Utility of B-RAF DNA mutation in diagnosis and treatment of cancer

Authors

Dave S B Hoon, Department of Translational Molecular Medicine, John Wayne Cancer Institute (JWCI) at Providence Saint John's Health Center, Santa Monica, CA 90404 USA.Follow

Document Type

Patent

Publication Date

2-26-2008

Abstract

The present invention discloses a method of detecting a wild-type or mutant B-RAF gene in a body fluid sample from a subject. Also disclosed are methods of using B-RAF as a biomarker for detecting cancer, predicting the outcome of cancer, and monitoring the treatment of cancer or the status of cancer. Furthermore, the invention discloses methods and compositions for detecting a mutant gene with a peptide nucleic acid clamp capable of hybridizing to a wild-type gene and a locked nucleic acid probe capable of hybridizing to a mutant of the gene.

Area of Special Interest

Cancer

Specialty/Research Institute

Oncology

Location

United States

Comments

Patent Number: 9,556,491

Assignee

JOHN WAYNE CANCER INSTITUTE (Santa Monica, CA)

Family ID

39721826

Serial Number

12/037,798

Tech ID

07-JWCI-052