Providence’s research in kidney health and diseases is on the cutting edge of identifying molecular signatures of diabetic kidney disease and development of new biomarkers and treatment targets. Our work is broadly translational from cellular and molecular biology to studies in mouse models to translational studies in humans and clinical trials of novel therapies. We also conduct research in a broad spectrum of other types of kidney diseases and treatments: glomerular diseases, hypertension and kidney vascular disease, nutritional approaches, patient-centered outcomes, and health services research. Importantly, Providence has funded a major initiative to establish a system-wide Chronic Kidney Disease registry that will greatly amplify both the quality-of-care we deliver and the research we conduct in our communities. We truly are at a tipping point. Astounding scientific breakthroughs will change the landscape toward kidney health and better life for people with kidney diseases.

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Submissions from 2018

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Redefining kidney disease progression after cardiac surgery: Now what?, Juan N Pulido

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Pazopanib with low fat meal (PALM) in advanced renal cell carcinoma., Melissa A Reimers, Maryann M Shango, Stephanie Daignault-Newton, Rachel Dedinsky, Danielle Karsies, Shawna Kraft, Liam Riddle, Jeremy A Felton, Bo Wen, Christina Gersch, James M Rae, Bruce G Redman, and Ajjai S Alva

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The 2017 Diabetes Educator and the Diabetes Self-Management Education National Practice Survey., Joanne Rinker, Jane K Dickinson, Michelle L Litchman, Ann S Williams, Leslie E Kolb, Carla Cox, and Ruth D Lipman

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Reevaluating Warm Ischemia Time as a Predictor of Renal Function Outcomes After Robotic Partial Nephrectomy., Daniel C Rosen, Muthumeena Kannappan, David J Paulucci, Alp Tuna Beksac, Kyrollis Attalla, Ronney Abaza, Daniel D Eun, Akshay Bhandari, Ashok K Hemal, James Porter, and Ketan K Badani

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Delivery Outcomes, Emergency Room Visits, and Psychological Aspects of Gestational Diabetes: Results From a Community Hospital Multiethnic Cohort., Harsimran Singh, Khajika Soyoltulga, Taylor Fong, and John Billimek

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Are Independent Double-Checks Vital Prior to Safe Subcutaneous Insulin Administration?, Sarah Turecek

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Race in America: What Does It Mean for Diabetes and CKD?, Katherine Tuttle

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Dulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7): a multicentre, open-label, randomised trial., Katherine Tuttle, Mark C Lakshmanan, Brian Rayner, Robert S Busch, Alan G Zimmermann, D Bradley Woodward, and Fady T Botros

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Diabetic Kidney Disease (c. 2018)., Katherine R Tuttle

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Medication Therapy Management after Hospitalization in CKD: A Randomized Clinical Trial., Katherine R Tuttle, Radica Z Alicic, Robert A Short, Joshua J Neumiller, Brian J Gates, Kenn B Daratha, Celestina Barbosa-Leiker, Sterling M McPherson, Naomi S Chaytor, Brad P Dieter, Stephen M Setter, and Cynthia F Corbett

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JAK1/JAK2 inhibition by baricitinib in diabetic kidney disease: results from a Phase 2 randomized controlled clinical trial., Katherine R. Tuttle, Frank C Brosius, Sharon G Adler, Matthias Kretzler, Ravindra L Mehta, James A Tumlin, Yoshiya Tanaka, Masakazu Haneda, Jiajun Liu, Maria E Silk, Tracy E Cardillo, Kevin L Duffin, Joseph V Haas, William L Macias, Fabio P Nunes, and Jonathan M Janes

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GLP-1 receptor agonists, CKD, and eGFR trajectory - Authors' reply., Katherine R Tuttle, Mark C Lakshmanan, Brian Rayner, Robert S Busch, Alan G Zimmermann, D Bradley Woodward, and Fady T Botros

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Lesser eGFR Decline with Dulaglutide Regardless of Weight Changes in People with Type 2 Diabetes and Moderate to Severe Chronic Kidney Disease (AWARD-7), Katherine R. Tuttle, Mark Lakshmanan, Brian L. Rayner, Robert S. Busch, Alan G. Zimmermann, Brad Woodward, and Fady T. Botros

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Development of an International Standard Set of Value-Based Outcome Measures for Patients With Chronic Kidney Disease: A Report of the International Consortium for Health Outcomes Measurement (ICHOM) CKD Working Group., Wouter R Verberne, Zofia Das-Gupta, Andrew S Allegretti, Hans A J Bart, Wim van Biesen, Guillermo García-García, Elizabeth Gibbons, Eduardo Parra, Marc H Hemmelder, Kitty J Jager, Markus Ketteler, Charlotte Roberts, Muhamed Al Rohani, Matthew J Salt, Andrea Stopper, Türkan Terkivatan, Katherine Tuttle, Chih-Wei Yang, David C Wheeler, and Willem Jan W Bos

Improving Hepatitis B Vaccination Rates in Patients with Type 1 and Type II Diabetes Mellitus, Qian Zhou, Alyssa Nelson, and Shelley Schoepflin Sanders

Submissions from 2017

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Diabetic Kidney Disease: Challenges, Progress, and Possibilities., Radica Z Alicic, Michele T Rooney, and Katherine Tuttle

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The Northwest Participant and Clinical Interactions Network: Increasing opportunities for patients to participate in research across the Northwestern United States., Laura-Mae Baldwin, Laurie Hassell, Cindi Laukes, Michelle Doyle, Anne Reedy, Brenda Mollis, Sandra Albritton, Elizabeth Ciemins, Robert Coker, Jeannine Brant, Katherine Tuttle, Laura Baker, and Bonnie Ramsey

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Role of Physical Activity for Weight Loss and Weight Maintenance., Carla E Cox

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Dietary strategies for cardiovascular health., Brad P Dieter and Katherine R Tuttle

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Cigarette smoking and cardio-renal events in patients with atherosclerotic renal artery stenosis., Christopher A Drummond, Pamela S Brewster, Wencan He, Kaili Ren, Yanmei Xie, Katherine Tuttle, Steven T Haller, Kenneth Jamerson, Lance D Dworkin, Donald E Cutlip, Timothy P Murphy, Ralph B D'Agostino, William L Henrich, Jiang Tian, Joseph I Shapiro, and Christopher J Cooper

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A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus., Yuqing He, Yuanlin Ding, Biyu Liang, Juanjuan Lin, Taek-Kyun Kim, Haibing Yu, Hanwei Hang, and Kai Wang

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Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy., Adeera Levin, Marcello Tonelli, Joseph Bonventre, Josef Coresh, Jo-Ann Donner, Agnes B Fogo, Caroline S Fox, Ron T Gansevoort, Hiddo J L Heerspink, Meg Jardine, Bertram Kasiske, Anna Köttgen, Matthias Kretzler, Andrew S Levey, Valerie A Luyckx, Ravindra Mehta, Orson Moe, Gregorio Obrador, Neesh Pannu, Chirag R Parikh, Vlado Perkovic, Carol Pollock, Peter Stenvinkel, Katherine R Tuttle, David C Wheeler, and Kai-Uwe Eckardt

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Cellular Signaling Pathways in Insulin Resistance-Systems Biology Analyses of Microarray Dataset Reveals New Drug Target Gene Signatures of Type 2 Diabetes Mellitus., Syed Aun Muhammad, Waseem Raza, Thanh Nguyen, Baogang Bai, Xiaogang Wu, and Jake Chen

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Therapeutic Considerations for Antihyperglycemic Agents in Diabetic Kidney Disease., Joshua J Neumiller, Radica Alicic, and Katherine Tuttle

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Risk of glucose intolerance and gestational diabetes mellitus in relation to maternal habitual snoring during early pregnancy., Chunfang Qiu, Wayne Lawrence, Bizu Gelaye, Lee Stoner, Ihunnaya O Frederick, Daniel A Enquobahrie, Tanya K Sorensen, and Michelle A Williams

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Back to the Future: Glomerular Hyperfiltration and the Diabetic Kidney., Katherine Tuttle MD

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Circulating early- and mid-pregnancy microRNAs and risk of gestational diabetes., Pandora L Wander, Edward J Boyko, Karin Hevner, Viraj J Parikh, Mahlet G Tadesse, Tanya K Sorensen, Michelle A Williams, and Daniel A Enquobahrie

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Identification of the Causes for Chronic Hypokalemia: Importance of Urinary Sodium and Chloride Excretion., Kun-Lin Wu, Chih-Jen Cheng, Chih-Chen Sung, Ming-Hua Tseng, Yu-Juei Hsu, Sung-Sen Yang, Tom Chau, and Shih-Hua Lin

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Diabetes and CKD in the United States Population, 2009-2014., Leila R Zelnick, Noel S Weiss, Bryan R Kestenbaum, Cassianne Robinson-Cohen, Patrick J Heagerty, Katherine Tuttle, Yoshio N Hall, Irl B Hirsch, and Ian H de Boer

Submissions from 2014

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Stenting and medical therapy for atherosclerotic renal-artery stenosis., Christopher J Cooper, Timothy P Murphy, Donald E Cutlip, Kenneth Jamerson, William Henrich, Diane M Reid, David J Cohen, Alan H Matsumoto, Michael Steffes, Michael R Jaff, Martin R Prince, Eldrin F Lewis, Katherine Tuttle MD, Joseph I Shapiro, John H Rundback, Joseph M Massaro, Ralph B D'Agostino, and Lance D Dworkin

Reconciling the R.E.N.A.L. Nephrometry Tool and the updated NCCN Management Guidelines for Kidney Cancer. “Upholding Oncological Principles and Avoiding Chronic Kidney Disease.”, Mark J. Kelly

Submissions from 2009

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Should albuminuria be a focus of antihypertensive therapy goals?, Radica Alicic, Sandeep A Saha, Robert A Short, and Katherine Tuttle MD

A Resident Created Protocol for the Treatment of Diabetic Ketoacidosis in the ICU, Jason Hughes, DO

A Resident Created Protocol for the Treatment of Diabetic Ketoacidosis in the ICU, Jason Hughes, DO