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Submissions from 2023

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Long-Term Results of Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy: The Randomized Phase II OPRA Trial., Floris S Verheij, Dana M Omer, Hannah Williams, Sabrina T Lin, Li-Xuan Qin, James T Buckley, Hannah M Thompson, Jonathan B Yuval, Jin K Kim, Richard F Dunne, Jorge Marcet, Peter Cataldo, Blase Polite, Daniel O Herzig, David Liska, Samuel Oommen, Charles M Friel, Charles Ternent, Andrew L Coveler, Steven Hunt, Anita Gregory, Madhulika G Varma, Brian L Bello, Joseph C Carmichael, John Krauss, Ana Gleisner, José G Guillem, Larissa Temple, Karyn A Goodman, Neil H Segal, Andrea Cercek, Rona Yaeger, Garrett M Nash, Maria Widmar, Iris H Wei, Emmanouil P Pappou, Martin R Weiser, Philip B Paty, J Joshua Smith, Abraham J Wu, Marc J Gollub, Leonard B Saltz, and Julio Garcia-Aguilar

Multi-omic characterization of RCC1 expression and its association with molecular alterations, immune phenotypes, and cancer outcomes. ASCO, Abst:3128, 6/2023., B Warnecke, Dave Hoon, and See full list of authors in comments

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Is therapeutic lymph node dissection of value for lymph node recurrence in melanoma?, Ana K Wilson, Kristel Lourdault, Tara Ostad, Stacey Stern, and Richard Essner

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Is There an Age Threshold for Active Surveillance in Highly Suspicious Subcentimeter Thyroid Nodules?, Stephanie Young and Melanie Goldfarb

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Therapy of autoimmune inflammation in sporadic amyotrophic lateral sclerosis: Dimethyl fumarate and H-151 downregulate inflammatory cytokines in the cGAS-STING pathway., Kurosh Zamiri, Santosh Kesari, Ketema Paul, Sung Hee Hwang, Bruce Hammock, Karolina Elżbieta Kaczor-Urbanowicz, Andrzej Urbanowicz, Lucy Gao, Julian Whitelegge, and Milan Fiala

Submissions from 2022

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Orteronel for Metastatic Hormone-Sensitive Prostate Cancer: A Multicenter, Randomized, Open-Label Phase III Trial (SWOG-1216)., Neeraj Agarwal, Catherine M Tangen, Maha H A Hussain, Shilpa Gupta, Melissa Plets, Primo N Lara, Andrea L Harzstark, Przemyslaw W Twardowski, Channing J Paller, Dylan Zylla, Matthew R Zibelman, Ellis Levine, Bruce J Roth, Amir Goldkorn, Daniel A Vaena, Manish Kohli, Tony Crispino, Nicholas J Vogelzang, Ian M Thompson, and David I Quinn

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Multi-modal molecular programs regulate melanoma cell state., Miles C Andrews, Junna Oba, Chang-Jiun Wu, Haifeng Zhu, Tatiana Karpinets, Caitlin A Creasy, Marie-Andrée Forget, Xiaoxing Yu, Xingzhi Song, Xizeng Mao, A Gordon Robertson, Gabriele Romano, Peng Li, Elizabeth M Burton, Yiling Lu, Robert Szczepaniak Sloane, Khalida M Wani, Kunal Rai, Alexander J Lazar, Lauren E Haydu, Matias A Bustos, Jianjun Shen, Yueping Chen, Margaret B Morgan, Jennifer A Wargo, Lawrence N Kwong, Cara L Haymaker, Elizabeth A Grimm, Patrick Hwu, Dave S B Hoon, Jianhua Zhang, Jeffrey E Gershenwald, Michael A Davies, P Andrew Futreal, Chantale Bernatchez, and Scott E Woodman

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Rare adverse events following Covid-19 vaccination: A review, Mohammad Barary, Akanksha Sharma, and See full list of authors in comments

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Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia., Laura Barreyro, Avery M Sampson, Chiharu Ishikawa, Kathleen M Hueneman, Kwangmin Choi, Mario A Pujato, Somchai Chutipongtanate, Michael Wyder, Wendy D Haffey, Eric O'Brien, Mark Wunderlich, Vighnesh Ramesh, Ellen M Kolb, Cem Meydan, Yaseswini Neelamraju, Lyndsey C Bolanos, Susanne Christie, Molly A Smith, Madeline Niederkorn, Tomoya Muto, Santosh Kesari, Francine E Garrett-Bakelman, Boris Bartholdy, Britta Will, Matthew T Weirauch, James C Mulloy, Zartash Gul, Stephen Medlin, Rhett A Kovall, Ari M Melnick, John P Perentesis, Kenneth D Greis, Elmar Nurmemmedov, William L Seibel, and Daniel T Starczynowski

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Automatic Analysis of Asymmetry in Facial Paralysis Patients Using Landmark-Based Measures., Digbalay Bose, Krishna Somandepalli, Tymon Tai, Courtney Voelker, Shrikanth Narayanan, and Amit Kochhar

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Phase 2 study of AV-GBM-1 (a tumor-initiating cell targeted dendritic cell vaccine) in newly diagnosed Glioblastoma patients: safety and efficacy assessment., Daniela A Bota, Thomas H Taylor, David E Piccioni, Christopher M Duma, Renato V LaRocca, Santosh Kesari, Jose Carrillo, Mehrdad Abedi, Robert D Aiken, Frank P K Hsu, Xiao-Tang Kong, Candace Hsieh, Peter G Bota, Gabriel I Nistor, Hans S Keirstead, and Robert O Dillman

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QLTI-26. INTEGRATION OF NEURO-ONCOLOGY CLINICAL PATHWAYS IN PROVIDENCE SOUTHERN CALIFORNIA CLINICAL RESEARCH NETWORK, Brad Bott, Nanor Bozoyan, Trisha Babcock, Kristen Cushman, Akanksha Sharma, Naveed Wagle, Jose Carrillo, Tiffany Juarez, and Santosh Kesari

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Prognostic Utility of CpG Island Hypermethylated Phenotype in Early-Stage Invasive Primary Melanomas., Matias A Bustos and Dave Hoon

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Cell-free plasma microRNAs that identify patients with glioblastoma., Matias A Bustos, Negin Rahimzadeh, Suyeon Ryu, Rebecca Gross, Linh T Tran, Victor M Renteria-Lopez, Romela Irene Ramos, Amy Eisenberg, Parvinder Hothi, Santosh Kesari, Garni Barkhoudarian, Yuki Takasumi, Charles Cobbs, Daniel F Kelly, and Dave Hoon

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DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness., Arnaud Carrier, Cécile Desjobert, Loic Ponger, Laurence Lamant, Matias A Bustos, Jorge Torres-Ferreira, Rui Henrique, Carmen Jeronimo, Luisa Lanfrancone, Audrey Delmas, Gilles Favre, Antoine Daunay, Florence Busato, Dave S B Hoon, Jorg Tost, Chantal Etievant, Joëlle Riond, and Paola B Arimondo

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QLTI-22. IMPROVING BRAIN CANCER PATIENT ACCESS TO CLINICAL TRIALS ACROSS SEVEN COMMUNITY HOSPITALS, THE PROVIDENCE SOUTHERN CALIFORNIA CLINICAL RESEARCH NETWORK, Jose Carrillo, Naveed Wagle, Akanksha Sharma, Tiffany Juarez, Minhdan Nguyen, Judy D Truong, Timothy E. Byun, Brad Bott, Nanor Bozoyan, David J Park, and Santosh Kesari

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Smart Consumer Wearables as Digital Diagnostic Tools: A Review., Shweta Chakrabarti, Nupur Biswas, Lawrence D Jones, Santosh Kesari, and Shashaanka Ashili

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Topical therapy for regression and melanoma prevention of congenital giant nevi., Yeon Sook Choi, Tal H Erlich, Max von Franque, Inbal Rachmin, Jessica L Flesher, Erik B Schiferle, Yi Zhang, Marcello Pereira da Silva, Alva Jiang, Allison S Dobry, Mack Su, Sharon Germana, Sebastian Lacher, Orly Freund, Ezra Feder, Jose L Cortez, Suyeon Ryu, Tamar Babila Propp, Yedidyah Leo Samuels, Labib R Zakka, Marjan Azin, Christin E Burd, Norman E Sharpless, X Shirley Liu, Clifford Meyer, William Gerald Austen, Branko Bojovic, Curtis L Cetrulo, Martin C Mihm, Dave S Hoon, Shadmehr Demehri, Elena B Hawryluk, and David E Fisher

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NCMP-07. CASE SERIES OF REGULARLY SCHEDULED MANNITOL INFUSIONS SHOWING WITH PROLONGED CLINICAL BENEFIT FOR MANAGEMENT OF CEREBRAL EDEMA IN GLIOMAS, Jared Chow, Jose Carrillo, Santosh Kesari, Akanksha Sharma, Minhdan Nguyen, Judy D Truong, and Naveed Wagle

Neoadjuvant chemotherapy improves outcomes in resectable pancreatic adenocarcinoma, Wade Christopher, Sean Nassoiy, Rebecca Marcus, Jennifer Keller, Shu-Ching Chang, Trevan Fischer, Anton Bilchik, and Melanie Goldfarb

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Sentinel lymph node melanoma metastases: Assessment of tumor burden for clinical prediction of outcome in the first Multicenter Selective Lymphadenectomy Trial (MSLT-I)., Alistair J Cochran, Duan-Ren Wen, Rong-Rong Huang, Payam Abrishami, Chandra Smart, Scott Binder, Richard A Scolyer, John F Thompson, Stacey Stern, Lisa Van Kreuningen, David E Elashoff, Myung-Shin Sim, He-Jing Wang, Mark Faries, and MSLT-I Study Group

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Genomic Correlates of Outcome in Tumor-Infiltrating Lymphocyte Therapy for Metastatic Melanoma., Caitlin A Creasy, Yuzhong Jeff Meng, Marie-Andrée Forget, Tatiana Karpinets, Katarzyna Tomczak, Chip Stewart, Carlos A Torres-Cabala, Shari Pilon-Thomas, Amod A Sarnaik, James J Mule, Levi Garraway, Matias A Bustos, Jianhua Zhang, Sapna P Patel, Adi Diab, Isabella C Glitza, Cassian Yee, Hussein Tawbi, Michael K Wong, Jennifer McQuade, Dave S B Hoon, Michael A Davies, Patrick Hwu, Rodabe N Amaria, Cara Haymaker, Rameen Beroukhim, and Chantale Bernatchez

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Easing the Journey-an Updated Review of Palliative Care for the Patient with High-Grade Glioma., Rita C Crooms, Margaret O Johnson, Heather Leeper, Ambereen Mehta, Michelle McWhirter, and Akanksha Sharma

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Epigenetic Signatures Predict Pathologic Nodal Stage in Breast Cancer Patients with Estrogen Receptor-Positive, Clinically Node-Positive Disease., Miquel Ensenyat-Mendez, Dennis Rünger, Javier I Orozco, Julie Le, Jennifer L Baker, Joanne Weidhaas, Diego M Marzese, and Maggie L DiNome

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How I treat brain metastases of melanoma., Z Eroglu, T O Topcu, H M Yu, and K A Margolin

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Correction: Interplay between soluble CD74 and macrophage-migration inhibitory factor drives tumor growth and influences patient survival in melanoma., Yasunari Fukuda, Matias A Bustos, Sung-Nam Cho, Jason Roszik, Suyeon Ryu, Victor M Lopez, Jared K Burks, Jeffrey E Lee, Elizabeth A Grimm, Dave S B Hoon, and Suhendan Ekmekcioglu

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Interplay between soluble CD74 and macrophage-migration inhibitory factor drives tumor growth and influences patient survival in melanoma., Yasunari Fukuda, Matias A Bustos, Sung-Nam Cho, Jason Roszik, Suyeon Ryu, Victor M Renteria-Lopez, Jared K Burks, Jeffrey E Lee, Elizabeth A Grimm, Dave Hoon, and Suhendan Ekmekcioglu

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Differentiation of Subjective Cognitive Decline, Mild Cognitive Impairment, and Dementia Using qEEG/ERP-Based Cognitive Testing and Volumetric MRI in an Outpatient Specialty Memory Clinic., Aarthi S Ganapathi, Ryan M Glatt, Tess H Bookheimer, Emily S Popa, Morgan L Ingemanson, Casey J Richards, John F Hodes, Kyron P Pierce, Colby B Slyapich, Fatima Iqbal, Jenna Mattinson, Melanie G Lampa, Jaya M Gill, Ynez M Tongson, Claudia L Wong, Mihae Kim, Verna R Porter, Santosh Kesari, Somayeh Meysami, Karen J Miller, Jennifer E Bramen, David A Merrill, and Prabha Siddarth

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Verification of a Novel Minimally Invasive Device for the Isolation of Rare Circulating Tumor Cells (CTC) in Cancer Patients' Blood., Paul Friedrich Geus, Felix Hehnen, Sophia Krakowski, Klaus Lücke, Dave Hoon, Nikolaj Frost, Ulrich Kertzscher, and Gabi Wendt

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Differences in the management of thyroid nodules in children and adolescents as compared to adults., Melanie Goldfarb and Catherine Dinauer

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Survivorship, Quality of Life, and Transition to Adult Care for Pediatric and Adolescent Thyroid Cancer Survivors., Melanie Goldfarb and Aime T Franco

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Safety of Tumor Treating Fields (TTFields) therapy in pediatric patients with malignant brain tumors: Post-marketing surveillance data., Stewart Goldman, Ashley Margol, Eugene I Hwang, Kazuhiro Tanaka, Bogdana Suchorska, John R Crawford, and Santosh Kesari

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Clinical Course of Two Patients with COVID-19 Respiratory Failure After Administration of the Anticancer Small Molecule, RRx-001., Terese Catherine Hammond, Raymond C Lee, Bryan Oronsky, Tony R Reid, Scott Caroen, Tiffany M Juarez, Jaya Gill, Annie Heng, and Santosh Kesari

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Long-Term Outcomes of Patients on a Phase II Prospective Trial of Oligometastatic Hormone-Sensitive Prostate Cancer Treated with Androgen Deprivation and External Beam Radiation., Claire Hao, Colton Ladbury, Yung Lyou, Saro Manoukian, Christopher Ruel, Paul Frankel, Tanya Dorff, Jeffrey Wong, Sumanta Pal, Przemyslaw Twardowski, and Savita Dandapani

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Predicting Regional Lymph Node Recurrence in the Modern Age of Tumor-Positive Sentinel Node Melanoma: The Role of the First Postoperative Ultrasound., Jennifer Keller, Stacey Stern, Shu-Ching Chang, Rebecca Marcus, Jessica Weiss, Sean Nassoiy, Wade Christopher, Trevan Fischer, and Richard Essner

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Psychedelic-Assisted Therapy and Psychedelic Science: A Review and Perspective on Opportunities in Neurosurgery and Neuro-Oncology., Daniel F Kelly, Keith Heinzerling, Akanksha Sharma, Shanthi Gowrinathan, Karina Sergi, and Regin Jay Mallari

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BETA PRIME: Phase I study of AdAPT-001 as monotherapy and combined with a checkpoint inhibitor in superficially accessible, treatment-refractory solid tumors., Santosh Kesari, Alberto Bessudo, Brian R Gastman, Anthony P Conley, Victoria M Villaflor, Lisle M Nabell, DeLisa Madere, Emma Chacon, Christina Spencer, Li Li, Christopher Larson, Tony Reid, Scott Caroen, Bryan Oronsky, Meaghan Stirn, Jeannie Williams, and Minal A Barve

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Genomic Amplification of, Yuta Kobayashi, Matias A Bustos, Yoshiaki Shoji, Ron D Jachimowicz, Yosef Shiloh, and Dave S B Hoon

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Urine Cell-Free MicroRNAs in Localized Prostate Cancer Patients., Yoko Koh, Matias A Bustos, Jamie Moon, Rebecca Gross, Romela Irene Ramos, Suyeon Ryu, Jane Choe, Selena Y Lin, Warren M Allen, David L Krasne, Timothy G Wilson, and Dave Hoon

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More autopsy studies are needed to understand the pathogenesis of severe COVID-19., Scott P Layne, Kathie-Anne Walters, John C Kash, and Jeffery K Taubenberger

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Correction: miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway., Wan Li, Jie Yi, Xiangjin Zheng, Shiwei Liu, Weiqi Fu, Liwen Ren, Li Li, Dave Hoon, Jinhua Wang, and Guanhua Du

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Systemic Therapy Is Associated with Improved Oncologic Outcomes in Resectable Stage II/III Intrahepatic Cholangiocarcinoma: An Examination of the National Cancer Database over the Past Decade., Rebecca Marcus, Wade Christopher, Jennifer Keller, Sean Nassoiy, Shu-Ching Chang, Melanie Goldfarb, Ronald Wolf, and Zeljka Jutric

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Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy., Shijun Ma, Yue Zhao, Wee Chyan Lee, Li-Teng Ong, Puay Leng Lee, Zemin Jiang, Gokce Oguz, Zhitong Niu, Min Liu, Jian Yuan Goh, Wenyu Wang, Matias A Bustos, Sidse Ehmsen, Adaikalavan Ramasamy, Dave Hoon, Henrik J Ditzel, Ern Yu Tan, Qingfeng Chen, and Qiang Yu

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Reply by Authors., Surena F Matin, Phillip M Pierorazio, Nir Kleinmann, John L Gore, Ahmad Shabsigh, Brian Hu, Karim Chamie, Guilherme Godoy, Scott G Hubosky, Marcelino Rivera, Michael O'Donnell, Marcus Quek, Jay D Raman, John J Knoedler, Douglas Scherr, Christopher Weight, Alon Weizer, Michael Woods, Hristos Kaimakliotis, Angela B Smith, Jennifer M Linehan, Jonathan Coleman, Mitchell R Humphreys, Raymond Pak, David Lifshitz, Michael Verni, Ifat Klein, Marina Konorty, Dalit Strauss-Ayali, Gil Hakim, Elyse Seltzer, Mark Schoenberg, and Seth P Lerner

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ATF6-mediated signaling contributes to PARP Inhibitor Resistance in Ovarian Cancer., Alexandra McMellen, Tomomi M Yamamoto, Lubna Qamar, Brooke E Sanders, Lily L Nguyen, Daniela Ortiz Chavez, Jaidev Bapat, Amber Berning, Miriam D Post, Joshua Johnson, Kian Behbakht, Elmar Nurmemmedov, Edward B Chuong, and Benjamin G Bitler

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Handgrip Strength Is Related to Hippocampal and Lobar Brain Volumes in a Cohort of Cognitively Impaired Older Adults with Confirmed Amyloid Burden., Somayeh Meysami, Cyrus A Raji, Ryan M. Glatt, Emily S Popa, Aarthi Ganapathi, Tess Bookheimer, Colby B Slyapich, Kyron P Pierce, Casey J Richards, Melanie G Lampa, Jaya Mini Gill, Molly Rapozo, John F Hodes, Ynez M Tongson, Claudia L Wong, Mihae Kim, Verna R Porter, Scott Kaiser, Stella Panos, Richelin V Dye, Karen J Miller, Susan Y Bookheimer, Neil A Martin, Santosh Kesari, Daniel F Kelly, Jennifer Bramen, Prabha Siddarth, and David A Merrill

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Therapeutic Value of Sentinel Lymph Node Biopsy in Patients With Melanoma: A Randomized Clinical Trial., Multicenter Selective Lymphadenectomy Trials Study Group, Jessica S Crystal, John F Thompson, John Hyngstrom, Corrado Caracò, Jonathan S Zager, Tiina Jahkola, Tawnya L Bowles, Elisabetta Pennacchioli, Peter D Beitsch, Harald J Hoekstra, Marc Moncrieff, Christian Ingvar, Alexander van Akkooi, Michael S Sabel, Edward A Levine, Doreen Agnese, Michael Henderson, Reinhard Dummer, Rogerio I Neves, Carlo Riccardo Rossi, John M Kane, Steven Trocha, Frances Wright, David R Byrd, Maurice Matter, Eddy C Hsueh, Alastair MacKenzie-Ross, Mark Kelley, Patrick Terheyden, Tara L Huston, Jeffrey D Wayne, Heather Neuman, B Mark Smithers, Charlotte E Ariyan, Darius Desai, Jeffrey E Gershenwald, Shlomo Schneebaum, Anja Gesierich, Lisa K Jacobs, James M Lewis, Kelly M McMasters, Cristina O'Donoghue, Andre van der Westhuizen, Armando Sardi, Richard Barth, Robert Barone, J Greg McKinnon, Craig L Slingluff, Jeffrey M Farma, Erwin Schultz, Randall P Scheri, Sergi Vidal-Sicart, Manuel Molina, Alessandro A E Testori, Lee Foshag, Lisa Van Kreuningen, He-Jing Wang, Myung-Shin Sim, Richard A Scolyer, David E Elashoff, Alistair J Cochran, and Mark B Faries

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Treatment Utilization and Outcomes for Locally Advanced Rectal Cancer in Older Patients., Sean Nassoiy, Wade Christopher, Rebecca Marcus, Jennifer Keller, Jessica Weiss, Shu-Ching Chang, Leland Foshag, Richard Essner, Trevan Fischer, and Melanie Goldfarb

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Evolving management of early stage pancreatic adenocarcinoma in older patients., Sean Nassoiy, Wade O Christopher, Rebecca Marcus, Jennifer Keller, Jessica Weiss, Shu-Ching Chang, Richard Essner, Lee Foshag, Trevan Fischer, and Melanie Goldfarb

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IFI16-dependent STING signaling is a crucial regulator of anti-HER2 immune response in HER2+ breast cancer., Li-Teng Ong, Wee Chyan Lee, Shijun Ma, Gokce Oguz, Zhitong Niu, Yi Bao, Mubaraka Yusuf, Puay Leng Lee, Jian Yuan Goh, Panpan Wang, Kylie Su Mei Yong, Qingfeng Chen, Wenyu Wang, Adaikalavan Ramasamy, Dave Hoon, Henrik J Ditzel, Ern Yu Tan, Soo Chin Lee, and Qiang Yu

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A Case of Brachial Lymph Node Recurrences after the Resection of Locally Advanced Breast Cancer., Kayono Onishi, Rurina Watanuki, Takamichi Yokoe, Tsuguo Iwatani, Chisako Yamauchi, and Tatsuya Onishi

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ASO Author Reflections: Breast-Conserving Therapy: A Safe Option in Young Patients with Early-Stage Breast Cancer., Javier I Orozco, Crystal E Fancher, and Janie Grumley

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ASO Visual Abstract: Machine Learning-Based Epigenetic Classifiers for Axillary Staging of Patients with ER-Positive Early-Stage Breast Cancer., Javier I J Orozco, Julie Le, Miquel Ensenyat-Mendez, Jennifer L Baker, Joanne Weidhaas, Alexandra Klomhaus, Diego M Marzese, and Maggie L DiNome

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ASO Visual Abstract: Impact of Locoregional Treatment on Survival in Young Patients with Early-Stage Breast Cancer Undergoing Upfront Surgery., Javier I Orozco, Jennifer Keller, Shu-Ching Chang, Crystal E Fancher, and Janie Grumley

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Impact of Locoregional Treatment on Survival in Young Patients with Early-Stage Breast Cancer undergoing Upfront Surgery., Javier I Orozco, Jennifer Keller, Shu-Ching Chang, Crystal E Fancher, and Janie Grumley

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ASO Author Reflections: Molecular Signatures May Render Surgical Staging of the Axilla Obsolete., Javier I Orozco, Julie Le, Jennifer L Baker, Diego M Marzese, and Maggie L DiNome

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Machine Learning-Based Epigenetic Classifiers for Axillary Staging of Patients with ER-Positive Early-Stage Breast Cancer., Javier I Orozco, Julie Le, Miquel Ensenyat-Mendez, Jennifer L Baker, Joanne Weidhaas, Alexandra Klomhaus, Diego M Marzese, and Maggie L DiNome

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Molecular alterations associated with improved outcome in patients with glioblastoma treated with Tumor-Treating Fields., Manjari Pandey, Joanne Xiu, Sandeep Mittal, Jia Zeng, Michelle Saul, Santosh Kesari, Amir Azadi, Herbert Newton, Karina Deniz, Katherine Ladner, Ashley Sumrall, W Michael Korn, and Emil Lou

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MTAP loss: a possible therapeutic approach for glioblastoma., C Pawan K Patro, Nupur Biswas, Sandeep C Pingle, Feng Lin, Misa Anekoji, Lawrence D Jones, Santosh Kesari, Feng Wang, and Shashaanka Ashili

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Genetic polymorphisms and correlation with treatment induced cardiotoxicity and prognosis in breast cancer patients., Parvin Peddi, Peter A Fasching, Duan Liu, Emmanuel Quinaux, Nicholas J Robert, Vicente Valero, John Crown, Carla Falkson, Adam Brufsky, Julie M Cunningham, Richard M Weinshilboum, Tadeusz Pienkowski, Wolfgang Eiermann, Miguel Martín, Valerie Bee, Xiaoyan Wang, Liewei Wang, Eric Yang, Dennis J Slamon, and Sara A Hurvitz

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Does Residual Invasive Disease in Wide Local Excision after Diagnosis with Partial Biopsy Technique Influence Survival in Melanoma? Matched-Pair Analysis of Multicenter Selective Lymphadenectomy Trial I and II., Judi Anne B Ramiscal, Stacey L Stern, Ana K Wilson, Patrick D Lorimer, Nathaniel A Lee, Melanie R Goldfarb, Leland J Foshag, and Trevan D Fischer

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Dense data enables 21th century clinical trials., Jared C Roach, John F Hodes, Cory C Funk, William R Shankle, David A Merrill, Leroy Hood, and Jennifer Bramen

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A Phase III, Multicenter, Randomized Controlled Trial Investigating 1-cm Versus 2-cm Surgical Excision Margins for Stage II Primary Cutaneous Melanoma (MelMarT-II)., Alexander J Rossi, Emily A Verbus, Mark Faries, Marc Moncrieff, Michael Henderson, Jonathan M Hernandez, and Michael C Lowe

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Disparities in the impact of the AJCC 8th edition staging system on differentiated thyroid cancer outcomes., Juan A Santamaria-Barria, Amanda N Graff-Baker, Shu-Ching Chang, Adam Khader, Anthony J Scholer, Mary Garland-Kledzik, and Melanie Goldfarb

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Validating biologic age in selecting elderly patients with pancreatic cancer for surgical resection., Anthony J Scholer, Rebecca Marcus, Mary Garland-Kledzik, Shu-Ching Chang, Adam Khader, Juan Santamaria-Barria, Zeljka Jutric, Ronald Wolf, and Melanie Goldfarb

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Glioblastoma Embryonic-like Stem Cells Exhibit Immune-Evasive Phenotype., Borja Sesé, Sandra Íñiguez-Muñoz, Miquel Ensenyat-Mendez, Pere Llinàs-Arias, Guillem Ramis, Javier I Orozco, Silvia Fernández de Mattos, Priam Villalonga, and Diego M Marzese

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The impact of mentoring on early career faculty: Assessment of a virtual mentoring program., Akanksha Sharma, Heather Leeper, Soo Bang, Donna Molaie, and Alyx B. Porter

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Advances in the Diagnosis and Treatment of Leptomeningeal Disease., Akanksha Sharma, Justin T Low, and Priya Kumthekar

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Efficacy and safety of trifluridine/tipiracil in older and younger patients with metastatic gastric or gastroesophageal junction cancer: subgroup analysis of a randomized phase 3 study (TAGS)., Kohei Shitara, Toshihiko Doi, Hisashi Hosaka, Peter Thuss-Patience, Armando Santoro, Federico Longo, Ozgur Ozyilkan, Irfan Cicin, David J Park, Aziz Zaanan, Carles Pericay, Mustafa Özgüroğlu, Maria Alsina, Lukas Makris, Karim A Benhadji, and David H Ilson

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A phase 1b single-arm trial of intratumoral oncolytic virus V937 in combination with pembrolizumab in patients with advanced melanoma: results from the CAPRA study., Ann W Silk, Steven O'Day, Howard L Kaufman, Jennifer Bryan, Jacqueline T Norrell, Casey Imbergamo, Daniella Portal, Edwin Zambrano-Acosta, Marisa Palmeri, Seymour Fein, Cai Wu, Leslie Guerreiro, Daniel Medina, Praveen K Bommareddy, Andrew Zloza, Bernard A Fox, Carmen Ballesteros-Merino, Yixin Ren, Darren Shafren, Mark Grose, Joshua A Vieth, and Janice M Mehnert

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Anomaly Detection Framework for Wearables Data: A Perspective Review on Data Concepts, Data Analysis Algorithms and Prospects., Jithin S Sunny, C Pawan K Patro, Khushi Karnani, Sandeep C Pingle, Feng Lin, Misa Anekoji, Lawrence D Jones, Santosh Kesari, and Shashaanka Ashili

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Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae, Yapeng Su, Dan Yuan, Daniel G. Chen, Rachel H. Ng, Kai Wang, Jongchan Choi, Sarah Li, Sunga Hong, Rongyu Zhang, Jingyi Xie, Sergey A Kornilov, Kelsey Scherler, Ana Jimena Pavlovitch-Bedzyk, Shen Dong, Christopher Lausted, Inyoul Lee, Shannon Fallen, Chengzhen L Dai, Priyanka Baloni, Brett Smith, Venkata R Duvvuri, Kristin G. Anderson, Jing Li, Fan Yang, Caroline J. Duncombe, Denise J. McCulloch, Clifford Rostomily, Pamela Troisch, Jing Zhou, Sean Mackay, Quinn DeGottardi, Damon H. May, Ruth Taniguchi, Rachel M. Gittelman, Mark Klinger, Thomas M. Snyder, Ryan Roper, Gladys Wojciechowska, Kim Murray, Rick Edmark, Simon Evans, Lesley Jones, Yong Zhou, Lee Rowen, Rachel Liu, William Chour, Heather A Algren, William R Berrington, Julie A Wallick, Rebecca A. Cochran, Mary Micikas, ISB-Swedish COVID19 Biobanking Unit, Terri Wrin, Christos J. Petropoulos, Hunter R. Cole, Trevan D Fischer, Wei Wei, Dave SB Hoon, Nathan D Price, Naeha Subramanian, Joshua A. Hill, Jennifer J Hadlock, Andrew T. Magis, Antoni Ribas, Lewis L. Lanier, Scott D. Boyd, Jeffrey A. Bluestone, Helen Chu, Leroy Hood, Raphael Gottardo, Philip D. Greenberg, Mark M. Davis, Jason D Goldman, and James R. Heath

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Critical appraisal of minimally invasive keyhole surgery for intracranial meningioma in a large case series., Jai Deep Thakur, Regin Jay Mallari, Alex Corlin, Samantha Yawitz, Amy Eisenberg, John Rhee, Walavan Sivakumar, Howard Krauss, Neil A Martin, Chester Griffiths, Garni Barkhoudarian, and Daniel F Kelly

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The TARGIT-A Randomized Trial: TARGIT-IORT Versus Whole Breast Radiation Therapy: Long-Term Local Control and Survival., Jayant S Vaidya, Max Bulsara, Frederik Wenz, Elena Sperk, Samuele Massarut, Michael Alvarado, Norman R Williams, Chris Brew-Graves, Marcelle Bernstein, Dennis Holmes, Lorenzo Vinante, Steffi Pigorsch, Steinar Lundgren, Valery Uhl, David Joseph, Jeffrey S Tobias, and TARGIT-A authors

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CTNI-51. FEASIBILITY AND SAFETY OF NEUROSURGICAL RESECTION AND INTRA-OPERATIVE RADIATION THERAPY USING THE XOFT AXXENT ELECTRONIC BRACHYTHERAPY SYSTEM AND BEVACIZUMAB IN RECURRENT GLIOBLASTOMA, Naveed Wagle, Garni Barkhoudarian, Lisa Chaiken, Robert Wollman, Akanksha Sharma, Jose Carrillo, Minhdan Nguyen, Judy D Truong, Jared Chow, Emma Chacon, and Santosh Kesari

Geno4ME: establishment of an equitable whole-genome sequencing-based platform for clinical screening in a large healthcare system, Josiah Wagner, I A. Lucas-Beckett, K R. Emery, B A. Cosgrove, John T. Welle, K Jade, N D. Wagner, J Rinaldi, Lindsay Dickey, K G. Jones, L Yuan, E M. Shull, J Clemens, Keri Vartanian, A T. Magis, M B. Campbell, Brian Piening, Carlo Bifulco, and Ora K. Gordon

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Novel Therapeutics and Treatment Strategies for Medullary Thyroid Cancer., Evan Walgama, Naifa Busaidy, and Mark Zafereo

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Germline biomarkers predict toxicity to anti-PD1/PDL1 checkpoint therapy., Joanne Weidhaas, Nicholas Marco, Aaron W Scheffler, Anusha Kalbasi, Kirk Wilenius, Emily Rietdorf, Jaya Mini Gill, Mara Heilig, Caroline Desler, Robert K Chin, Tania Kaprealian, Susan McCloskey, Ann Raldow, Naga P Raja, Santosh Kesari, Jose Carrillo, Alexandra Drakaki, Mark Scholz, and Donatello Telesca

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Design and Validation of a Whole-Genome Sequencing- Based Assay for Population Health, John Welle, Brian D. Piening, Josiah T Wagner, Isabelle Lucas-Beckett, T Ward, Benjamin Cosgrove, Eric Shull, R Rattray, Marina Pukay, M Ricks, Kimberly K Childers, Jennifer M Linehan, Mary Campbell, Ora K Gordon, and Carlo Bifulco

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778 Botensilimab, a novel innate/adaptive immune activator, plus or minus balstilimab (anti-PD-1) in “cold” and I-O refractory metastatic solid tumors, Breelyn Wilky, Kim Margolin, Rachel E Sanborn, Steven O'Day, and See full list of authors in comments

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Surgical approach to pediatric mediastinal masses based on imaging characteristics., Stephanie Young, R Luke Rettig, Ian V Hutchinson, Michael G Sutcliffe, and Roman M Sydorak

Submissions from 2021

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The miR-181a-SFRP4 axis regulates Wnt activation to drive stemness and platinum resistance in ovarian cancer., Anil Belur Nagaraj, Matthew Knarr, Sreeja Sekhar, R Shae Connor, Peronne Joseph, Olga Kovalenko, Alexis Fleming, Arshia Surti, Elmar Nurmemmedov, Luca Beltrame, Sergio Marchini, Michael Kahn, and Analisa DiFeo

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COVID-19 in Patients With Pre-existing Neurologic Disorders: Clinical Course and Outcomes (2608), Svetlana Blitshteyn, Akanksha Sharma, and See full list of authors in comments

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DNA Damage Response in Glioblastoma: Mechanism for Treatment Resistance and Emerging Therapeutic Strategies., Alipi Bonm and Santosh Kesari

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Marizomib alone or in combination with bevacizumab in patients with recurrent glioblastoma: Phase I/II clinical trial data., Daniela A Bota, Warren Mason, Santosh Kesari, Rajiv Magge, Benjamin Winograd, Ileana Elias, Steven D Reich, Nancy Levin, Mohit Trikha, and Annick Desjardins

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Cost-effectiveness of Hypertension Treatment by Pharmacists in Black Barbershops., Kelsey B Bryant, Andrew E Moran, Dhruv S Kazi, Yiyi Zhang, Joanne Penko, Natalia Ruiz-Negrón, Pamela Coxson, Ciantel A Blyler, Kathleen Lynch, Laura P Cohen, Gabriel S Tajeu, Valy Fontil, Norma B Moy, Joseph E Ebinger, Florian Rader, Kirsten Bibbins-Domingo, and Brandon K Bellows

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Nonpeptidic, Polo-Box Domain-Targeted Inhibitors of PLK1 Block Kinase Activity, Induce Its Degradation and Target-Resistant Cells., Danda Chapagai, Gurusankar Ramamoorthy, Jessy Varghese, Elmar Nurmemmedov, Campbell McInnes, and Michael D Wyatt

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Primary Chemoablation of Low-Grade Intermediate-Risk Non-Muscle-Invasive Bladder Cancer Using UGN-102, A Mitomycin-Containing Reverse Thermal Gel (Optima II): A Phase 2b, Open-Label, Single-Arm Trial., K Kent Chevli, Neal D Shore, Andrew Trainer, Angela B Smith, Daniel Saltzstein, Yaron Ehrlich, Jay D Raman, Boris Friedman, Richard D'Anna, David Morris, Brian Hu, Mark Tyson, Alexander Sankin, Max Kates, Jennifer Linehan, Douglas Scherr, Steven Kester, Michael Verni, Karim Chamie, Lawrence Karsh, Arnold Cinman, Andrew Meads, Soumi Lahiri, Madlen Malinowski, Nimrod Gabai, Sunil Raju, Mark Schoenberg, Elyse Seltzer, and William C Huang

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Undifferentiated Carcinoma With Osteoclast-Like Giant Cells of the Pancreas Discovered on Positron Emission Tomography Performed for Lymphoma Staging., Wade O Christopher, Trevan D Fischer, and Anton J Bilchik

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SNO 2020 diversity survey: defining demographics, racial biases, career success metrics and a path forward for the field of neuro-oncology., Ugonma N Chukwueke, Elizabeth Vera, Alvina Acquaye, Shawn L Hervey-Jumper, Yazmin Odia, Laura J Klesse, Erin Dunbar, Akanksha Sharma, Ekokobe Fonkem, Alissa A Thomas, Tamra E Werbowetski-Ogilvie, Sandra Camelo-Piragua, Na Tosha N Gatson, Macarena I de la Fuente, Terri S Armstrong, Alyx B Porter, and Sadhana Jackson

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Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19., Felice D'Agnillo, Kathie-Anne Walters, Yongli Xiao, Zong-Mei Sheng, Kelsey Scherler, Jaekeun Park, Sebastian Gygli, Luz Angela Rosas, Kaitlyn Sadtler, Heather Kalish, Charles A Blatti, Ruoqing Zhu, Lisa Gatzke, Colleen Bushell, Matthew J Memoli, Steven O'Day, Trevan Fischer, Terese C Hammond, Raymond C Lee, J Christian Cash, Matthew E Powers, Grant E O'Keefe, Kelly J Butnor, Amy V Rapkiewicz, William D Travis, Scott P Layne, John C Kash, and Jeffery K Taubenberger

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Correction to: Gliosarcoma vs. glioblastoma: a retrospective case series using molecular profiling., Christopher Dardis, David Donner, Nader Sanai, Joanne Xiu, Sandeep Mittal, Sharon K Michelhaugh, Manjari Pandey, Santosh Kesari, Amy B Heimberger, Zoran Gatalica, Michael W Korn, Ashley L Sumrall, and Surasak Phuphanich

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Gliosarcoma vs. glioblastoma: a retrospective case series using molecular profiling., Christopher Dardis, David Donner, Nader Sanai, Joanne Xiu, Sandeep Mittal, Sharon K Michelhaugh, Manjari Pandey, Santosh Kesari, Amy B Heimberger, Zoran Gatalica, Michael W Korn, Ashley L Sumrall, and Surasak Phuphanich

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Remdesivir and Mortality in Patients with COVID-19., George A Diaz, Alyssa B Christensen, Tobias Pusch, Delaney Goulet, Shu-Ching Chang, Gary L Grunkemeier, Paul A McKelvey, Ari Robicsek, Tom French, Guilford T Parsons, Glenn Doherty, Charles Laurenson, Ryan Roper, Jennifer Hadlock, Cameron J Cover, Brent Footer, Philip Robinson, Mary Micikas, Jennifer E Marfori, Charlotte Cronenweth, Yogavedya Mukkamala, Jamie Mackiewicz, Ekra Rai, Martha Dickinson Matson, Jodie Davila, Justin Rueda, Reda Tipton, Heather Algren, Brittney C Ward, Stephen Malkoski, Tyler Gluckman, Gregory B Tallman, Henry Arguinchona, Terese C Hammond, Steven Standaert, Joshua Christensen, Jose F Echaiz, Robert Choi, Daniel McClung, Albert Pacifico, Martin Fee, Farjad Sarafian, William R Berrington, and Jason D Goldman

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Disparities in Amputation Rates for Non-metastatic Extremity Soft Tissue Sarcomas and the Impact on Survival., Joshua C Dilday, Daniel W Nelson, Trevan D Fischer, and Melanie Goldfarb

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Neoadjuvant talimogene laherparepvec plus surgery versus surgery alone for resectable stage IIIB-IVM1a melanoma: a randomized, open-label, phase 2 trial., R Dummer, D E Gyorki, J Hyngstrom, A C Berger, R Conry, L Demidov, A Sharma, S A Treichel, H Radcliffe, K S Gorski, A Anderson, E Chan, M Faries, and M I Ross

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Modified RANO, Immunotherapy RANO, and Standard RANO Response to Convection-Enhanced Delivery of IL4R-Targeted Immunotoxin MDNA55 in Recurrent Glioblastoma., Benjamin M Ellingson, John Sampson, Achal Singh Achrol, Manish K Aghi, Krystof Bankiewicz, Chencai Wang, Martin Bexon, Steven Brem, Andrew Brenner, Sajeel Chowdhary, John R Floyd, Seunggu Han, Santosh Kesari, Dina Randazzo, Michael A Vogelbaum, Frank Vrionis, Miroslaw Zabek, Nicholas Butowski, Melissa Coello, Nina Merchant, and Fahar Merchant

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Cryopreserved placental tissue allograft accelerates time to continence following robot-assisted radical prostatectomy., Peter A Elliott, Stephanie Hsiang, Ramkishen Narayanan, James Bierylo, Shu-Ching Chang, Przemyslaw Twardowski, and Timothy G Wilson

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Current Triple-Negative Breast Cancer Subtypes: Dissecting the Most Aggressive Form of Breast Cancer., Miquel Ensenyat-Mendez, Pere Llinàs-Arias, Javier I J Orozco, Sandra Íñiguez-Muñoz, Matthew P Salomon, Borja Sesé, Maggie L DiNome, and Diego M Marzese

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A phase I study of the WT2725 dosing emulsion in patients with advanced malignancies., Siqing Fu, David E Piccioni, Hongtao Liu, Rimas V Lukas, Santosh Kesari, Dawit Aregawi, David S Hong, Kenichiro Yamaguchi, Kate Whicher, Yi Zhang, Yu-Luan Chen, Nagaraju Poola, John Eddy, and David Blum