Molecular lymphatic mapping of sentinel lymph nodes

Authors

Dave S B Hoon, Department of Translational Molecular Medicine, John Wayne Cancer Institute (JWCI) at Providence Saint John's Health Center, Santa Monica, CA 90404 USA.Follow
Bret Taback

Document Type

Patent

Publication Date

8-15-2003

Abstract

The present invention describes a method for identification and labeling of sentinel lymph nodes (SLNs) and the presence or absence of lymph node metastases as an important diagnostic and prognostic factor in early stage cancers of all types. The method, know as Molecular Lymphatic Mapping, uses traditional dye/radioactive tracer based techniques in conjunction with a nucleic acid marker to identify and label the SLN, not only for current diagnostic methods, but for archival purposes. In addition, MLM can be used to deliver a therapeutic gene or genes to the SLN to activate tumor immunity to tumor cells, and/or to inhibit tumor metastases. The methods may be combined with therapeutic intervention including chemotherapy and radiotherapy.

Clinical Institute

Cancer

Specialty/Research Institute

Oncology

Location

United States

Comments

Patent Number: 7,897,336

Assignee

John Wayne Cancer Institute (Santa Monica, CA)

Family ID

31888295

Serial Number

10/641,595

Tech ID

02-JWCI-033