Providence’s research in kidney health and diseases is on the cutting edge of identifying molecular signatures of diabetic kidney disease and development of new biomarkers and treatment targets. Our work is broadly translational from cellular and molecular biology to studies in mouse models to translational studies in humans and clinical trials of novel therapies. We also conduct research in a broad spectrum of other types of kidney diseases and treatments: glomerular diseases, hypertension and kidney vascular disease, nutritional approaches, patient-centered outcomes, and health services research. Importantly, Providence has funded a major initiative to establish a system-wide Chronic Kidney Disease registry that will greatly amplify both the quality-of-care we deliver and the research we conduct in our communities. We truly are at a tipping point. Astounding scientific breakthroughs will change the landscape toward kidney health and better life for people with kidney diseases.

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Books from 2023

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Analysis of eGFR vs CrCl to monitor for renal dose adjustments within Central Refill, Briana Thompson and Angela Koerner

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Targeting of insulin receptor endocytosis as a treatment to insulin resistance., Bryce Tim, Valentina L Kouznetsova, Santosh Kesari, and Igor F Tsigelny

2023 Cardiometabolic Health Congress (CMHC) Women’s Health and Wellness Masterclass, Katherine Tuttle

“90% of people with chronic kidney disease don’t know they have it. Do you know the risk factors?”, Katherine Tuttle

“Cardiorenal Disease: Can reducing the risks improve outcomes?”, Katherine Tuttle

Chair – Targeting Muscle, Kidney & Liver, Katherine Tuttle

CKD in Diabetes and the Journey to Kidney Health, Katherine Tuttle

Clinicopathologic Conference “ Nephrotic Syndrome”, Katherine Tuttle

“Comparative effectiveness of GLP-1 receptor agonists vs DPP-4 inhibitors in patients type 2 diabetes, Katherine Tuttle

“Comparative effectiveness of GLP-1 receptor agonists vs. SGLT2 inhibitors”, Katherine Tuttle

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Destination Kidney Health for Diabetes and CKD, Katherine Tuttle

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Digging deep into cells to find mechanisms of kidney protection by SGLT2 inhibitors., Katherine Tuttle

Effects of Long COVID, Katherine Tuttle

“FDA Approved Empagliflozin for Adults with Chronic Kidney Disease at Risk of Progression”, Katherine Tuttle

“FDA approves new indication for Jardiance”, Katherine Tuttle

“GLP1 RAs and Kidney Outcomes in Diabetes”, Katherine Tuttle

Harvard Medical School – Diabetes Comorbidities and Complications, Katherine Tuttle

“Implementation of a New Era of Goal-Directed Medical Therapy for Patients with Cardiorenal Disease”, Katherine Tuttle

“Incretin Trials: Trying new directions”, Katherine Tuttle

“Jardiance approved for adults with Chronic Kidney Disease”, Katherine Tuttle

KDIGO Conference on CKD, Rome Italy, Katherine Tuttle

Kidney Health in View for Diabetes and CKD, Katherine Tuttle

Late breaking clinical trials: “Asi in CKD”, Katherine Tuttle

Most Powerful Tools Ever to Slow the Progression of Diabetic Kidney Disease: How and When to Use them Optimally”, Katherine Tuttle

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Multidisciplinary Strategies for Implementation, Katherine Tuttle

National Academies of Sciences, Engineering, and Medicine, Preparing the Future Workforce in Drug Research and Development Workshop – Speaker, Katherine Tuttle

“ Non-insulin therapies for people living with T2D”, Katherine Tuttle

“On par with the biggest breakthroughs in medicine”, Katherine Tuttle

“Outsize benefit seen in trial of drug for kidney disease”, Katherine Tuttle

“Prediction of kidney failure using multiple data domains in glomerulonephropathy: A CureGN study”, Katherine Tuttle

“Preserving Kidney Health in Diabetes”, Katherine Tuttle

Protective effects of GLP-1 Receptor Agonists, Katherine Tuttle

Providence IM/FM Resident’s Lecture “CKD in Diabetes and Beyond. Entering A New Era of Kidney Health” Spokane, WA, Katherine Tuttle

“Racial and Ethnic Disparities in Acute Care Utilization Among Patients with Glomerular Disease”, Katherine Tuttle

"Randomized trial of semaglutide for diabetic kidney disease in type 1 diabetes", Katherine Tuttle

Research presented at the American Society of Nephrology meeting, Katherine Tuttle

“Safety evaluation of empagliflozin for patients with type 2 diabetes and chronic kidney disease”, Katherine Tuttle

“Scientists find promising new drug for chronic kidney disease”, Katherine Tuttle

“SGLT2 inhibitors and GLP-1 receptor agonist: mechanisms of beneficial action beyond, Katherine Tuttle

“Spokane doctor’s breakthrough kidney disease treatment shows promising results”, Katherine Tuttle

“The Journey to Kidney Health is the Reward for People with Diabetes and CKD”, Katherine Tuttle

“The Kidney | SGLT2 Inhibitors and GLP-1”, Katherine Tuttle

“Therapeutic Transformation of Kidney Care by Groundbreaking Clinical Trials”, Katherine Tuttle

“There is no excuse for the number of people we have on dialysis”, Katherine Tuttle

“Tirzepaztide reduces albuminuria in patients with type 2 diabetes”, Katherine Tuttle

“Unmet need: The epidemiology of CKD & type 1 diabetes”, Katherine Tuttle

USPSTF Kidney Caucus Meeting - Speaker, Katherine Tuttle

A Quality Improvement Initiative to Bridge Gaps in Treatment and Interprofessional Care of CKD, Katherine Tuttle, Radica Alicic, Cami Jones, Lindsey Kornowske, Kenn Daratha, and See full list of authors in comments

Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Research Diversity (AIM-AHEAD), Katherine Tuttle, Radica Alicic, Cami Jones, Lindsey Kornowske, Kenn Daratha, and See full list of authors in comments

Assessment of Medication Adherence Among Adults with Glomerular Disease, Katherine Tuttle, Radica Alicic, Cami Jones, Lindsey Kornowske, Kenn Daratha, and See full list of authors in comments

Design and Baseline Characteristics of the FIND-CKD Trial: Efficacy of Finerernone on Kidney Disease Progression in People with non-diabetic CKD, Katherine Tuttle, Radica Alicic, Cami Jones, Lindsey Kornowske, Kenn Daratha, and See full list of authors in comments

Diabetic Kidney Disease Collaborative (DKD-C): Addressing the Urgent and Unmet Needs of People with CKD, Katherine Tuttle, Radica Alicic, Cami Jones, Lindsey Kornowske, Kenn Daratha, and See full list of authors in comments

Dynamic Bayesian Networks (DBN) Predicted ≥40% Decline in eGFR over Six Years, Katherine Tuttle, Radica Alicic, Cami Jones, Lindsey Kornowske, Kenn Daratha, and See full list of authors in comments

Incidence of Chronic Kidney Disease in Prediabetes, Katherine Tuttle, Radica Alicic, Cami Jones, Lindsey Kornowske, Kenn Daratha, and See full list of authors in comments

Interim Results from FINE-REAL: A Prospective Study Providing Insights into the Use of Finerenone in Routine Clinical Settings, Katherine Tuttle, Radica Alicic, Cami Jones, Lindsey Kornowske, Kenn Daratha, and See full list of authors in comments

Kidney Failure Risk Equation Prediction in a Real-World Population with CKD, Katherine Tuttle, Radica Alicic, Cami Jones, Lindsey Kornowske, Kenn Daratha, and See full list of authors in comments

Kidney Transcriptomics of Blood Pressure (BP) in Minimal Change Disease (MDC) and Focal Segmental Glomerulosclerosis (FSGS), Katherine Tuttle, Radica Alicic, Cami Jones, Lindsey Kornowske, Kenn Daratha, and See full list of authors in comments

Major Adverse Kidney Disease Events in a Real-World Population with Diabetes, Katherine Tuttle, Radica Alicic, Cami Jones, Lindsey Kornowske, Kenn Daratha, and See full list of authors in comments

Predictors of Major Adverse Kidney Disease Events in a Real-World Population with IgA Nephropathy, Katherine Tuttle, Radica Alicic, Cami Jones, Lindsey Kornowske, Kenn Daratha, and See full list of authors in comments

Predictors of major adverse kidney disease in a real-world population with IgA nephropathy, Katherine Tuttle, Ken Daratha, Radica Alicic, Joshua J Neumiller, and See all authors in comments

Major adverse kidney disease events in a real-world population with diabetes, Katherine Tuttle, Ken Daratha, Joshua J Neumiller, Radica Alicic, and See all authors in comments

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Kidney-Heart Connection: Implications of Chronic Kidney Disease for Screening and Prevention of Heart Failure., Katherine Tuttle and Carolyn S P Lam

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The authors reply., Katherine R Tuttle, Heidrun Bosch-Traberg, David Z I Cherney, Samy Hadjadj, Ofri Mosenzon, Søren Rasmussen, and Stephen C Bain

Comparative effectiveness of GLP-1 receptor agonists vs DPP-4 inhibitors in patients with type 2 diabetes and moderate/severe chronic kidney disease, Katherine Tuttle and See all authors in comments

Diabetic Kidney Disease Collaborative (DKD-C): Addressing the urgent and unmet needs of people with chronic kidney disease and diabetes, Katherine Tuttle and See all authors in comments

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Indicators of Kidney Fibrosis in Patients with Type 2 Diabetes and Chronic Kidney Disease Treated with Dulaglutide., Katherine Tuttle, Jonathan Matthew Wilson, Yanzhu Lin, Hui-Rong Qian, Federica Genovese, Morten Asser Karsdal, Kevin L Duffin, and Fady T Botros

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Indicators of Kidney Fibrosis in Patients With Type 2 Diabetes and Chronic Kidney Disease Treated With Dulaglutide., Katherine Tuttle, Jonathan Matthew Wilson, Yanzhu Lin, Hui-Rong Qian, Federica Genovese, Morten Asser Karsdal, Kevin L Duffin, and Fady T Botros

Changing Landscape of Diabetic Kidney Disease Treatment, including the Robert W. Schrier, MD, Endowed Lectureship, Katherine Tuttle (moderator)

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Robot-assisted partial nephrectomy for complex renal tumors: Analysis of a large multi-institutional database., Burak Ucpinar, Jordan Miller Rich, Kennedy E Okhawere, Shirin Razdan, Osama Zaytoun, Laura Zuluaga, Indu Saini, Michael D Stifelman, Ronney Abaza, Daniel D Eun, Akshay Bhandari, Ashok K Hemal, James Porter, Simone Crivellero, Ahmed Mansour, Phillip M Pierorazio, and Ketan K Badani

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Association of COVID-19 Versus COVID-19 Vaccination With Kidney Function and Disease Activity in Primary Glomerular Disease: A Report of the Cure Glomerulonephropathy Study., Chia-Shi Wang, Dorey A Glenn, Margaret Helmuth, Abigail R Smith, Andrew S Bomback, Pietro A Canetta, Gaia M Coppock, Myda Khalid, Katherine Tuttle, Raed Bou-Matar, Larry A Greenbaum, Bruce M Robinson, Lawrence B Holzman, William E Smoyer, Michelle N Rheault, Debbie Gipson, Laura H Mariani, and Cure Glomerulonephropathy (CureGN) Study Consortium

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Tobacco exposure in adults and children with proteinuric glomerulopathies: a NEPTUNE cohort study., Linda Wang, Bayle Smith-Salzberg, Kevin Ec Meyers, Dorey A Glenn, Katherine R Tuttle, Vimal K Derebail, Tammy M Brady, Keisha Gibson, Abigail R Smith, Michelle M O'Shaughnessy, Tarak Srivastava, Gentzon Hall, Jarcy Zee, Markus Bitzer, and Christine B Sethna

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Advances in Chronic Kidney Disease Care in Type 2 Diabetes, Carol Wysham and Katherine Tuttle

Submissions from 2022

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The impact of a Medicare Public Health Emergency policy change for continuous glucose monitors on utilization and total cost of care for diabetes, Momoka Abe, Katie Norton, and Jenifer Smith

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Benefits and risks of apps for patients., David T Ahn

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Unusual Case of Non-HIV Patient With Multifocal Pyomyositis: Developed on Appropriate Antibiotic Therapy., Elisa Akagi and Ashish Bhargava

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Use of Glucose-Lowering Agents in Diabetes and CKD., Radica Alicic, Joshua J Neumiller, Rodolfo J Galindo, and Katherine Tuttle

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Diabetic Kidney Disease Back in Focus: Management Field Guide for Health Care Professionals in the 21st Century., Radica Alicic and Susanne B Nicholas

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Use of Glucose-Lowering Agents in Diabetes and CKD., Radica Z Alicic, Joshua J Neumiller, Rodolfo J Galindo, and Katherine R Tuttle

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Gut microbiota analyses of Saudi populations for type 2 diabetes-related phenotypes reveals significant association., Fahad A Al-Muhanna, Alexa K Dowdell, Abdulmohsen H Al Eleq, Waleed I Albaker, Andrew W Brooks, Ali I Al-Sultan, Abdullah M Al-Rubaish, Khaled R Alkharsah, Raed M Sulaiman, Abdulaziz A Al-Quorain, Cyril Cyrus, Rudaynah A Alali, Chittibabu Vatte, Fred L Robinson, Xin Zhou, Michael P Snyder, Afnan F Almuhanna, Brendan J Keating, Brian D. Piening, and Amein K Al-Ali

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Are angiotensin-converting enzyme inhibitors/angiotensin receptor blockers associated with reduced severe acute respiratory syndrome coronavirus 2 infections and improved outcomes, and does race matter?, John Armato, Ralph A DeFronzo, Shih-Ting Chiu, Deanna Rider, and Ronald Ruby

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CKD Series Episode 1: Identifying Patients at Risk for DKD Onset or Progression, George Bakris, Rajiv Agarwal, and Katherine Tuttle

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CKD Series Episode 2: Counseling Patients about CKD, George Bakris, Rajiv Agarwal, and Katherine Tuttle

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CKD Series Episode 3: Updated Approach to Managing CKD in Patients with T2DM, George Bakris, Rajiv Agarwal, and Katherine Tuttle

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CKD Series Episode 4: Implications of Non-steroidal MRAs for DKD, George Bakris, Rajiv Agarwal, and Katherine Tuttle

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CKD Series Episode 5: New and Emerging Therapies and Approaches for CKD, George Bakris, Rajiv Agarwal, and Katherine Tuttle

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On-Clamp vs. Off-Clamp Robot-Assisted Partial Nephrectomy for cT2 Renal Tumors: Retrospective Propensity-Score-Matched Multicenter Outcome Analysis., Aldo Brassetti, Giovanni E Cacciamani, Andrea Mari, Juan D Garisto, Riccardo Bertolo, Chandru P Sundaram, Ithaar Derweesh, Ahmet Bindayi, Prokar Dasgupta, James R Porter, Alexander Mottrie, Luigi Schips, Koon Ho Rah, David Y T Chen, Chao Zhang, Kenneth Jacobsohn, Umberto Anceschi, Alfredo M Bove, Manuela Costantini, Mariaconsiglia Ferriero, Riccardo Mastroianni, Leonardo Misuraca, Gabriele Tuderti, Alexander Kutikov, Wesley M White, Stephen T Ryan, Francesco Porpiglia, Jihad Kaouk, Andrea Minervini, Inderbir Gill, Riccardo Autorino, and Giuseppe Simone

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Retroperitoneal Robot-assisted Partial Nephrectomy: A Systematic Review and Pooled Analysis of Comparative Outcomes., Umberto Carbonara, Fabio Crocerossa, Riccardo Campi, Alessandro Veccia, Giovanni E Cacciamani, Daniele Amparore, Enrico Checcucci, Davide Loizzo, Angela Pecoraro, Michele Marchioni, Chiara Lonati, Chandru P Sundaram, Reza Mehrazin, James R Porter, Jihad H Kaouk, Francesco Porpiglia, Pasquale Ditonno, and Riccardo Autorino

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Hemoglobin A1c Reduction With the GLP-1 Receptor Agonist Semaglutide Is Independent of Baseline eGFR:, David Z I Cherney, Samy Hadjadj, Jack Lawson, Ofri Mosenzon, Katherine Tuttle, Blaz Vrhnjak, Søren Rasmussen, and Stephen C Bain

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Post-acute COVID-19 syndrome and kidney diseases: what do we know?, Sidar Copur, Metehan Berkkan, Carlo Basile, Katherine Tuttle, and Mehmet Kanbay

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Future of kidney imaging: Functional magnetic resonance imaging and kidney disease progression., Sidar Copur, Furkan Yavuz, Alan A Sag, Katherine Tuttle, and Mehmet Kanbay

Future of kidney imaging: Functional magnetic resonance imaging and kidney disease progression, Sidar Copur, Furkan Yavuz, Alan A. Sag, Katherine Tuttle, and Mehmet Kanbay

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Is there any robust evidence showing that SGLT2 inhibitor use predisposes to acute kidney injury?, Sidar Copur, Abdullah Yildiz, Carlo Basile, Katherine Tuttle, and Mehmet Kanbay

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Intraoperative Hypotension and Acute Kidney Injury in Non-cardiac Surgery at a Large Tertiary Care Medical Center., Elizabeth Davison, Amanda Affleck, and Kenn Daratha

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Diabetes management in chronic kidney disease: a consensus report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO)., Ian H de Boer, Kamlesh Khunti, Tami Sadusky, Katherine Tuttle, Joshua J Neumiller, Connie M Rhee, Sylvia E Rosas, Peter Rossing, and George Bakris

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Diabetes Management in Chronic Kidney Disease: A Consensus Report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO)., Ian H de Boer, Kamlesh Khunti, Tami Sadusky, Katherine Tuttle, Joshua J Neumiller, Connie M Rhee, Sylvia E Rosas, Peter Rossing, and George Bakris

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Immune Checkpoint Inhibitor Induced Type 1 Diabetes Mellitus: A Pembrolizumab Case Study, Michael R. Dirks Jr.

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A Century of Diabetes Success: The Past as Prologue, Boris Draznin, Mikhail Kosiborod, Katherine Tuttle, and Clifford Goodman (moderator)

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COPD Exacerbations, Brad Drummond, Allison Lambert, Kristina Montemayor, and Dave Furfaro

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Carfilzomib-Induced Thrombotic Microangiopathy: Focus on Pathogenesis., Odianosen Eigbire-Molen, Daniela Hermelin, and Douglas Blackall

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Design, recruitment, and baseline characteristics of the EMPA-KIDNEY trial., EMPA-KIDNEY Collaborative Group and Katherine Tuttle (EMPA-KIDNEY Collaborative Group)