Publication Title
Nature genetics
Document Type
Article
Publication Date
7-1-2017
Keywords
Adult; Chromosome Mapping; Chromosomes, Human, X; Computational Biology; Computer Simulation; Family Health; Genetic Markers; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Haplotypes; Humans; Male; Neoplasms, Germ Cell and Embryonal; Polymorphism, Single Nucleotide; Risk; Testicular Neoplasms; Young Adult
Abstract
The international Testicular Cancer Consortium (TECAC) combined five published genome-wide association studies of testicular germ cell tumor (TGCT; 3,558 cases and 13,970 controls) to identify new susceptibility loci. We conducted a fixed-effects meta-analysis, including, to our knowledge, the first analysis of the X chromosome. Eight new loci mapping to 2q14.2, 3q26.2, 4q35.2, 7q36.3, 10q26.13, 15q21.3, 15q22.31, and Xq28 achieved genome-wide significance (P < 5 × 10
Clinical Institute
Cancer
Specialty/Research Institute
Oncology
Specialty/Research Institute
Institute for Systems Biology
