Detection of cancer cells in body fluids

Authors

Dave S B Hoon, Department of Translational Molecular Medicine, John Wayne Cancer Institute (JWCI) at Providence Saint John's Health Center, Santa Monica, CA 90404 USA.Follow

Document Type

Patent

Publication Date

9-14-2005

Abstract

A method of detecting circulating melanoma or carcinoma cells in a subject. The method comprises obtaining a body fluid from a subject and detecting the expression of a panel of genes in the body fluid, wherein the expression of the panel of genes indicates the presence of circulating melanoma or carcinoma cells in the subject. Genes useful for detecting melanoma cells includes GalNAc-T, MAGE-A3, MART-1, PAX-3, and TRP-2; genes useful for detecting carcinoma cells include C-Met, MAGE-A3, Stanniocalcin-1, Stanniocalcin-2, mammaglobin, HSP27, GalNAc-T, CK20, and .beta.-HCG. Also disclosed are kits containing agents for detecting the expression of these genes.

Clinical Institute

Cancer

Specialty/Research Institute

Oncology

Location

United States

Comments

Patent Number: 8,039,218

Assignee

John Wayne Cancer Institute (Santa Monica, CA)

Family ID

33543973

Serial Number

11/227,575

Tech ID

02-JWCI-035