Use of ID4 for diagnosis and treatment of cancer

Authors

Dave S B Hoon, Department of Translational Molecular Medicine, John Wayne Cancer Institute (JWCI) at Providence Saint John's Health Center, Santa Monica, CA 90404 USA.Follow
Naoyuki Umetani

Document Type

Patent

Publication Date

4-2-2009

Abstract

The invention relates to a method of determining whether a human subject is suffering from or at risk for developing pancreatic cancer by determining the methylation level of an ID4 gene promoter or the expression level of an ID4 gene in a biological sample from a human subject. Also disclosed are a method of analyzing the methylation level of an ID4 gene promoter or the expression level of an ID4 gene in a pancreatic cancer cell, and a method of inhibiting the methylation of an ID4 gene promoter or enhancing the expression of an ID4 gene by contacting a pancreatic cancer cell with a compound that decreases the methylation level of an ID4 gene promoter or increases the expression level of an ID4 gene in the cell.

Clinical Institute

Cancer

Specialty/Research Institute

Oncology

Location

United States

Comments

Patent Number: 7,888,033

Assignee

John Wayne Cancer Institute (Santa Monica, CA)

Family ID

42828725

Serial Number

12/417,577

Tech ID

05-JWCI-047