Providence’s research in kidney health and diseases is on the cutting edge of identifying molecular signatures of diabetic kidney disease and development of new biomarkers and treatment targets. Our work is broadly translational from cellular and molecular biology to studies in mouse models to translational studies in humans and clinical trials of novel therapies. We also conduct research in a broad spectrum of other types of kidney diseases and treatments: glomerular diseases, hypertension and kidney vascular disease, nutritional approaches, patient-centered outcomes, and health services research. Importantly, Providence has funded a major initiative to establish a system-wide Chronic Kidney Disease registry that will greatly amplify both the quality-of-care we deliver and the research we conduct in our communities. We truly are at a tipping point. Astounding scientific breakthroughs will change the landscape toward kidney health and better life for people with kidney diseases.

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Submissions from 2024

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A framework towards digital twins for type 2 diabetes., Yue Zhang, Guangrong Qin, Boris Aguilar, Noa Rappaport, James T Yurkovich, Lance Pflieger, Sui Huang, Leroy Hood, and Ilya Shmulevich

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A new era in the science and care of kidney diseases., Carmine Zoccali, Francesca Mallamaci, Liz Lightstone, Vivek Jha, Carol Pollock, Katherine Tuttle, Peter Kotanko, Andrzej Wiecek, Hans Joachim Anders, Giuseppe Remuzzi, Kamyar Kalantar-Zadeh, Adeera Levin, and Raymond Vanholder

Submissions from 2023

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Modifiability of Composite Cardiovascular Risk Associated With Chronic Kidney Disease in Type 2 Diabetes With Finerenone., Rajiv Agarwal, Bertram Pitt, Peter Rossing, Stefan D Anker, Gerasimos Filippatos, Luis M Ruilope, Csaba P Kovesdy, Katherine Tuttle, Muthiah Vaduganathan, Christoph Wanner, Sameer Bansilal, Martin Gebel, Amer Joseph, Robert Lawatscheck, and George L Bakris

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Impact of Finerenone-Induced Albuminuria Reduction on Chronic Kidney Disease Outcomes in Type 2 Diabetes : A Mediation Analysis., Rajiv Agarwal, Wanzhu Tu, Alfredo E Farjat, Youssef M K Farag, Robert Toto, Sanjay Kaul, Robert Lawatscheck, Katja Rohwedder, Luis M Ruilope, Peter Rossing, Bertram Pitt, Gerasimos Filippatos, Stefan D Anker, George L Bakris, FIDELIO-DKD and FIGARO-DKD Investigators, and Katherine Tuttle

“Intensifying Diabetes Therapies to Achieve Personalized Treatment Goals”, Radica Alicic

Incidence of chronic kidney disease in prediabetes, Radica Alicic, Ken Daratha, Joshua J Neumiller, Katherine Tuttle, and See all authors in comments

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Author Response to "Insulin Dosing Safety in CKD"., Radica Alicic, Joshua J Neumiller, Rodolfo J Galindo, and Katherine Tuttle

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Mechanisms and clinical applications of incretin therapies for diabetes and chronic kidney disease., Radica Alicic, Joshua J Neumiller, and Katherine Tuttle

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Incretin Therapies for Patients with Type 2 Diabetes and Chronic Kidney Disease., Radica Z Alicic and Joshua J Neumiller

Kidney disease outcomes with semaglutide versus placebo across baseline KDIGO risk categories: a post-hoc analysis of SUSTAIN 6, SC Bain, Katherine Tuttle, and See Full List of Authors in Comments

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A nontraditional presentation and treatment for emphysematous cystitis., Benjamin Becker, Asher George, and Ryan Owen

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Kidney Biopsy Utility: Patient and Clinician Perspectives from the Kidney Precision Medicine Project., Lauren Bernard, Ashley R Wang, Steven Menez, Joel M Henderson, Ashveena Dighe, Glenda V Roberts, Christine Stutzke, Katherine Tuttle, R Tyler Miller, and Kidney Precision Medicine Project

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Resection Techniques During Robotic Partial Nephrectomy: A Systematic Review., Riccardo Bertolo, Alessio Pecoraro, Umberto Carbonara, Daniele Amparore, Pietro Diana, Stijn Muselaers, Michele Marchioni, Maria Carmen Mir, Alessandro Antonelli, Ketan Badani, Alberto Breda, Ben Challacombe, Jihad Kaouk, Alexandre Mottrie, Francesco Porpiglia, Jim Porter, Andrea Minervini, and Riccardo Campi

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Identifying Systemic errors in refilling insulin to prevent another hospitalization: An RCA, John Butler, Mikayla Button, Jared Fincher, Rakin Solaiman, and Michael Woodfin

A quality improvement initiative to bridge gaps in treatment and interprofessional care of chronic kidney disease, DA Cappel, Katherine Tuttle, and See all authors in comments

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Partial versus radical nephrectomy for complex renal mass: multicenter comparative analysis of functional outcomes (Rosula collaborative group)., Clara Cerrato, Margaret F Meagher, Riccardo Autorino, Giuseppe Simone, Bo Yang, Robert G Uzzo, Alexander Kutikov, Francesco Porpiglia, Umberto Capitanio, Francesco Montorsi, James R Porter, Alp T Beksac, Dhruv Puri, Mimi Nguyen, Luke Wang, Kevin Hakimi, Sohail Dhanji, Franklin Liu, Maria A Cerruto, Savio D Pandolfo, Andrea Minervini, Clayton Lau, Aron Monish, Daniel Eun, Alexandre Mottrie, Carmen Mir, Chandru Sundaram, Alessandro Antonelli, Jihad Kaouk, and Ithaar H Derweesh

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Partial or radical nephrectomy for complex renal mass: a comparative analysis of oncological outcomes and complications from the ROSULA (Robotic Surgery for Large Renal Mass) Collaborative Group., Clara Cerrato, Devin Patel, Riccardo Autorino, Giuseppe Simone, Bo Yang, Robert Uzzo, Francesco Porpiglia, Umberto Capitanio, James Porter, Alp Tuna Beksac, Andrea Minervini, Alessandro Antonelli, Maria Angela Cerruto, Clayton Lau, Akbar Ashrafi, Daniel Eun, Alexandre Mottrie, Carmen Mir, Margaret F Meagher, Dhruv Puri, Mimi Nguyen, Sohail Dhanji, Franklin Liu, Savio D Pandolfo, Alexander Kutikov, Francesco Montorsi, Inderbir S Gill, Chandru Sundaram, Jihad Kaouk, and Ithaar H Derweesh

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Home Dialysis Curriculum Implementation for Health Care Workers Using Project ECHO Principles: A Feasibility Report From NKF-KDOQI., Christopher T Chan, Barbara Dommert-Breckler, Jordan Cannon, Renin Cassidy, Karen Crampton, Danilo Concepcion, Stephanie Hutchinson, Jessica Joseph, Rajnish Mehrotra, Gary Moore, Nancy Pierce, Matthew B Rivara, and Katy Wilkens

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Metaverse Surgical Planning with Three-dimensional Virtual Models for Minimally Invasive Partial Nephrectomy., Enrico Checcucci, Daniele Amparore, Gabriele Volpi, Sabrina De Cillis, Federico Piramide, Paolo Verri, Alberto Piana, Michele Sica, Cecilia Gatti, Paolo Alessio, Alberto Quarà, Mariano Burgio, Marco Colombo, Giovanni Busacca, Alex Mottrie, Edward Cherullo, Alberto Breda, Alessandro Antonelli, Renaud Bollens, Andrea Minervini, James R Porter, Riccardo Schiavina, Riccardo Autorino, Ashutosh Tewari, Michele Di Dio, Cristian Fiori, and Francesco Porpiglia

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Age of Onset and Disease Course in Biopsy-Proven Minimal Change Disease: An Analysis From the Cure Glomerulonephropathy Network., Dhruti P Chen, Margaret E Helmuth, Abigail R Smith, Pietro A Canetta, Isabelle Ayoub, Krzysztof Mucha, Mahmoud Kallash, Jeffrey B Kopp, Rasheed Gbadegesin, Brenda W Gillespie, Larry A Greenbaum, Rulan S Parekh, Tracy E Hunley, C John Sperati, David T Selewski, Jason Kidd, Aftab Chishti, Kimberly Reidy, Amy K Mottl, Debbie S Gipson, Tarak Srivastava, Katherine E Twombley, CureGN Consortium, and Katherine Tuttle

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Belzutifan plus cabozantinib for patients with advanced clear cell renal cell carcinoma previously treated with immunotherapy: an open-label, single-arm, phase 2 study., Toni K Choueiri, David F McDermott, Jaime Merchan, Todd M Bauer, Robert Figlin, Elisabeth I Heath, M Dror Michaelson, Edward Arrowsmith, Anishka D'Souza, Song Zhao, Ananya Roy, Rodolfo Perini, Donna Vickery, and Scott S Tykodi

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Does Offloading with Felt Foot Plates Heal Diabetic Foot Ulcers?, Deborah Christensen and Albert Botchway

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Improving Metabolic Monitoring during Transfers of Care for Psychiatric Patients Discharged from the Inpatient Psychiatric Residency Service on an Antipsychotic Medication – Part 2, Allison Cohen and Anisha Boetel

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Empagliflozin in Patients with Chronic Kidney Disease., The EMPA-KIDNEY Collaborative Group, William G Herrington, Natalie Staplin, Christoph Wanner, Jennifer B Green, Sibylle J Hauske, Jonathan R Emberson, David Preiss, Parminder Judge, Kaitlin J Mayne, Sarah Y A Ng, Emily Sammons, Doreen Zhu, Michael Hill, Will Stevens, Karl Wallendszus, Susanne Brenner, Alfred K Cheung, Zhi-Hong Liu, Jing Li, Lai Seong Hooi, Wen Liu, Takashi Kadowaki, Masaomi Nangaku, Adeera Levin, David Cherney, Aldo P Maggioni, Roberto Pontremoli, Rajat Deo, Shinya Goto, Xavier Rossello, Katherine R Tuttle, Dominik Steubl, Michaela Petrini, Dan Massey, Jens Eilbracht, Martina Brueckmann, Martin J Landray, Colin Baigent, Richard Haynes, Radica Alicic, Ann Cooper, and Lisa Davis

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Tirzepatide decreases systolic and diastolic blood pressure., Sidar Copur, Atalay Demiray, David Cherney, Katherine Tuttle, and Mehmet Kanbay

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Tirzepatide and potential use for metabolically healthy obesity., Sidar Copur, Cem Tanriover, Furkan Yavuz, Katherine R Tuttle, and Mehmet Kanbay

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Is there any robust evidence showing that SGLT2 inhibitor use predisposes to acute kidney injury?, Sidar Copur, Abdullah Yildiz, Carlo Basile, Katherine R Tuttle, and Mehmet Kanbay

Needs Assessment: Characterizing resident knowledge gaps in inpatient care of persons with Cystic Fibrosis to inform a quality improvement educational intervention, S Eglin, M Drobny, and AA Lambert

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Empagliflozin in Patients with Chronic Kidney Disease., EMPA-KIDNEY Collaborative Group, William G Herrington, Natalie Staplin, Christoph Wanner, Jennifer B Green, Sibylle J Hauske, Jonathan R Emberson, David Preiss, Parminder Judge, Kaitlin J Mayne, Sarah Y A Ng, Emily Sammons, Doreen Zhu, Michael Hill, Will Stevens, Karl Wallendszus, Susanne Brenner, Alfred K Cheung, Zhi-Hong Liu, Jing Li, Lai Seong Hooi, Wen Liu, Takashi Kadowaki, Masaomi Nangaku, Adeera Levin, David Cherney, Aldo P Maggioni, Roberto Pontremoli, Rajat Deo, Shinya Goto, Xavier Rossello, Katherine Tuttle, Dominik Steubl, Michaela Petrini, Dan Massey, Jens Eilbracht, Martina Brueckmann, Martin J Landray, Colin Baigent, Richard Haynes, and The EMPA-KIDNEY Collaborative Group

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Objective assessment of intraoperative skills for robot-assisted partial nephrectomy (RAPN)., Rui Farinha, Alberto Breda, James Porter, Alexandre Mottrie, Ben Van Cleynenbreugel, Jozef Vander Sloten, Angelo Mottaran, and Anthony G Gallagher

Efficacy, and safety of remdesivir in people with moderately and severely reduced kidney function hospitalized for COVID-19: The REDPINE study, JRS Fernandez, Katherine Tuttle, and See full list of authors in comments

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Continuous Glucose Monitoring to Optimize Management of Diabetes in Patients with Advanced CKD., Rodolfo J Galindo, Ian H de Boer, Joshua J Neumiller, and Katherine R Tuttle

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Continuous Glucose Monitoring to Optimize Management of Diabetes in Patients with Advanced CKD., Rodolfo J Galindo, Ian H de Boer, Joshua J Neumiller, and Katherine R Tuttle

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National Trends in Glucagon Prescriptions Among U.S. Adults With Diabetes and End-Stage Kidney Disease Treated by Dialysis: 2013-2017., Rodolfo J Galindo, Shealeigh A Inselman, Guillermo E Umpierrez, Bobak Moazzami, Jair Munoz Mendoza, Mohammed K Ali, Katherine R Tuttle, and Rozalina G McCoy

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960-P: Hemodialysis-Related Glycemic Patterns among People with Insulin-Treated Type 2 (T2D) Diabetes—Role of Continuous Glucose Monitoring (CGM), Rodolfo J. Galindo, Bobak Mozzami, Amany Y.G. Gerges, Limin Peng, Katherine R. Tuttle, and Guillermo Umpierrez

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961-P: Comparison of Glucose Metrics by Capillary Blood Glucose and Continuous Glucose Monitoring among People with Type 2 Diabetes on Hemodialysis, Rodolfo J. Galindo, Bobak Mozzami, Amany Y.G. Gerges, Limin Peng, Katherine R. Tuttle, and Guillermo Umpierrez

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960-P: Hemodialysis-Related Glycemic Patterns among People with Insulin-Treated Type 2 (T2D) Diabetes—Role of Continuous Glucose Monitoring (CGM), Rodolfo J. Galindo, Katherine Tuttle, and See full list of authors in comments

Long COVID and the Heart, Tyler Gluckman

Temporal Shifts In Guideline-directed Medical Therapy Prescribed At Discharge To Heart Failure Patients In A Large US Integrated Health System, Tyler Gluckman, ST Chiu, J Remick, and See full list of authors in comments

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Monitoring and Surveillance of Patients with Gastroenteropancreatic Neuroendocrine Tumors Undergoing Radioligand Therapy., Thorvardur R Halfdanarson, Nadine Mallak, Scott Paulson, Chandrikha Chandrasekharan, Mona Natwa, Ayse Tuba Kendi, and Hagen F Kennecke

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Biliary and pancreatic stents., Samuel Han; Jorge V Obando; Amit Bhatt; Juan Carlos Bucobo; Dennis Chen; Andrew P Copland; Koushik K Das; Mohit Girotra; Allon Kahn; Kumar Krishnan; Sonali S Sakaria; Monica Saumoy; Guru Trikudanathan; Arvind J Trindade; Julie Yang; Ryan J Law; ASGE Technology Committee Chair; David R Lichtenstein; and (previous Committee Chair, 2019-2021)

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Rationale and design of a randomised phase III registration trial investigating finerenone in participants with type 1 diabetes and chronic kidney disease: The FINE-ONE trial., Hiddo J L Heerspink, Andreas L Birkenfeld, David Z I Cherney, Helen M Colhoun, Linong Ji, Chantal Mathieu, Per-Henrik Groop, Richard E Pratley, Sylvia E Rosas, Peter Rossing, Jay S Skyler, Katherine R Tuttle, Robert Lawatscheck, Charlie Scott, Robert Edfors, Markus F Scheerer, Peter Kolkhof, and Janet B McGill

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People with type 1 diabetes and chronic kidney disease urgently need new therapies: a call for action., Hiddo Jl Heerspink, David Zi Cherney, Per-Henrik Groop, Chantal Matthieu, Peter Rossing, Katherine R Tuttle, and Janet B McGill

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Effects of Tirzepatide Versus Insulin Glargine on Cystatin C-Based Kidney Function: A SURPASS-4 Post Hoc Analysis., Hiddo J L Heerspink, Naveed Sattar, Imre Pavo, Axel Haupt, Kevin L Duffin, Zhengyu Yang, Russell J Wiese, Jonathan M Wilson, Andrea Hemmingway, David Z I Cherney, and Katherine Tuttle

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Tirzepatide reduces albuminuria in patients with type 2 diabetes: post-hoc pooled analysis of SURPASS 1-5, Hiddo J. Heerspink, Katherine Tuttle, and See full list of authors in comments

Design, and baseline characteristics of the FIND-CKD trial: Efficacy of Finerenone on kidney disease progression in people with non[1]diabetic chronic kidney disease, HJL Heerspink, Katherine Tuttle, and See all authors in comments

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Factors impacting adherence to antidiabetic medications and health outcomes in diabetes mellitus patients in Medicare populations, Kelli Hoang, Kelly Simpson, and Danny Wallenslager

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Generally-healthy individuals with aberrant bowel movement frequencies show enrichment for microbially-derived blood metabolites associated with impaired kidney function., James P Johnson, Christian Diener, Anne E Levine, Tomasz Wilmanski, David L Suskind, Alexandra Ralevski, Jennifer J Hadlock, Andrew T Magis, Leroy Hood, Noa Rappaport, and Sean M Gibbons

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Standardized Follow-Up Recommendations Improve Reporting of Incidental Renal Lesions in a Community Setting., Michael G Johnston, Skyler Burke, Chance M Brock, Saralyn Beckius, and Scott King

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The risk for chronic kidney disease in metabolically healthy obese patients: A systematic review and meta-analysis., Mehmet Kanbay, Sidar Copur, Dimitrie Siriopol, Abdullah B Yildiz, Metehan Berkkan, Kathherine R Tuttle, and Carmine Zoccali

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The risk for chronic kidney disease in metabolically healthy obese patients: A systematic review and meta-analysis., Mehmet Kanbay, Sidar Copur, Dimitrie Siriopol, Abdullah B Yildiz, Metehan Berkkan, Kathherine R Tuttle, and Carmine Zoccali

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Effect of tirzepatide on blood pressure and lipids: A meta-analysis of randomized controlled trials., Mehmet Kanbay, Sidar Copur, Dimitrie Siriopol, Abdullah Burak Yildiz, Abduzhappar Gaipov, Daniel H van Raalte, and Katherine Tuttle

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Novel Prediction Equations for Absolute Risk Assessment of Total Cardiovascular Disease Incorporating Cardiovascular-Kidney-Metabolic Health: A Scientific Statement From the American Heart Association., Sadiya S Khan, Josef Coresh, Michael J Pencina, Chiadi E Ndumele, Janani Rangaswami, Sheryl L Chow, Latha P Palaniappan, Laurence S Sperling, Salim S Virani, Jennifer E Ho, Ian J Neeland, Katherine Tuttle, Radhika Rajgopal Singh, Mitchell S V Elkind, Donald M Lloyd-Jones, and American Heart Association

Real-World Outcomes of Impella 5 in Patients with Cardiogenic Shock: Analysis of the SURPASS Registry, A Kilic, Jacob Abraham, and See full list of authors in comments

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Transcatheter Aortic Valve Replacement Outcomes in End-Stage Renal Disease Patients on Hemodialysis Requiring Midodrine., Ethan C Korngold, Ruyun Jin, Kateri Spinelli, V Kumar, Brydan Curtis, Sameer Gafoor, Derek Phan, Daniel Spoon, Aidan Raney, Lisa McCabe, and Brandon Jones

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Racial and Ethnic Disparities in Acute Care Utilization Among Patients With Glomerular Disease., Jill R Krissberg, Michelle M O'Shaughnessy, Abigail R Smith, Margaret E Helmuth, Salem Almaani, Diego H Aviles, Kaye E Brathwaite, Yi Cai, Daniel Cattran, Rasheed Gbadegesin, Dorey A Glenn, Larry A Greenbaum, Sandra Iragorri, Koyal Jain, Myda Khalid, Jason Kidd, Jeffrey Kopp, Richard Lafayette, Jerome C Lane, Francesca Lugani, Jordan G Nestor, Rulan S Parekh, Kimberly Reidy, David T Selewski, Christine B Sethna, C John Sperati, Katherine Tuttle, Katherine Twombley, Tetyana L Vasylyeva, Donald J Weaver, Scott E Wenderfer, Keisha Gibson, and CureGN Consortium

Assessment of medication adherence among adults with glomerular disease, JR Krissberg, Katherine Tuttle, and See all authors in comments

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The Effect of Preoperative Carbohydrate Intake on Length of Stay and Postoperative Recovery Following Laparoscopic Living Donor Nephrectomy., Morgan Kuiper, Melanie Gillingham, Julie Martin, Daniella Gardner, and Sandra Van Calcar

“Research Coordinator Mentoring Program – Participant Presentations”, Kelli Kuykendall

Comparison of clinical diabetes outcomes of patients managed via telemedicine pharmacists during the COVID pandemic relative to continued management by primary care clinics, Trevor Laursen and Stephanie Chan

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Equity and Quality of Global CKD Care - what are we waiting for?, Valerie A Luyckx, Ayah Elmaghrabi, Manisha Sahay, Nicole Scholes-Robertson, Laura Sola, Tobias Speare, Elliot K Tannor, Katherine Tuttle, and Ikechi G Okpechi

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Precision nephrology identified tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis., Laura H Mariani, Sean Eddy, Fadhl M AlAkwaa, Phillip J McCown, Jennifer L Harder, Viji Nair, Felix Eichinger, Sebastian Martini, Adebowale D Ademola, Vincent Boima, Heather N Reich, Jamal El Saghir, Bradley Godfrey, Wenjun Ju, Emily C Tanner, Virginia Vega-Warner, Noel L Wys, Sharon G Adler, Gerald B Appel, Ambarish Athavale, Meredith A Atkinson, Serena M Bagnasco, Laura Barisoni, Elizabeth Brown, Daniel C Cattran, Gaia M Coppock, Katherine M Dell, Vimal K Derebail, Fernando C Fervenza, Alessia Fornoni, Crystal A Gadegbeku, Keisha L Gibson, Laurence A Greenbaum, Sangeeta R Hingorani, Michelle A Hladunewich, Jeffrey B Hodgin, Marie C Hogan, Lawrence B Holzman, J Ashley Jefferson, Frederick J Kaskel, Jeffrey B Kopp, Richard A Lafayette, Kevin V Lemley, John C Lieske, Jen-Jar Lin, Rajarasee Menon, Kevin E Meyers, Patrick H Nachman, Cynthia C Nast, Michelle M O'Shaughnessy, Edgar A Otto, Kimberly J Reidy, Kamalanathan K Sambandam, John R Sedor, Christine B Sethna, Pamela Singer, Tarak Srivastava, Cheryl L Tran, Katherine Tuttle, Suzanne M Vento, Chia-Shi Wang, Akinlolu O Ojo, Dwomoa Adu, Debbie S Gipson, Howard Trachtman, and Matthias Kretzler

Prediction of kidney failure using multiple data domains in glomerulonephropathy: A CureGN study, LH Mariani, Katherine Tuttle, and See all authors in comments

Comparison of in-clinic only to in-clinic plus virtual mental health screens of adults with cystic fibrosis during SARS-CoV-2 pandemic, KG Mertz, M Ingoldby, T Vance, and AA Lambert

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Glucagon-like peptide-1 receptor agonists in diabetic kidney disease: A review of their kidney and heart protection., Erin D Michos, George L Bakris, Helena W Rodbard, and Katherine Tuttle

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Glucagon-like peptide-1 receptor agonists in diabetic kidney disease: A review of their kidney and heart protection., Erin D Michos, George L Bakris, Helena W Rodbard, and Katherine R Tuttle

Improvement: Increasing staff and patient awareness of and knowledge of genetic therapy research, JE Milton, A Chavez, K Kuykendall, and AA Lambert

Quality Improvement: Increasing staff and patient awareness of and knowledge of genetic therapy research, Joan Milton

“Cardiac Amyloid Pearls & Pitfalls”, Deirdre Mooney

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Diabetes Management in Chronic Kidney Disease: Synopsis of the KDIGO 2022 Clinical Practice Guideline Update., Sankar D Navaneethan, Sophia Zoungas, M Luiza Caramori, Juliana C N Chan, Hiddo J L Heerspink, Clint Hurst, Adrian Liew, Erin D Michos, Wasiu A Olowu, Tami Sadusky, Nikhil Tandon, Katherine R Tuttle, Christoph Wanner, Katy G Wilkens, Jonathan C Craig, David J Tunnicliffe, Marcello Tonelli, Michael Cheung, Amy Earley, Peter Rossing, Ian H de Boer, and Kamlesh Khunti

A synopsis of the evidence for the science and clinical management of cardiovascular-kidney-metabolic (CKM) syndrome: A Scientific Statement from the American Heart Association., C Ndumele, Katherine Tuttle, and See all authors in comments

First-line therapy in T2D: Has Metformin been “dethroned, Joshua J Neumiller and Radica Alicic

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Incorporating Evidence and Guidelines for Personalized Care of Diabetes and Chronic Kidney Disease., Joshua J Neumiller, Radica Alicic, and Katherine Tuttle

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Disparities in the Use of SGLT2 Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Adults With CKD in the United States., Susanne B Nicholas, Radica Alicic, and Jenny Shen

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Disparities in the Use of SGLT2 Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Adults With CKD in the United States., Susanne B Nicholas, Radica Z Alicic, and Jenny Shen

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Prescription of guideline-directed medical therapies in patients with diabetes and chronic kidney disease from the CURE-CKD Registry, 2019-2020., Susanne B Nicholas, Kenn Daratha, Radica Alicic, Cami R Jones, Lindsey M Kornowske, Joshua J Neumiller, Samuel T Fatoba, Sheldon X Kong, Rakesh Singh, Keith C Norris, and Katherine Tuttle

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Operative and oncological outcomes of salvage robotic radical and partial nephrectomy: a multicenter experience., Kennedy E Okhawere, Ralph Grauer, Laura Zuluaga, Kirolos N Meilika, Burak Ucpinar, Alp Tuna Beksac, Shirin Razdan, Indu Saini, Chiya Abramowitz, Ronney Abaza, Daniel D Eun, Akshay Bhandari, Ashok K Hemal, James Porter, Michael D Stifelman, Mani Menon, and Ketan K Badani

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Transperitoneal Versus Retroperitoneal Robotic-Assisted Partial Nephrectomy in Patients with Obesity., Kennedy E Okhawere, Jordan Miller Rich, Alp Tuna Beksac, Laura Zuluaga, Indu Saini, Burak Ucpinar, Joshua Levieddin, Iretiayo T Joel, Anthony Deluxe, Michael D Stifelman, Simone Crivellaro, Ronney Abaza, Daniel D Eun, Akshay Bhandari, Ashok K Hemal, James Porter, Ahmed Mansour, Phillip M Pierorazio, Osama Zaytoun, and Ketan K Badani

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Long-term efficacy of high-frequency (10 kHz) spinal cord stimulation for the treatment of painful diabetic neuropathy: 24-Month results of a randomized controlled trial., Erika A Petersen, Thomas G Stauss, James A Scowcroft, Michael J Jaasma, Elizabeth S Brooks, Deborah R Edgar, Judith L White, Shawn M Sills, Kasra Amirdelfan, Maged N Guirguis, Jijun Xu, Cong Yu, Ali Nairizi, Denis G Patterson, Kostandinos C Tsoulfas, Michael J Creamer, Vincent Galan, Richard H Bundschu, Neel D Mehta, Dawood Sayed, Shivanand P Lad, David J DiBenedetto, Khalid A Sethi, Johnathan H Goree, Matthew T Bennett, Nathan J Harrison, Atef F Israel, Paul Chang, Paul W Wu, Charles E Argoff, Christian E Nasr, Rod S Taylor, David L Caraway, and Nagy A Mekhail

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Noninvasive testing for advanced fibrosis in patients with diabetes with fatty liver disease needs further evaluation of cutoff values., Pankaj Rajvanshi and Srikrishna Gurumurthy

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(543) Sex Differences in Clinical Presentation and Outcomes of Adults Hospitalized with COVID-19 Pneumonia After Administration of Infliximab, Abatacept or Cenicriviroc: Subgroup Analysis from the ACTIV-1 Master Protocol, Adriana Rauseo, Tatyana Der, Radica Alicic, Bindu Balani, Caryn Morse, Pearl Zakroysky, Linda Shaw, Jane Atkinson, and William G. Powderly

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Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis., Michelle N Rheault, Charles E Alpers, Jonathan Barratt, Stewart Bieler, Pietro Canetta, Dong-Wan Chae, Gaia Coppock, Ulysses Diva, Loreto Gesualdo, Hiddo J L Heerspink, Jula K Inrig, Gianna M Kirsztajn, Donald Kohan, Radko Komers, Laura A Kooienga, Kenneth Lieberman, Alex Mercer, Irene L Noronha, Vlado Perkovic, Jai Radhakrishnan, William Rote, Brad Rovin, Vladimir Tesar, Hernán Trimarchi, James Tumlin, Muh Geot Wong, Howard Trachtman, DUPRO Steering Committee and DUPLEX Investigators, and Katherine Tuttle

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Spontaneous Rupture of a Previously Asymptomatic Giant Angiomyolipoma, Reed Ritterbusch

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Real-World Effectiveness of SGLT2 Inhibitors Vs Metformin As First-Line Therapy in Type 2 Diabetes, Patricia Rodriguez, Samuel Gratzl, Ryan Lee, Sarah Gilson, Peter Smits, Nicholas L Stucky, and Tyler J Gluckman

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Mitomycin Gel (UGN-101) as a Kidney-sparing Treatment for Upper Tract Urothelial Carcinoma in Patients with Imperative Indications and High-grade Disease., Kyle M Rose, Katie S Murray, Craig Labbate, Solomon Woldu, Jennifer Linehan, Joseph Jacob, Hristos Kaimakliotis, Rian Dickstein, Adam Feldman, Surena F Matin, Yair Lotan, Mitchell R Humphreys, and Wade J Sexton

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The rationale, design and baseline data of FLOW, a kidney outcomes trial with once-weekly semaglutide in people with type 2 diabetes and chronic kidney disease., Peter Rossing, Florian M M Baeres, George Bakris, Heidrun Bosch-Traberg, Mette Gislum, Stephen C L Gough, Thomas Idorn, Jack Lawson, Kenneth W Mahaffey, Johannes F E Mann, Henriette Mersebach, Vlado Perkovic, Katherine Tuttle, and Richard Pratley

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The rationale, design and baseline data of FLOW, a kidney outcomes trial with once-weekly semaglutide in people with type 2 diabetes and chronic kidney disease., Peter Rossing, Florian M M Baeres, George Bakris, Heidrun Bosch-Traberg, Mette Gislum, Stephen C L Gough, Thomas Idorn, Jack Lawson, Kenneth W Mahaffey, Johannes F E Mann, Henriette Mersebach, Vlado Perkovic, Katherine Tuttle, and Richard Pratley

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1460-P: Prevalence of Chronic Kidney Disease Associated with Type 1 Diabetes in the U.S., Peter Rossing, Per-Henrik Groop, Rakesh Singh, Robert Lawatscheck, and Katherine Tuttle

Phase II doseselection, randomized double-blind trial of the ASI, BI 690517, alone and in combination with EMPA in people with CKD, P Rossing, Katherine Tuttle, and Full List of Authors in Comments

Prevalence of chronic kidney disease associated with type 1 diabetes in the US, P Rossing, Katherine Tuttle, and See full list of authors in comments

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Evaluation of an Integrated Intervention to Address Clinical Care and Social Needs Among Patients with Type 2 Diabetes., Sarah E Roth, Benjamin Gronowski, Kyle Jones, Rachel A Smith, Sonya Kauffman Smith, Keri B Vartanian, and Bill J. Wright

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Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial., William E Russell, Brian N Bundy, Mark S Anderson, Laura A Cooney, Stephen E Gitelman, Robin S Goland, Peter A Gottlieb, Carla J Greenbaum, Michael J Haller, Jeffrey P Krischer, Ingrid M Libman, Peter S Linsley, S Alice Long, Sandra M Lord, Daniel J Moore, Wayne V Moore, Antoinette M Moran, Andrew B Muir, Philip Raskin, Jay S Skyler, John M Wentworth, Diane K Wherrett, Darrell M Wilson, Anette-Gabriele Ziegler, and Kevan C Herold

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Outcomes with Finerenone in Participants with Stage 4 CKD and Type 2 Diabetes: A FIDELITY Subgroup Analysis., Pantelis Sarafidis, Rajiv Agarwal, Bertram Pitt, Christoph Wanner, Gerasimos Filippatos, John Boletis, Katherine R Tuttle, Luis M Ruilope, Peter Rossing, Robert Toto, Stefan D Anker, Zhi-Hong Liu, Amer Joseph, Christiane Ahlers, Meike Brinker, Robert Lawatscheck, George Bakris, and FIDELIO-DKD and FIGARO-DKD Investigators

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Comprehensive Understanding of Hispanic Caregivers: Focus on Innovative Methods and Validations., Ujala Sehar, Priyanka Rawat, Moumita Choudhury, Annette Boles, John Culberson, Hafiz Khan, Keya Malhotra, Tanisha Basu, and P Hemachandra Reddy

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Off-clamp Versus On-clamp Robot-assisted Partial Nephrectomy: A Propensity-matched Analysis., Gopal Sharma, Milap Shah, Puneet Ahluwalia, Prokar Dasgupta, Benjamin J Challacombe, Mahendra Bhandari, Rajesh Ahlawat, Sudhir Rawal, Nicolo M Buffi, Ananthakrishanan Sivaraman, James R Porter, Craig Rogers, Alexandre Mottrie, Ronney Abaza, Khoon Ho Rha, Daniel Moon, Thyavihally B Yuvaraja, Dipen J Parekh, Umberto Capitanio, Kris K Maes, Francesco Porpiglia, Levent Turkeri, and Gagan Gautam

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Robot-assisted partial nephrectomy in morbidly obese patients: a VCQI database study., Gopal Sharma, Gurpremjit Singh, Puneet Ahluwalia, Prokar Dasgupta, Benjamin J Challacombe, Mahendra Bhandari, Rajesh Ahlawat, Sudhir Rawal, Nicolo M Buffi, Sivaraman Ananth, James R Porter, Craig Rogers, Alexandre Mottrie, Ronney Abaza, Khoon Ho Rha, Daniel Moon, Thyavihally B Yuvaraja, Dipen J Parekh, Umberto Capitanio, Kris K Maes, Francesco Porpiglia, Levent Turkeri, and Gagan Gautam

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Response to COVID-19: The Outpatient Dialysis Setting., Jeffrey Silberzweig, Sylvia Wu, Matthew Sinclair, Thomas Watson, Nancy Welder, Danilo Concepcion, Jerry Yee, Felicia Speed, Daniel Cukor, Brigitte Schiller, and Daniel Weiner

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Clinical Practice Panel: Diabetes Mellitus Management in a Medical-Surgical Unit, Jane Tajonera

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Hospital-Based, Community Teaching Kitchen Integrates Diabetes Education, Culinary Medicine, and Food Assistance: Case Study During the COVID-19 Pandemic., Jacob P Tanumihardjo, Heidi Davis, Jill Christensen, Rachel A Smith, Sonya Kauffman Smith, and Kathryn E Gunter

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Enhancing Chronic-Disease Education through Integrated Medical and Social Care: Exploring the Beneficial Role of a Community Teaching Kitchen in Oregon., Jacob P Tanumihardjo, Heidi Davis, Mengqi Zhu, Helen On, Kayla K Guillory, and Jill Christensen