Shafi, Collin W Blackburn, Jens R Chapman, Nicholas U Ahn, Randall E Marcus, and Todd J Albert

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Factors Associated with the Maintenance of Cost-Effectiveness at 5 Years in Adult Spinal Deformity Corrective Surgery., Peter G Passias, Jamshaid M Mir, Pooja Dave, Justin S Smith, Renaud Lafage, Jeffrey Gum, Breton G Line, Bassel Diebo, Alan H Daniels, David Kojo Hamilton, Thomas J Buell, Justin K Scheer, Robert K Eastlack, Jeffrey P Mullin, Gregory M Mundis, Naobumi Hosogane, Mitsuru Yagi, Andrew J Schoenfeld, Juan S Uribe, Neel Anand, Praveen V Mummaneni, Dean Chou, Eric O Klineberg, Khaled M Kebaish, Stephen J Lewis, Munish C Gupta, Han Jo Kim, Robert A Hart, Lawrence G Lenke, Christopher P Ames, Christopher I Shaffrey, Frank J Schwab, Virginie Lafage, Richard A Hostin, Shay Bess, Douglas C Burton, and International Spine Study Group

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Neurosurgical bleeding in platelet storage pool disorder: a case report., Clifford A Pierre, Kirsten W Alcorn, Dong Chen, Joanna Fesler, Daniel Landis, Zachary Litvack, Barbara A Konkle, and Livia Hegerova

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COVID-19 Vaccine Related Cervical Radiculitis and Parsonage-Turner Syndrome: Case Report and Review of the Literature., Zachary C Taylor, Ravi S Nunna, Angela Tran, Matias Costa, Maxwell Gruber, Periklis Godolias, and Zachary Litvack

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The Postoperative Airway Compromise Score-First Steps to Developing a Postoperative Tool for the Assessment of Upper Airway-Related Complications Following Anterior Cervical Spine Surgery., Alexander von Glinski, Clifford A Pierre, Christopher Elia, Basem Ishak, Periklis Godolias, Ronen Blecher, Joseph R Detorri, Daniel C Norvell, Luke Jouppi, Julius Gerstmeyer, Steven A Deem, J Blake Golden, Thomas A Schildhauer, Rod J Oskouian, and Jens R Chapman

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When Will Peer-Review Become A.I.-Review?, Karsten Wiechert, Jeffrey C Wang, and Jens R Chapman

Submissions from 2023

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Comprehensive Venous Outflow Predicts Functional Outcomes in Patients with Acute Ischemic Stroke Treated by Thrombectomy., G Adusumilli, T D Faizy, S Christensen, M Mlynash, Yince Loh, G W Albers, M G Lansberg, J Fiehler, and J J Heit

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Would you do it again? Discrepancies between patient and surgeon perceptions following adult spine deformity surgery., Shay Bess, Breton Line, Christopher Ames, Douglas Burton, Gregory Mundis, Robert Eastlack, Robert A Hart, Munish Gupta, Eric Klineberg, Han Jo Kim, Richard Hostin, Khaled Kebaish, Virgine Lafage, Renaud Lafage, Frank Schwab, Christopher Shaffrey, and Justin S Smith

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Postoperative Discharge to Acute Rehabilitation or Skilled Nursing Facility Compared to Home Does Not Reduce Hospital Readmissions, Return to Surgery or Improve Outcomes Following Adult Spine Deformity Surgery., Shay Bess, Breton G Line, Pierce Nunley, Christopher Ames, Douglas Burton, Gregory Mundis, Robert Eastlack, Robert A Hart, Munish Gupta, Eric Klineberg, Han Jo Kim, Michael Kelly, Richard Hostin, Khaled Kebaish, Virgine Lafage, Renaud Lafage, Frank Schwab, Christopher Shaffrey, Justin S Smith, and International Spine Study Group

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Non-Invasive Transcutaneous Afferent Patterned Stimulation Therapy Offers Action Tremor Relief in Parkinson's Disease., Salima Brillman, Pravin Khemani, Stuart H Isaacson, Rajesh Pahwa, Ruta Deshpande, Vivien Zraick, Apoorva Rajagopal, Dhira Khosla, and Kathryn H Rosenbluth

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The aging brain: risk factors and interventions for long term brain health in women., Jessica Z K Caldwell and Nancy B. Isenberg

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High-dose vitamin D3 supplementation in relapsing-remitting multiple sclerosis: a randomised clinical trial, Sandra D Cassard, Kathryn C Fitzgerald, Peiqing Qian, Susan A Emrich, Christina J Azevedo, Andrew D Goodman, Elizabeth A Sugar, Daniel Pelletier, Emmanuelle Waubant, and Ellen M Mowry

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Longitudinal Changes in Cognitive Test Scores in Patients With Relapsing Remitting Multiple Sclerosis: An Analysis of the DECIDE Dataset., Nina Castrogiovanni, Jop Mostert, Pavle Repovic, James D Bowen, Bernard M J Uitdehaag, Eva M M Strijbis, Gary R Cutter, and Marcus W Koch

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Vertebral-Venous fistulas: Single center experience and practical treatment approach., Matias Costa, Mohammed Basamh, Juan Vivanco-Suarez, Daniel Casanova, Matias Baldoncini, Abdullah Alobaid, Yince Loh, Akshal Patel, Cameron G McDougall, and Stephen J Monteith

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Novel Technique of Head-Mounted Augmented Reality-Assisted Endovascular Neurosurgery: Proof of Concept on a Flow Model., Matias Costa, Clifford A Pierre, Mohammed Basamh, Juan Vivanco-Suarez, Matias Baldoncini, and Stephen Monteith

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Transcranial Doppler emboli monitoring for stroke prevention after flow diverting stents., Matias Costa, Paul Schmitt, Jaleel N, Matias Baldoncini, Juan Vivanco-Suarez, Colleen Douville, Yince Loh, Akshal Patel, Stephen Monteith, and Bipin Chaurasia

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Longitudinal Assessment of Modern Spine Surgery Training: 10-Year Follow-up of a Nationwide Survey of Residency and Spine Fellowship Program Directors., Alan H Daniels, Daniel Alsoof, Christopher L McDonald, Andrew S Zhang, Bassel G Diebo, Craig P Eberson, Eren O Kuris, William Lavelle, Christopher P Ames, Christopher I Shaffrey, and Robert A Hart

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Height Gain Following Correction of Adult Spinal Deformity., Bassel G Diebo, Zachary L Tataryn, Daniel Alsoof, Renaud Lafage, Robert A Hart, Peter G Passias, Christopher P Ames, Justin K Scheer, Stephen J Lewis, Christopher I Shaffrey, Douglas C Burton, Vedat Deviren, Breton G Line, Alex Soroceanu, D Kojo Hamilton, Eric O Klineberg, Gregory M Mundis, Han Jo Kim, Jeffrey L Gum, Justin S Smith, Juan S Uribe, Michael P Kelly, Khaled M Kebaish, Munish C Gupta, Pierce D Nunley, Robert K Eastlack, Richard Hostin, Themistocles S Protopsaltis, Lawrence G Lenke, Frank J Schwab, Shay Bess, Virginie Lafage, and Alan H Daniels

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Identification and surveillance of rare relapse-initiating stem cells during complete remission post-transplantation., Marios Dimitriou, Teresa Mortera-Blanco, Magnus Tobiasson, Stefania Mazzi, Madeleine Lehander, Kari Högstrand, Mohsen Karimi, Gunilla Walldin, Monika Jansson, Sofie Vonlanthen, Per Ljungman, Saskia M C Langemeijer, Tetsuichi Yoshizato, Eva S Hellstrom-Lindberg, Petter S Woll, and Sten Eirik W Jacobsen

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Impact of Race/Ethnicity on Hospital Resource Utilization After Elective Anterior Cervical Decompression and Fusion for Degenerative Myelopathy., Jerry Y Du, Collin W Blackburn, Jens R Chapman, Nicholas U Ahn, and Randall E Marcus

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Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex., Mean-Hwan Kim, Cristina Radaelli, Elliot R Thomsen, Deja Monet, Thomas Chartrand, Nikolas L Jorstad, Joseph T Mahoney, Michael J Taormina, Brian Long, Katherine Baker, Trygve E Bakken, Luke Campagnola, Tamara Casper, Michael Clark, Nick Dee, Florence D'Orazi, Clare Gamlin, Brian E Kalmbach, Sara Kebede, Brian R Lee, Lindsay Ng, Jessica Trinh, Charles Cobbs, Ryder P Gwinn, C Dirk Keene, Andrew L Ko, Jeffrey G Ojemann, Daniel L Silbergeld, Staci A Sorensen, Jim Berg, Kimberly A Smith, Philip R Nicovich, Tim Jarsky, Hongkui Zeng, Jonathan T Ting, Boaz P Levi, and Ed Lein

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Relapse recovery in relapsing-remitting multiple sclerosis: An analysis of the CombiRx dataset., Marcus W Koch, Ester Moral, Luis Brieva, Jop Mostert, Eva Mm Strijbis, Jacynthe Comtois, P Repovic, J D Bowen, Jerry S Wolinsky, Fred D Lublin, and Gary Cutter

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Threshold definitions for significant change on the timed 25-foot walk and nine-hole peg test in primary progressive multiple sclerosis., Marcus W Koch, Pavle Repovic, Jop Mostert, James D Bowen, Jacynthe Comtois, Eva Strijbis, Bernard Uitdehaag, and Gary Cutter

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No Delayed Ruptures on Long-Term Follow-Up of a Case Series of Persistently Filling Saccular Internal Carotid Artery Aneurysms After Flow Diversion With the Pipeline Embolization Device., Ryan P Lee, Meghana Bhimreddy, Jennifer Kim, Robert T Wicks, Risheng Xu, Matthew Bender, Wuyang Yang, Shahab Aldin Sattari, Alice Hung, Christopher M Jackson, L Fernando Gonzalez, Judy Huang, Rafael Tamargo, Cameron G McDougall, and Justin M Caplan

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Stereotactic and Functional Neurosurgery Convection-Enhanced Delivery of Autologous Cerebrospinal Fluid Enhances Basal Ganglia Visualization during MRI-Guided Deep Brain Stimulation Surgery., Shayan Moosa, Aaron E Bond, Tony R Wang, Faraz Farzad, Ashok R Asthagiri, and W Jeffrey Elias

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The impact of baseline cervical malalignment on the development of proximal junctional kyphosis following surgical correction of thoracolumbar adult spinal deformity., Lara Passfall, Bailey Imbo, Virginie Lafage, Renaud Lafage, Justin S Smith, Breton Line, Andrew J Schoenfeld, Themistocles Protopsaltis, Alan H Daniels, Khaled M Kebaish, Jeffrey L Gum, Heiko Koller, D Kojo Hamilton, Richard Hostin, Munish Gupta, Neel Anand, Christopher P Ames, Robert Hart, Douglas Burton, Frank J Schwab, Christopher I Shaffrey, Eric O Klineberg, Han Jo Kim, Shay Bess, and Peter G Passias

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Economic burden of nonoperative treatment of adult spinal deformity., Peter G Passias, Waleed Ahmad, Pooja Dave, Renaud Lafage, Virginie Lafage, Jamshaid Mir, Eric O Klineberg, Khaled M Kabeish, Jeffrey L Gum, Breton G Line, Robert A Hart, Douglas Burton, Justin S Smith, Christopher P Ames, Christopher I Shaffrey, Frank Schwab, Richard Hostin, Thomas Buell, D Kojo Hamilton, and Shay Bess

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Identifying Subsets of Patients With Adult Spinal Deformity Who Maintained a Positive Response to Nonoperative Management., Peter G Passias, Waleed Ahmad, Peter Tretiakov, Oscar Krol, Frank Segreto, Renaud Lafage, Virginie Lafage, Alex Soroceanu, Alan Daniels, Jeffrey Gum, Breton Line, Andrew J Schoenfeld, Shaleen Vira, Robert Hart, Douglas Burton, Justin S Smith, Christopher P Ames, Christopher Shaffrey, Frank Schwab, Shay Bess, and International Spine Study Group

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Critical Analysis of Radiographic and Patient Reported Outcomes Following Anterior/Posterior Staged vs. Same Day Surgery in Patients Undergoing Identical Corrective Surgery for Adult Spinal Deformity., Peter G Passias, Waleed Ahmad, Peter S Tretiakov, Renaud Lafage, Virginie Lafage, Andrew J Schoenfeld, Breton Line, Alan Daniels, Jamshaid M Mir, Munish Gupta, Gregory Mundis, Robert Eastlack, Pierce Nunley, D Kojo Hamilton, Richard Hostin, Robert Hart, Douglas C Burton, Christopher Shaffrey, Frank Schwab, Christopher Ames, Justin S Smith, Shay Bess, Eric O Klineberg, and International Spine Study Group

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Efficacy of Varying Surgical Approaches on Achieving Optimal Alignment in Adult Spinal Deformity Surgery., Peter G Passias, Waleed Ahmad, Tyler K Williamson, Jordan Lebovic, Khaled Kebaish, Renaud Lafage, Virginie Lafage, Breton Line, Andrew J Schoenfeld, Bassel G Diebo, Eric O Klineberg, Han Jo Kim, Christopher P Ames, Alan H Daniels, Justin S Smith, Christopher I Shaffrey, Douglas C Burton, Robert A Hart, Shay Bess, Frank J Schwab, Munish C Gupta, and International Spine Study Group

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Patient-specific Cervical Deformity Corrections With Consideration of Associated Risk: Establishment of Risk Benefit Thresholds for Invasiveness Based on Deformity and Frailty Severity., Peter G Passias, Katherine E Pierce, Tyler K Williamson, Jordan Lebovic, Andrew J Schoenfeld, Renaud Lafage, Virginie Lafage, Jeffrey L Gum, Robert Eastlack, Han Jo Kim, Eric O Klineberg, Alan H Daniels, Themistocles S Protopsaltis, Gregory M Mundis, Justin K Scheer, Paul Park, Dean Chou, Breton Line, Robert A Hart, Douglas C Burton, Shay Bess, Frank J Schwab, Christopher I Shaffrey, Justin S Smith, and Christopher P Ames

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Incremental benefits of circumferential minimally invasive surgery for increasingly frail patients with adult spinal deformity., Peter G Passias, Peter S Tretiakov, Pierce D Nunley, Michael Y Wang, Paul Park, Adam S Kanter, David O Okonkwo, Robert K Eastlack, Gregory M Mundis, Dean Chou, Nitin Agarwal, Richard G Fessler, Juan S Uribe, Neel Anand, Khoi D Than, Gregory Brusko, Kai-Ming Fu, Jay D Turner, Vivian P Le, Breton G Line, Christopher P Ames, Justin S Smith, Christopher I Shaffrey, Robert A Hart, Douglas Burton, Renaud Lafage, Virginie Lafage, Frank Schwab, Shay Bess, and Praveen V Mummaneni

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Cost Benefit of Implementation of Risk Stratification Models for Adult Spinal Deformity Surgery., Peter G Passias, Tyler K Williamson, Nicholas A Kummer, Ferran Pellisé, Virginie Lafage, Renaud Lafage, Miguel Serra-Burriel, Justin S Smith, Breton Line, Shaleen Vira, Jeffrey L Gum, Sleiman Haddad, Francisco Javier Sánchez Pérez-Grueso, Andrew J Schoenfeld, Alan H Daniels, Dean Chou, Eric O Klineberg, Munish C Gupta, Khaled M Kebaish, Michael P Kelly, Robert A Hart, Douglas C Burton, Frank Kleinstück, Ibrahim Obeid, Christopher I Shaffrey, Ahmet Alanay, Christopher P Ames, Frank J Schwab, Richard A Hostin, Shay Bess, and International Spine Study Group

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Are We Focused on the Wrong Early Postoperative Quality Metrics? Optimal Realignment Outweighs Perioperative Risk in Adult Spinal Deformity Surgery., Peter G Passias, Tyler K Williamson, Jamshaid M Mir, Justin S Smith, Virginie Lafage, Renaud Lafage, Breton Line, Alan H Daniels, Jeffrey L Gum, Andrew J Schoenfeld, David Kojo Hamilton, Alex Soroceanu, Justin K Scheer, Robert Eastlack, Gregory M Mundis, Bassel Diebo, Khaled M Kebaish, Richard A Hostin, Munish C Gupta, Han Jo Kim, Eric O Klineberg, Christopher P Ames, Robert A Hart, Douglas C Burton, Frank J Schwab, Christopher I Shaffrey, Shay Bess, and On Behalf Of The International Spine Study Group

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Bimekizumab treatment in biologic DMARD-naïve patients with active psoriatic arthritis: 52-week efficacy and safety results from the phase III, randomised, placebo-controlled, active reference BE OPTIMAL study., Christopher T Ritchlin, Laura C Coates, Iain B McInnes, Philip Mease, Joseph F Merola, Yoshiya Tanaka, Akihiko Asahina, Laure Gossec, Alice B Gottlieb, Richard B Warren, Barbara Ink, Rajan Bajracharya, Vishvesh Shende, Jason Coarse, and Robert Bm Landewé

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Embolization as stand-alone strategy for pediatric low-grade brain arteriovenous malformations., Aaron Rodriguez-Calienes, Juan Vivanco-Suarez, Matias Costa, Johssy Yelma Echevarria-Quispe, Rodolfo Rodríguez-Varela, Santiago Ortega-Gutierrez, and Giancarlo Saal-Zapata

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Remission of severe myasthenia gravis after autologous stem cell transplantation., Monica I Schlatter, Soumya S Yandamuri, Kevin C O'Connor, Richard J Nowak, Minh C Pham, Abeer H Obaid, Callee Redman, Marie Provost, Peter A McSweeney, Michael L Pearlman, Michael T Tees, J D Bowen, Richard A Nash, and George E Georges

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Association of age and inflammatory disease activity in the pivotal natalizumab clinical trials in relapsing-remitting multiple sclerosis., Eva M Strijbis, Eline Coerver, Jop Mostert, Zoé L E van Kempen, Joep Killestein, Jacynthe Comtois, Pavle Repovic, James D Bowen, Gary Cutter, and Marcus Koch

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Guidelines for the Neurocritical Care Management of Aneurysmal Subarachnoid Hemorrhage., Miriam M Treggiari, Alejandro A Rabinstein, Katharina M Busl, Meghan M Caylor, Giuseppe Citerio, Steven Deem, Michael Diringer, Elizabeth Fox, Sarah Livesay, Kevin N Sheth, Jose I Suarez, and Stavropoula Tjoumakaris

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The ISSG-AO Complication Intervention Score, but Not Major/Minor Designation, is Correlated With Length of Stay Following Adult Spinal Deformity Surgery., Joseph B Wick, Andrew Blandino, Justin S Smith, Breton G Line, Virginie Lafage, Renaud Lafage, Han Jo Kim, Peter G Passias, Jeffrey L Gum, Khaled M Kebaish, Robert K Eastlack, Alan Daniels, Gregory Mundis, Richard Hostin, Themistocles Protopsaltis, D Kojo Hamilton, Michael P Kelly, Munish Gupta, Robert A Hart, Frank J Schwab, Douglas C Burton, Christopher P Ames, Lawrence G Lenke, Christopher I Shaffrey, Shay Bess, Eric Klineberg, and International Spine Study Group

Submissions from 2022

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Effects of Cervical Spine Exercise Protocol on Neck Pain, Pericervical Muscle Endurance, and Range of Motion in Medical Students: A Prospective Study., Bryan G Anderson, Brett Benzinger, Jason Chickness, Chris Hietanen, Kylan Hill, Jean-Marc P Lucas, Joshua Tuck, and Michael Ghassibi

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Author Correction: Human neocortical expansion involves glutamatergic neuron diversification., Jim Berg, Staci A Sorensen, Jonathan T Ting, Jeremy A Miller, Thomas Chartrand, Anatoly Buchin, Trygve E Bakken, Agata Budzillo, Nick Dee, Song-Lin Ding, Nathan W Gouwens, Rebecca D Hodge, Brian Kalmbach, Changkyu Lee, Brian R Lee, Lauren Alfiler, Katherine Baker, Eliza Barkan, Allison Beller, Kyla Berry, Darren Bertagnolli, Kris Bickley, Jasmine Bomben, Thomas Braun, Krissy Brouner, Tamara Casper, Peter Chong, Kirsten Crichton, Rachel Dalley, Rebecca de Frates, Tsega Desta, Samuel Dingman Lee, Florence D'Orazi, Nadezhda Dotson, Tom Egdorf, Rachel Enstrom, Colin Farrell, David Feng, Olivia Fong, Szabina Furdan, Anna A Galakhova, Clare Gamlin, Amanda Gary, Alexandra Glandon, Jeff Goldy, Melissa Gorham, Natalia A Goriounova, Sergey Gratiy, Lucas Graybuck, Hong Gu, Kristen Hadley, Nathan Hansen, Tim S Heistek, Alex M Henry, Djai B Heyer, DiJon Hill, Chris Hill, Madie Hupp, Tim Jarsky, Sara Kebede, Lisa Keene, Lisa Kim, Mean-Hwan Kim, Matthew Kroll, Caitlin Latimer, Boaz P Levi, Katherine E Link, Matthew Mallory, Rusty Mann, Desiree Marshall, Michelle Maxwell, Medea McGraw, Delissa McMillen, Erica Melief, Eline J Mertens, Leona Mezei, Norbert Mihut, Stephanie Mok, Gabor Molnar, Alice Mukora, Lindsay Ng, Kiet Ngo, Philip R Nicovich, Julie Nyhus, Gaspar Olah, Aaron Oldre, Victoria Omstead, Attila Ozsvar, Daniel Park, Hanchuan Peng, Trangthanh Pham, Christina A Pom, Lydia Potekhina, Ramkumar Rajanbabu, Shea Ransford, David Reid, Christine Rimorin, Augustin Ruiz, David Sandman, Josef Sulc, Susan M Sunkin, Aaron Szafer, Viktor Szemenyei, Elliot R Thomsen, Michael Tieu, Amy Torkelson, Jessica Trinh, Herman Tung, Wayne Wakeman, Femke Waleboer, Katelyn Ward, René Wilbers, Grace Williams, Zizhen Yao, Jae-Guen Yoon, Costas Anastassiou, Anton Arkhipov, Pal Barzo, Amy Bernard, Charles Cobbs, Philip C de Witt Hamer, Richard G Ellenbogen, Luke Esposito, Manuel Ferreira, Ryder P Gwinn, Michael J Hawrylycz, Patrick R Hof, Sander Idema, Allan R Jones, C Dirk Keene, Andrew L Ko, Gabe J Murphy, Lydia Ng, Jeffrey G Ojemann, Anoop P Patel, John W Phillips, Daniel L Silbergeld, Kimberly Smith, Bosiljka Tasic, Rafael Yuste, Idan Segev, Christiaan P J de Kock, Huibert D Mansvelder, Gabor Tamas, Hongkui Zeng, Christof Koch, and Ed S Lein

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Concurrent brain-responsive and vagus nerve stimulation for treatment of drug-resistant focal epilepsy., Mesha-Gay Brown, Stefan Sillau, Danielle McDermott, Lia D Ernst, David C Spencer, Dario J Englot, Hernán F J González, Proleta Datta, Ioannis Karakis, Danielle Becker, John D Rolston, Amir Arain, Vikram R Rao, Michael J Doherty, Alexandra Urban, and Cornelia Drees

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Relationships Between Health-Related Quality of Life and Speech Perception in Bimodal and Bilateral Cochlear Implant Users., Nadav Brumer, Elizabeth Elkins, Jake Hillyer, Chantel Hazlewood, and Alexandra Parbery-Clark

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Deep Brain Stimulation Surgery Using a Mobile Intraoperative CT Scanner., Daniel Cavalcante, Muhammad S Ghauri, and Ryder P Gwinn

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Into the Spine Metaverse: Reflections on a future, Jens R Chapman, Jeffrey C Wang, and Karsten Wiechert

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Magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results., G Rees Cosgrove, Nir Lipsman, Andres M Lozano, Jin Woo Chang, Casey Halpern, Pejman Ghanouni, Howard Eisenberg, Paul Fishman, Takaomi Taira, Michael L Schwartz, Nathan McDannold, Michael Hayes, Susie Ro, Binit Shah, Ryder Gwinn, Veronica E Santini, Kullervo Hynynen, and W Jeff Elias

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Clinically Important Difference: 4 Tips Toward a Better Understanding., Joseph R Dettori, Daniel C Norvell, and Jens R Chapman

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Patient satisfaction after multiple revision surgeries for adult spinal deformity., Wesley M Durand, Alan H Daniels, Kevin DiSilvestro, Renaud Lafage, Bassel G Diebo, Peter G Passias, Han Jo Kim, Themistocles Protopsaltis, Virginie Lafage, Justin S Smith, Christopher I Shaffrey, Munish C Gupta, Eric O Klineberg, Frank Schwab, Jeffrey L Gum, Gregory M Mundis, Robert K Eastlack, Khaled Kebaish, Alex Soroceanu, Richard A Hostin, Douglas Burton, Shay Bess, Christopher P Ames, Robert A Hart, D Kojo Hamilton, and International Spine Study Group

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Low-Density Pedicle Screw Constructs Are Associated With Lower Incidence of Proximal Junctional Failure in Adult Spinal Deformity Surgery., Wesley M Durand, Kevin J DiSilvestro, Han Jo Kim, David K Hamilton, Renaud Lafage, Peter G Passias, Themistocles S Protopsaltis, Virginie Lafage, Justin S Smith, Christopher I Shaffrey, Munish C Gupta, Eric O Klineberg, Frank J Schwab, Jeffrey L Gum, Gregory M Mundis, Robert K Eastlack, Khaled M Kebaish, Alexandra Soroceanu, Richard A Hostin, Douglas C Burton, Shay Bess, Christopher P Ames, Robert A Hart, Alan H Daniels, and International Spine Study Group

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Compassionate-use pocapavir and immunoglobulin therapy for treatment of rituximab-associated enterovirus meningoencephalitis., Samantha Epstein, Riddhi Thakkar, Kathryn T Fong, James Ng, David R Bearden, Nischay Mishra, Kiran T Thakur, and Claire S Riley

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A double-blind, placebo-controlled, single-ascending-dose intravenous infusion study of rHIgM22 in subjects with multiple sclerosis immediately following a relapse., Benjamin M Greenberg, J D Bowen, Enrique Alvarez, Moses Rodriguez, Anthony O Caggiano, Arthur E Warrington, Ping Zhao, and Andrew Eisen

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Vasoplegia Following Complex Spine Surgery: Incidence and Risk., Basem Ishak, Juan N Pulido, Alexander von Glinski, Darius Ansari, Rod J Oskouian, and Jens R Chapman

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Agent-based computational modeling of glioblastoma predicts that stromal density is central to oncolytic virus efficacy., Adrianne L Jenner, Munisha Smalley, David Goldman, William F Goins, Charles Cobbs, Ralph B Puchalski, E Antonio Chiocca, Sean Lawler, Paul Macklin, Aaron Goldman, and Morgan Craig

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An atypical clinical course of a 71-year-old man with right arm weakness and ataxia., Pravin Khemani, Michael Elliott, and Todd Levine

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The timed 25-foot walk is a more sensitive outcome measure than the EDSS for PPMS trials: an analysis of the PROMISE clinical trial dataset., Marcus W Koch, Jop Mostert, P Repovic, J D Bowen, Jacynthe Comtois, Eva Strijbis, Bernard Uitdehaag, and Gary Cutter

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Evolution of the AO Spine Sacral and Pelvic Classification System: a systematic review., Barry Ting Sheen Kweh, Jin W Tee, F Cumhur Oner, Klaus J Schnake, Emiliano N Vialle, Frank Kanziora, Shanmuganathan Rajasekaran, Marcel Dvorak, Jens R Chapman, Lorin M Benneker, Gregory Schroeder, and Alexander R Vaccaro

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Global Validation of the AO Spine Upper Cervical Injury Classification: Geographic Region Affects Reliability and Reproducibility., Mark J Lambrechts, Gregory D Schroeder, Brian A Karamian, Jose A Canseco, Richard Bransford, Cumhur Oner, Lorin M Benneker, Frank Kandziora, Rajasekaran Shanmuganathan, Rishi Kanna, Andrei F Joaquim, Jens R Chapman, Emiliano Vialle, Mohammad El-Sharkawi, Marcel Dvorak, Klaus Schnake, Christopher K Kepler, Alexander R Vaccaro, and AO Spine Upper Cervical Injury Classification International Members

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Decompression only versus fusion in octogenarians with spinal epidural abscesses: early complications, clinical and radiological outcome with 2-year follow-up., Pavlina Lenga, Gelo Gülec, Awais Akbar Bajwa, Mohammed Issa, Rod J Oskouian, Jens R Chapman, Karl Kiening, Andreas W Unterberg, and Basem Ishak

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Radiological Features in Type II Odontoid Fractures in Older Adults After High- and Low-Energy Trauma., Pavlina Lenga, Mohammed Issa, Lennart Krull, Karl Kiening, Andreas W Unterberg, Till Schneider, Rod J Oskouian, Jens R Chapman, and Basem Ishak

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A scalable and modular automated pipeline for stitching of large electron microscopy datasets., Gayathri Mahalingam, Russel Torres, Daniel Kapner, Eric T Trautman, Tim Fliss, Shamishtaa Seshamani, Eric Perlman, Rob Young, Samuel Kinn, JoAnn Buchanan, Marc M Takeno, Wenjing Yin, Daniel J Bumbarger, Ryder P Gwinn, Julie Nyhus, Ed Lein, Steven J Smith, R Clay Reid, Khaled A Khairy, Stephan Saalfeld, Forrest Collman, and Nuno Macarico da Costa

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Disruption of cellular iron homeostasis by, Nunziata Maio, Russell P Saneto, Richard Steet, Márcio A Sotero de Menezes, Cindy Skinner, and Tracey A Rouault

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Patient-Reported Outcomes and Predictive Factors following Focused Ultrasound Thalamotomy for Essential Tremor., Shayan Moosa, Andrew Craver, David Asuzu, Matthew Eames, Tony R Wang, and William Jeffrey Elias

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Effect of sodium phenylbutyrate/taurursodiol on tracheostomy/ventilation-free survival and hospitalisation in amyotrophic lateral sclerosis: long-term results from the CENTAUR trial., Sabrina Paganoni, Suzanne Hendrix, Samuel P Dickson, Newman Knowlton, James D Berry, Michael Elliott, Samuel Maiser, Chafic Karam, James B Caress, Margaret Ayo Owegi, Adam Quick, James Wymer, Stephen A Goutman, Daragh Heitzman, Terry D Heiman-Patterson, Carlayne Jackson, Colin Quinn, Jeffrey D Rothstein, Edward J Kasarskis, Jonathan Katz, Liberty Jenkins, Shafeeq S Ladha, Timothy M Miller, Stephen N Scelsa, Tuan H Vu, Christina Fournier, Kristin M Johnson, Andrea Swenson, Namita Goyal, Gary L Pattee, Suma Babu, Marianne Chase, Derek Dagostino, Meghan Hall, Gale Kittle, Mathew Eydinov, Joseph Ostrow, Lindsay Pothier, Rebecca Randall, Jeremy M Shefner, Alexander V Sherman, Eric Tustison, Prasha Vigneswaran, Hong Yu, Joshua Cohen, Justin Klee, Rudolph Tanzi, Walter Gilbert, Patrick Yeramian, and Merit Cudkowicz

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Examination of the Economic Burden of Frailty in Patients With Adult Spinal Deformity Undergoing Surgical Intervention., Peter G Passias, Waleed Ahmad, Nicholas Kummer, Renaud Lafage, Virginie Lafage, Khaled Kebaish, Alan Daniels, Eric Klineberg, Alex Soroceanu, Jeffrey Gum, Breton Line, Robert A Hart, Douglas Burton, Robert Eastlack, Amit Jain, Justin S Smith, Christopher P Ames, Christopher Shaffrey, Frank Schwab, Richard Hostin, and Shay Bess

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The Benefit of Addressing Malalignment In Revision Surgery for Proximal Junctional Kyphosis Following ASD Surgery., Peter G Passias, Oscar Krol, Tyler K Williamson, Virginie Lafage, Renaud Lafage, Justin S Smith, Breton Line, Shaleen Vira, Shaina Lipa, Alan Daniels, Bassel Diebo, Andrew Schoenfeld, Jeffrey Gum, Khaled Kebaish, Paul Park, Gregory Mundis, Richard Hostin, Manush Gupta, Robert Eastlack, Neel Anand, Christopher Ames, Robert A Hart, Douglas Burton, Frank J Schwab, Christopher Shaffrey, Eric Klineberg, and Shay Bess

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Improvements in Outcomes and Cost after Adult Spinal Deformity Corrective Surgery between 2008 and 2019., Peter G Passias, Nicholas Kummer, Bailey Imbo, Virginie Lafage, Renaud Lafage, Justin S Smith, Breton Line, Shaleen Vira, Andrew J Schoenfeld, Jeffrey L Gum, Alan H Daniels, Eric O Klineberg, Munish C Gupta, Khaled M Kebaish, Amit Jain, Brian J Neuman, Dean Chou, Leah Y Carreon, Robert A Hart, Douglas C Burton, Christopher I Shaffrey, Christopher P Ames, Frank J Schwab, Richard A Hostin, Shay Bess, and International Spine Study Group

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Highest Achievable Outcomes for Patients Undergoing Cervical Deformity Corrective Surgery by Frailty., Peter G Passias, Nicholas Kummer, Tyler K Williamson, Kevin Moattari, Virginie Lafage, Renaud Lafage, Han Jo Kim, Alan H Daniels, Jeffrey L Gum, Bassel G Diebo, Themistocles S Protopsaltis, Gregory M Mundis, Robert K Eastlack, Alexandra Soroceanu, Justin K Scheer, D Kojo Hamilton, Eric O Klineberg, Breton Line, Robert A Hart, Douglas C Burton, Praveen Mummaneni, Dean Chou, Paul Park, Frank J Schwab, Christopher I Shaffrey, Shay Bess, Christopher P Ames, and Justin S Smith

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Establishment of an Individualized Distal Junctional Kyphosis Risk Index following the Surgical Treatment of Adult Cervical Deformities., Peter G Passias, Sara Naessig, Navraj Sagoo, Lara Passfall, Waleed Ahmad, Renaud Lafage, Virginie Lafage, Shaleen Vira, Andrew J Schoenfeld, Cheongeun Oh, Themistocles Protopsaltis, Han Jo Kim, Alan Daniels, Robert A Hart, Douglas Burton, Eric O Klineberg, Shay Bess, Frank Schwab, Christopher Shaffrey, Christopher P Ames, Justin S Smith, and International Spine Study Group

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Predictive Analytics for Determining Extended Operative Time in Corrective Adult Spinal Deformity Surgery., Peter G Passias, Gregory W Poorman, Dennis Vasquez-Montes, Nicholas Kummer, Gregory Mundis, Neel Anand, Samantha R Horn, Frank A Segreto, Lara Passfall, Oscar Krol, Bassel Diebo, Doug Burton, Aaron Buckland, Michael Gerling, Alex Soroceanu, Robert Eastlack, D Kojo Hamilton, Robert A Hart, Frank Schwab, Virginie Lafage, Christopher Shaffrey, Daniel Sciubba, Shay Bess, Christopher Ames, Eric Klineberg, and International Spine Study Group

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Clinical and radiographic benefits of skipping C7 instrumentation in posterior cervicothoracic fusion: a retrospective analysis., Saavan Patel, Morteza Sadeh, Matthew K Tobin, Nauman S Chaudhry, C Gragnaniello, and Sergey Neckrysh

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Podcast on B Cell-Targeting Therapies and Other Multiple Sclerosis Concerns During COVID-19., Robert K Shin, P Repovic, and Joseph R Berger

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Transient Opening of the Blood-Brain Barrier by Vasoactive Peptides to Increase CNS Drug Delivery: Reality Versus Wishful Thinking?, Matthew A Smith-Cohn, Nicholas B Burley, and Stuart A Grossman

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The MSIS-29 and SF-36 as outcomes in secondary progressive MS trials., Eva Mm Strijbis, Pavle Repovic, Jop Mostert, James D Bowen, Bernard Mj Uitdehaag, Gary Cutter, and Marcus W Koch

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Clinical application of the "sellar barrier's concept" for predicting intraoperative CSF leak in endoscopic endonasal surgery for pituitary adenomas with a machine learning analysis., J F Villalonga, D Solari, R Cuocolo, V De Lucia, L Ugga, C Gragnaniello, J I Pailler, A Cervio, A Campero, L M Cavallo, and P Cappabianca

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"Special Collections: Creating Order in the Chaos"., Jeffrey C Wang, Karsten Wiechert, and Jens R Chapman

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Spine Surgery has Always had Multi-Specialty Roots: Time for Nonoperative Spine Care to Catch up and Join the Club., Karsten Wiechert, Jens R Chapman, and Jeffrey C Wang

Submissions from 2021

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Quality of life in individuals newly diagnosed with multiple sclerosis or clinically isolated syndrome., Kevin N Alschuler, Daniel Whibley, Anna L Kratz, Mark P Jensen, Annette Wundes, Gloria von Geldern, Peiqing Qian, Charles H Bombardier, and Dawn M Ehde

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Predictors of Extended Hospitalization and Early Reoperation After Elective Lumbar Disc Arthroplasty., Darius Ansari, Justin T DesLaurier, Saavan Patel, Jens R Chapman, and Rod J Oskouian

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Three-stage revision arthroplasty for the treatment of fungal periprosthetic joint infection: outcome analysis of a novel treatment algorithm : a prospective study., Hinnerk Baecker, Sven Frieler, Jan Geßmann, Stephan Pauly, Thomas A Schildhauer, and Yannik Hanusrichter

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Evaluation of FKBP5 as a cortisol activity biomarker in patients with ACTH-dependent Cushing syndrome., Irina Bancos, Betul Ayse Hatipoglu, Kevin C J Yuen, Lakshmi Chandramohan, Sandeep Chaudhari, and Andreas G Moraitis

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Safety evaluation of shorter infusion for ocrelizumab in a substudy of the Phase IIIb CHORDS trial., Robert A Bermel, Emmanuelle Waubant, Gabriel Pardo, Ann Bass, P Repovic, Scott Newsome, John W Lindsey, Deidre Kile, Ashish Pradhan, Bruno Musch, and Aram Zabeti

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Exercise training and cognition in multiple sclerosis: The GET Smart trial protocol., Charles H Bombardier, Robert W Motl, Ralph H B Benedict, Nancy Temkin, P Qian, Katharine Alexander, Annabeth Evans, Andrea Thomas, Kristin Toms, Cathea M Carey, and George H Kraft

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Examining Delayed Recall in Cochlear Implant Users Using the Montreal Cognitive Assessment, California Verbal Learning Test, Third Edition, and Item Specific Deficit Approach: Preliminary Results., Nadav Brumer, Elizabeth Elkins, Jennifer Parada, Jake Hillyer, and Alexandra Parbery-Clark

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Global coronal decompensation and adult spinal deformity surgery: comparison of upper-thoracic versus lower-thoracic proximal fixation for long fusions., Thomas J Buell, Christopher I Shaffrey, Han Jo Kim, Eric O Klineberg, Virginie Lafage, Renaud Lafage, Themistocles S Protopsaltis, Peter G Passias, Gregory M Mundis, Robert K Eastlack, Vedat Deviren, Michael P Kelly, Alan H Daniels, Jeffrey L Gum, Alex Soroceanu, D Kojo Hamilton, Munish C Gupta, Douglas C Burton, Richard A Hostin, Khaled M Kebaish, Robert A Hart, Frank J Schwab, Shay Bess, Christopher P Ames, Justin S Smith, and International Spine Study Group (ISSG)

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Operative Treatment of Severe Scoliosis in Symptomatic Adults: Multicenter Assessment of Outcomes and Complications With Minimum 2-Year Follow-up., Thomas J Buell, Justin S Smith, Christopher I Shaffrey, Han Jo Kim, Eric O Klineberg, Virginie Lafage, Renaud Lafage, Themistocles S Protopsaltis, Peter G Passias, Gregory M Mundis, Robert K Eastlack, Vedat Deviren, Michael P Kelly, Alan H Daniels, Jeff L Gum, Alex Soroceanu, D Kojo Hamilton, Munish C Gupta, Douglas C Burton, Richard A Hostin, Khaled M Kebaish, Robert A Hart, Frank J Schwab, Shay Bess, and Christopher P Ames

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Mifepristone as Bridge or Adjunct Therapy in the Management of Challenging Cushing Disease Cases., Alice Y Chang, Sasan Mirfakhraee, Elizabeth E King, Kelley J Moloney, Diane M Donegan, and Kevin Cj Yuen

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Essentialism and Spine Surgery in Times of Pandemia: With Reflections on the Contributions of the Late Friedrich P. Magerl., Jens R Chapman, Jeffrey C Wang, and Karsten Wiechert

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Claiming the Scientific High Ground: New Frontiers and Ancient Wisdoms in the Age of COVID-19., Jens R Chapman, Karsten Wiechert, and Jeffrey C Wang

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Microsurgical Clipping of Carotid-Ophthalmic Tandem Aneurysms: Case Report and Surgical Nuances., Matias Costa, Matías Baldoncini, Zachary L Tataryn, Mickaela Echavarria Demichelis, Agustin Conde, Cynthia Purves, Alice Giotta Lucifero, Juha Hernesniemi, and Sabino Luzzi

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Types of Stroke Among People Living With HIV in the United States., Heidi M Crane, Robin M Nance, Tigran Avoundjian, Barbara N Harding, Bridget M Whitney, Felicia C Chow, Kyra J Becker, Christina M Marra, Joseph R Zunt, Emily L Ho, Rizwan Kalani, Andrew Huffer, Greer A Burkholder, Amanda L Willig, Richard D Moore, William C Mathews, Joseph J Eron, Sonia Napravnik, William B Lober, Greg S Barnes, Justin McReynolds, Matthew J Feinstein, Susan R Heckbert, Michael S Saag, Mari M Kitahata, Joseph A C Delaney, and David L Tirschwell