Cancer stem cell assay-guided chemotherapy improves survival of patients with recurrent glioblastoma in a randomized trial.
Document Type
Article
Publication Date
5-16-2023
Publication Title
Cell Rep Med
Keywords
oregon; portland
Abstract
Therapy-resistant cancer stem cells (CSCs) contribute to the poor clinical outcomes of patients with recurrent glioblastoma (rGBM) who fail standard of care (SOC) therapy. ChemoID is a clinically validated assay for identifying CSC-targeted cytotoxic therapies in solid tumors. In a randomized clinical trial (NCT03632135), the ChemoID assay, a personalized approach for selecting the most effective treatment from FDA-approved chemotherapies, improves the survival of patients with rGBM (2016 WHO classification) over physician-chosen chemotherapy. In the ChemoID assay-guided group, median survival is 12.5 months (95% confidence interval [CI], 10.2-14.7) compared with 9 months (95% CI, 4.2-13.8) in the physician-choice group (p = 0.010) as per interim efficacy analysis. The ChemoID assay-guided group has a significantly lower risk of death (hazard ratio [HR] = 0.44; 95% CI, 0.24-0.81; p = 0.008). Results of this study offer a promising way to provide more affordable treatment for patients with rGBM in lower socioeconomic groups in the US and around the world.
Clinical Institute
Neurosciences (Brain & Spine)
Clinical Institute
Cancer
Department
Neurosciences
Department
Oncology
Department
Pharmacy
Recommended Citation
Ranjan, Tulika; Sengupta, Soma; Glantz, Michael J; Green, Richard M; Yu, Alexander; Aregawi, Dawit; Chaudhary, Rekha; Chen, Ricky; Zuccarello, Mario; Lu-Emerson, Christine; Moulding, Hugh D; Belman, Neil; Glass, Jon; Mammoser, Aaron; Anderson, Mark; Valluri, Jagan; Marko, Nicholas; Schroeder, Jason; Jubelirer, Steven; Chow, Frances; Claudio, Pier Paolo; Alberico, Anthony M; Lirette, Seth T; Denning, Krista L; and Howard, Candace M, "Cancer stem cell assay-guided chemotherapy improves survival of patients with recurrent glioblastoma in a randomized trial." (2023). Articles, Abstracts, and Reports. 7349.
https://digitalcommons.providence.org/publications/7349
