DNA markers for management of cancer

Authors

Dave S B Hoon, Department of Translational Molecular Medicine, John Wayne Cancer Institute (JWCI) at Providence Saint John's Health Center, Santa Monica, CA 90404 USA.Follow
Bret Taback

Document Type

Patent

Publication Date

3-25-2004

Abstract

A method is provided for assessing allelic losses and hypermethylation of genes in CpG tumor promotor region on specific chromosomal regions in cancer patients, including melanoma, neuroblastoma breast, colorectal, and prostate cancer patients. The method relies on the evidence that free DNA and hypermethylation of genes in CpG tumor promotor region may be identified in the bone marrow, serum, plasma, and tumor tissue samples of cancer patients. Methods of melanoma, neuroblastoma, colorectal cancer, breast cancer and prostate cancer detection, staging, and prognosis are also provided.

Area of Special Interest

Cancer

Specialty/Research Institute

Oncology

Location

United States

Comments

Patent Number: 7,718,364

Assignee

John Wayne Cancer Institute (Santa Monica, CA); Taback, Bret (Santa Monica, CA)

Family ID

33131682

Serial Number

10/809,965

Tech ID

03-JWCI-037