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Publication Date
2025
Keywords
oregon, ppmc, oregon gme
Disciplines
Medical Education
Abstract
Introduction: •HBV reactivation is a known phenomenon affecting those with prior HBV infection. In rare cases, this occurs spontaneously, but most often reactivation will occur while the host is immunocompromised. •Hepatitis B Virus (HBV) remains in the nucleus of hepatocytes and cannot be fully eradicated. •The following case highlights important considerations regarding HBV. Case Presentation: •A 78 y.o. male presented with emesis and progressive painless jaundice. •Prior history of treated HCV, Hepatocellular Carcinoma, HBV vaccination, and autoimmune Interstitial Lung Disease on Mycophenolate. •No recent risk factors, such as alcohol use, IV drug use, or sexual activity. •Previous tests for Hepatitis B Surface Antibody (HBsAb) were positive and negative for Hepatitis B Surface Antigen (HBsAg) in 2015. Learning Points: •This case demonstrates multiple important lessons: at risk.First, it’s important to recognize the risk factors that place pa tients at risk for decompensation. Second, initiating immunosuppression necessitates appropriate screen ing and risk stratification. Third, Hepatitis B Core Antibody (HBcAb) testing should be performed to look for prior infection as testing for HBsAg and HBsAb alone is insufficient in those
Specialty/Research Institute
Graduate Medical Education
