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Submissions from 2024

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Using Machine Learning and miRNA for the Diagnosis of Esophageal Cancer., Vishnu A Aravind, Valentina L Kouznetsova, Santosh Kesari, and Igor F Tsigelny

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Data leakage in deep learning studies of translational EEG., Geoffrey Brookshire, Jake Kasper, Nicholas M Blauch, Yunan Charles Wu, Ryan M. Glatt, David A Merrill, Spencer Gerrol, Keith J Yoder, Colin Quirk, and Ché Lucero

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Generating real-world evidence in Alzheimer's disease: Considerations for establishing a core dataset., James E Galvin, Jeffrey L Cummings, Mihaela Levitchi Benea, Carl de Moor, Ricardo F Allegri, Alireza Atri, Howard Chertkow, Claire Paquet, Verna R Porter, Craig W Ritchie, Sietske A M Sikkes, Michael R Smith, Christina Marsica Grassi, and Ivana Rubino

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Neurocognitive Effects of an Online Brain Health Program and Weekly Telehealth Support Group in Older Adults with Subjective Memory Loss: A Pilot Study., Ryan M. Glatt, Amylee Amos, David A Merrill, John F Hodes, Claudia L Wong, Karen J Miller, and Prabha Siddarth

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A phase I dose-escalation study of pulsatile afatinib in patients with recurrent or progressive brain cancer., Tiffany Juarez, Jaya Mini Gill, Annie Heng, Jose Carrillo, Naveed Wagle, Natsuko Nomura, Minhdan Nguyen, Judy D Truong, Lucia Dobrawa, Walavan Sivakumar, Garni Barkhoudarian, Daniel F Kelly, and Santosh Kesari

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The RAPID Consortium: A Platform for Clinical and Translational Pituitary Tumor Research., Michael Karsy, Varun Kshettry, Paul Gardner, Michael Chicoine, Juan C Fernandez-Miranda, James J Evans, Garni Barkhoudarian, Douglas Hardesty, Won Kim, Gabriel Zada, Tomiko Crocker, Ildiko Torok, and Andrew Little

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Pilot Study of High-Dose Pemetrexed in Patients with Progressive Chordoma., Santosh Kesari, Naveed Wagle, Jose Carrillo, Akanksha Sharma, Minhdan Nguyen, Judy D Truong, Jaya Mini Gill, Raffi Nersesian, Natsuko Nomura, Elnaz Rahbarlayegh, Garni Barkhoudarian, Walavan Sivakumar, Daniel F Kelly, Howard Krauss, Matias A Bustos, Dave Hoon, Lars Anker, Arun S Singh, Kamalesh K Sankhala, and Tiffany Juarez

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The impact of physical exercise on hippocampal atrophy in mild cognitive impairment and Alzheimer's disease: a meta-analysis., Gavin T Kress, Emily S Popa, David A Merrill, Jennifer E Bramen, and Prabha Siddarth

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Parkinson's Disease Diagnosis Using miRNA Biomarkers and Deep Learning., Alex Kumar, Valentina L Kouznetsova, Santosh Kesari, and Igor F Tsigelny

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Histological assessment of microtia cartilage, a potential source of autograft tissue in ear reconstruction., David D Lam, Neel V Hegde, Divya D Patel, Daniel L Lakeland, Nicholas Guardino, Amit Kochhar, and Francesca V Mariani

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Hypoxia drives shared and distinct transcriptomic changes in two invasive glioma stem cell lines., Valerie J Marallano, Mary E Ughetta, Rut Tejero, Sidhanta Nanda, Rohana Ramalingam, Lauren Stalbow, Anirudh Sattiraju, Yong Huang, Aarthi Ramakrishnan, Li Shen, Alexandre Wojcinski, Santosh Kesari, Hongyan Zou, Alexander M Tsankov, and Roland H Friedel

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Evaluation of the EMulate Therapeutics Voyager's ultra-low radiofrequency energy in murine model of glioblastoma., Rajesh Mukthavaram, Pengfei Jiang, Sandra Pastorino, Natsuko Nomura, Feng Lin, and Santosh Kesari

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Thrombectomy With the pRESET vs Solitaire Stent Retrievers as First-Line Large Vessel Occlusion Stroke Treatment: A Randomized Clinical Trial., Raul G Nogueira, Donald Lobsien, Joachim Klisch, Daniel Pielenz, Elmar Lobsien, Eric Sauvageau, Nima Aghaebrahim, Markus Möhlenbruch, Dominik Vollherbst, Christian Ulfert, Hormozd Bozorgchami, Wayne Clark, Ryan Priest, Edgar A Samaniego, Santiago Ortega-Gutierrez, Malik Ghannam, Demetrius Lopes, Joshua Billingsley, Kiffon Keigher, Diogo C Haussen, Alhamza R Al-Bayati, Adnan Siddiqui, Elad Levy, Michael Chen, Stephan Munich, Peter Schramm, Tobias Boppel, Sandra Narayanan, Bradley A Gross, Christian Roth, Tobias Boeckh-Behrens, Ameer Hassan, Johanna Fifi, Ron F Budzik, Jason Tarpley, Robert M Starke, Eytan Raz, Gary Brogan, David S Liebeskind, and Ricardo A Hanel

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Exercise-Related Physical Activity Relates to Brain Volumes in 10,125 Individuals., Cyrus A Raji, Somayeh Meysami, Sam Hashemi, Saurabh Garg, Nasrin Akbari, Gouda Ahmed, Yosef Gavriel Chodakiewitz, Thanh Duc Nguyen, Kellyann Niotis, David A Merrill, and Rajpaul Attariwala

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The neurosurgery research & education foundation-young neurosurgeons committee webinar series: Providing education and inspiration during the COVID-19 pandemic., Ana G Rodriguez-Armendariz, Max A Saint-Germain, Adham M Khalafallah, Sakibul Huq, Neil D Almeida, David L Dornbos, Christopher S Graffeo, Walavan Sivakumar, Debraj Mukherjee, and Jeremiah N Johnson

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Most Promising Approaches to Improve Brain AVM Management: ARISE I Consensus Recommendations., Edgar A Samaniego, Guilherme Dabus, Philip M Meyers, Peter T Kan, Juhana Frösen, Giuseppe Lanzino, Babu G Welch, Victor Volovici, Fernando Gonzalez, Johana Fifi, Fady T Charbel, Brian L Hoh, Alexander Khalessi, Michael P Marks, Alejandro Berenstein, Victor M Pereira, Mark Bain, Geoffrey P Colby, Sandra Narayanan, Satoshi Tateshima, Adnan H Siddiqui, Ajay K Wakhloo, Adam S Arthur, Michael T Lawton, and ARISE I Consortium

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ARISE I Consensus Review on the Management of Intracranial Aneurysms., Stavropoula I Tjoumakaris, Ricardo Hanel, J Mocco, M Ali-Aziz Sultan, Michael Froehler, Barry B Lieber, Alexander Coon, Satoshi Tateshima, David J Altschul, Sandra Narayanan, Kareem El Naamani, Phil Taussky, Brian L Hoh, Philip Meyers, Matthew J Gounis, David S Liebeskind, Victor Volovici, Gabor Toth, Adam Arthur, Ajay K Wakhloo, and ARISE I Consortium

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Safety and effectiveness assessment of the surpass evolve (SEASE): a post-market international multicenter study., Juan Vivanco-Suarez, Mahmoud Dibas, Demetrius Klee Lopes, Ricardo A Hanel, Mario Martínez-Galdámez, Aaron Rodriguez-Calienes, Gustavo M Cortez, Johanna T Fifi, Alex Devarajan, Gabor Toth, Thomas Patterson, David Altschul, Vitor M Pereira, Eileen Liu, Ajit S Puri, Anna Luisa Kuhn, Waldo R Guerrero, Priyank Khandelwal, Ivo Bach, Peter Kan, Gautam Edhayan, Curtis Given, Sandra Narayanan, Bradley A Gross, Mudassir Farooqui, Milagros Galecio-Castillo, Shahram Derakhshani, and Santiago Ortega-Gutierrez

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Colorectal Cancer Detection via Metabolites and Machine Learning., Rachel Yang, Igor F Tsigelny, Santosh Kesari, and Valentina L Kouznetsova

Submissions from 2023

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Impact of Eating a Carbohydrate-Restricted Diet on Cortical Atrophy in a Cross-Section of Amyloid Positive Patients with Alzheimer's Disease: A Small Sample Study., Jennifer Bramen, Prabha Siddarth, Emily S Popa, Gavin T Kress, Molly Rapozo, John F Hodes, Aarthi Ganapathi, Colby B Slyapich, Ryan M. Glatt, Kyron P Pierce, Verna R Porter, Claudia L Wong, Mihae Kim, Richelin V Dye, Stella Panos, Tess Bookheimer, Tori Togashi, Spencer Loong, Cyrus A Raji, Susan Y Bookheimer, Jared C Roach, and David A Merrill

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Binned Data Provide Better Imputation of Missing Time Series Data from Wearables., Shweta Chakrabarti, Nupur Biswas, Khushi Karnani, Vijay Padul, Lawrence D Jones, Santosh Kesari, and Shashaanka Ashili

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Two-Stage Deep-Learning Classifier for Diagnostics of Lung Cancer Using Metabolites., Ashvin Choudhary, Jianpeng Yu, Valentina L Kouznetsova, Santosh Kesari, and Igor F Tsigelny

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BETA prime: a first-in-man phase 1 study of AdAPT-001, an armed oncolytic adenovirus for solid tumors., Anthony P Conley, Christina L Roland, Alberto Bessudo, Brian R Gastman, Victoria M Villaflor, Christopher Larson, Tony R Reid, Scott Caroen, Bryan Oronsky, Meaghan Stirn, Jeannie Williams, Erica Burbano, Angelique Coyle, Minal A Barve, Naveed Wagle, Nacer Abrouk, and Santosh Kesari

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Capicua (CIC) mutations in gliomas in association with MAPK activation for exposing a potential therapeutic target., Sourat Darabi, Joanne Xiu, Timothy Samec, Santosh Kesari, Jose Carrillo, Sonikpreet Aulakh, Kyle M Walsh, Soma Sengupta, Ashley Sumrall, David Spetzler, Michael Glantz, and Michael J Demeure

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Nature-themed video intervention may improve cardiovascular safety of psilocybin-assisted therapy for alcohol use disorder., Keith Heinzerling, Karina Sergi, Micah Linton, Rhianna Rich, Brittany Youssef, Inez Bentancourt, Jennifer Bramen, Prabha Siddarth, Louie Schwartzberg, and Daniel F Kelly

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SMARTfit Dual-Task Exercise Improves Cognition and Physical Function in Older Adults With Mild Cognitive Impairment: Results of a Community-Based Pilot Study., Sameer Jhaveri, Matthew Romanyk, Ryan Glatt, and Nikhil Satchidanand

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Synergism in actions of HBV with aflatoxin in cancer development., Joshua Jin, Valentina L Kouznetsova, Santosh Kesari, and Igor F Tsigelny

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Patient Perception of Education, Care Coordination, and Psychological Distress After Developing Facial Paralysis: A Qualitative Study., Natalie R Kenton, Merai Estafanous, Kyohei Itamura, Ania Filus, Shanthi Gowrinathan, Neil A Martin, Walavan Sivakumar, Garni Barkhoudarian, Patrick J Byrne, and Amit Kochhar

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Response to OKN-007 and NAC in a Patient with Unilateral Hearing Loss and Chronic Tinnitus from Vestibular Schwannoma., Santosh Kesari, Andy Liu, Jaya Mini Gill, Minhdan Nguyen, Judy D Truong, Raffi Nersesian, Emma Chacon, Akanksha Sharma, Naveed Wagle, Chester Griffiths, Gregory Frazer, Max Zats, Shinwook Kang, Matthew B West, Richard D Kopke, and Tiffany Juarez

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Activity of pemetrexed in pre-clinical chordoma models and humans., Santosh Kesari, Feng Wang, Tiffany Juarez, Shashaanka Ashili, C Pawan K Patro, Jose Carrillo, Minhdan Nguyen, Judy D Truong, Joan Levy, Josh Sommer, Daniel M Freed, Joanne Xiu, Yuki Takasumi, Eric Bouffet, and Jaya Mini Gill

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Case Report of AdAPT-001-Mediated Sensitization to a Previously Failed Checkpoint Inhibitor in a Metastatic Chordoma Patient., Santosh Kesari, Jeannie Williams, Erica Burbano, Meaghan Stirn, Scott Caroen, Bryan Oronsky, Tony Reid, and Chris Larson

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Minimally Invasive Techniques for Facial Rejuvenation Utilizing Polydioxanone Threads., Amit Kochhar, Parvesh Kumar, and Kian Karimi

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Preliminary validation of a structural magnetic resonance imaging metric for tracking dementia-related neurodegeneration and future decline., Gavin T Kress, Emily S Popa, Paul M Thompson, Susan Y Bookheimer, Sophia I Thomopoulos, Christopher R K Ching, Hong Zheng, Daniel A Hirsh, David A Merrill, Stella Panos, Cyrus A Raji, Prabha Siddarth, and Jennifer E Bramen

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Diagnostics of Thyroid Cancer Using Machine Learning and Metabolomics., Alyssa Kuang, Valentina L Kouznetsova, Santosh Kesari, and Igor F Tsigelny

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Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma: A Phase 3 Prospective Externally Controlled Cohort Trial., Linda M Liau, Keyoumars Ashkan, Steven Brem, Jian L Campian, John E Trusheim, Fabio M Iwamoto, David D Tran, George Ansstas, Charles Cobbs, Jason A Heth, Michael E Salacz, Stacy D'Andre, Robert D Aiken, Yaron A Moshel, Joo Y Nam, Clement P Pillainayagam, Stephanie A Wagner, Kevin A Walter, Rekha Chaudhary, Samuel A Goldlust, Ian Y Lee, Daniela A Bota, Heinrich Elinzano, Jai Grewal, Kevin Lillehei, Tom Mikkelsen, Tobias Walbert, Steven Abram, Andrew J Brenner, Matthew G Ewend, Simon Khagi, Darren S Lovick, Jana Portnow, Lyndon Kim, William G Loudon, Nina L Martinez, Reid C Thompson, David E Avigan, Karen L Fink, Francois J Geoffroy, Pierre Giglio, Oleg Gligich, Dietmar Krex, Scott M Lindhorst, Jose Lutzky, Hans-Jörg Meisel, Minou Nadji-Ohl, Lhagva Sanchin, Andrew Sloan, Lynne P Taylor, Julian K Wu, Erin M Dunbar, Arnold B Etame, Santosh Kesari, David Mathieu, David E Piccioni, David S Baskin, Michel Lacroix, Sven-Axel May, Pamela Z New, Timothy J Pluard, Steven A Toms, Victor Tse, Scott Peak, John L Villano, James D Battiste, Paul J Mulholland, Michael L Pearlman, Kevin Petrecca, Michael Schulder, Robert M Prins, Alton L Boynton, and Marnix L Bosch

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Acoustic resonance therapy is safe and effective for the treatment of nasal congestion in rhinitis: A randomized sham-controlled trial., Amber U Luong, Michael Yong, Peter H Hwang, Bryant Y Lin, Paramesh Gopi, Vivek Mohan, Yifei Ma, Jacob Johnson, David M Yen, Richard S DeMera, and Benjamin S Bleier

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Neuroinflammation: A Modifiable Pathway Linking Obesity, Alzheimer's disease, and Depression., Maria Ly, Gary Z Yu, Ali Mian, Austin Cramer, Somayeh Meysami, David A Merrill, Amjad Samara, Sarah A Eisenstein, Tamara Hershey, Ganesh M Babulal, Eric J Lenze, John C Morris, Tammie L S Benzinger, and Cyrus A Raji

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A prospective multi-center observational study of surgical versus non-surgical management for pituitary apoplexy., Adam N Mamelak, Andrew S Little, Paul A Gardner, João Paulo Almeida, Pablo Recinos, Pranay Soni, Varun R Kshettry, John A Jane, Garni Barkhoudarian, Daniel F Kelly, Robert Dodd, Debraj Mukherjee, Zachary C Gersey, Noriaki Fukuhara, Hiroshi Nishioka, Eui-Hyun Kim, Claude-Fabien Litré, Elliott Sina, Mia W Mazer, Yujie Cui, and Vivien Bonert

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A combined exercise and cognitive training intervention induces fronto-cingulate cortical plasticity in first-episode psychosis patients., S C McEwen, B Jarrahi, J Ventura, K L Subotnik, J Nguyen, S M Woo, and K H Nuechterlein

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Arterial Bypass in the Treatment of Complex Middle Cerebral Artery Aneurysms: Lessons Learned from Forty Patients., Sophie F Peeters, Geoffrey P Colby, Wi Jin Kim, Whi Inh Bae, Hiro Sparks, Kara Reitz, Satoshi Tateshima, Reza Jahan, Viktor Szeder, May Nour, Gary R Duckwiler, Fernando Vinuela, Neil A Martin, and Anthony C Wang

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Proximal Internal Carotid Artery Occlusion and Extracranial-Intracranial Bypass for Treatment of Fusiform and Giant Internal Carotid Artery Aneurysms., Sophie M Peeters, Geoffrey P Colby, Wi Jin Kim, Whi Inh Bae, Hiro Sparks, Kara Reitz, Satoshi Tateshima, Reza Jahan, Viktor Szeder, May Nour, Gary R Duckwiler, Fernando Vinuela, Neil A Martin, and Anthony C Wang

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Intravenous Administration of Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSC) for Acute Respiratory Distress Syndrome Due to COVID-19 Infection., Jesus A Perez, Juan J Parcero Valdes, Ruben Corral Moreno, Leonardo I Gomez Cuevas, Jose J Lopez, Thomas Ichim, Kristen McGreevy, Feng Lin, Santosh Kesari, and Souvik Datta

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Exploring the role of cerebrospinal fluid as analyte in neurologic disorders., Sandeep C Pingle, Feng Lin, Misa S Anekoji, C Pawan K Patro, Souvik Datta, Lawrence D Jones, Santosh Kesari, and Shashaanka Ashili

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Single-Dose Psilocybin Treatment for Major Depressive Disorder: A Randomized Clinical Trial., Charles L Raison, Gerard Sanacora, Joshua Woolley, Keith Heinzerling, Boadie W Dunlop, Randall T Brown, Rishi Kakar, Michael Hassman, Rupal P Trivedi, Reid Robison, Natalie Gukasyan, Sandeep M Nayak, Xiaojue Hu, Kelley C O'Donnell, Benjamin Kelmendi, Jordan Sloshower, Andrew D Penn, Ellen Bradley, Daniel F Kelly, Tanja Mletzko, Christopher R Nicholas, Paul R Hutson, Gary Tarpley, Malynn Utzinger, Kelsey Lenoch, Kasia Warchol, Theraysa Gapasin, Mike C Davis, Courtney Nelson-Douthit, Steffanie Wilson, Carrie Brown, William Linton, Stephen Ross, and Roland R Griffiths

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Visceral and Subcutaneous Abdominal Fat Predict Brain Volume Loss at Midlife in 10,001 Individuals., Cyrus A Raji, Somayeh Meysami, Sam Hashemi, Saurabh Garg, Nasrin Akbari, Ahmed Gouda, Yosef Gavriel Chodakiewitz, Thanh Duc Nguyen, Kellyann Niotis, David A Merrill, and Rajpaul Attariwala

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Association between Cannabis Use and Tinnitus in US Adults., Francis Reyes Orozco, Matthew Lin, Bhavishya Clark, Joni K Doherty, John S Oghalai, Courtney C J Voelker, and Janet S Choi

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Editorial. Overcoming implementation barriers in enhanced recovery using theory-based approaches., Walavan Sivakumar

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Letter to the editor regarding "Vascular anomalies in patients with growth hormone-secreting pituitary adenomas: illustrative case report and systematic review of the literature"., Walavan Sivakumar and William T Couldwell

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Enhanced recovery after brain tumor surgery: pilot protocol implementation in a large healthcare system., Walavan Sivakumar, Jian Guan, Jean-Philippe Langevin, Garni Barkhoudarian, Daniel F Kelly, and Neil A Martin

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Biological functions of the Olig gene family in brain cancer and therapeutic targeting., Jenny Szu, Igor F Tsigelny, Alexandre Wojcinski, and Santosh Kesari

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Clinical Outcomes of Stereotactic Radiosurgery-Related Radiation Necrosis in Patients with Intracranial Metastasis from Melanoma., Holly M Thomson, Shannon P Fortin Ensign, Victoria S Edmonds, Akanksha Sharma, Richard J Butterfield, Steven E Schild, Jonathan B Ashman, Richard S Zimmerman, Naresh P Patel, Alan H Bryce, Sujay A Vora, Terence T Sio, and Alyx B Porter

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Targeting of insulin receptor endocytosis as a treatment to insulin resistance., Bryce Tim, Valentina L Kouznetsova, Santosh Kesari, and Igor F Tsigelny

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Editorial: Diet and multiple sclerosis., Tyler J Titcomb, Barbara Giesser, Scott M Plafker, Ilana B Katz Sand, and Terry L Wahls

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Role of Senataxin in Amyotrophic Lateral Sclerosis., Andrew Tsui, Valentina L Kouznetsova, Santosh Kesari, Milan Fiala, and Igor F Tsigelny

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Diagnostics of ovarian cancer via metabolite analysis and machine learning., Jerry Z Yao, Igor F Tsigelny, Santosh Kesari, and Valentina L Kouznetsova

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Cost-effectiveness Analysis of Inferior Turbinate Reduction and Immunotherapy in Allergic Rhinitis., Michael Yong, Kaishan Aravinthan, Keshinisuthan Kirubalingam, Andrew Thamboo, Peter H Hwang, Kari Nadeau, and Evan Walgama

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In Response to Cost-effectiveness Analysis of Inferior Turbinate Reduction and Immunotherapy in Allergic Rhinitis., Michael Yong, Kaishan Aravinthan, Keshinisuthan Kirubalingam, Andrew Thamboo, Peter H Hwang, Kari Nadeau, and Evan Walgama

Submissions from 2022

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HIV Antiretroviral Medication Neuropenetrance and Neurocognitive Outcomes in HIV+ Adults: A Review of the Literature Examining the Central Nervous System Penetration Effectiveness Score., Alyssa Arentoft, Katie Troxell, Karen Alvarez, Maral Aghvinian, Monica Rivera Mindt, Mariana Cherner, Kathleen Van Dyk, Jill Razani, Michaela Roxas, and Melissa Gavilanes

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HIV Antiretroviral Medication Neuropenetrance and Neurocognitive Outcomes in HIV+ Adults: A Review of the Literature Examining the Central Nervous System Penetration Effectiveness Score., Alyssa Arentoft, Katie Troxell, Karen Alvarez, Maral Aghvinian, Monica Rivera Mindt, Mariana Cherner, Kathleen Van Dyk, Jill Razani, Michaela Roxas, and Melissa Gavilanes

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The Role of Subcutaneous Radiofrequency-Assisted Liposculpture in the Facial Plastic Surgeon's Practice., Demetri Arnaoutakis, Amit Kochhar, Isabelle Magro, and Kian Karimi

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Severe Airway Edema Following Calcium Hydroxylapatite (CaHA) Injection Augmentation., Michela Borrelli, Tasha Nasrollahi, Jonathan Raskin, Sana Khan, and Omid B Mehdizadeh

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Phase 2 study of AV-GBM-1 (a tumor-initiating cell targeted dendritic cell vaccine) in newly diagnosed Glioblastoma patients: safety and efficacy assessment., Daniela A Bota, Thomas H Taylor, David E Piccioni, Christopher M Duma, Renato V LaRocca, Santosh Kesari, Jose Carrillo, Mehrdad Abedi, Robert D Aiken, Frank P K Hsu, Xiao-Tang Kong, Candace Hsieh, Peter G Bota, Gabriel I Nistor, Hans S Keirstead, and Robert O Dillman

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Real-World Evidence of Transcutaneous Afferent Patterned Stimulation for Essential Tremor., Salima Brillman, Kalea Colletta, Sally Borucki, Peter T Lin, Olga Waln, Melita Petrossian, Pravin Khemani, Apoorva Rajagopal, Kathryn H Rosenbluth, and Dhira Khosla

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Smart Consumer Wearables as Digital Diagnostic Tools: A Review., Shweta Chakrabarti, Nupur Biswas, Lawrence D Jones, Santosh Kesari, and Shashaanka Ashili

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Encephaloduroarteriosynangiosis Operative Technique and Intraoperative Anesthesia Management: Treatment From Both Sides of the Curtain., Julie L Chan, Miguel D Quintero-Consuegra, Robin M Babadjouni, Daniel Chang, Zachary R Barnard, Neil A Martin, Keren Ziv, Barbara M Van de Wiele, and Nestor R Gonzalez

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Physician satisfaction with telemedicine and in-person visits in otolaryngology., Janet S Choi, Matthew Lin, Soyun Park, Faiz Abdur-Rahman, James H Kim, and Courtney C J Voelker

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Easing the Journey-an Updated Review of Palliative Care for the Patient with High-Grade Glioma., Rita C Crooms, Margaret O Johnson, Heather Leeper, Ambereen Mehta, Michelle McWhirter, and Akanksha Sharma

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Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium., Gabriel A de Erausquin, Heather Snyder, Traolach S Brugha, Sudha Seshadri, Maria Carrillo, Rajesh Sagar, Yueqin Huang, Charles Newton, Carmela Tartaglia, Charlotte Teunissen, Krister Håkanson, Rufus Akinyemi, Kameshwar Prasad, Giovanni D'Avossa, Gabriela Gonzalez-Aleman, Akram Hosseini, George D Vavougios, Perminder Sachdev, John Bankart, Niels Peter Ole Mors, Richard Lipton, Mindy Katz, Peter T Fox, Mohammad Zia Katshu, M Sriram Iyengar, Galit Weinstein, Hamid R Sohrabi, Rachel Jenkins, Dan J Stein, Jacques Hugon, Venetsanos Mavreas, John Blangero, Carlos Cruchaga, Murali Krishna, Ovais Wadoo, Rodrigo Becerra, Igor Zwir, William T Longstreth, Golo Kroenenberg, Paul Edison, Elizabeta Mukaetova-Ladinska, Ekkehart Staufenberg, Mariana Figueredo-Aguiar, Agustín Yécora, Fabiana Vaca, Hernan P Zamponi, Vincenzina Lo Re, Abdul Majid, Jonas Sundarakumar, Hector M Gonzalez, Mirjam I Geerlings, Ingmar Skoog, Alberto Salmoiraghi, Filippo Martinelli Boneschi, Vibuthi N Patel, Juan M Santos, Guillermo Rivera Arroyo, Antonio Caballero Moreno, Pascal Felix, Carla Gallo, Hidenori Arai, Masahito Yamada, Takeshi Iwatsubo, Malveeka Sharma, Nandini Chakraborty, Catterina Ferreccio, Dickens Akena, Carol Brayne, Gladys Maestre, Sarah Williams Blangero, Luis I Brusco, Prabha Siddarth, Timothy M Hughes, Alfredo Ramírez Zuñiga, Joseph Kambeitz, Agustin Ruiz Laza, Norrina Allen, Stella Panos, David A Merrill, Agustín Ibáñez, Debby Tsuang, Nino Valishvili, Srishti Shrestha, Sophia Wang, Vasantha Padma, Kaarin J Anstey, Vijayalakshmi Ravindrdanath, Kaj Blennow, Paul Mullins, Emilia Łojek, Anand Pria, Thomas H Mosley, Penny Gowland, Timothy D Girard, Richard Bowtell, and Farhaan S Vahidy

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The Emergence of Virtual Tumor Boards in Neuro-Oncology: Opportunities and Challenges., Chukwuyem Ekhator, Santosh Kesari, Ramya Tadipatri, Ekokobe Fonkem, and Jai Grewal

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A case of recurrent aneurysm resulting from dual antiplatelet plus anticoagulation after confirmed aneurysm closure following coil-assisted flow diversion., Thomas R Geisbush, Benjamin Pulli, Dylan N Wolman, Arjun V Pendharkar, and Nicholas A Telischak

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Clinical Course of Two Patients with COVID-19 Respiratory Failure After Administration of the Anticancer Small Molecule, RRx-001., Terese Catherine Hammond, Raymond C Lee, Bryan Oronsky, Tony R Reid, Scott Caroen, Tiffany M Juarez, Jaya Gill, Annie Heng, and Santosh Kesari

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Psychedelic-Assisted Therapy and Psychedelic Science: A Review and Perspective on Opportunities in Neurosurgery and Neuro-Oncology., Daniel F Kelly, Keith Heinzerling, Akanksha Sharma, Shanthi Gowrinathan, Karina Sergi, and Regin Jay Mallari

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Minimally Invasive Techniques for Facial Rejuvenation Utilizing Polydioxanone Threads., Amit Kochhar, Parvesh Kumar, and Kian Karimi

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Transcutaneous Radiofrequency Microneedling in the Facial Plastic Surgeon's Practice: A Review., Isabelle Magro, Amit Kochhar, Demetri Arnaoutakis, and Kian Karimi

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Handgrip Strength Is Related to Hippocampal and Lobar Brain Volumes in a Cohort of Cognitively Impaired Older Adults with Confirmed Amyloid Burden., Somayeh Meysami, Cyrus A Raji, Ryan M. Glatt, Emily S Popa, Aarthi Ganapathi, Tess Bookheimer, Colby B Slyapich, Kyron P Pierce, Casey J Richards, Melanie G Lampa, Jaya Mini Gill, Molly Rapozo, John F Hodes, Ynez M Tongson, Claudia L Wong, Mihae Kim, Verna R Porter, Scott Kaiser, Stella Panos, Richelin V Dye, Karen J Miller, Susan Y Bookheimer, Neil A Martin, Santosh Kesari, Daniel F Kelly, Jennifer Bramen, Prabha Siddarth, and David A Merrill

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Minimally invasive pericranial flap harvest through a supraorbital eyebrow craniotomy: Technical note in salvage skull base reconstruction., Madeline G Olson, Michael B Avery, Shauna Javaherian, Walavan Sivakumar, Daniel F Kelly, Chester Griffiths, and Garni Barkhoudarian

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MTAP loss: a possible therapeutic approach for glioblastoma., C Pawan K Patro, Nupur Biswas, Sandeep C Pingle, Feng Lin, Misa Anekoji, Lawrence D Jones, Santosh Kesari, Feng Wang, and Shashaanka Ashili

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Correction: Phase 1 First-in-Human Dose Escalation and Dose Expansion Study of KLS-1 (64Zinc Aspartate) in Patients With Cancer and Neurodegenerative Diseases., Jesus A Perez, Javier J Lopez, Claudia C Torres Badillo, Jaya Gill, Santosh Kesari, Peter Novak, Max Temnikov, Roman Byshovets, and Oleg Bychkov

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Phase 1 First-in-Human Dose Escalation and Dose Expansion Study of KLS-1 (64Zinc Aspartate) in Patients With Cancer and Neurodegenerative Diseases., Jesus A Perez, Javier J Lopez, Claudia C Torres Badillo, Jaya Gill, Santosh Kesari, Peter Novak, Max Temnikov, Roman Byshovets, and Oleg Bychkov

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Detection of perillyl alcohol and its metabolite perillic acid in postsurgical glioblastoma tissue after intranasal administration of NEO100: illustrative case., Axel H Schönthal, Steve Swenson, Phillip A Bonney, Naveed Wagle, Vincent F Simmon, Anna J Mathew, Kyle M Hurth, and Thomas C Chen

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Advances in the Diagnosis and Treatment of Leptomeningeal Disease., Akanksha Sharma, Justin T Low, and Priya Kumthekar

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The Committee on Advanced Subspecialty Training-accredited postgraduate neurosurgery fellowship application experience: a national survey., Nathan A Shlobin, Christopher S Graffeo, David L Dornbos, Debraj Mukherjee, Walavan Sivakumar, and Jeremiah Johnson

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Anomaly Detection Framework for Wearables Data: A Perspective Review on Data Concepts, Data Analysis Algorithms and Prospects., Jithin S Sunny, C Pawan K Patro, Khushi Karnani, Sandeep C Pingle, Feng Lin, Misa Anekoji, Lawrence D Jones, Santosh Kesari, and Shashaanka Ashili

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Critical appraisal of minimally invasive keyhole surgery for intracranial meningioma in a large case series., Jai Deep Thakur, Regin Jay Mallari, Alex Corlin, Samantha Yawitz, Amy Eisenberg, John Rhee, Walavan Sivakumar, Howard Krauss, Neil A Martin, Chester Griffiths, Garni Barkhoudarian, and Daniel F Kelly

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Germline biomarkers predict toxicity to anti-PD1/PDL1 checkpoint therapy., Joanne Weidhaas, Nicholas Marco, Aaron W Scheffler, Anusha Kalbasi, Kirk Wilenius, Emily Rietdorf, Jaya Mini Gill, Mara Heilig, Caroline Desler, Robert K Chin, Tania Kaprealian, Susan McCloskey, Ann Raldow, Naga P Raja, Santosh Kesari, Jose Carrillo, Alexandra Drakaki, Mark Scholz, and Donatello Telesca

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The role of BAG3 in dilated cardiomyopathy and its association with Charcot-Marie-Tooth disease type 2., Nitya Yerabandi, Valentina L Kouznetsova, Santosh Kesari, and Igor F Tsigelny

Submissions from 2021

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The miR-181a-SFRP4 axis regulates Wnt activation to drive stemness and platinum resistance in ovarian cancer., Anil Belur Nagaraj, Matthew Knarr, Sreeja Sekhar, R Shae Connor, Peronne Joseph, Olga Kovalenko, Alexis Fleming, Arshia Surti, Elmar Nurmemmedov, Luca Beltrame, Sergio Marchini, Michael Kahn, and Analisa DiFeo

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Marizomib alone or in combination with bevacizumab in patients with recurrent glioblastoma: Phase I/II clinical trial data., Daniela A Bota, Warren Mason, Santosh Kesari, Rajiv Magge, Benjamin Winograd, Ileana Elias, Steven D Reich, Nancy Levin, Mohit Trikha, and Annick Desjardins

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Gamified Dual-Task Training for Individuals with Parkinson Disease: An Exploratory Study on Feasibility, Safety, and Efficacy., Lee-Kuen Chua, Yu-Chen Chung, David Bellard, Laura Swan, Nicole Gobreial, Amanda Romano, Ryan M. Glatt, Michael A Bonaguidi, Darrin J Lee, Yi Jin, Charles Y Liu, and Beth E Fisher

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Effects of Pyridostigmine on Esophageal and Pharyngeal Motility in Dysphagic Patients Undergoing High-Resolution Manometry., Shumon I Dhar, Nogah Nativ-Zeltzer, Omid B Mehdizadeh, Apoorva T Ramaswamy, Yuval Nachalon, and Peter C Belafsky

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Consensus on diagnosis and management of Cushing's disease: a guideline update., Maria Fleseriu, Richard Auchus, Irina Bancos, Anat Ben-Shlomo, Jerome Bertherat, Nienke R Biermasz, Cesar L Boguszewski, Marcello D Bronstein, Michael Buchfelder, John D Carmichael, Felipe F Casanueva, Frederic Castinetti, Philippe Chanson, James Findling, Mônica Gadelha, Eliza B Geer, Andrea Giustina, Ashley Grossman, Mark Gurnell, Ken Ho, Adriana G Ioachimescu, Ursula B Kaiser, Niki Karavitaki, Laurence Katznelson, Daniel F Kelly, André Lacroix, Ann McCormack, Shlomo Melmed, Mark Molitch, Pietro Mortini, John Newell-Price, Lynnette Nieman, Alberto M Pereira, Stephan Petersenn, Rosario Pivonello, Hershel Raff, Martin Reincke, Roberto Salvatori, Carla Scaroni, Ilan Shimon, Constantine A Stratakis, Brooke Swearingen, Antoine Tabarin, Yutaka Takahashi, Marily Theodoropoulou, Stylianos Tsagarakis, Elena Valassi, Elena V Varlamov, Greisa Vila, John Wass, Susan M Webb, Maria C Zatelli, and Beverly M K Biller

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A phase I study of the WT2725 dosing emulsion in patients with advanced malignancies., Siqing Fu, David E Piccioni, Hongtao Liu, Rimas V Lukas, Santosh Kesari, Dawit Aregawi, David S Hong, Kenichiro Yamaguchi, Kate Whicher, Yi Zhang, Yu-Luan Chen, Nagaraju Poola, John Eddy, and David Blum

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Assessment of Discrepancies Between Follow-up Infarct Volume and 90-Day Outcomes Among Patients With Ischemic Stroke Who Received Endovascular Therapy., Aravind Ganesh, Johanna M Ospel, Bijoy K Menon, Andrew M Demchuk, Ryan A McTaggart, Raul G Nogueira, Alexandre Y Poppe, Mohammed A Almekhlafi, Ricardo A Hanel, Götz Thomalla, Staffan Holmin, Volker Puetz, Brian A van Adel, Jason Tarpley, Michael Tymianski, Michael D Hill, Mayank Goyal, and ESCAPE-NA1 Trial Investigators

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The effect of specific binding proteins on immunoassay measurements of total and free thyroid hormones and cortisol., Anastasia Gant Kanegusuku, Katherine A Araque, Hung Nguyen, Bin Wei, Saman Hosseini, and Steven J Soldin

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Neuro-Advocacy-Professionalism in Action., Barbara Giesser and Marisa Kanof

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The Young Neurosurgeons Committee of the American Association of Neurological Surgeons: the first 30 years., Sakibul Huq, Chris A Philips, Walavan Sivakumar, David L Dornbos, Christopher S Graffeo, Debraj Mukherjee, Stacey Q Wolfe, and Jeremiah N Johnson

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The Effects of Cardiorespiratory and Motor Skill Fitness on Intrinsic Functional Connectivity of Neural Networks in Individuals with Parkinson's Disease., Behnaz Jarrahi, Sarah C McEwen, Daniel P Holschneider, Dawn M Schiehser, Andrew J Petkus, Megan E Gomez, Jack D Van Horn, Vincent Filoteo, Michael W Jakowec, and Giselle M Petzinger

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Correction to: Mesenchymal stem cells in the treatment of severe COVID-19., Santosh Kesari, Gregory C Kasper, Lev Verkh, Terese C Hammond, Marla L Matal, Jay W Hammerling, Nikolai Tankovich, Adrianus P Lim, Kevin H Zhao, Tiffany Juarez, Roberta E Redfern, Jaya Mini Gill, Natsuko Nomura, Audrey Hiemer, Annie Heng, and Jessica Shoemaker

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Burnout among medical students interested in neurosurgery during the COVID-19 era., Adham M Khalafallah, Adrian E Jimenez, Shravika Lam, Abhishek Gami, David L Dornbos, Walavan Sivakumar, Jeremiah N Johnson, and Debraj Mukherjee

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Orbital Surgical Guidelines-Clinical Evaluation., Howard Krauss