Our expanded team of specialists – many of whom completed fellowships and residencies at prestigious academic centers – offers comprehensive services for treating any condition of the brain, spine and nervous system. With nearly 50 subspecialties represented, we offer complex and minimally invasive surgery as well as ongoing care for pituitary and skull base tumors, stroke, peripheral nerve disease, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, ALS, epilepsy and more.

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Submissions from 2023

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Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson's Disease., Vibhor Krishna, Paul S Fishman, Howard M Eisenberg, Michael Kaplitt, Gordon Baltuch, Jin Woo Chang, Wei-Chieh Chang, Raul Martinez Fernandez, Marta Del Alamo, Casey H Halpern, Pejman Ghanouni, Roberto Eleopra, Rees Cosgrove, Jorge Guridi, Ryder Gwinn, Pravin Khemani, Andres M Lozano, Nathan McDannold, Alfonso Fasano, Marius Constantinescu, Ilana Schlesinger, Arif Dalvi, and W Jeff Elias

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Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex., Brian R Lee, Rachel Dalley, Jeremy A Miller, Thomas Chartrand, Jennie Close, Rusty Mann, Alice Mukora, Lindsay Ng, Lauren Alfiler, Katherine Baker, Darren Bertagnolli, Krissy Brouner, Tamara Casper, Eva Csajbok, Nicholas Donadio, Stan L W Driessens, Tom Egdorf, Rachel Enstrom, Anna A Galakhova, Amanda Gary, Emily Gelfand, Jeff Goldy, Kristen Hadley, Tim S Heistek, Dijon Hill, Wen-Hsien Hou, Nelson Johansen, Nik Jorstad, Lisa Kim, Agnes Katalin Kocsis, Lauren Kruse, Michael Kunst, Gabriela León, Brian Long, Matthew Mallory, Michelle Maxwell, Medea McGraw, Delissa McMillen, Erica J Melief, Gabor Molnar, Marty T Mortrud, Dakota Newman, Julie Nyhus, Ximena Opitz-Araya, Attila Ozsvár, Trangthanh Pham, Alice Pom, Lydia Potekhina, Ram Rajanbabu, Augustin Ruiz, Susan M Sunkin, Ildikó Szöts, Naz Taskin, Bargavi Thyagarajan, Michael Tieu, Jessica Trinh, Sara Vargas, David Vumbaco, Femke Waleboer, Sarah Walling-Bell, Natalie Weed, Grace Williams, Julia Wilson, Shenqin Yao, Thomas Zhou, Pál Barzó, Trygve Bakken, Charles Cobbs, Nick Dee, Richard G Ellenbogen, Luke Esposito, Manuel Ferreira, Nathan W Gouwens, Benjamin Grannan, Ryder P Gwinn, Jason S Hauptman, Rebecca Hodge, Tim Jarsky, C Dirk Keene, Andrew L Ko, Anders Rosendal Korshoej, Boaz P Levi, Kaare Meier, Jeffrey G Ojemann, Anoop Patel, Jacob Ruzevick, Daniel L Silbergeld, Kimberly Smith, Jens Christian Sørensen, Jack Waters, Hongkui Zeng, Jim Berg, Marco Capogna, Natalia A Goriounova, Brian Kalmbach, Christiaan P J de Kock, Huib D Mansvelder, Staci A Sorensen, Gabor Tamas, Ed S Lein, and Jonathan T Ting

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No Delayed Ruptures on Long-Term Follow-Up of a Case Series of Persistently Filling Saccular Internal Carotid Artery Aneurysms After Flow Diversion With the Pipeline Embolization Device., Ryan P Lee, Meghana Bhimreddy, Jennifer Kim, Robert T Wicks, Risheng Xu, Matthew Bender, Wuyang Yang, Shahab Aldin Sattari, Alice Hung, Christopher M Jackson, L Fernando Gonzalez, Judy Huang, Rafael Tamargo, Cameron G McDougall, and Justin M Caplan

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No Delayed Ruptures on Long-Term Follow-Up of a Case Series of Persistently Filling Saccular Internal Carotid Artery Aneurysms After Flow Diversion With the Pipeline Embolization Device., Ryan P Lee, Meghana Bhimreddy, Jennifer Kim, Robert T Wicks, Risheng Xu, Matthew Bender, Wuyang Yang, Shahab Aldin Sattari, Alice Hung, Christopher M Jackson, L Fernando Gonzalez, Judy Huang, Rafael Tamargo, Cameron G McDougall, and Justin M Caplan

Transforming Treatment Approaches in Head and Neck Cancer: The Potential of Immunotherapy in Neoadjuvant, Adjuvant and Metastatic Disease, R Leidner

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Radiofrequency Ablation Provides Rapid and Durable Pain Relief for the Palliative Treatment of Lytic Bone Metastases Independent of Radiation Therapy: Final Results from the OsteoCool Tumor Ablation Post-Market Study., Jason Levy, Elizabeth David, Thomas Hopkins, Jonathan Morris, Nam D Tran, Hamed Farid, Francesco Massari, William G O'Connell, Alexander Vogel, Afshin Gangi, Peter Sunenshine, Robert Dixon, Nicolas Von der Höh, and Sandeep Bagla

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Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma: A Phase 3 Prospective Externally Controlled Cohort Trial., Linda M Liau, Keyoumars Ashkan, Steven Brem, Jian L Campian, John E Trusheim, Fabio M Iwamoto, David D Tran, George Ansstas, Charles Cobbs, Jason A Heth, Michael E Salacz, Stacy D'Andre, Robert D Aiken, Yaron A Moshel, Joo Y Nam, Clement P Pillainayagam, Stephanie A Wagner, Kevin A Walter, Rekha Chaudhary, Samuel A Goldlust, Ian Y Lee, Daniela A Bota, Heinrich Elinzano, Jai Grewal, Kevin Lillehei, Tom Mikkelsen, Tobias Walbert, Steven Abram, Andrew J Brenner, Matthew G Ewend, Simon Khagi, Darren S Lovick, Jana Portnow, Lyndon Kim, William G Loudon, Nina L Martinez, Reid C Thompson, David E Avigan, Karen L Fink, Francois J Geoffroy, Pierre Giglio, Oleg Gligich, Dietmar Krex, Scott M Lindhorst, Jose Lutzky, Hans-Jörg Meisel, Minou Nadji-Ohl, Lhagva Sanchin, Andrew Sloan, Lynne P Taylor, Julian K Wu, Erin M Dunbar, Arnold B Etame, Santosh Kesari, David Mathieu, David E Piccioni, David S Baskin, Michel Lacroix, Sven-Axel May, Pamela Z New, Timothy J Pluard, Steven A Toms, Victor Tse, Scott Peak, John L Villano, James D Battiste, Paul J Mulholland, Michael L Pearlman, Kevin Petrecca, Michael Schulder, Robert M Prins, Alton L Boynton, and Marnix L Bosch

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Long-term survival after salvage pemetrexed for refractory primary T-cell lymphoma of the CNS., Andy Liu, Huda Alalami, Xuemo Fan, Chirag Patil, Jaya M Gill, Santosh Kesari, and Jethro Hu

Poster Presented at the International Stroke Conference, T Lowenkopf, Alyx Lesko, and See all authors in comments

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Neuroinflammation: A Modifiable Pathway Linking Obesity, Alzheimer's disease, and Depression., Maria Ly, Gary Z Yu, Ali Mian, Austin Cramer, Somayeh Meysami, David A Merrill, Amjad Samara, Sarah A Eisenstein, Tamara Hershey, Ganesh M Babulal, Eric J Lenze, John C Morris, Tammie L S Benzinger, and Cyrus A Raji

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A prospective multi-center observational study of surgical versus non-surgical management for pituitary apoplexy., Adam N Mamelak, Andrew S Little, Paul A Gardner, João Paulo Almeida, Pablo Recinos, Pranay Soni, Varun R Kshettry, John A Jane, Garni Barkhoudarian, Daniel F Kelly, Robert Dodd, Debraj Mukherjee, Zachary C Gersey, Noriaki Fukuhara, Hiroshi Nishioka, Eui-Hyun Kim, Claude-Fabien Litré, Elliott Sina, Mia W Mazer, Yujie Cui, and Vivien Bonert

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Treatment of adult deformity surgery by orthopedic and neurological surgeons: trends in treatment, techniques, and costs by specialty., Christopher L McDonald, Rodrigo A Saad Berreta, Daniel Alsoof, Alex Homer, Janine Molino, Christopher P Ames, Christopher I Shaffrey, D Kojo Hamilton, Bassel G Diebo, Eren O Kuris, Robert A Hart, and Alan H Daniels

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A combined exercise and cognitive training intervention induces fronto-cingulate cortical plasticity in first-episode psychosis patients., S C McEwen, B Jarrahi, J Ventura, K L Subotnik, J Nguyen, S M Woo, and K H Nuechterlein

Multicenter Flow Diversion for Intracranial Aneurysms: Intracranial Hemorrhage & Thromboembolic Complications In A Multi-Center Cohort of 200 Patients, R Meister, Alyx Lesko, and See all authors in comments

Multicenter Flow Diversion in 200 individuals for treatment of intracranial aneurysms, R Meister, Alyx Lesko, and See all authors in comments

Characterizing cancer’s dark matter, short-lived proteins, and defective ribosomal products, presented by cancer and contained in the DPV-001 cancer vaccine, R Meng, Will Redmond, Carlo Bifulco, Rachel Sanborn, RB Bell, Walter Urba, Rom Leidner, Brian Piening, Bernard Fox, and See full list of authors in comments

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Novel TCF4:TCF12 heterodimer inhibits glioblastoma growth., Svetlana A Mikheeva, Cory C Funk, Philip J Horner, Robert C Rostomily, and Andrei M Mikheev

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A Guide to Expanding the Use of Buprenorphine Beyond Standard Initiations for Opioid Use Disorder., James Miller, Michael A Brooks, Kelly Wurzel, Emily J Cox, and John F Wurzel

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Clinical Practice Panel: Stand by Me: Using an Enhanced Recovery After Surgery (ERAS)Checklist to Guide Early Mobility of Postoperative Craniotomy Patients on a Progressive Care Unit, Alyssa Mooney, Jerome Codilla, Joanna Arraiza, Sohl Chapman, Nkiru Chukwudi, and Ronald Rosales

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Stereotactic and Functional Neurosurgery Convection-Enhanced Delivery of Autologous Cerebrospinal Fluid Enhances Basal Ganglia Visualization during MRI-Guided Deep Brain Stimulation Surgery., Shayan Moosa, Aaron E Bond, Tony R Wang, Faraz Farzad, Ashok R Asthagiri, and W Jeffrey Elias

PD-1 expression on tumor-infiltrating T-lymphocytes as determinant of the head and neck cancer tumor immune microenvironment rather than anatomical site, T Muijlwijk, Bernard Fox, and See full list of authors in comments

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Preliminary experience with a novel facet-based lateral mass drill guide for the placement of lateral mass screws compared to freehand technique: a cadaveric study., Gregory M Mundis, Eric C Olsson, Robert A Hart, Seth K Williams, Ryan Martyn, Douglas G Orndorff, Anastasia L Berg, Nicholas A Russell, and Frank Vizesi

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External Validation of an Artificial Intelligence Device for Intracranial Hemorrhage Detection., Gabriel Neves, Pranav I Warman, Anmol Warman, Roshan Warman, Tulio Bueso, Jason D Vadhan, and Thomas Windisch

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Optimum duration of hyperventilation during electroencephalography., Kalarickal J Oommen and Jonathan Kopel

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TN-RS: a novel scoring system predicts Gamma Knife Radiosurgery outcome for trigeminal neuralgia patients., Alon Orlev, James Feghali, Gil Kimchi, Lian Sun, Clifford A Pierre, Cristian Gragnaniello, Cristian Cotrutz, Christopher Loiselle, Sandra Vermeulen, and Zachary Litvack

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Mechanical Venous Thrombectomy Using Indigo Aspiration System: A Case Report., Riichi A Ota, Gabriel Neves, Victor C Montalvan, Thomas Windisch, and Saif Bushnaq

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The impact of baseline cervical malalignment on the development of proximal junctional kyphosis following surgical correction of thoracolumbar adult spinal deformity., Lara Passfall, Bailey Imbo, Virginie Lafage, Renaud Lafage, Justin S Smith, Breton Line, Andrew J Schoenfeld, Themistocles Protopsaltis, Alan H Daniels, Khaled M Kebaish, Jeffrey L Gum, Heiko Koller, D Kojo Hamilton, Richard Hostin, Munish Gupta, Neel Anand, Christopher P Ames, Robert Hart, Douglas Burton, Frank J Schwab, Christopher I Shaffrey, Eric O Klineberg, Han Jo Kim, Shay Bess, and Peter G Passias

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Economic burden of nonoperative treatment of adult spinal deformity., Peter G Passias, Waleed Ahmad, Pooja Dave, Renaud Lafage, Virginie Lafage, Jamshaid Mir, Eric O Klineberg, Khaled M Kabeish, Jeffrey L Gum, Breton G Line, Robert A Hart, Douglas Burton, Justin S Smith, Christopher P Ames, Christopher I Shaffrey, Frank Schwab, Richard Hostin, Thomas Buell, D Kojo Hamilton, and Shay Bess

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Identifying Subsets of Patients With Adult Spinal Deformity Who Maintained a Positive Response to Nonoperative Management., Peter G Passias, Waleed Ahmad, Peter Tretiakov, Oscar Krol, Frank Segreto, Renaud Lafage, Virginie Lafage, Alex Soroceanu, Alan Daniels, Jeffrey Gum, Breton Line, Andrew J Schoenfeld, Shaleen Vira, Robert Hart, Douglas Burton, Justin S Smith, Christopher P Ames, Christopher Shaffrey, Frank Schwab, Shay Bess, and International Spine Study Group

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Critical Analysis of Radiographic and Patient Reported Outcomes Following Anterior/Posterior Staged vs. Same Day Surgery in Patients Undergoing Identical Corrective Surgery for Adult Spinal Deformity., Peter G Passias, Waleed Ahmad, Peter S Tretiakov, Renaud Lafage, Virginie Lafage, Andrew J Schoenfeld, Breton Line, Alan Daniels, Jamshaid M Mir, Munish Gupta, Gregory Mundis, Robert Eastlack, Pierce Nunley, D Kojo Hamilton, Richard Hostin, Robert Hart, Douglas C Burton, Christopher Shaffrey, Frank Schwab, Christopher Ames, Justin S Smith, Shay Bess, Eric O Klineberg, and International Spine Study Group

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Efficacy of Varying Surgical Approaches on Achieving Optimal Alignment in Adult Spinal Deformity Surgery., Peter G Passias, Waleed Ahmad, Tyler K Williamson, Jordan Lebovic, Khaled Kebaish, Renaud Lafage, Virginie Lafage, Breton Line, Andrew J Schoenfeld, Bassel G Diebo, Eric O Klineberg, Han Jo Kim, Christopher P Ames, Alan H Daniels, Justin S Smith, Christopher I Shaffrey, Douglas C Burton, Robert A Hart, Shay Bess, Frank J Schwab, Munish C Gupta, and International Spine Study Group

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Patient-specific Cervical Deformity Corrections With Consideration of Associated Risk: Establishment of Risk Benefit Thresholds for Invasiveness Based on Deformity and Frailty Severity., Peter G Passias, Katherine E Pierce, Tyler K Williamson, Jordan Lebovic, Andrew J Schoenfeld, Renaud Lafage, Virginie Lafage, Jeffrey L Gum, Robert Eastlack, Han Jo Kim, Eric O Klineberg, Alan H Daniels, Themistocles S Protopsaltis, Gregory M Mundis, Justin K Scheer, Paul Park, Dean Chou, Breton Line, Robert A Hart, Douglas C Burton, Shay Bess, Frank J Schwab, Christopher I Shaffrey, Justin S Smith, and Christopher P Ames

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Incremental benefits of circumferential minimally invasive surgery for increasingly frail patients with adult spinal deformity., Peter G Passias, Peter S Tretiakov, Pierce D Nunley, Michael Y Wang, Paul Park, Adam S Kanter, David O Okonkwo, Robert K Eastlack, Gregory M Mundis, Dean Chou, Nitin Agarwal, Richard G Fessler, Juan S Uribe, Neel Anand, Khoi D Than, Gregory Brusko, Kai-Ming Fu, Jay D Turner, Vivian P Le, Breton G Line, Christopher P Ames, Justin S Smith, Christopher I Shaffrey, Robert A Hart, Douglas Burton, Renaud Lafage, Virginie Lafage, Frank Schwab, Shay Bess, and Praveen V Mummaneni

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Cost Benefit of Implementation of Risk Stratification Models for Adult Spinal Deformity Surgery., Peter G Passias, Tyler K Williamson, Nicholas A Kummer, Ferran Pellisé, Virginie Lafage, Renaud Lafage, Miguel Serra-Burriel, Justin S Smith, Breton Line, Shaleen Vira, Jeffrey L Gum, Sleiman Haddad, Francisco Javier Sánchez Pérez-Grueso, Andrew J Schoenfeld, Alan H Daniels, Dean Chou, Eric O Klineberg, Munish C Gupta, Khaled M Kebaish, Michael P Kelly, Robert A Hart, Douglas C Burton, Frank Kleinstück, Ibrahim Obeid, Christopher I Shaffrey, Ahmet Alanay, Christopher P Ames, Frank J Schwab, Richard A Hostin, Shay Bess, and International Spine Study Group

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Are We Focused on the Wrong Early Postoperative Quality Metrics? Optimal Realignment Outweighs Perioperative Risk in Adult Spinal Deformity Surgery., Peter G Passias, Tyler K Williamson, Jamshaid M Mir, Justin S Smith, Virginie Lafage, Renaud Lafage, Breton Line, Alan H Daniels, Jeffrey L Gum, Andrew J Schoenfeld, David Kojo Hamilton, Alex Soroceanu, Justin K Scheer, Robert Eastlack, Gregory M Mundis, Bassel Diebo, Khaled M Kebaish, Richard A Hostin, Munish C Gupta, Han Jo Kim, Eric O Klineberg, Christopher P Ames, Robert A Hart, Douglas C Burton, Frank J Schwab, Christopher I Shaffrey, Shay Bess, and On Behalf Of The International Spine Study Group

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Elevation of cannabis knowledge: higher learning, Savannah Marie Patterson and Anisha Boetel

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Arterial Bypass in the Treatment of Complex Middle Cerebral Artery Aneurysms: Lessons Learned from Forty Patients., Sophie F Peeters, Geoffrey P Colby, Wi Jin Kim, Whi Inh Bae, Hiro Sparks, Kara Reitz, Satoshi Tateshima, Reza Jahan, Viktor Szeder, May Nour, Gary R Duckwiler, Fernando Vinuela, Neil A Martin, and Anthony C Wang

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Proximal Internal Carotid Artery Occlusion and Extracranial-Intracranial Bypass for Treatment of Fusiform and Giant Internal Carotid Artery Aneurysms., Sophie M Peeters, Geoffrey P Colby, Wi Jin Kim, Whi Inh Bae, Hiro Sparks, Kara Reitz, Satoshi Tateshima, Reza Jahan, Viktor Szeder, May Nour, Gary R Duckwiler, Fernando Vinuela, Neil A Martin, and Anthony C Wang

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Reply to American Society of Transplant Surgeons Recommendations on Best Practices in Donation After Circulatory Death Organ Procurement "Questions on Best Practices in DCD"., Harry Peled and James Bernat

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Intravenous Administration of Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSC) for Acute Respiratory Distress Syndrome Due to COVID-19 Infection., Jesus A Perez, Juan J Parcero Valdes, Ruben Corral Moreno, Leonardo I Gomez Cuevas, Jose J Lopez, Thomas Ichim, Kristen McGreevy, Feng Lin, Santosh Kesari, and Souvik Datta

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Long-term efficacy of high-frequency (10 kHz) spinal cord stimulation for the treatment of painful diabetic neuropathy: 24-Month results of a randomized controlled trial., Erika A Petersen, Thomas G Stauss, James A Scowcroft, Michael J Jaasma, Elizabeth S Brooks, Deborah R Edgar, Judith L White, Shawn M Sills, Kasra Amirdelfan, Maged N Guirguis, Jijun Xu, Cong Yu, Ali Nairizi, Denis G Patterson, Kostandinos C Tsoulfas, Michael J Creamer, Vincent Galan, Richard H Bundschu, Neel D Mehta, Dawood Sayed, Shivanand P Lad, David J DiBenedetto, Khalid A Sethi, Johnathan H Goree, Matthew T Bennett, Nathan J Harrison, Atef F Israel, Paul Chang, Paul W Wu, Charles E Argoff, Christian E Nasr, Rod S Taylor, David L Caraway, and Nagy A Mekhail

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A Survey on Monitoring and Management of Cerebral Vasospasm and Delayed Cerebral Ischemia After Subarachnoid Hemorrhage: The Mantra Study., Edoardo Picetti, Pierre Bouzat, Mary Kay Bader, Giuseppe Citerio, Raimund Helbok, Janneke Horn, Robert Loch Macdonald, Victoria McCredie, Geert Meyfroidt, Cássia Righy, Chiara Robba, Deepak Sharma, Wade S Smith, Jose I Suarez, Andrew Udy, Stefan Wolf, and Fabio S Taccone

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Exploring the role of cerebrospinal fluid as analyte in neurologic disorders., Sandeep C Pingle, Feng Lin, Misa S Anekoji, C Pawan K Patro, Souvik Datta, Lawrence D Jones, Santosh Kesari, and Shashaanka Ashili

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Emotion regulation and the salience network: a hypothetical integrative model of fibromyalgia., Ana Margarida Pinto, Rinie Geenen, Tor D Wager, Mark A Lumley, Winfried Häuser, Eva Kosek, Jacob N Ablin, Kirstine Amris, Jaime Branco, Dan Buskila, João Castelhano, Miguel Castelo-Branco, Leslie J Crofford, Mary-Ann Fitzcharles, Marina López-Solà, Mariana Luís, Tiago Reis Marques, Philip J Mease, Filipe Palavra, Jamie L Rhudy, Lucina Q Uddin, Paula Castilho, Johannes W G Jacobs, and José A P da Silva

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Reply to 'Imbalance of threat and soothing systems in fibromyalgia: rephrasing an established mechanistic model?'., Ana Margarida Pinto, Rinie Geenen, Tor D Wager, Mark A Lumley, Winfried Häuser, Eva Kosek, Jacob N Ablin, Kirstine Amris, Jaime Branco, Dan Buskila, João Castelhano, Miguel Castelo-Branco, Leslie J Crofford, Mary-Ann Fitzcharles, Marina López-Solà, Mariana Luís, Tiago Reis Marques, Philip Mease, Filipe Palavra, Jamie L Rhudy, Lucina Q Uddin, Paula Castilho, Johannes W G Jacobs, and José A P da Silva

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Neurophysiological and psychosocial mechanisms of fibromyalgia: A comprehensive review and call for an integrative model., Ana Margarida Pinto, Mariana Luís, Rinie Geenen, Filipe Palavra, Mark A Lumley, Jacob N Ablin, Kirstine Amris, Jaime Branco, Dan Buskila, João Castelhano, Miguel Castelo-Branco, Leslie J Crofford, Mary-Ann Fitzcharles, Winfried Häuser, Eva Kosek, Philip J Mease, Tiago Reis Marques, Johannes W G Jacobs, Paula Castilho, and José A P da Silva

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A novel scoring system concept for de novo spinal infection treatment, the Spinal Infection Treatment Evaluation Score (SITE Score): a proof-of-concept study., Jonathan Pluemer, Yevgeniy Freyvert, Nathan Pratt, Jerry E Robinson, Jared A Cooke, Zachary L Tataryn, Clifford A Pierre, Periklis Godolias, Sven Frieler, Alexander von Glinski, Emre Yilmaz, Zeyad A Daher, Hamzah A Al-Awadi, Mitchell H Young, Rod J Oskouian, and Jens R Chapman

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Clinical outcomes and proximal junctional failure in adult spinal deformity patients corrected to normative alignment versus functional alignment., Themistocles S Protopsaltis, Fares Ani, Alexandra Soroceanu, Renaud Lafage, Han Jo Kim, Eaman Balouch, Zoe Norris, Justin S Smith, Alan H Daniels, Eric O Klineberg, Christopher P Ames, Robert Hart, Shay Bess, Christopher I Shaffrey, Frank J Schwab, Lawrence G Lenke, Virginie Lafage, and Munish C Gupta

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Transient "Person-in-the-Barrel" Syndrome After Cardiac Surgery: A Call to Awareness and Proactive Hemodynamic Management in Patients With Severe Vertebral Arterial Disease., Juan N Pulido, William E Berg, Teresa E Wagner, and Roland A Hernandez

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Single-Dose Psilocybin Treatment for Major Depressive Disorder: A Randomized Clinical Trial., Charles L Raison, Gerard Sanacora, Joshua Woolley, Keith Heinzerling, Boadie W Dunlop, Randall T Brown, Rishi Kakar, Michael Hassman, Rupal P Trivedi, Reid Robison, Natalie Gukasyan, Sandeep M Nayak, Xiaojue Hu, Kelley C O'Donnell, Benjamin Kelmendi, Jordan Sloshower, Andrew D Penn, Ellen Bradley, Daniel F Kelly, Tanja Mletzko, Christopher R Nicholas, Paul R Hutson, Gary Tarpley, Malynn Utzinger, Kelsey Lenoch, Kasia Warchol, Theraysa Gapasin, Mike C Davis, Courtney Nelson-Douthit, Steffanie Wilson, Carrie Brown, William Linton, Stephen Ross, and Roland R Griffiths

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Visceral and Subcutaneous Abdominal Fat Predict Brain Volume Loss at Midlife in 10,001 Individuals., Cyrus A Raji, Somayeh Meysami, Sam Hashemi, Saurabh Garg, Nasrin Akbari, Ahmed Gouda, Yosef Gavriel Chodakiewitz, Thanh Duc Nguyen, Kellyann Niotis, David A Merrill, and Rajpaul Attariwala

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Cancer stem cell assay-guided chemotherapy improves survival of patients with recurrent glioblastoma in a randomized trial., Tulika Ranjan, Soma Sengupta, Michael J Glantz, Richard M Green, Alexander Yu, Dawit Aregawi, Rekha Chaudhary, Ricky Chen, Mario Zuccarello, Christine Lu-Emerson, Hugh D Moulding, Neil Belman, Jon Glass, Aaron Mammoser, Mark Anderson, Jagan Valluri, Nicholas Marko, Jason Schroeder, Steven Jubelirer, Frances Chow, Pier Paolo Claudio, Anthony M Alberico, Seth T Lirette, Krista L Denning, and Candace M Howard

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Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting., Kirsi J Rautajoki, Serafiina Jaatinen, Anja Hartewig, Aliisa M Tiihonen, Matti Annala, Iida Salonen, Masi Valkonen, Vili Simola, Elisa M Vuorinen, Anni Kivinen, Minna J Rauhala, Riikka Nurminen, Kendra K Maass, Sirpa-Liisa Lahtela, Arja Jukkola, Olli Yli-Harja, Pauli Helén, Kristian W Pajtler, Pekka Ruusuvuori, Joonas Haapasalo, Wei Zhang, Hannu Haapasalo, and Matti Nykter

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Association between Cannabis Use and Tinnitus in US Adults., Francis Reyes Orozco, Matthew Lin, Bhavishya Clark, Joni K Doherty, John S Oghalai, Courtney C J Voelker, and Janet S Choi

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Bimekizumab treatment in biologic DMARD-naïve patients with active psoriatic arthritis: 52-week efficacy and safety results from the phase III, randomised, placebo-controlled, active reference BE OPTIMAL study., Christopher T Ritchlin, Laura C Coates, Iain B McInnes, Philip Mease, Joseph F Merola, Yoshiya Tanaka, Akihiko Asahina, Laure Gossec, Alice B Gottlieb, Richard B Warren, Barbara Ink, Rajan Bajracharya, Vishvesh Shende, Jason Coarse, and Robert Bm Landewé

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A Remotely Coached Multimodal Lifestyle Intervention for Alzheimer's Disease Ameliorates Functional and Cognitive Outcomes., Jared C Roach, Molly Rapozo, Junko Hara, Gwênlyn Glusman, Jennifer Lovejoy, William R Shankle, Leroy Hood, COCOA Consortium, Cory C Funk, Gwênlyn Glusman, Leroy Hood, Jennifer Lovejoy, Andrew T Magis, and Nathan D Price

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Embolization as stand-alone strategy for pediatric low-grade brain arteriovenous malformations., Aaron Rodriguez-Calienes, Juan Vivanco-Suarez, Matias Costa, Johssy Yelma Echevarria-Quispe, Rodolfo Rodríguez-Varela, Santiago Ortega-Gutierrez, and Giancarlo Saal-Zapata

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Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma., Miriam I Rosenberg, Erez Greenstein, Martin Buchkovich, Ayelet Peres, Eric Santoni-Rugiu, Lei Yang, Martin Mikl, Zalman Vaksman, David L Gibbs, Dan Reshef, Amy Salovin, Meredith S Irwin, Arlene Naranjo, Igor Ulitsky, Pedro A de Alarcon, Katherine K Matthay, Victor Weigman, Gur Yaari, Jessica A Panzer, Nir Friedman, and John M Maris

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Robot-Assisted Transcranial Doppler Versus Transthoracic Echocardiography for Right to Left Shunt Detection., Mark N Rubin, Ruchir Shah, Thomas Devlin, Teddy S Youn, Michael F Waters, John J Volpi, Aaron Stayman, Colleen Douville, Ted Lowenkopf, Georgios Tsivgoulis, and Andrei V Alexandrov

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Immunotherapy responsiveness and risk of relapse in Down syndrome regression disorder., Jonathan D Santoro, Noemi A Spinazzi, Robyn A Filipink, Panteha Hayati-Rezvan, Ryan Kammeyer, Lina Patel, Elise A Sannar, Luke Dwyer, Abhik K Banerjee, Mellad Khoshnood, Saba Jafarpour, Natalie K Boyd, Rebecca Partridge, Grace Y Gombolay, Alison Christy, Diego Real de Asua, Maria Del Carmen Ortega, Melanie A Manning, Heather Van Mater, Gordan Worley, Cathy Franklin, Maria A Stanley, Ruth Brown, George T Capone, Eileen A Quinn, and Michael S Rafii

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Hybrid repair of an innominate artery pseudoaneurysm after blunt traumatic injury in a bovine arch., Keyuree Satam, Sabina Sorondo, Michael Paisley, and Venita Chandra

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Remission of severe myasthenia gravis after autologous stem cell transplantation., Monica I Schlatter, Soumya S Yandamuri, Kevin C O'Connor, Richard J Nowak, Minh C Pham, Abeer H Obaid, Callee Redman, Marie Provost, Peter A McSweeney, Michael L Pearlman, Michael T Tees, J D Bowen, Richard A Nash, and George E Georges

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Comprehensive Understanding of Hispanic Caregivers: Focus on Innovative Methods and Validations., Ujala Sehar, Priyanka Rawat, Moumita Choudhury, Annette Boles, John Culberson, Hafiz Khan, Keya Malhotra, Tanisha Basu, and P Hemachandra Reddy

Impact of Patient Characteristics and COVID 19 on Last Known Well to Arrival, T Singh, Alyx Lesko, and See all authors in comments

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Editorial. Overcoming implementation barriers in enhanced recovery using theory-based approaches., Walavan Sivakumar

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Letter to the editor regarding "Vascular anomalies in patients with growth hormone-secreting pituitary adenomas: illustrative case report and systematic review of the literature"., Walavan Sivakumar and William T Couldwell

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Enhanced recovery after brain tumor surgery: pilot protocol implementation in a large healthcare system., Walavan Sivakumar, Jian Guan, Jean-Philippe Langevin, Garni Barkhoudarian, Daniel F Kelly, and Neil A Martin

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Evaluating the efficacy and safety of transitioning patients with multiple sclerosis from natalizumab to ocrelizumab (OCTAVE)., Kyle Smoot, Horia Marginean, Tiffany Gervasi-Follmar, Chiayi Chen, Pavle Repovic, and Stanley Cohan

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Facial nerve palsy: An early sign of COVID-19., Michael Somero, Elisa Akagi, and Ashish Bhargava

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Processing speed and memory test performance are associated with different brain region volumes in Veterans and others with progressive multiple sclerosis., Rebecca I Spain, Andrea Hildebrand, Carin S Waslo, William D Rooney, Joshua Emmons, Daniel L Schwartz, Mark S Freedman, M Mateo Paz Soldan, Pavle Repovic, Andrew J Solomon, John Rinker, Mitchell Wallin, Jodie K Haselkorn, Olaf Stuve, Robert H Gross, and Aaron P Turner

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Association of age and inflammatory disease activity in the pivotal natalizumab clinical trials in relapsing-remitting multiple sclerosis., Eva M Strijbis, Eline Coerver, Jop Mostert, Zoé L E van Kempen, Joep Killestein, Jacynthe Comtois, Pavle Repovic, James D Bowen, Gary Cutter, and Marcus Koch

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ALSUntangled #71: Nuedexta., Yuyao Sun, Michael Benatar, Javier Mascías Cadavid, Dave Ennist, Paul Wicks, Kim Staats, Morgan Beauchamp, Sartaj Jhooty, Gary Pattee, Andrew Brown, Tulio Bertorini, Paul Barkhaus, Mark Bromberg, Greg Carter, Richard Bedlack, and Xiaoyan Li

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Biological functions of the Olig gene family in brain cancer and therapeutic targeting., Jenny Szu, Igor F Tsigelny, Alexandre Wojcinski, and Santosh Kesari

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Keynote: Escaping a Code Stroke: Impact of Escape Room Methodology on Nurses’ Attitudes towards Acute Stroke Management Guidelines, Diana D. Tai

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Clinical Outcomes of Stereotactic Radiosurgery-Related Radiation Necrosis in Patients with Intracranial Metastasis from Melanoma., Holly M Thomson, Shannon P Fortin Ensign, Victoria S Edmonds, Akanksha Sharma, Richard J Butterfield, Steven E Schild, Jonathan B Ashman, Richard S Zimmerman, Naresh P Patel, Alan H Bryce, Sujay A Vora, Terence T Sio, and Alyx B Porter

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Targeting of insulin receptor endocytosis as a treatment to insulin resistance., Bryce Tim, Valentina L Kouznetsova, Santosh Kesari, and Igor F Tsigelny

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Editorial: Diet and multiple sclerosis., Tyler J Titcomb, Barbara Giesser, Scott M Plafker, Ilana B Katz Sand, and Terry L Wahls

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Maternal Group B Streptococcus Prophylaxis Improvement using an Electronic Medical Record Dynamic Order Set., Mark Tomlinson, Rachael Baker, Jennifer Ulrich, Maulin P. Shah, Horia Marginean, and Stephen Girolami

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Guidelines for the Neurocritical Care Management of Aneurysmal Subarachnoid Hemorrhage., Miriam M Treggiari, Alejandro A Rabinstein, Katharina M Busl, Meghan M Caylor, Giuseppe Citerio, Steven Deem, Michael Diringer, Elizabeth Fox, Sarah Livesay, Kevin N Sheth, Jose I Suarez, and Stavropoula Tjoumakaris

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Calibration of a comprehensive predictive model for the development of proximal junctional kyphosis and failure in adult spinal deformity patients with consideration of contemporary goals and techniques., Peter S Tretiakov, Renaud Lafage, Justin S Smith, Breton G Line, Bassel G Diebo, Alan H Daniels, Jeffrey Gum, Themistocles Protopsaltis, D Kojo Hamilton, Alex Soroceanu, Justin K Scheer, Robert K Eastlack, Gregory Mundis, Pierce D Nunley, Eric O Klineberg, Khaled Kebaish, Stephen Lewis, Lawrence Lenke, Richard Hostin, Munish C Gupta, Christopher P Ames, Robert A Hart, Douglas Burton, Christopher I Shaffrey, Frank Schwab, Shay Bess, Han Jo Kim, Virginie Lafage, and Peter G Passias

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Role of Senataxin in Amyotrophic Lateral Sclerosis., Andrew Tsui, Valentina L Kouznetsova, Santosh Kesari, Milan Fiala, and Igor F Tsigelny

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Posterior cervical congenital dermal sinus tract: case report and review of literature., Amir Vokshoor, Harseerat Jajj, Tiffany Grunwald, Steven E Kolker, and Jack Petros

A Retrospective Study Comparing Clinical Outcomes For Thrombectomy-treated Patients With Large Vessel Occlusion Who Met Or Did Not Meet AHA/ASA Eligibility Criteria, J Wallace, Alyx Lesko, and See all authors in comments

Retrospective safety study of low severity intracranial hemorrhage patients, evaluating a care protocol aimed at keeping patients at spoke hospitals, J Wallace, Alyx Lesko, and See all authors in comments

Using CD39/CD103 to Isolate Tumor-Reactive CD8 TIL: Bench to Bedside, AD Weinberg

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The ISSG-AO Complication Intervention Score, but Not Major/Minor Designation, is Correlated With Length of Stay Following Adult Spinal Deformity Surgery., Joseph B Wick, Andrew Blandino, Justin S Smith, Breton G Line, Virginie Lafage, Renaud Lafage, Han Jo Kim, Peter G Passias, Jeffrey L Gum, Khaled M Kebaish, Robert K Eastlack, Alan Daniels, Gregory Mundis, Richard Hostin, Themistocles Protopsaltis, D Kojo Hamilton, Michael P Kelly, Munish Gupta, Robert A Hart, Frank J Schwab, Douglas C Burton, Christopher P Ames, Lawrence G Lenke, Christopher I Shaffrey, Shay Bess, Eric Klineberg, and International Spine Study Group

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Real-World Safety and Effectiveness After 5 Years of Dimethyl Fumarate Treatment in Black and Hispanic Patients with Multiple Sclerosis in ESTEEM., Mitzi J Williams, Lilyana Amezcua, Angel Chinea, Stanley Cohan, Annette Okai, Darin T Okuda, Wendy Vargas, Nick Belviso, Ivan Božin, Xiaotong Jiang, James B Lewin, Jennifer Lyons, Changyu Shen, Sarah M England, and Nydjie Grimes

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Hypothermia is associated with improved neurological outcomes after mechanical thrombectomy., Risheng Xu, Sumil K Nair, Collin B Kilgore, Michael E Xie, Christopher M Jackson, Ferdinand Hui, Phillipe Gailloud, Cameron G McDougall, L Fernando Gonzalez, Judy Huang, Rafael J Tamargo, and Justin Caplan

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Diagnostics of ovarian cancer via metabolite analysis and machine learning., Jerry Z Yao, Igor F Tsigelny, Santosh Kesari, and Valentina L Kouznetsova

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Use of multiple rods and proximal junctional kyphosis in adult spinal deformity surgery., Jichao Ye, Sachin Gupta, Ali S Farooqi, Tsung-Cheng Yin, Alex Soroceanu, Frank J Schwab, Virginie Lafage, Michael P Kelly, Khaled Kebaish, Richard Hostin, Jeffrey L Gum, Justin S Smith, Christopher I Shaffrey, Justin K Scheer, Themistocles S Protopsaltis, Peter G Passias, Eric O Klineberg, Han Jo Kim, Robert A Hart, D Kojo Hamilton, Christopher P Ames, and Munish C Gupta

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Cost-effectiveness Analysis of Inferior Turbinate Reduction and Immunotherapy in Allergic Rhinitis., Michael Yong, Kaishan Aravinthan, Keshinisuthan Kirubalingam, Andrew Thamboo, Peter H Hwang, Kari Nadeau, and Evan Walgama

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In Response to Cost-effectiveness Analysis of Inferior Turbinate Reduction and Immunotherapy in Allergic Rhinitis., Michael Yong, Kaishan Aravinthan, Keshinisuthan Kirubalingam, Andrew Thamboo, Peter H Hwang, Kari Nadeau, and Evan Walgama

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Therapy of autoimmune inflammation in sporadic amyotrophic lateral sclerosis: Dimethyl fumarate and H-151 downregulate inflammatory cytokines in the cGAS-STING pathway., Kurosh Zamiri, Santosh Kesari, Ketema Paul, Sung Hee Hwang, Bruce Hammock, Karolina Elżbieta Kaczor-Urbanowicz, Andrzej Urbanowicz, Lucy Gao, Julian Whitelegge, and Milan Fiala

Submissions from 2022

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Effects of Cervical Spine Exercise Protocol on Neck Pain, Pericervical Muscle Endurance, and Range of Motion in Medical Students: A Prospective Study., Bryan G Anderson, Brett Benzinger, Jason Chickness, Chris Hietanen, Kylan Hill, Jean-Marc P Lucas, Joshua Tuck, and Michael Ghassibi

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HIV Antiretroviral Medication Neuropenetrance and Neurocognitive Outcomes in HIV+ Adults: A Review of the Literature Examining the Central Nervous System Penetration Effectiveness Score., Alyssa Arentoft, Katie Troxell, Karen Alvarez, Maral Aghvinian, Monica Rivera Mindt, Mariana Cherner, Kathleen Van Dyk, Jill Razani, Michaela Roxas, and Melissa Gavilanes

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HIV Antiretroviral Medication Neuropenetrance and Neurocognitive Outcomes in HIV+ Adults: A Review of the Literature Examining the Central Nervous System Penetration Effectiveness Score., Alyssa Arentoft, Katie Troxell, Karen Alvarez, Maral Aghvinian, Monica Rivera Mindt, Mariana Cherner, Kathleen Van Dyk, Jill Razani, Michaela Roxas, and Melissa Gavilanes

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Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial., Robert H Baloh, J Patrick Johnson, Pablo Avalos, Peggy Allred, Soshana Svendsen, Genevieve Gowing, Kristina Roxas, Amanda Wu, Becky Donahue, Sheryl Osborne, George Lawless, Brandon Shelley, Koral Wheeler, Carolyn Prina, Dana Fine, Tami Kendra-Romito, Haniah Stokes, Vicki Manoukian, Abirami Muthukumaran, Leslie Garcia, Maria G Bañuelos, Marlesa Godoy, Catherine Bresee, Hong Yu, Doniel Drazin, Lindsey Ross, Robert Naruse, Harish Babu, Eric A Macklin, Ashley Vo, Ashraf Elsayegh, Warren Tourtellotte, Marcel Maya, Matthew Burford, Frank Diaz, Chirag G Patil, Richard A Lewis, and Clive N Svendsen

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Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease., Priyanka Baloni, Matthias Arnold, Luna Buitrago, Kwangsik Nho, Herman Moreno, Kevin Huynh, Barbara Brauner, Gregory Louie, Alexandra Kueider-Paisley, Karsten Suhre, Andrew J Saykin, Kim Ekroos, Peter J Meikle, Leroy Hood, Nathan D Price, Alzheimer’s Disease Metabolomics Consortium, P Murali Doraiswamy, Cory C Funk, A Iván Hernández, Gabi Kastenmüller, Rebecca Baillie, Xianlin Han, and Rima Kaddurah-Daouk

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Rare adverse events following Covid-19 vaccination: A review, Mohammad Barary, Akanksha Sharma, and See full list of authors in comments

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Author Correction: Human neocortical expansion involves glutamatergic neuron diversification., Jim Berg, Staci A Sorensen, Jonathan T Ting, Jeremy A Miller, Thomas Chartrand, Anatoly Buchin, Trygve E Bakken, Agata Budzillo, Nick Dee, Song-Lin Ding, Nathan W Gouwens, Rebecca D Hodge, Brian Kalmbach, Changkyu Lee, Brian R Lee, Lauren Alfiler, Katherine Baker, Eliza Barkan, Allison Beller, Kyla Berry, Darren Bertagnolli, Kris Bickley, Jasmine Bomben, Thomas Braun, Krissy Brouner, Tamara Casper, Peter Chong, Kirsten Crichton, Rachel Dalley, Rebecca de Frates, Tsega Desta, Samuel Dingman Lee, Florence D'Orazi, Nadezhda Dotson, Tom Egdorf, Rachel Enstrom, Colin Farrell, David Feng, Olivia Fong, Szabina Furdan, Anna A Galakhova, Clare Gamlin, Amanda Gary, Alexandra Glandon, Jeff Goldy, Melissa Gorham, Natalia A Goriounova, Sergey Gratiy, Lucas Graybuck, Hong Gu, Kristen Hadley, Nathan Hansen, Tim S Heistek, Alex M Henry, Djai B Heyer, DiJon Hill, Chris Hill, Madie Hupp, Tim Jarsky, Sara Kebede, Lisa Keene, Lisa Kim, Mean-Hwan Kim, Matthew Kroll, Caitlin Latimer, Boaz P Levi, Katherine E Link, Matthew Mallory, Rusty Mann, Desiree Marshall, Michelle Maxwell, Medea McGraw, Delissa McMillen, Erica Melief, Eline J Mertens, Leona Mezei, Norbert Mihut, Stephanie Mok, Gabor Molnar, Alice Mukora, Lindsay Ng, Kiet Ngo, Philip R Nicovich, Julie Nyhus, Gaspar Olah, Aaron Oldre, Victoria Omstead, Attila Ozsvar, Daniel Park, Hanchuan Peng, Trangthanh Pham, Christina A Pom, Lydia Potekhina, Ramkumar Rajanbabu, Shea Ransford, David Reid, Christine Rimorin, Augustin Ruiz, David Sandman, Josef Sulc, Susan M Sunkin, Aaron Szafer, Viktor Szemenyei, Elliot R Thomsen, Michael Tieu, Amy Torkelson, Jessica Trinh, Herman Tung, Wayne Wakeman, Femke Waleboer, Katelyn Ward, René Wilbers, Grace Williams, Zizhen Yao, Jae-Guen Yoon, Costas Anastassiou, Anton Arkhipov, Pal Barzo, Amy Bernard, Charles Cobbs, Philip C de Witt Hamer, Richard G Ellenbogen, Luke Esposito, Manuel Ferreira, Ryder P Gwinn, Michael J Hawrylycz, Patrick R Hof, Sander Idema, Allan R Jones, C Dirk Keene, Andrew L Ko, Gabe J Murphy, Lydia Ng, Jeffrey G Ojemann, Anoop P Patel, John W Phillips, Daniel L Silbergeld, Kimberly Smith, Bosiljka Tasic, Rafael Yuste, Idan Segev, Christiaan P J de Kock, Huibert D Mansvelder, Gabor Tamas, Hongkui Zeng, Christof Koch, and Ed S Lein