Institute for Systems Biology (ISB) is a Providence-affiliated cross-disciplinary non-profit biomedical research organization based in Seattle. We focus on some of the most pressing issues in human health, including aging, brain health, cancer, COVID-19, the human microbiome, as well as many infectious diseases. ISB’s science is translational, and we champion sound scientific research that results in real-world clinical impacts. Learn more at isbscience.org, and see our published research papers here.

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Submissions from 2024

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Proteomic changes induced by longevity-promoting interventions in mice., Adam R Burns, Jack Wiedrick, Alicia Feryn, Michal Maes, Mukul K Midha, David H Baxter, Seamus R Morrone, Timothy J Prokop, Charu Kapil, Michael R Hoopmann, Ulrike Kusebauch, Eric W Deutsch, Noa Rappaport, Kengo Watanabe, Robert L Moritz, Richard A Miller, Jodi A Lapidus, and Eric S Orwoll

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Integrative systems biology reveals NKG2A-biased immune responses correlate with protection in infectious disease, autoimmune disease, and cancer., Daniel G Chen, Jingyi Xie, Jongchan Choi, Rachel H Ng, Rongyu Zhang, Sarah Li, Rick Edmark, Hong Zheng, Ben Solomon, Katie M Campbell, Egmidio Medina, Antoni Ribas, Purvesh Khatri, Lewis L Lanier, Philip J Mease, Jason D Goldman, Yapeng Su, and James R Heath

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Metagenomic estimation of dietary intake from human stool., Christian Diener and Sean M Gibbons

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The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank., Janith Don, Andrew J Schork, Gwênlyn Glusman, Noa Rappaport, Steve R Cummings, David Duggan, Anish Raju, Kajsa-Lotta Georgii Hellberg, Sophia Gunn, Stefano Monti, Thomas Perls, Jodi Lapidus, Laura H Goetz, Paola Sebastiani, and Nicholas J Schork

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TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction., Patrick T Griffin, Alice E Kane, Alexandre Trapp, Jien Li, Matthew Arnold, Jesse R Poganik, Ryan J Conway, Maeve S McNamara, Margarita V Meer, Noah Hoffman, João A Amorim, Xiao Tian, Michael R MacArthur, Sarah J Mitchell, Amber L Mueller, Colleen Carmody, Daniel L Vera, Csaba Kerepesi, Kejun Ying, Nicole Noren Hooten, James R Mitchell, Michele K Evans, Vadim N Gladyshev, and David A Sinclair

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A data-driven approach to improve wellness and reduce recurrence in cancer survivors., Ramkumar Hariharan, Leroy Hood, and Nathan D Price

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Contribution of Microorganisms with the Clade II Nitrous Oxide Reductase to Suppression of Surface Emissions of Nitrous Oxide., Kristopher A Hunt, Alex V Carr, Anne E Otwell, Jacob J Valenzuela, Kathleen S Walker, Emma R Dixon, Lauren M Lui, Torben N Nielsen, Samuel Bowman, Frederick von Netzer, Ji-Won Moon, Christopher W Schadt, Miguel Rodriguez, Kenneth Lowe, Dominique Joyner, Katherine J Davis, Xiaoqin Wu, Romy Chakraborty, Matthew W Fields, Jizhong Zhou, Terry C Hazen, Adam P Arkin, Scott D Wankel, Nitin S Baliga, and David A Stahl

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Maternal-fetal outcomes in patients with immune-mediated inflammatory diseases, with consideration of comorbidities: a retrospective cohort study in a large U.S. healthcare system., Yeon Mi Hwang, Qi Wei, Samantha N Piekos, Bhargav Vemuri, Sevda Molani, Philip Mease, Leroy Hood, and Jennifer Hadlock

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Forum on immune digital twins: a meeting report., Reinhard Laubenbacher, Fred Adler, Gary An, Filippo Castiglione, Stephen Eubank, Luis L Fonseca, James Glazier, Tomas Helikar, Marti Jett-Tilton, Denise Kirschner, Paul Macklin, Borna Mehrad, Beth Moore, Virginia Pasour, Ilya Shmulevich, Amber Smith, Isabel Voigt, Thomas E Yankeelov, and Tjalf Ziemssen

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Toward mechanistic medical digital twins: some use cases in immunology., Reinhard Laubenbacher, Fred Adler, Gary An, Filippo Castiglione, Stephen Eubank, Luis L Fonseca, James Glazier, Tomas Helikar, Marti Jett-Tilton, Denise Kirschner, Paul Macklin, Borna Mehrad, Beth Moore, Virginia Pasour, Ilya Shmulevich, Amber Smith, Isabel Voigt, Thomas E Yankeelov, and Tjalf Ziemssen

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Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19., Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang, Jeremy Manry, Yoann Seeleuthner, Yu Zhang, Alexandre Bolze, Matthieu Chaldebas, Baptiste Milisavljevic, Adrian Gervais, Paul Bastard, Takaki Asano, Lucy Bizien, Federica Barzaghi, Hassan Abolhassani, Ahmad Abou Tayoun, Alessandro Aiuti, Ilad Alavi Darazam, Luis M Allende, Rebeca Alonso-Arias, Andrés Augusto Arias, Gokhan Aytekin, Peter Bergman, Simone Bondesan, Yenan T Bryceson, Ingrid G Bustos, Oscar Cabrera-Marante, Sheila Carcel, Paola Carrera, Giorgio Casari, Khalil Chaïbi, Roger Colobran, Antonio Condino-Neto, Laura E Covill, Ottavia M Delmonte, Loubna El Zein, Carlos Flores, Peter K Gregersen, Marta Gut, Filomeen Haerynck, Rabih Halwani, Selda Hancerli, Lennart Hammarström, Nevin Hatipoğlu, Adem Karbuz, Sevgi Keles, Christèle Kyheng, Rafael Leon-Lopez, Jose Luis Franco, Davood Mansouri, Javier Martinez-Picado, Ozge Metin Akcan, Isabelle Migeotte, Pierre-Emmanuel Morange, Guillaume Morelle, Andrea Martin-Nalda, Giuseppe Novelli, Antonio Novelli, Tayfun Ozcelik, Figen Palabiyik, Qiang Pan-Hammarström, Rebeca Pérez de Diego, Laura Planas-Serra, Daniel E Pleguezuelo, Carolina Prando, Aurora Pujol, Luis Felipe Reyes, Jacques G Rivière, Carlos Rodriguez-Gallego, Julian Rojas, Patrizia Rovere-Querini, Agatha Schlüter, Mohammad Shahrooei, Ali Sobh, Pere Soler-Palacin, Yacine Tandjaoui-Lambiotte, Imran Tipu, Cristina Tresoldi, Jesus Troya, Diederik van de Beek, Mayana Zatz, Pawel Zawadzki, Saleh Zaid Al-Muhsen, Mohammed Faraj Alosaimi, Fahad M Alsohime, Hagit Baris-Feldman, Manish J Butte, Stefan N Constantinescu, Megan A Cooper, Clifton L Dalgard, Jacques Fellay, James R Heath, Yu-Lung Lau, Richard P Lifton, Tom Maniatis, Trine H Mogensen, Horst von Bernuth, Alban Lermine, Michel Vidaud, Anne Boland, Jean-François Deleuze, Robert Nussbaum, Amanda Kahn-Kirby, France Mentre, Sarah Tubiana, Guy Gorochov, Florence Tubach, Pierre Hausfater, Isabelle Meyts, Shen-Ying Zhang, Anne Puel, Luigi D Notarangelo, Stephanie Boisson-Dupuis, Helen C Su, Bertrand Boisson, Emmanuelle Jouanguy, Jean-Laurent Casanova, Qian Zhang, Laurent Abel, and Aurélie Cobat

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Mixed Wolbachia infections resolve rapidly during in vitro evolution, Cade Mirchandani, Pingting Wang, Jodie Jacobs, Maximilian Genetti, Evan Pepper-Tunick, William T Sullivan, Russ Corbett-Detig, and Shelbi L Russell

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The intersection of frailty and metabolism., Manish Mishra, Judy Wu, Alice E Kane, and Susan E Howlett

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Gene regulatory network topology governs resistance and treatment escape in glioma stem-like cells., James H Park, Parvinder Hothi, Adrian Lopez Garcia de Lomana, Min Pan, Rachel Calder, Serdar Turkarslan, Wei-Ju Wu, Hwahyung Lee, Anoop P Patel, Charles Cobbs, Sui Huang, and Nitin S Baliga

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Aberrant DNA methylation distorts developmental trajectories in atypical teratoid/rhabdoid tumors., Meeri Pekkarinen, Kristiina Nordfors, Joonas Uusi-Mäkelä, Ville Kytölä, Anja Hartewig, Laura Huhtala, Minna Rauhala, Henna Urhonen, Sergei Häyrynen, Ebrahim Afyounian, Olli Yli-Harja, Wei Zhang, Pauli Helen, Olli Lohi, Hannu Haapasalo, Joonas Haapasalo, Matti Nykter, Juha Kesseli, and Kirsi J Rautajoki

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Meta-analysis of the human upper respiratory tract microbiome reveals robust taxonomic associations with health and disease., Nick Quinn-Bohmann, Jose A Freixas-Coutin, Jin Seo, Ruth Simmons, Christian Diener, and Sean M Gibbons

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Global Release of Translational Repression Across Plasmodiums Host-to-Vector Transmission Event., Kelly T Rios, James P McGee, Aswathy Sebastian, Robert L Moritz, Marina Feric, Sabrina Absalon, Kristian E Swearingen, and Scott E Lindner

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Detection of the Arabidopsis Proteome and Its Post-translational Modifications and the Nature of the Unobserved (Dark) Proteome in PeptideAtlas, Klaas J van Wijk, Tami Leppert, Zhi Sun, Alyssa Kearly, Margaret Li, Luis Mendoza, Isabell Guzchenko, Erica Debley, Georgia Sauermann, Pratyush Routray, Sagunya Malhotra, Andrew Nelson, Qi Sun, and Eric W Deutsch

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SpectiCal: m/ z Calibration of MS2 Peptide Spectra Using Known Low Mass Ions, Nathan H Zhang and Eric W Deutsch

Submissions from 2023

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Temporal Profiling of Host Proteome against Different, Prabhakar Babele, Mukul K Midha, Kanury V S Rao, and Ajay Kumar

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Integrated unbiased multiomics defines disease-independent placental clusters in common obstetrical syndromes., Oren Barak, Tyler Lovelace, Samantha Piekos, Tianjiao Chu, Zhishen Cao, Elena Sadovsky, Jean-Francois Mouillet, Yingshi Ouyang, W Tony Parks, Leroy Hood, Nathan D Price, Panayiotis V Benos, and Yoel Sadovsky

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Microbial community-scale metabolic modeling predicts personalized short-chain-fatty-acid production profiles in the human gut., Nick Bohmann, Tomasz Wilmanski, Lisa Levy, Johanna W Lampe, Thomas Gurry, Noa Rappaport, Christian Diener, and Sean M Gibbons

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spongEffects: ceRNA modules offer patient-specific insights into the miRNA regulatory landscape., Fabio Boniolo, Markus Hoffmann, Norman Roggendorf, Bahar Tercan, Jan Baumbach, Mauro A A Castro, A Gordon Robertson, Dieter Saur, and Markus List

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Single-haplotype comparative genomics provides insights into lineage-specific structural variation during cat evolution., Kevin R Bredemeyer, LaDeana Hillier, Andrew J Harris, Graham M Hughes, Nicole M Foley, Colleen Lawless, Rachel A Carroll, Jessica Storer, Mark A Batzer, Edward S Rice, Brian W Davis, Terje Raudsepp, Stephen J O'Brien, Leslie A Lyons, Wesley C Warren, and William J Murphy

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Non-Mass Spectrometric Targeted Single-Cell Metabolomics., Hanjun Cheng, Yin Tang, Zhonghan Li, Zhili Guo, James R Heath, Min Xue, and Wei Wei

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Evolutionary constraint and innovation across hundreds of placental mammals., Matthew J Christmas, Irene M Kaplow, Diane P Genereux, Michael X Dong, Graham M Hughes, Xue Li, Patrick F Sullivan, Allyson G Hindle, Gregory Andrews, Joel C Armstrong, Matteo Bianchi, Ana M Breit, Mark Diekhans, Cornelia Fanter, Nicole M Foley, Daniel B Goodman, Linda Goodman, Kathleen C Keough, Bogdan Kirilenko, Amanda Kowalczyk, Colleen Lawless, Abigail L Lind, Jennifer R S Meadows, Lucas R Moreira, Ruby W Redlich, Louise Ryan, Ross Swofford, Alejandro Valenzuela, Franziska Wagner, Ola Wallerman, Ashley R Brown, Joana Damas, Kaili Fan, John Gatesy, Jenna Grimshaw, Jeremy Johnson, Sergey V Kozyrev, Alyssa J Lawler, Voichita D Marinescu, Kathleen M Morrill, Austin Osmanski, Nicole S Paulat, BaDoi N Phan, Steven K Reilly, Daniel E Schäffer, Cynthia Steiner, Megan A Supple, Aryn P Wilder, Morgan E Wirthlin, James R Xue, Zoonomia Consortium §, Bruce W Birren, Steven Gazal, Robert M Hubley, Klaus-Peter Koepfli, Tomas Marques-Bonet, Wynn K Meyer, Martin Nweeia, Pardis C Sabeti, Beth Shapiro, Arian F A Smit, Mark S Springer, Emma C Teeling, Zhiping Weng, Michael Hiller, Danielle L Levesque, Harris A Lewin, William J Murphy, Arcadi Navarro, Benedict Paten, Katherine S Pollard, David A Ray, Irina Ruf, Oliver A Ryder, Andreas R Pfenning, Kerstin Lindblad-Toh, and Elinor K Karlsson

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Trans-Proteomic Pipeline: Robust Mass Spectrometry-Based Proteomics Data Analysis Suite., Eric W Deutsch, Luis Mendoza, David D Shteynberg, Michael R Hoopmann, Zhi Sun, Jimmy K Eng, and Robert L Moritz

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Proteomics Standards Initiative at Twenty Years: Current Activities and Future Work., Eric W Deutsch, Juan Antonio Vizcaíno, Andrew R Jones, Pierre-Alain Binz, Henry Lam, Joshua Klein, Wout Bittremieux, Yasset Perez-Riverol, David L Tabb, Mathias Walzer, Sylvie Ricard-Blum, Henning Hermjakob, Steffen Neumann, Tytus D Mak, Shin Kawano, Luis Mendoza, Tim Van Den Bossche, Ralf Gabriels, Nuno Bandeira, Jeremy Carver, Benjamin Pullman, Zhi Sun, Nils Hoffmann, Jim Shofstahl, Yunping Zhu, Luana Licata, Federica Quaglia, Silvio C E Tosatto, and Sandra E Orchard

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Coarse graining the human gut microbiome., Christian Diener and Sean M Gibbons

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More is Different: Metabolic Modeling of Diverse Microbial Communities., Christian Diener and Sean M Gibbons

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The transcriptomic landscape of normal and ineffective erythropoiesis at single-cell resolution., Raymond T Doty, Christopher G Lausted, Adam D Munday, Zhantao Yang, Xiaowei Yan, Changting Meng, Qiang Tian, and Janis L Abkowitz

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Characterizing the Impact of Communication on Cellular and Collective Behavior Using a Three-Dimensional Multiscale Cellular Model., Moriah Echlin, Boris Aguilar, and Ilya Shmulevich

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Editorial: Translational phenomics and its applications in immunotherapy., Hai Fang, Liye Chen, Leroy Hood, and Qiang Tian

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An approach for collaborative development of a federated biomedical knowledge graph-based question-answering system: Question-of-the-Month challenges., Karamarie Fecho, Chris Bizon, Tursynay Issabekova, Sierra Moxon, Anne E Thessen, Shervin Abdollahi, Sergio E Baranzini, Basazin Belhu, William E Byrd, Lawrence Chung, Andrew Crouse, Marc P Duby, Stephen Ferguson, Aleksandra Foksinska, Laura Forero, Jennifer Friedman, Vicki Gardner, Gwênlyn Glusman, Jennifer Hadlock, Kristina Hanspers, Eugene Hinderer, Charlotte Hobbs, Gregory Hyde, Sui Huang, David Koslicki, Philip Mease, Sandrine Muller, Christopher J Mungall, Stephen A Ramsey, Jared Roach, Irit Rubin, Shepherd H Schurman, Anath Shalev, Brett Smith, Karthik Soman, Sarah Stemann, Andrew I Su, Casey Ta, Paul B Watkins, Mark D Williams, Chunlei Wu, Colleen H Xu, and Biomedical Data Translator Consortium

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Effects of HLA single chain trimer design on peptide presentation and stability., Kathryn A K Finton, Peter B Rupert, Della J Friend, Ana Dinca, Erica S Lovelace, Matthew Buerger, Domnita V Rusnac, Ulysses Foote-McNabb, William Chour, James R Heath, Jean S Campbell, Robert H Pierce, and Roland K Strong

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Abstract 4876: A systems pharmacology approach to discover synergistic targeted therapy combinations, Cameron T. Flower, Chunmei Liu, James R Heath, Wei Wei, and Forest M. White

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Abstract 901: Monitoring of Neoantigens and Adoptively Transferred Personalized NeoTCR T Cell Populations in the Tumor and PBMCs of Patients with Solid Tumors, Susan Foy, Cliff Wang, Benjamin Yuen, Sara Said, Boi Quach, Jonathan Hoover, Saparya Nayak, Theresa Hunter, Zheng Pan, Chad Smith, Tyler Borrman, Eric Stawiski, Alphonsus H.C. Ng, Yue Lu, James R Heath, and Stefanie Mandl

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Single-cell gene set scoring with nearest neighbor graph smoothed data (gssnng)., David L Gibbs, Michael K Strasser, and Sui Huang

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The neuronal chromatin landscape in adult schizophrenia brains is linked to early fetal development., Kiran Girdhar, Jaroslav Bendl, Andrew M Baumgartner, Karen Therrien, Sanan Venkatesh, Deepika Mathur, Pengfei Dong, Samir Rahman, Steven P Kleopoulos, Ruth Misir, Sarah M Reach, Pavan K Auluck, Stefano Marenco, David A Lewis, Vahram Haroutunian, Cory C Funk, Georgios Voloudakis, Gabriel E Hoffman, John F Fullard, and Panos Roussos

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ARAX: a graph-based modular reasoning tool for translational biomedicine., Amy K Glen, Chunyu Ma, Luis Mendoza, Finn Womack, E C Wood, Meghamala Sinha, Liliana Acevedo, Lindsey G Kvarfordt, Ross C Peene, Shaopeng Liu, Andrew S Hoffman, Jared C Roach, Eric W Deutsch, Stephen A Ramsey, and David Koslicki

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Interoperable slide microscopy viewer and annotation tool for imaging data science and computational pathology., Chris Gorman, Davide Punzo, Igor Octaviano, Steven Pieper, William J R Longabaugh, David A Clunie, Ron Kikinis, Andrey Y Fedorov, and Markus D Herrmann

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A large-scale targeted proteomics of serum and tissue shows the utility of classifying high grade and low grade meningioma tumors., Ankit Halder, Deeptarup Biswas, Aparna Chauhan, Adrita Saha, Shreeman Auromahima, Deeksha Yadav, Mehar Un Nissa, Gayatri Iyer, Shashwati Parihari, Gautam Sharma, Sridhar Epari, Prakash Shetty, Aliasgar Moiyadi, Graham Roy Ball, and Sanjeeva Srivastava

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Publisher Correction: The DNA sequence and analysis of human chromosome 14., Roland Heilig, Ralph Eckenberg, Jean-Louis Petit, Núria Fonknechten, Corinne Da Silva, Laurence Cattolico, Michaël Levy, Valérie Barbe, Véronique de Berardinis, Abel Ureta-Vidal, Eric Pelletier, Virginie Vico, Véronique Anthouard, Lee Rowen, Anup Madan, Shizhen Qin, Hui Sun, Hui Du, Kymberlie Pepin, François Artiguenave, Catherine Robert, Corinne Cruaud, Thomas Brüls, Olivier Jaillon, Lucie Friedlander, Gaelle Samson, Philippe Brottier, Susan Cure, Béatrice Ségurens, Franck Anière, Sylvie Samain, Hervé Crespeau, Nissa Abbasi, Nathalie Aiach, Didier Boscus, Rachel Dickhoff, Monica Dors, Ivan Dubois, Cynthia Friedman, Michel Gouyvenoux, Rose James, Anuradha Madan, Barbara Mairey-Estrada, Sophie Mangenot, Nathalie Martins, Manuela Ménard, Sophie Oztas, Amber Ratcliffe, Tristan Shaffer, Barbara Trask, Benoit Vacherie, Chadia Bellemere, Caroline Belser, Marielle Besnard-Gonnet, Delphine Bartol-Mavel, Magali Boutard, Stéphanie Briez-Silla, Stephane Combette, Virginie Dufossé-Laurent, Carolyne Ferron, Christophe Lechaplais, Claudine Louesse, Delphine Muselet, Ghislaine Magdelenat, Emilie Pateau, Emmanuelle Petit, Peggy Sirvain-Trukniewicz, Arnaud Trybou, Nathalie Vega-Czarny, Elodie Bataille, Elodie Bluet, Isabelle Bordelais, Maria Dubois, Corinne Dumont, Thomas Guérin, Sébastien Haffray, Rachid Hammadi, Jacqueline Muanga, Virginie Pellouin, Dominique Robert, Edith Wunderle, Gilbert Gauguet, Alice Roy, Laurent Sainte-Marthe, Jean Verdier, Claude Verdier-Discala, LaDeana Hillier, Lucinda Fulton, John McPherson, Fumihiko Matsuda, Richard Wilson, Claude Scarpelli, Gábor Gyapay, Patrick Wincker, William Saurin, Francis Quétier, Robert Waterston, Leroy Hood, and Jean Weissenbach

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Serum miRNA profiles are altered in patients with primary sclerosing cholangitis receiving high-dose ursodeoxycholic acid., Jessica T Hochberg, Aalam Sohal, Priya Handa, Bryan D Maliken, Take-Kyun Kim, Kai Wang, Eric Gochanour, Yu Li, J Bart Rose, James E Nelson, Keith D Lindor, Nicholas F LaRusso, and Kris V Kowdley

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Improved Analysis of Cross-Linking Mass Spectrometry Data with Kojak 2.0, Advanced by Integration into the Trans-Proteomic Pipeline., Michael R Hoopmann, David D Shteynberg, Alex Zelter, Michael Riffle, Andrew S Lyon, David A Agard, Qing Luan, Brad J Nolen, Michael J MacCoss, Trisha N Davis, and Robert L Moritz

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Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design., Leora I Horwitz, Tanayott Thaweethai, Shari B Brosnahan, Mine S Cicek, Megan L Fitzgerald, Jason D Goldman, Rachel Hess, S L Hodder, Vanessa L Jacoby, Michael R Jordan, Jerry A Krishnan, Adeyinka O Laiyemo, Torri D Metz, Lauren Nichols, Rachel E Patzer, Anisha Sekar, Nora G Singer, Lauren E Stiles, Barbara S Taylor, Shifa Ahmed, Heather A Algren, Khamal Anglin, Lisa Aponte-Soto, Hassan Ashktorab, Ingrid V Bassett, Brahmchetna Bedi, Nahid Bhadelia, Christian Bime, Marie-Abele C Bind, Lora J Black, Andra L Blomkalns, Hassan Brim, Mario Castro, James Chan, Alexander W Charney, Benjamin K Chen, Li Qing Chen, Peter Chen, David Chestek, Lori B Chibnik, Dominic C Chow, Helen Y Chu, Rebecca G Clifton, Shelby Collins, Maged M Costantine, Sushma K Cribbs, Steven G Deeks, John D Dickinson, Sarah E Donohue, Matthew S Durstenfeld, Ivette F Emery, Kristine M Erlandson, Julio C Facelli, Rachael Farah-Abraham, Aloke V Finn, Melinda S Fischer, Valerie J Flaherman, Judes Fleurimont, Vivian Fonseca, Emily J Gallagher, Jennifer C Gander, Maria Laura Gennaro, Kelly S Gibson, Minjoung Go, Steven N Goodman, Joey P Granger, Frank L Greenway, John W Hafner, Jenny E Han, Michelle S Harkins, Kristine S P Hauser, James R Heath, Carla R Hernandez, On Ho, Matthew K Hoffman, Susan E Hoover, Carol R Horowitz, Harvey Hsu, Priscilla Y Hsue, Brenna L Hughes, Prasanna Jagannathan, Judith A James, Janice John, Sarah Jolley, S E Judd, Joy J Juskowich, Diane G Kanjilal, Elizabeth W Karlson, Stuart D Katz, J Daniel Kelly, Sara W Kelly, Arthur Y Kim, John P Kirwan, Kenneth S Knox, Andre Kumar, Michelle F Lamendola-Essel, Margaret Lanca, Joyce K Lee-Lannotti, R Craig Lefebvre, Bruce D Levy, Janet Y Lin, Brian P Logarbo, Jennifer K Logue, Michele T Longo, Carlos A Luciano, Karen Lutrick, Shahdi K Malakooti, Gail Mallett, Gabrielle Maranga, Jai G Marathe, Vincent C Marconi, Gailen D Marshall, Christopher F Martin, Jeffrey N Martin, Heidi T May, Grace A McComsey, Dylan McDonald, Hector Mendez-Figueroa, Lucio Miele, Murray A Mittleman, Sindhu Mohandas, Christian Mouchati, Janet M Mullington, Girish N Nadkarni, Erica R Nahin, Robert B Neuman, Lisa T Newman, Amber Nguyen, Janko Z Nikolich, Igho Ofotokun, Princess U Ogbogu, Anna Palatnik, Kristy T S Palomares, Tanyalak Parimon, Samuel Parry, Sairam Parthasarathy, Thomas F Patterson, Ann Pearman, Michael J Peluso, Priscilla Pemu, Christian M Pettker, Beth A Plunkett, Kristen Pogreba-Brown, Athena Poppas, J Zachary Porterfield, John G Quigley, Davin K Quinn, Hengameh Raissy, Candida J Rebello, Uma M Reddy, Rebecca Reece, Harrison T Reeder, Franz P Rischard, Johana M Rosas, Clifford J Rosen, Nadine G Rouphael, Dwight J Rouse, Adam M Ruff, Christina Saint Jean, Grecio J Sandoval, Jorge L Santana, Shannon M Schlater, Frank C Sciurba, Caitlin Selvaggi, Sudha Seshadri, Howard D Sesso, Dimpy P Shah, Eyal Shemesh, Zaki A Sherif, Daniel J Shinnick, Hyagriv N Simhan, Upinder Singh, Amber Sowles, Vignesh Subbian, Jun Sun, Mehul S Suthar, Larissa J Teunis, John M Thorp, Amberly Ticotsky, Alan T N Tita, Robin Tragus, Katherine R Tuttle, Alfredo E Urdaneta, P J Utz, Timothy M VanWagoner, Andrew Vasey, Suzanne D Vernon, Crystal Vidal, Tiffany Walker, Honorine D Ward, David E Warren, Ryan M Weeks, Steven J Weiner, Jordan C Weyer, Jennifer L Wheeler, Sidney W Whiteheart, Zanthia Wiley, Natasha J Williams, Juan P Wisnivesky, John C Wood, Lynn M Yee, Natalie M Young, Sokratis N Zisis, and Andrea S Foulkes

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Timing of selective serotonin reuptake inhibitor use and risk for preterm birth and related adverse events, Yeon Mi Huang, Ryan Roper, Samantha N. Piekos, Daniel A. Enquobahrie, Mary F. Herbert, Alison G. Paquette, Priyanka Baloni, Nathan D Price, Leroy Hood, and Jennifer J Hadlock

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Organotypic Models for Functional Drug Testing of Human Cancers, Yu Ling Huang, Lindsay K. Dickerson, Heidi Kenerson, Xiuyun Jiang, Venu Pillarisetty, Qiang Tian, Leroy Hood, Taranjit S. Gujral, and Raymond S. Yeung

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Addressing barriers in FAIR data practices for biomedical data., Laura D Hughes, Ginger Tsueng, Jack DiGiovanna, Thomas D Horvath, Luke V Rasmussen, Tor C Savidge, Thomas Stoeger, Serdar Turkarslan, Qinglong Wu, Chunlei Wu, Andrew I Su, Lars Pache, and NIAID Systems Biology Data Dissemination Working Group

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Adoption of a National Prophylactic Anticoagulation Guideline for Hospitalized Pregnant Women with COVID-19: Retrospective Cohort Study., Yeon-Mi Hwang, Samantha Piekos, Tanya Sorensen, Leroy Hood, and Jennifer Hadlock

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The Association of Biomolecular Resource Facilities Proteome Informatics Research Group Study on Metaproteomics (iPRG-2020)., Pratik D Jagtap, Michael R Hoopmann, Benjamin A Neely, Antony Harvey, Lukas Käll, Yasset Perez-Riverol, Milky K Abajorga, Julie A Thomas, Susan T Weintraub, and Magnus Palmblad

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Plasmodium GPI-anchored micronemal antigen is essential for parasite transmission through the mosquito host., Charlie Jennison, Janna M Armstrong, Dorender A Dankwa, Nina Hertoghs, Sudhir Kumar, Biley A Abatiyow, Myo Naung, Nana K Minkah, Kristian E Swearingen, Robert Moritz, Alyssa E Barry, Stefan H I Kappe, and Ashley M Vaughan

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Comprehensive Overview of Bottom-Up Proteomics using Mass Spectrometry., Yuming Jiang, Devasahayam Arokia Balaya Rex, Dina Schuster, Benjamin A Neely, Germán L Rosano, Norbert Volkmar, Amanda Momenzadeh, Trenton M Peters-Clarke, Susan B Egbert, Simion Kreimer, Emma H Doud, Oliver M Crook, Amit Kumar Yadav, Muralidharan Vanuopadath, Martín L Mayta, Anna G Duboff, Nicholas M Riley, Robert L Moritz, and Jesse G Meyer

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Generally-healthy individuals with aberrant bowel movement frequencies show enrichment for microbially-derived blood metabolites associated with impaired kidney function., James P Johnson, Christian Diener, Anne E Levine, Tomasz Wilmanski, David L Suskind, Alexandra Ralevski, Jennifer J Hadlock, Andrew T Magis, Leroy Hood, Noa Rappaport, and Sean M Gibbons

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Mixed anhydrides at the intersection between peptide and RNA autocatalytic sets: evolution of biological coding., S A Kauffman and N Lehman

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A third transition in science?, Stuart A Kauffman and Andrea Roli

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The Crux Toolkit for Analysis of Bottom-Up Tandem Mass Spectrometry Proteomics Data., Attila Kertesz-Farkas, Frank Lawrence Nii Adoquaye Acquaye, Kishankumar Bhimani, Jimmy K Eng, William E Fondrie, Charles Grant, Michael R Hoopmann, Andy Lin, Yang Y Lu, Robert L Moritz, Michael J MacCoss, and William Stafford Noble

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2019 Association of Biomolecular Resource Facilities Multi-Laboratory Data-Independent Acquisition Proteomics Study., Joanna Kirkpatrick, Paul M Stemmer, Brian C Searle, Laura E Herring, LeRoy Martin, Mukul K Midha, Brett S Phinney, Baozhen Shan, Magnus Palmblad, Yan Wang, Pratik D Jagtap, and Benjamin A Neely

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Structural analysis of human G-protein-coupled receptor 17 ligand binding sites., Saravanan Konda Mani, Ramesh Thiyagarajan, Olli Yli-Harja, Meenakshisundaram Kandhavelu, and Akshaya Murugesan

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A comprehensive spectral assay library to quantify the Halobacterium salinarum NRC-1 proteome by DIA/SWATH-MS., Ulrike Kusebauch, Alan P R Lorenzetti, David S Campbell, Min Pan, David Shteynberg, Charu Kapil, Mukul K Midha, Adrián López García de Lomana, Nitin Baliga, and Robert L Moritz

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Apposition of Fibroblasts With Metaplastic Gastric Cells Promotes Dysplastic Transition., Su-Hyung Lee, Ela W Contreras Panta, David Gibbs, Yoonkyung Won, Jimin Min, Changqing Zhang, Joseph T Roland, Se-Hoon Hong, Yoojin Sohn, Evan Krystofiak, Bogun Jang, Lorenzo Ferri, Veena Sangwan, Jiannis Ragoussis, Sophie Camilleri-Broët, Joseph Caruso, Chira Chen-Tanyolac, Michael Strasser, Philippe Gascard, Thea D Tlsty, Sui Huang, Eunyoung Choi, and James R Goldenring

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Growth phase estimation for abundant bacterial populations sampled longitudinally from human stool metagenomes., Joe J Lim, Christian Diener, James Wilson, Jacob J Valenzuela, Nitin S Baliga, and Sean M Gibbons

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A Genome-Scale Atlas Reveals Complex Interplay of Transcription and Translation in an Archaeon., Alan P R Lorenzetti, Ulrike Kusebauch, Lívia S Zaramela, Wei-Ju Wu, João P P de Almeida, Serdar Turkarslan, Adrián L G de Lomana, José V Gomes-Filho, Ricardo Z N Vêncio, Robert L Moritz, Tie Koide, and Nitin S Baliga

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cyjShiny: A cytoscape.js R Shiny Widget for network visualization and analysis., Augustin Luna, Omar Shah, Chris Sander, and Paul Shannon

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Disease-specific loss of microbial cross-feeding interactions in the human gut, Vanessa R. Marcelino, Caitlin Welsh, Christian Diener, Emily L. Gulliver, Emily L. Rutten, Remy B. Young, Edward M. Giles, Sean M Gibbons, Chris Greening, and Samuel C. Forster

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Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19., Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang, Jeremy Manry, Yoann Seeleuthner, Yu Zhang, Alexandre Bolze, Matthieu Chaldebas, Baptiste Milisavljevic, Adrian Gervais, Paul Bastard, Takaki Asano, Lucy Bizien, Federica Barzaghi, Hassan Abolhassani, Ahmad Abou Tayoun, Alessandro Aiuti, Ilad Alavi Darazam, Luis M Allende, Rebeca Alonso-Arias, Andrés Augusto Arias, Gokhan Aytekin, Peter Bergman, Simone Bondesan, Yenan T Bryceson, Ingrid G Bustos, Oscar Cabrera-Marante, Sheila Carcel, Paola Carrera, Giorgio Casari, Khalil Chaïbi, Roger Colobran, Antonio Condino-Neto, Laura E Covill, Ottavia M Delmonte, Loubna El Zein, Carlos Flores, Peter K Gregersen, Marta Gut, Filomeen Haerynck, Rabih Halwani, Selda Hancerli, Lennart Hammarström, Nevin Hatipoğlu, Adem Karbuz, Sevgi Keles, Christèle Kyheng, Rafael Leon-Lopez, Jose Luis Franco, Davood Mansouri, Javier Martinez-Picado, Ozge Metin Akcan, Isabelle Migeotte, Pierre-Emmanuel Morange, Guillaume Morelle, Andrea Martin-Nalda, Giuseppe Novelli, Antonio Novelli, Tayfun Ozcelik, Figen Palabiyik, Qiang Pan-Hammarström, Rebeca Pérez de Diego, Laura Planas-Serra, Daniel E Pleguezuelo, Carolina Prando, Aurora Pujol, Luis Felipe Reyes, Jacques G Rivière, Carlos Rodriguez-Gallego, Julian Rojas, Patrizia Rovere-Querini, Agatha Schlüter, Mohammad Shahrooei, Ali Sobh, Pere Soler-Palacin, Yacine Tandjaoui-Lambiotte, Imran Tipu, Cristina Tresoldi, Jesus Troya, Diederik van de Beek, Mayana Zatz, Pawel Zawadzki, Saleh Zaid Al-Muhsen, Mohammed Faraj Alosaimi, Fahad M Alsohime, Hagit Baris-Feldman, Manish J Butte, Stefan N Constantinescu, Megan A Cooper, Clifton L Dalgard, Jacques Fellay, James R Heath, Yu-Lung Lau, Richard P Lifton, Tom Maniatis, Trine H Mogensen, Horst von Bernuth, Alban Lermine, Michel Vidaud, Anne Boland, Jean-François Deleuze, Robert Nussbaum, Amanda Kahn-Kirby, France Mentre, Sarah Tubiana, Guy Gorochov, Florence Tubach, Pierre Hausfater, COVID Human Genetic Effort, COVIDeF Study Group, French COVID Cohort Study Group, CoV-Contact Cohort, COVID-STORM Clinicians, COVID Clinicians, Orchestra Working Group, Amsterdam UMC Covid-19 Biobank, NIAID-USUHS COVID Study Group, Isabelle Meyts, Shen-Ying Zhang, Anne Puel, Luigi D Notarangelo, Stephanie Boisson-Dupuis, Helen C Su, Bertrand Boisson, Emmanuelle Jouanguy, Jean-Laurent Casanova, Qian Zhang, Laurent Abel, and Aurélie Cobat

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Vacuum Insulated Probe Heated Electrospray Ionization Source Enhances Microflow Rate Chromatography Signals in the Bruker timsTOF Mass Spectrometer., Mukul K Midha, Charu Kapil, Michal Maes, David H Baxter, Seamus R Morrone, Timothy J Prokop, and Robert L Moritz

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Novel TCF4:TCF12 heterodimer inhibits glioblastoma growth., Svetlana A Mikheeva, Cory C Funk, Philip J Horner, Robert C Rostomily, and Andrei M Mikheev

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Optimizing preclinical models of ageing for translation to clinical trials., Sarah J Mitchell, Michael R MacArthur, and Alice E Kane

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The scalable precision medicine open knowledge engine (SPOKE): a massive knowledge graph of biomedical information., John H Morris, Karthik Soman, Rabia E Akbas, Xiaoyuan Zhou, Brett Smith, Elaine C Meng, Conrad C Huang, Gabriel Cerono, Gundolf Schenk, Angela Rizk-Jackson, Adil Harroud, Lauren Sanders, Sylvain V Costes, Krish Bharat, Arjun Chakraborty, Alexander R Pico, Taline Mardirossian, Michael Keiser, Alice Tang, Josef Hardi, Yongmei Shi, Mark Musen, Sharat Israni, Sui Huang, Peter W Rose, Charlotte A Nelson, and Sergio E Baranzini

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Optimization of Instrument Parameters for Efficient Phosphopeptide Identification and Localization by Data-dependent Analysis Using Orbitrap Tribrid Mass Spectrometers, Seamus R. Morrone, Michael R Hoopmann, David Shteynberg, Ulrike Kusebauch, and Robert L Moritz

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Integrated analysis of proteomics, epigenomics and metabolomics data revealed divergent pathway activation patterns in the recent versus chronic post-traumatic stress disorder., Seid Muhie, Aarti Gautam, Burook Misganaw, Ruoting Yang, Synthia H Mellon, Allison Hoke, Janine Flory, Bernie Daigle, Kevin Swift, PTSD Systems Biology Consortium, Leroy Hood, Francis J Doyle, Owen M Wolkowitz, Charles R Marmar, Kerry Ressler, Rachel Yehuda, Rasha Hammamieh, and Marti Jett

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Molecular signatures of post-traumatic stress disorder in war-zone-exposed veteran and active-duty soldiers., Seid Muhie, Aarti Gautam, Ruoting Yang, Burook Misganaw, Bernie J Daigle, Synthia H Mellon, Janine D Flory, Duna Abu-Amara, Inyoul Lee, Kai Wang, Ryan Rampersaud, PTSD Systems Biology Consortium, Leroy Hood, Rachel Yehuda, Charles R Marmar, Owen M Wolkowitz, Kerry J Ressler, Francis J Doyle, Rasha Hammamieh, and Marti Jett

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Signaling landscape of mitochondrial non-coding RNAs., Gnanavel Mutharasu, Akshaya Murugesan, Saravnan Kondamani, Ramesh Thiyagarajan, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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Stereochemical engineering yields a multifunctional peptide macrocycle inhibitor of Akt2 by fine-tuning macrocycle-cell membrane interactions., Arundhati Nag, Amirhossein Mafi, Samir Das, Mary Beth Yu, Belen Alvarez-Villalonga, Soo-Kyung Kim, Yapeng Su, William A Goddard, and James R Heath

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Toward an Integrated Machine Learning Model of a Proteomics Experiment., Benjamin A Neely, Viktoria Dorfer, Lennart Martens, Isabell Bludau, Robbin Bouwmeester, Sven Degroeve, Eric W Deutsch, Siegfried Gessulat, Lukas Käll, Pawel Palczynski, Samuel H Payne, Tobias Greisager Rehfeldt, Tobias Schmidt, Veit Schwämmle, Julian Uszkoreit, Juan Antonio Vizcaíno, Mathias Wilhelm, and Magnus Palmblad

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Computational capabilities of a multicellular reservoir computing system., Vladimir Nikolić, Moriah Echlin, Boris Aguilar, and Ilya Shmulevich

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Insights into mammalian TE diversity through the curation of 248 genome assemblies., Austin B Osmanski, Nicole S Paulat, Jenny Korstian, Jenna R Grimshaw, Michaela Halsey, Kevin A M Sullivan, Diana D Moreno-Santillán, Claudia Crookshanks, Jacquelyn Roberts, Carlos Garcia, Matthew G Johnson, Llewellyn D Densmore, Richard D Stevens, Jeb Rosen, Jessica Storer, Robert Hubley, Arian F A Smit, Liliana M Dávalos, Elinor K Karlsson, Kerstin Lindblad-Toh, and David A Ray

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Chiropterans Are a Hotspot for Horizontal Transfer of DNA Transposons in Mammalia., Nicole S Paulat, Jessica Storer, Diana D Moreno-Santillán, Austin B Osmanski, Kevin A M Sullivan, Jenna R Grimshaw, Jennifer Korstian, Michaela Halsey, Carlos J Garcia, Claudia Crookshanks, Jaquelyn Roberts, Arian F A Smit, Robert Hubley, Jeb Rosen, Emma C Teeling, Sonja C Vernes, Eugene Myers, Martin Pippel, Thomas Brown, Michael Hiller, Danny Rojas, Liliana M Dávalos, Kerstin Lindblad-Toh, Elinor K Karlsson, and David A Ray

MtrA modulates Mycobacterium tuberculosis cell division in host microenvironments to mediate intrinsic resistance and drug tolerance., Eliza J R Peterson, Aaron N Brooks, David J Reiss, Amardeep Kaur, Julie Do, Min Pan, Wei-Ju Wu, Robert Morrison, Vivek Srinivas, Warren Carter, Mario L Arrieta-Ortiz, Rene A Ruiz, Apoorva Bhatt, and Nitin S Baliga

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What Can Ribo-Seq, Immunopeptidomics, and Proteomics Tell Us About the Noncanonical Proteome?, John R Prensner, Jennifer G Abelin, Leron W Kok, Karl R Clauser, Jonathan M Mudge, Jorge Ruiz-Orera, Michal Bassani-Sternberg, Robert L Moritz, Eric W Deutsch, and Sebastiaan van Heesch

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Neoantigen-targeted CD8+ T cell responses with PD-1 blockade therapy, Cristina Puig-Saus, Barbara Sennino, Songming Peng, Clifford L Wang, Zheng Pan, Benjamin Yuen, Bhamini Purandare, Duo An, Boi B Quach, Diana Nguyen, Huiming Xia, Sameeha Jilani, Kevin Shao, Claire McHugh, John Greer, Phillip Peabody, Saparya Nayak, Jonathan Hoover, Sara Said, Kyle Jacoby, Olivier Dalmas, Susan P Foy, Andrew Conroy, Michael C Yi, Christine Shieh, William Lu, Katharine Heeringa, Yan Ma, Shahab Chizari, Melissa J Pilling, Marc Ting, Ramya Tunuguntla, Salemiz Sandoval, Robert Moot, Theresa Hunter, Sidi Zhao, Justin D Saco, Ivan Perez-Garcilazo, Egmidio Medina, Agustin Vega-Crespo, Ignacio Baselga-Carretero, Gabriel Abril-Rodriguez, Grace Cherry, Deborah J Wong, Jasreet Hundal, Bartosz Chmielowski, Daniel E Speiser, Michael T Bethune, Xiaoyan R Bao, Alena Gros, Obi L Griffith, Malachi Griffith, James R Heath, Alex Franzusoff, Stefanie J Mandl, and Antoni Ribas

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A meta-analysis of rice phosphoproteomics data to understand variation in cell signalling across the rice pan-genome., Kerry A Ramsbottom, Ananth Prakash, Yasset Perez Riverol, Oscar Martin Camacho, Zhi Sun, Deepti J Kundu, Emily Bowler-Barnett, Maria Martin, Jun Fan, Dmytro Chebotarov, Kenneth L McNally, Eric W Deutsch, Juan Antonio Vizcaíno, and Andrew R Jones

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Biological BMI uncovers hidden health risks and is more responsive to lifestyle shifts, Noa Rappaport and Kengo Watanabe

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ProteomicsML: An Online Platform for Community-Curated Data sets and Tutorials for Machine Learning in Proteomics., Tobias G Rehfeldt, Ralf Gabriels, Robbin Bouwmeester, Siegfried Gessulat, Benjamin A Neely, Magnus Palmblad, Yasset Perez-Riverol, Tobias Schmidt, Juan Antonio Vizcaíno, and Eric W Deutsch

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The complete sequence of a human Y chromosome., Arang Rhie, Sergey Nurk, Monika Cechova, Savannah J Hoyt, Dylan J Taylor, Nicolas Altemose, Paul W Hook, Sergey Koren, Mikko Rautiainen, Ivan A Alexandrov, Jamie Allen, Mobin Asri, Andrey V Bzikadze, Nae-Chyun Chen, Chen-Shan Chin, Mark Diekhans, Paul Flicek, Giulio Formenti, Arkarachai Fungtammasan, Carlos Garcia Giron, Erik Garrison, Ariel Gershman, Jennifer L Gerton, Patrick G S Grady, Andrea Guarracino, Leanne Haggerty, Reza Halabian, Nancy F Hansen, Robert Harris, Gabrielle A Hartley, William T Harvey, Marina Haukness, Jakob Heinz, Thibaut Hourlier, Robert M Hubley, Sarah E Hunt, Stephen Hwang, Miten Jain, Rupesh K Kesharwani, Alexandra P Lewis, Heng Li, Glennis A Logsdon, Julian K Lucas, Wojciech Makalowski, Christopher Markovic, Fergal J Martin, Ann M Mc Cartney, Rajiv C McCoy, Jennifer McDaniel, Brandy M McNulty, Paul Medvedev, Alla Mikheenko, Katherine M Munson, Terence D Murphy, Hugh E Olsen, Nathan D Olson, Luis F Paulin, David Porubsky, Tamara Potapova, Fedor Ryabov, Steven L Salzberg, Michael E G Sauria, Fritz J Sedlazeck, Kishwar Shafin, Valery A Shepelev, Alaina Shumate, Jessica M Storer, Likhitha Surapaneni, Angela M Taravella Oill, Françoise Thibaud-Nissen, Winston Timp, Marta Tomaszkiewicz, Mitchell R Vollger, Brian P Walenz, Allison C Watwood, Matthias H Weissensteiner, Aaron M Wenger, Melissa A Wilson, Samantha Zarate, Yiming Zhu, Justin M Zook, Evan E Eichler, Rachel J O'Neill, Michael C Schatz, Karen H Miga, Kateryna D Makova, and Adam M Phillippy

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Editorial: Insights in human and medical genomics: 2022., Jared C. Roach and Maxim B. Freidin

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Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames., Clara-L Sandmann, Jana F Schulz, Jorge Ruiz-Orera, Marieluise Kirchner, Matthias Ziehm, Eleonora Adami, Maike Marczenke, Annabel Christ, Nina Liebe, Johannes Greiner, Aaron Schoenenberger, Michael B Muecke, Ning Liang, Robert L Moritz, Zhi Sun, Eric W Deutsch, Michael Gotthardt, Jonathan M Mudge, John R Prensner, Thomas E Willnow, Philipp Mertins, Sebastiaan van Heesch, and Norbert Hubner

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The NCI Imaging Data Commons as a platform for reproducible research in computational pathology., Daniela P Schacherer, Markus D Herrmann, David A Clunie, Henning Höfener, William Clifford, William J R Longabaugh, Steve Pieper, Ron Kikinis, Andrey Fedorov, and André Homeyer

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Single-molecule Sequencing of an Animal Mitochondrial Genome Reveals Chloroplast-like Architecture and Repeat-mediated Recombination., Joel Sharbrough, Laura Bankers, Emily Cook, Peter D Fields, Joseph Jalinsky, Kyle E McElroy, Maurine Neiman, John M Logsdon, and Jeffrey L Boore

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Prediction of HLA genotypes from single-cell transcriptome data., Benjamin D Solomon, Hong Zheng, Laura W Dillon, Jason D Goldman, Christopher S Hourigan, James R Heath, and Purvesh Khatri

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Genome-wide coancestry reveals details of ancient and recent male-driven reticulation in baboons., Erik F Sørensen, R Alan Harris, Liye Zhang, Muthuswamy Raveendran, Lukas F K Kuderna, Jerilyn A Walker, Jessica Storer, Martin Kuhlwilm, Claudia Fontsere, Lakshmi Seshadri, Christina M Bergey, Andrew S Burrell, Juraj Bergman, Jane E Phillips-Conroy, Fekadu Shiferaw, Kenneth L Chiou, Idrissa S Chuma, Julius D Keyyu, Julia Fischer, Marie-Claude Gingras, Sejal Salvi, Harshavardhan Doddapaneni, Mikkel H Schierup, Mark A Batzer, Clifford J Jolly, Sascha Knauf, Dietmar Zinner, Kyle K-H Farh, Tomas Marques-Bonet, Kasper Munch, Christian Roos, and Jeffrey Rogers

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Framework of the, Jessica Storer, Jerilyn A Walker, Jasmine N Baker, Shifat Hossain, Christian Roos, Travis J Wheeler, and Mark A Batzer

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Extensive Independent Amplification of Platy-1 Retroposons in Tamarins, Genus, Jessica Storer, Jerilyn A Walker, Thomas O Beckstrom, and Mark A Batzer

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Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection., Tanayott Thaweethai, Sarah E Jolley, Elizabeth W Karlson, Emily B Levitan, Bruce Levy, Grace A McComsey, Lisa McCorkell, Girish N Nadkarni, Sairam Parthasarathy, Upinder Singh, Tiffany A Walker, Caitlin A Selvaggi, Daniel J Shinnick, Carolin C M Schulte, Rachel Atchley-Challenner, George A Alba, Radica Alicic, Natasha Altman, Khamal Anglin, Urania Argueta, Hassan Ashktorab, Gaston Baslet, Ingrid V Bassett, Lucinda Bateman, Brahmchetna Bedi, Shamik Bhattacharyya, Marie-Abele Bind, Andra L Blomkalns, Hector Bonilla, Patricia A Bush, Mario Castro, James Chan, Alexander W Charney, Peter Chen, Lori B Chibnik, Helen Y Chu, Rebecca G Clifton, Maged M Costantine, Sushma K Cribbs, Sylvia I Davila Nieves, Steven G Deeks, Alexandria Duven, Ivette F Emery, Nathan Erdmann, Kristine M Erlandson, Kacey C Ernst, Rachael Farah-Abraham, Cheryl E Farner, Elen M Feuerriegel, Judes Fleurimont, Vivian Fonseca, Nicholas Franko, Vivian Gainer, Jennifer C Gander, Edward M Gardner, Linda N Geng, Kelly S Gibson, Minjoung Go, Jason D Goldman, Halle Grebe, Frank L Greenway, Mounira Habli, John Hafner, Jenny E Han, Keith A Hanson, James Heath, Carla Hernandez, Rachel Hess, Sally L Hodder, Matthew K Hoffman, Susan E Hoover, Beatrice Huang, Brenna L Hughes, Prasanna Jagannathan, Janice John, Michael R Jordan, Stuart D Katz, Elizabeth S Kaufman, John D Kelly, Sara W Kelly, Megan M Kemp, John P Kirwan, Jonathan D Klein, Kenneth S Knox, Jerry A Krishnan, Andre Kumar, Adeyinka O Laiyemo, Allison A Lambert, Margaret Lanca, Joyce K Lee-Iannotti, Brian P Logarbo, Michele T Longo, Carlos A Luciano, Karen Lutrick, Jason H Maley, Jai G Marathe, Vincent Marconi, Gailen D Marshall, Christopher F Martin, Yuri Matusov, Alem Mehari, Hector Mendez-Figueroa, Robin Mermelstein, Torri D Metz, Richard Morse, Jarrod Mosier, Christian Mouchati, Janet Mullington, Shawn N Murphy, Robert B Neuman, Janko Z Nikolich, Ighovwerha Ofotokun, Elizabeth Ojemakinde, Anna Palatnik, Kristy Palomares, Tanyalak Parimon, Samuel Parry, Jan E Patterson, Thomas F Patterson, Rachel E Patzer, Michael J Peluso, Priscilla Pemu, Christian M Pettker, Beth A Plunkett, Kristen Pogreba-Brown, Athena Poppas, John G Quigley, Uma Reddy, Rebecca Reece, Harrison Reeder, W B Reeves, Eric M Reiman, Franz Rischard, Jonathan Rosand, Dwight J Rouse, Adam Ruff, George Saade, Grecio J Sandoval, Shannon M Schlater, Fitzgerald Shepherd, Zaki A Sherif, Hyagriv Simhan, Nora G Singer, Daniel W Skupski, Amber Sowles, Jeffrey A Sparks, Fatima I Sukhera, Barbara S Taylor, Larissa Teunis, Robert J Thomas, John M Thorp, Paul Thuluvath, Amberly Ticotsky, Alan T Tita, Katherine R Tuttle, Alfredo E Urdaneta, Daisy Valdivieso, Timothy M VanWagoner, Andrew Vasey, Monica Verduzco-Gutierrez, Zachary S Wallace, Honorine D Ward, David E Warren, Steven J Weiner, Shelley Welch, Sidney W Whiteheart, Zanthia Wiley, Juan P Wisnivesky, Lynn M Yee, Sokratis Zisis, Leora I Horwitz, Andrea S Foulkes, and RECOVER Consortium

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Detection and editing of the updated Arabidopsis plastid- and mitochondrial-encoded proteomes through PeptideAtlas., Klaas J van Wijk, Stephane Bentolila, Tami Leppert, Qi Sun, Zhi Sun, Luis Mendoza, Margaret Li, and Eric W Deutsch

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Does the Ubiquitination Degradation Pathway Really Reach inside of the Chloroplast? A Re-Evaluation of Mass Spectrometry-Based Assignments of Ubiquitination., Klaas J van Wijk, Tami Leppert, Zhi Sun, and Eric W Deutsch

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Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle., Yaxi Wang, Larry A Gallagher, Pia A Andrade, Andi Liu, Ian R Humphreys, Serdar Turkarslan, Kevin J Cutler, Mario L Arrieta-Ortiz, Yaqiao Li, Matthew C Radey, Jeffrey S McLean, Qian Cong, David Baker, Nitin Baliga, S Brook Peterson, and Joseph D Mougous

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Discovery of a glutathione utilization pathway in Francisella that shows functional divergence between environmental and pathogenic species., Yaxi Wang, Hannah E Ledvina, Catherine A Tower, Stanimir Kambarev, Elizabeth Liu, James C Charity, Lieselotte S M Kreuk, Qing Tang, Qiwen Chen, Larry A Gallagher, Matthew C Radey, Guilhem F Rerolle, Yaqiao Li, Kelsi M Penewit, Serdar Turkarslan, Shawn J Skerrett, Stephen J Salipante, Nitin S Baliga, Joshua J Woodward, Simon L Dove, S Brook Peterson, Jean Celli, and Joseph D Mougous

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Cell population growth kinetics in the presence of stochastic heterogeneity of cell phenotype., Yue Wang, Joseph X Zhou, Edoardo Pedrini, Irit R Rubin, May Khalil, Roberto Taramelli, Hong Qian, and Sui Huang