Use of ID4 for diagnosis and treatment of cancer

Authors

Dave S B Hoon, Department of Translational Molecular Medicine, John Wayne Cancer Institute (JWCI) at Providence Saint John's Health Center, Santa Monica, CA 90404 USA.Follow
Naoyuki Umetani

Document Type

Patent

Publication Date

2-1-2006

Abstract

Methods for diagnosis and treatment of cancer using ID4 are disclosed. Specifically, epigenetic inactivation of ID4 in colorectal carcinomas and breast correlates with poor differentiation and unfavorable prognosis. Further, aberrant hypermethylation of ID4 gene promoter region increases risk of metastasis in colorectal and breast cancer.

Area of Special Interest

Cancer

Specialty/Research Institute

Oncology

Location

United States

Comments

Patent Number: 7,588,894

Assignee

John Wayne Cancern Institute (Santa Monica, CA)

Family ID

36777918

Serial Number

11/345,836

Tech ID

05-JWCI-047