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Publication Date
2025
Keywords
oregon, psvmc, oregon gme
Disciplines
Medical Education | Pulmonology | Rheumatology
Abstract
Introduction: Sarcoidosis is a disease of unknown etiology characterized by formation of small clusters of inflammatory cells that form granulomas. Heterogenous and typically involves multiple organ systems with varying degrees of morbidity and mortality. Poorly defined treatment landscape. The purpose of this study was to characterize a cohort of sarcoidosis patients in a combined rheumatology-pulmonary clinic according to organ involvement and treatment over 5 years. Discussion: •Single center academic study of a that is the first of its kind. •Data highlights complexity and heterogeneity of patients with sarcoidosis and utility of combined rheumatology – pulmonary clinic. •65.3% of patients exhibited multiorgan involvement, which is higher than in other studies. •Treatment regimens were complex, in general, corticosteroids, methotrexate, and azathioprine were the most common DMARDS observed. In terms of biologics, anti-TNF alpha medications were most common. •More patients with multiorgan involvement were often treated with a biologic. Biologic use was in 40% of patients with cardiac involvement, and in 76.4% of patients with neurologic involvement. •70.5% of patients with neuro-sarcoid involvement were treated with three or more medications, indicating refractory disease. Limitations and Future Steps: •Treatment and overall standard of care guidelines for sarcoidosis is limited. Majority of data in the literature is limited to observational studies, generally small case series and case reports. •The overall variability in treatment regimen, particularly surrounding neurologic sarcoidosis indicates the need for further research to better identify the best medication approach, particularly in refractory cases where the usual approach is not efficacious. •Limited prospective data, no true standard of care for treatment regimens in sarcoidosis. •Our study did not evaluate for disease activity and the efficacy of treatment regimens.
Area of Special Interest
Orthopedics & Sports Medicine
Specialty/Research Institute
Graduate Medical Education
Specialty/Research Institute
Pulmonary Medicine
Specialty/Research Institute
Rheumatology
