CXCL11 and SMICA as predictive biomarkers for efficacy of anti-CTLA4 immunotherapy

Document Type

Patent

Publication Date

4-20-2021

Keywords

oregon; portland; chiles

Abstract

Provided herein are methods for selecting a cancer patient for anti-CTLA-4 immunotherapy, or predicting whether a cancer patient will respond to anti-CTLA4 immunotherapy, based on measured levels of CXCL1 1 and/or sMICA. Such methods are useful for determining whether an anti-CTLA-4 immunotherapy is likely to improve overall survival of a cancer patient. Also provided herein are methods of treating a cancer patient with an anti-CTLA-4 immunotherapy, wherein the patient is first tested for levels of CXCL1 1 and/or sMICA. Also provided are methods for treating a cancer patient with a CXCL1 1 antagonist or sMICA ant agonist alone, or in combination with each other and/or with additional anti-cancer agents, such as a CTLA-4 antagonist.

Area of Special Interest

Cancer

Specialty/Research Institute

Oncology

Location

United States

Comments

Patent Number: 10,983,128

Assignee

BRISTOL-MYERS SQUIBB COMPANY (Princeton, NJ); Providence Health & Services (Portland, OR)

Family ID

55487083

Serial Number

15/547,304

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