Methods for diagnosis, prognosis and treatment of primary and metastatic basal-like breast cancer and other cancer types

Authors

Partha S. Ray
Sanjay Bagaria
Xiaojiang Cui, Providence St. Joseph HealthFollow
Jinhua Wang

Document Type

Patent

Publication Date

9-27-2013

Abstract

In one embodiment, a method of theranostic classification of a breast cancer tumor is provided, comprising obtaining a breast cancer tumor sample from a subject, detecting an expression level of FOXC1, comparing the expression level of FOXC1 to a predetermined cutoff level, and classifying the breast cancer tumor sample as belonging to a theranostic basal-like breast cancer tumor subtype or a theranostic hybrid basal-like breast cancer tumor subtype when the expression level of FOXC1 is higher than the predetermined cutoff level. In other embodiments, methods for predicting a prognosis of a basal-like breast cancer and methods of treating a basal-like breast cancer are provided.

Area of Special Interest

Cancer

Specialty/Research Institute

Oncology

Location

United States

Comments

Patent Number: 9,074,253

Assignee

JOHN WAYNE CANCER INSTITUTE (Santa Monica, CA)

Family ID

43544702

Serial Number

14/040,034

Tech ID

09-JWCI-101