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Submissions from 2023

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Editorial. Overcoming implementation barriers in enhanced recovery using theory-based approaches., Walavan Sivakumar

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Letter to the editor regarding "Vascular anomalies in patients with growth hormone-secreting pituitary adenomas: illustrative case report and systematic review of the literature"., Walavan Sivakumar and William T Couldwell

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Enhanced recovery after brain tumor surgery: pilot protocol implementation in a large healthcare system., Walavan Sivakumar, Jian Guan, Jean-Philippe Langevin, Garni Barkhoudarian, Daniel F Kelly, and Neil A Martin

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Evaluating the efficacy and safety of transitioning patients with multiple sclerosis from natalizumab to ocrelizumab (OCTAVE)., Kyle Smoot, Horia Marginean, Tiffany Gervasi-Follmar, Chiayi Chen, Pavle Repovic, and Stanley Cohan

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Facial nerve palsy: An early sign of COVID-19., Michael Somero, Elisa Akagi, and Ashish Bhargava

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Processing speed and memory test performance are associated with different brain region volumes in Veterans and others with progressive multiple sclerosis., Rebecca I Spain, Andrea Hildebrand, Carin S Waslo, William D Rooney, Joshua Emmons, Daniel L Schwartz, Mark S Freedman, M Mateo Paz Soldan, Pavle Repovic, Andrew J Solomon, John Rinker, Mitchell Wallin, Jodie K Haselkorn, Olaf Stuve, Robert H Gross, and Aaron P Turner

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Association of age and inflammatory disease activity in the pivotal natalizumab clinical trials in relapsing-remitting multiple sclerosis., Eva M Strijbis, Eline Coerver, Jop Mostert, Zoé L E van Kempen, Joep Killestein, Jacynthe Comtois, Pavle Repovic, James D Bowen, Gary Cutter, and Marcus Koch

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ALSUntangled #71: Nuedexta., Yuyao Sun, Michael Benatar, Javier Mascías Cadavid, Dave Ennist, Paul Wicks, Kim Staats, Morgan Beauchamp, Sartaj Jhooty, Gary Pattee, Andrew Brown, Tulio Bertorini, Paul Barkhaus, Mark Bromberg, Greg Carter, Richard Bedlack, and Xiaoyan Li

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Biological functions of the Olig gene family in brain cancer and therapeutic targeting., Jenny Szu, Igor F Tsigelny, Alexandre Wojcinski, and Santosh Kesari

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Keynote: Escaping a Code Stroke: Impact of Escape Room Methodology on Nurses’ Attitudes towards Acute Stroke Management Guidelines, Diana D. Tai

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Clinical Outcomes of Stereotactic Radiosurgery-Related Radiation Necrosis in Patients with Intracranial Metastasis from Melanoma., Holly M Thomson, Shannon P Fortin Ensign, Victoria S Edmonds, Akanksha Sharma, Richard J Butterfield, Steven E Schild, Jonathan B Ashman, Richard S Zimmerman, Naresh P Patel, Alan H Bryce, Sujay A Vora, Terence T Sio, and Alyx B Porter

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Targeting of insulin receptor endocytosis as a treatment to insulin resistance., Bryce Tim, Valentina L Kouznetsova, Santosh Kesari, and Igor F Tsigelny

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Editorial: Diet and multiple sclerosis., Tyler J Titcomb, Barbara Giesser, Scott M Plafker, Ilana B Katz Sand, and Terry L Wahls

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Guidelines for the Neurocritical Care Management of Aneurysmal Subarachnoid Hemorrhage., Miriam M Treggiari, Alejandro A Rabinstein, Katharina M Busl, Meghan M Caylor, Giuseppe Citerio, Steven Deem, Michael Diringer, Elizabeth Fox, Sarah Livesay, Kevin N Sheth, Jose I Suarez, and Stavropoula Tjoumakaris

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Calibration of a comprehensive predictive model for the development of proximal junctional kyphosis and failure in adult spinal deformity patients with consideration of contemporary goals and techniques., Peter S Tretiakov, Renaud Lafage, Justin S Smith, Breton G Line, Bassel G Diebo, Alan H Daniels, Jeffrey Gum, Themistocles Protopsaltis, D Kojo Hamilton, Alex Soroceanu, Justin K Scheer, Robert K Eastlack, Gregory Mundis, Pierce D Nunley, Eric O Klineberg, Khaled Kebaish, Stephen Lewis, Lawrence Lenke, Richard Hostin, Munish C Gupta, Christopher P Ames, Robert A Hart, Douglas Burton, Christopher I Shaffrey, Frank Schwab, Shay Bess, Han Jo Kim, Virginie Lafage, and Peter G Passias

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Role of Senataxin in Amyotrophic Lateral Sclerosis., Andrew Tsui, Valentina L Kouznetsova, Santosh Kesari, Milan Fiala, and Igor F Tsigelny

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Posterior cervical congenital dermal sinus tract: case report and review of literature., Amir Vokshoor, Harseerat Jajj, Tiffany Grunwald, Steven E Kolker, and Jack Petros

A Retrospective Study Comparing Clinical Outcomes For Thrombectomy-treated Patients With Large Vessel Occlusion Who Met Or Did Not Meet AHA/ASA Eligibility Criteria, J Wallace, Alyx Lesko, and See all authors in comments

Retrospective safety study of low severity intracranial hemorrhage patients, evaluating a care protocol aimed at keeping patients at spoke hospitals, J Wallace, Alyx Lesko, and See all authors in comments

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The ISSG-AO Complication Intervention Score, but Not Major/Minor Designation, is Correlated With Length of Stay Following Adult Spinal Deformity Surgery., Joseph B Wick, Andrew Blandino, Justin S Smith, Breton G Line, Virginie Lafage, Renaud Lafage, Han Jo Kim, Peter G Passias, Jeffrey L Gum, Khaled M Kebaish, Robert K Eastlack, Alan Daniels, Gregory Mundis, Richard Hostin, Themistocles Protopsaltis, D Kojo Hamilton, Michael P Kelly, Munish Gupta, Robert A Hart, Frank J Schwab, Douglas C Burton, Christopher P Ames, Lawrence G Lenke, Christopher I Shaffrey, Shay Bess, Eric Klineberg, and International Spine Study Group

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Real-World Safety and Effectiveness After 5 Years of Dimethyl Fumarate Treatment in Black and Hispanic Patients with Multiple Sclerosis in ESTEEM., Mitzi J Williams, Lilyana Amezcua, Angel Chinea, Stanley Cohan, Annette Okai, Darin T Okuda, Wendy Vargas, Nick Belviso, Ivan Božin, Xiaotong Jiang, James B Lewin, Jennifer Lyons, Changyu Shen, Sarah M England, and Nydjie Grimes

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Hypothermia is associated with improved neurological outcomes after mechanical thrombectomy., Risheng Xu, Sumil K Nair, Collin B Kilgore, Michael E Xie, Christopher M Jackson, Ferdinand Hui, Phillipe Gailloud, Cameron G McDougall, L Fernando Gonzalez, Judy Huang, Rafael J Tamargo, and Justin Caplan

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Diagnostics of ovarian cancer via metabolite analysis and machine learning., Jerry Z Yao, Igor F Tsigelny, Santosh Kesari, and Valentina L Kouznetsova

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In Response to Cost-effectiveness Analysis of Inferior Turbinate Reduction and Immunotherapy in Allergic Rhinitis., Michael Yong, Kaishan Aravinthan, Keshinisuthan Kirubalingam, Andrew Thamboo, Peter H Hwang, Kari Nadeau, and Evan Walgama

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Therapy of autoimmune inflammation in sporadic amyotrophic lateral sclerosis: Dimethyl fumarate and H-151 downregulate inflammatory cytokines in the cGAS-STING pathway., Kurosh Zamiri, Santosh Kesari, Ketema Paul, Sung Hee Hwang, Bruce Hammock, Karolina Elżbieta Kaczor-Urbanowicz, Andrzej Urbanowicz, Lucy Gao, Julian Whitelegge, and Milan Fiala

Submissions from 2022

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Effects of Cervical Spine Exercise Protocol on Neck Pain, Pericervical Muscle Endurance, and Range of Motion in Medical Students: A Prospective Study., Bryan G Anderson, Brett Benzinger, Jason Chickness, Chris Hietanen, Kylan Hill, Jean-Marc P Lucas, Joshua Tuck, and Michael Ghassibi

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HIV Antiretroviral Medication Neuropenetrance and Neurocognitive Outcomes in HIV+ Adults: A Review of the Literature Examining the Central Nervous System Penetration Effectiveness Score., Alyssa Arentoft, Katie Troxell, Karen Alvarez, Maral Aghvinian, Monica Rivera Mindt, Mariana Cherner, Kathleen Van Dyk, Jill Razani, Michaela Roxas, and Melissa Gavilanes

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HIV Antiretroviral Medication Neuropenetrance and Neurocognitive Outcomes in HIV+ Adults: A Review of the Literature Examining the Central Nervous System Penetration Effectiveness Score., Alyssa Arentoft, Katie Troxell, Karen Alvarez, Maral Aghvinian, Monica Rivera Mindt, Mariana Cherner, Kathleen Van Dyk, Jill Razani, Michaela Roxas, and Melissa Gavilanes

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Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial., Robert H Baloh, J Patrick Johnson, Pablo Avalos, Peggy Allred, Soshana Svendsen, Genevieve Gowing, Kristina Roxas, Amanda Wu, Becky Donahue, Sheryl Osborne, George Lawless, Brandon Shelley, Koral Wheeler, Carolyn Prina, Dana Fine, Tami Kendra-Romito, Haniah Stokes, Vicki Manoukian, Abirami Muthukumaran, Leslie Garcia, Maria G Bañuelos, Marlesa Godoy, Catherine Bresee, Hong Yu, Doniel Drazin, Lindsey Ross, Robert Naruse, Harish Babu, Eric A Macklin, Ashley Vo, Ashraf Elsayegh, Warren Tourtellotte, Marcel Maya, Matthew Burford, Frank Diaz, Chirag G Patil, Richard A Lewis, and Clive N Svendsen

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Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease., Priyanka Baloni, Matthias Arnold, Luna Buitrago, Kwangsik Nho, Herman Moreno, Kevin Huynh, Barbara Brauner, Gregory Louie, Alexandra Kueider-Paisley, Karsten Suhre, Andrew J Saykin, Kim Ekroos, Peter J Meikle, Leroy Hood, Nathan D Price, Alzheimer’s Disease Metabolomics Consortium, P Murali Doraiswamy, Cory C Funk, A Iván Hernández, Gabi Kastenmüller, Rebecca Baillie, Xianlin Han, and Rima Kaddurah-Daouk

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Rare adverse events following Covid-19 vaccination: A review, Mohammad Barary, Akanksha Sharma, and See full list of authors in comments

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Author Correction: Human neocortical expansion involves glutamatergic neuron diversification., Jim Berg, Staci A Sorensen, Jonathan T Ting, Jeremy A Miller, Thomas Chartrand, Anatoly Buchin, Trygve E Bakken, Agata Budzillo, Nick Dee, Song-Lin Ding, Nathan W Gouwens, Rebecca D Hodge, Brian Kalmbach, Changkyu Lee, Brian R Lee, Lauren Alfiler, Katherine Baker, Eliza Barkan, Allison Beller, Kyla Berry, Darren Bertagnolli, Kris Bickley, Jasmine Bomben, Thomas Braun, Krissy Brouner, Tamara Casper, Peter Chong, Kirsten Crichton, Rachel Dalley, Rebecca de Frates, Tsega Desta, Samuel Dingman Lee, Florence D'Orazi, Nadezhda Dotson, Tom Egdorf, Rachel Enstrom, Colin Farrell, David Feng, Olivia Fong, Szabina Furdan, Anna A Galakhova, Clare Gamlin, Amanda Gary, Alexandra Glandon, Jeff Goldy, Melissa Gorham, Natalia A Goriounova, Sergey Gratiy, Lucas Graybuck, Hong Gu, Kristen Hadley, Nathan Hansen, Tim S Heistek, Alex M Henry, Djai B Heyer, DiJon Hill, Chris Hill, Madie Hupp, Tim Jarsky, Sara Kebede, Lisa Keene, Lisa Kim, Mean-Hwan Kim, Matthew Kroll, Caitlin Latimer, Boaz P Levi, Katherine E Link, Matthew Mallory, Rusty Mann, Desiree Marshall, Michelle Maxwell, Medea McGraw, Delissa McMillen, Erica Melief, Eline J Mertens, Leona Mezei, Norbert Mihut, Stephanie Mok, Gabor Molnar, Alice Mukora, Lindsay Ng, Kiet Ngo, Philip R Nicovich, Julie Nyhus, Gaspar Olah, Aaron Oldre, Victoria Omstead, Attila Ozsvar, Daniel Park, Hanchuan Peng, Trangthanh Pham, Christina A Pom, Lydia Potekhina, Ramkumar Rajanbabu, Shea Ransford, David Reid, Christine Rimorin, Augustin Ruiz, David Sandman, Josef Sulc, Susan M Sunkin, Aaron Szafer, Viktor Szemenyei, Elliot R Thomsen, Michael Tieu, Amy Torkelson, Jessica Trinh, Herman Tung, Wayne Wakeman, Femke Waleboer, Katelyn Ward, René Wilbers, Grace Williams, Zizhen Yao, Jae-Guen Yoon, Costas Anastassiou, Anton Arkhipov, Pal Barzo, Amy Bernard, Charles Cobbs, Philip C de Witt Hamer, Richard G Ellenbogen, Luke Esposito, Manuel Ferreira, Ryder P Gwinn, Michael J Hawrylycz, Patrick R Hof, Sander Idema, Allan R Jones, C Dirk Keene, Andrew L Ko, Gabe J Murphy, Lydia Ng, Jeffrey G Ojemann, Anoop P Patel, John W Phillips, Daniel L Silbergeld, Kimberly Smith, Bosiljka Tasic, Rafael Yuste, Idan Segev, Christiaan P J de Kock, Huibert D Mansvelder, Gabor Tamas, Hongkui Zeng, Christof Koch, and Ed S Lein

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Severe Airway Edema Following Calcium Hydroxylapatite (CaHA) Injection Augmentation., Michela Borrelli, Tasha Nasrollahi, Jonathan Raskin, Sana Khan, and Omid B Mehdizadeh

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QLTI-26. INTEGRATION OF NEURO-ONCOLOGY CLINICAL PATHWAYS IN PROVIDENCE SOUTHERN CALIFORNIA CLINICAL RESEARCH NETWORK, Brad Bott, Nanor Bozoyan, Trisha Babcock, Kristen Cushman, Akanksha Sharma, Naveed Wagle, Jose Carrillo, Tiffany Juarez, and Santosh Kesari

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Real-World Evidence of Transcutaneous Afferent Patterned Stimulation for Essential Tremor., Salima Brillman, Kalea Colletta, Sally Borucki, Peter T Lin, Olga Waln, Melita Petrossian, Pravin Khemani, Apoorva Rajagopal, Kathryn H Rosenbluth, and Dhira Khosla

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Concurrent brain-responsive and vagus nerve stimulation for treatment of drug-resistant focal epilepsy., Mesha-Gay Brown, Stefan Sillau, Danielle McDermott, Lia D Ernst, David C Spencer, Dario J Englot, Hernán F J González, Proleta Datta, Ioannis Karakis, Danielle Becker, John D Rolston, Amir Arain, Vikram R Rao, Michael J Doherty, Alexandra Urban, and Cornelia Drees

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Relationships Between Health-Related Quality of Life and Speech Perception in Bimodal and Bilateral Cochlear Implant Users., Nadav Brumer, Elizabeth Elkins, Jake Hillyer, Chantel Hazlewood, and Alexandra Parbery-Clark

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Multi-modal characterization and simulation of human epileptic circuitry., Anatoly Buchin, Rebecca de Frates, Anirban Nandi, Rusty Mann, Peter Chong, Lindsay Ng, Jeremy Miller, Rebecca Hodge, Brian Kalmbach, Soumita Bose, Ueli Rutishauser, Stephen McConoughey, Ed Lein, Jim Berg, Staci Sorensen, Ryder Gwinn, Christof Koch, Jonathan Ting, and Costas A Anastassiou

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Vessel Wall Enhancement in Unilateral Primary Angiitis of the Central Nervous System., Adrian Budhram, Shailee S Shah, Christopher P Wood, Michael A Lane, Kyle E Smoot, and Brian G Weinshenker

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Cell-free plasma microRNAs that identify patients with glioblastoma., Matias A Bustos, Negin Rahimzadeh, Suyeon Ryu, Rebecca Gross, Linh T Tran, Victor M Renteria-Lopez, Romela Irene Ramos, Amy Eisenberg, Parvinder Hothi, Santosh Kesari, Garni Barkhoudarian, Yuki Takasumi, Charles Cobbs, Daniel F Kelly, and Dave Hoon

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Safety of Fingolimod in Patients with Multiple Sclerosis Switched from Natalizumab: Results from TRANSITION-A 2-Year, Multicenter, Observational, Cohort Study., Helmut Butzkueven, Paul S Giacomini, Stanley Cohan, Tjalf Ziemssen, Daniel Sienkiewicz, Ying Zhang, Yvonne Geissbühler, Diego Silva, Davorka Tomic, Harald Kropshofer, and Maria Trojano

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Local connectivity and synaptic dynamics in mouse and human neocortex., Luke Campagnola, Stephanie C Seeman, Thomas Chartrand, Lisa Kim, Alex Hoggarth, Clare Gamlin, Shinya Ito, Jessica Trinh, Pasha Davoudian, Cristina Radaelli, Mean-Hwan Kim, Travis Hage, Thomas Braun, Lauren Alfiler, Julia Andrade, Phillip Bohn, Rachel Dalley, Alex Henry, Sara Kebede, Mukora Alice, David Sandman, Grace Williams, Rachael Larsen, Corinne Teeter, Tanya L Daigle, Kyla Berry, Nadia Dotson, Rachel Enstrom, Melissa Gorham, Madie Hupp, Samuel Dingman Lee, Kiet Ngo, Philip R Nicovich, Lydia Potekhina, Shea Ransford, Amanda Gary, Jeff Goldy, Delissa McMillen, Trangthanh Pham, Michael Tieu, La'Akea Siverts, Miranda Walker, Colin Farrell, Martin Schroedter, Cliff Slaughterbeck, Charles Cobb, Richard Ellenbogen, Ryder P Gwinn, C Dirk Keene, Andrew L Ko, Jeffrey G Ojemann, Daniel L Silbergeld, Daniel Carey, Tamara Casper, Kirsten Crichton, Michael Clark, Nick Dee, Lauren Ellingwood, Jessica Gloe, Matthew Kroll, Josef Sulc, Herman Tung, Katherine Wadhwani, Krissy Brouner, Tom Egdorf, Michelle Maxwell, Medea McGraw, Christina Alice Pom, Augustin Ruiz, Jasmine Bomben, David Feng, Nika Hejazinia, Shu Shi, Aaron Szafer, Wayne Wakeman, John Phillips, Amy Bernard, Luke Esposito, Florence D D'Orazi, Susan Sunkin, Kimberly Smith, Bosiljka Tasic, Anton Arkhipov, Staci Sorensen, Ed Lein, Christof Koch, Gabe Murphy, Hongkui Zeng, and Tim Jarsky

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QLTI-22. IMPROVING BRAIN CANCER PATIENT ACCESS TO CLINICAL TRIALS ACROSS SEVEN COMMUNITY HOSPITALS, THE PROVIDENCE SOUTHERN CALIFORNIA CLINICAL RESEARCH NETWORK, Jose Carrillo, Naveed Wagle, Akanksha Sharma, Tiffany Juarez, Minhdan Nguyen, Judy D Truong, Timothy E. Byun, Brad Bott, Nanor Bozoyan, David J Park, and Santosh Kesari

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Deep Brain Stimulation Surgery Using a Mobile Intraoperative CT Scanner., Daniel Cavalcante, Muhammad S Ghauri, and Ryder P Gwinn

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Smart Consumer Wearables as Digital Diagnostic Tools: A Review., Shweta Chakrabarti, Nupur Biswas, Lawrence D Jones, Santosh Kesari, and Shashaanka Ashili

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Encephaloduroarteriosynangiosis Operative Technique and Intraoperative Anesthesia Management: Treatment From Both Sides of the Curtain., Julie L Chan, Miguel D Quintero-Consuegra, Robin M Babadjouni, Daniel Chang, Zachary R Barnard, Neil A Martin, Keren Ziv, Barbara M Van de Wiele, and Nestor R Gonzalez

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Into the Spine Metaverse: Reflections on a future, Jens R Chapman, Jeffrey C Wang, and Karsten Wiechert

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Physician satisfaction with telemedicine and in-person visits in otolaryngology., Janet S Choi, Matthew Lin, Soyun Park, Faiz Abdur-Rahman, James H Kim, and Courtney C J Voelker

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NCMP-07. CASE SERIES OF REGULARLY SCHEDULED MANNITOL INFUSIONS SHOWING WITH PROLONGED CLINICAL BENEFIT FOR MANAGEMENT OF CEREBRAL EDEMA IN GLIOMAS, Jared Chow, Jose Carrillo, Santosh Kesari, Akanksha Sharma, Minhdan Nguyen, Judy D Truong, and Naveed Wagle

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The Two Sides of Siponimod: Evidence for Brain and Immune Mechanisms in Multiple Sclerosis., Stanley Cohan, Ralph H B Benedict, Bruce A C Cree, John DeLuca, Le H Hua, and Jerold Chun

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Magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results., G Rees Cosgrove, Nir Lipsman, Andres M Lozano, Jin Woo Chang, Casey Halpern, Pejman Ghanouni, Howard Eisenberg, Paul Fishman, Takaomi Taira, Michael L Schwartz, Nathan McDannold, Michael Hayes, Susie Ro, Binit Shah, Ryder Gwinn, Veronica E Santini, Kullervo Hynynen, and W Jeff Elias

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Head-Mounted Augmented Reality in the Planning of Cerebrovascular Neurosurgical Procedures: A Single-Center Initial Experience., Matias Costa, Clifford Pierre, Juan Vivanco-Suarez, Matias Baldoncini, Zane Tymchak, Akshal Patel, and Stephen J Monteith

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Easing the Journey-an Updated Review of Palliative Care for the Patient with High-Grade Glioma., Rita C Crooms, Margaret O Johnson, Heather Leeper, Ambereen Mehta, Michelle McWhirter, and Akanksha Sharma

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PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains T, Egle Danileviciute, Ni Zeng, Christophe M Capelle, Nicole Paczia, Mark A Gillespie, Henry Kurniawan, Mohaned Benzarti, Myriam P Merz, Djalil Coowar, Sabrina Fritah, Daniela Maria Vogt Weisenhorn, Gemma Gomez Giro, Melanie Grusdat, Alexandre Baron, Coralie Guerin, Davide G Franchina, Cathy Léonard, Olivia Domingues, Sylvie Delhalle, Wolfgang Wurst, Jonathan D Turner, Jens Christian Schwamborn, Johannes Meiser, Rejko Krüger, Jeff Ranish, Dirk Brenner, Carole L Linster, Rudi Balling, Markus Ollert, and Feng Q Hefeng

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Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium., Gabriel A de Erausquin, Heather Snyder, Traolach S Brugha, Sudha Seshadri, Maria Carrillo, Rajesh Sagar, Yueqin Huang, Charles Newton, Carmela Tartaglia, Charlotte Teunissen, Krister Håkanson, Rufus Akinyemi, Kameshwar Prasad, Giovanni D'Avossa, Gabriela Gonzalez-Aleman, Akram Hosseini, George D Vavougios, Perminder Sachdev, John Bankart, Niels Peter Ole Mors, Richard Lipton, Mindy Katz, Peter T Fox, Mohammad Zia Katshu, M Sriram Iyengar, Galit Weinstein, Hamid R Sohrabi, Rachel Jenkins, Dan J Stein, Jacques Hugon, Venetsanos Mavreas, John Blangero, Carlos Cruchaga, Murali Krishna, Ovais Wadoo, Rodrigo Becerra, Igor Zwir, William T Longstreth, Golo Kroenenberg, Paul Edison, Elizabeta Mukaetova-Ladinska, Ekkehart Staufenberg, Mariana Figueredo-Aguiar, Agustín Yécora, Fabiana Vaca, Hernan P Zamponi, Vincenzina Lo Re, Abdul Majid, Jonas Sundarakumar, Hector M Gonzalez, Mirjam I Geerlings, Ingmar Skoog, Alberto Salmoiraghi, Filippo Martinelli Boneschi, Vibuthi N Patel, Juan M Santos, Guillermo Rivera Arroyo, Antonio Caballero Moreno, Pascal Felix, Carla Gallo, Hidenori Arai, Masahito Yamada, Takeshi Iwatsubo, Malveeka Sharma, Nandini Chakraborty, Catterina Ferreccio, Dickens Akena, Carol Brayne, Gladys Maestre, Sarah Williams Blangero, Luis I Brusco, Prabha Siddarth, Timothy M Hughes, Alfredo Ramírez Zuñiga, Joseph Kambeitz, Agustin Ruiz Laza, Norrina Allen, Stella Panos, David A Merrill, Agustín Ibáñez, Debby Tsuang, Nino Valishvili, Srishti Shrestha, Sophia Wang, Vasantha Padma, Kaarin J Anstey, Vijayalakshmi Ravindrdanath, Kaj Blennow, Paul Mullins, Emilia Łojek, Anand Pria, Thomas H Mosley, Penny Gowland, Timothy D Girard, Richard Bowtell, and Farhaan S Vahidy

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Clinically Important Difference: 4 Tips Toward a Better Understanding., Joseph R Dettori, Daniel C Norvell, and Jens R Chapman

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Machine learning in clinical diagnosis, prognostication, and management of acute traumatic spinal cord injury (SCI): A systematic review., Nicholas Dietz, Vaitheesh Jaganathan, Victoria Alkin, Jersey Mettille, Maxwell Boakye, and Doniel Drazin

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Patient satisfaction after multiple revision surgeries for adult spinal deformity., Wesley M Durand, Alan H Daniels, Kevin DiSilvestro, Renaud Lafage, Bassel G Diebo, Peter G Passias, Han Jo Kim, Themistocles Protopsaltis, Virginie Lafage, Justin S Smith, Christopher I Shaffrey, Munish C Gupta, Eric O Klineberg, Frank Schwab, Jeffrey L Gum, Gregory M Mundis, Robert K Eastlack, Khaled Kebaish, Alex Soroceanu, Richard A Hostin, Douglas Burton, Shay Bess, Christopher P Ames, Robert A Hart, D Kojo Hamilton, and International Spine Study Group

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Low-Density Pedicle Screw Constructs Are Associated With Lower Incidence of Proximal Junctional Failure in Adult Spinal Deformity Surgery., Wesley M Durand, Kevin J DiSilvestro, Han Jo Kim, David K Hamilton, Renaud Lafage, Peter G Passias, Themistocles S Protopsaltis, Virginie Lafage, Justin S Smith, Christopher I Shaffrey, Munish C Gupta, Eric O Klineberg, Frank J Schwab, Jeffrey L Gum, Gregory M Mundis, Robert K Eastlack, Khaled M Kebaish, Alexandra Soroceanu, Richard A Hostin, Douglas C Burton, Shay Bess, Christopher P Ames, Robert A Hart, Alan H Daniels, and International Spine Study Group

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The Emergence of Virtual Tumor Boards in Neuro-Oncology: Opportunities and Challenges., Chukwuyem Ekhator, Santosh Kesari, Ramya Tadipatri, Ekokobe Fonkem, and Jai Grewal

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Operative treatment outcomes for adult cervical deformity: a prospective multicenter assessment with mean 3-year follow-up., Elias Elias, Shay Bess, Breton G Line, Virginie Lafage, Renaud Lafage, Eric Klineberg, Han Jo Kim, Peter Passias, Zeina Nasser, Jeffrey L Gum, Khaled Kebaish, Robert Eastlack, Alan H Daniels, Gregory Mundis, Richard Hostin, Themistocles S Protopsaltis, Alex Soroceanu, D Kojo Hamilton, Michael P Kelly, Munish Gupta, Robert A Hart, Frank J Schwab, Douglas Burton, Christopher P Ames, Christopher I Shaffrey, and Justin S Smith

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Outcomes of operative treatment for adult spinal deformity: a prospective multicenter assessment with mean 4-year follow-up., Elias Elias, Shay Bess, Breton Line, Virginie Lafage, Renaud Lafage, Eric Klineberg, Han Jo Kim, Peter G Passias, Zeina Nasser, Jeffrey L Gum, Khal Kebaish, Robert Eastlack, Alan H Daniels, Gregory Mundis, Richard Hostin, Themistocles S Protopsaltis, Alex Soroceanu, D Kojo Hamilton, Michael P Kelly, Munish Gupta, Robert A Hart, Frank J Schwab, Douglas Burton, Christopher P Ames, Christopher I Shaffrey, and Justin S Smith

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Compassionate-use pocapavir and immunoglobulin therapy for treatment of rituximab-associated enterovirus meningoencephalitis., Samantha Epstein, Riddhi Thakkar, Kathryn T Fong, James Ng, David R Bearden, Nischay Mishra, Kiran T Thakur, and Claire S Riley

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How I treat brain metastases of melanoma., Z Eroglu, T O Topcu, H M Yu, and K A Margolin

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Erratum to 'Conversion From Knee Arthrodesis Back to Arthroplasty: A Particular Challenge in Combination With Fungal Periprosthetic Joint Infection' [Arthroplasty Today 6 (2020) 1038-1044]., Sven Frieler, Emre Yilmaz, Ryan Goodmanson, Yannik Hanusrichter, Thomas A Schildhauer, and Hinnerk Baecker

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Could bipolar depressed patients respond better to rTMS than unipolar depressed patients? A naturalistic, observational study., Larissa Gama-Chonlon, James M Scanlan, and Rebecca M Allen

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Differentiation of Subjective Cognitive Decline, Mild Cognitive Impairment, and Dementia Using qEEG/ERP-Based Cognitive Testing and Volumetric MRI in an Outpatient Specialty Memory Clinic., Aarthi S Ganapathi, Ryan M Glatt, Tess H Bookheimer, Emily S Popa, Morgan L Ingemanson, Casey J Richards, John F Hodes, Kyron P Pierce, Colby B Slyapich, Fatima Iqbal, Jenna Mattinson, Melanie G Lampa, Jaya M Gill, Ynez M Tongson, Claudia L Wong, Mihae Kim, Verna R Porter, Santosh Kesari, Somayeh Meysami, Karen J Miller, Jennifer E Bramen, David A Merrill, and Prabha Siddarth

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Functional status at 30 and 90 days after mild ischaemic stroke., Hannah Gardener, Leo A Romano, Eric E Smith, Iszet Campo-Bustillo, Yosef Khan, Sofie Tai, Nikesha Riley, Ralph L Sacco, Pooja Khatri, Heather M Alger, Brian Mac Grory, Deepak Gulati, Navdeep S Sangha, Karin E Olds, Curtis G Benesch, Adam G Kelly, Scott S Brehaut, Amit Kansara, Lee H Schwamm, and Jose G Romano

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Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists., Margaret Gatz, Wendy J Mack, Helena C Chui, E Meng Law, Giuseppe Barisano, M Linda Sutherland, James D Sutherland, Daniel Eid Rodriguez, Raul Quispe Gutierrez, Juan Copajira Adrian, Jesus Bani Cuata, Amy R Borenstein, Ellen E Walters, Andrei Irimia, Christopher J Rowan, L Samuel Wann, Adel H Allam, Randall C Thompson, Michael Miyamoto, David E Michalik, Daniel K Cummings, Edmond Seabright, Angela R Garcia, Paul L Hooper, Thomas S Kraft, Caleb E Finch, Gregory S Thomas, Jonathan Stieglitz, Benjamin C Trumble, Michael D Gurven, and Hillard Kaplan

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Video game rehabilitation for outpatient stroke (VIGoROUS): A multi-site randomized controlled trial of in-home, self-managed, upper-extremity therapy., Lynne V Gauthier, Deborah S Nichols-Larsen, Gitendra Uswatte, Nancy Strahl, Marie Simeo, Rachel Proffitt, Kristina Kelly, Roger Crawfis, Edward Taub, David Morris, Linda Pax Lowes, Victor Mark, and Alexandra Borstad

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A case of recurrent aneurysm resulting from dual antiplatelet plus anticoagulation after confirmed aneurysm closure following coil-assisted flow diversion., Thomas R Geisbush, Benjamin Pulli, Dylan N Wolman, Arjun V Pendharkar, and Nicholas A Telischak

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Qualitative Evaluation of Educational Content on Lateral Spine Surgery YouTube™ Demonstrations., Periklis Godolias, Kaarina Charlot, Angela Tran, Jonathan Plümer, Charlotte Cibura, Zeyad Daher, Marcel Dudda, Thomas A Schildhauer, Jens Chapman, and Rod J Oskouian

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Safety of Tumor Treating Fields (TTFields) therapy in pediatric patients with malignant brain tumors: Post-marketing surveillance data., Stewart Goldman, Ashley Margol, Eugene I Hwang, Kazuhiro Tanaka, Bogdana Suchorska, John R Crawford, and Santosh Kesari

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A double-blind, placebo-controlled, single-ascending-dose intravenous infusion study of rHIgM22 in subjects with multiple sclerosis immediately following a relapse., Benjamin M Greenberg, J D Bowen, Enrique Alvarez, Moses Rodriguez, Anthony O Caggiano, Arthur E Warrington, Ping Zhao, and Andrew Eisen

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Impact of neurofibromatosis type 1 in an adult community population., Timothy A Gregory, Peter Simon B Molina, Gregory D Phillips, and John W Henson

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Prospective biomarker study in newly diagnosed glioblastoma: Cyto-C clinical trial., Corinne E Griguer, Claudia R Oliva, Christopher S Coffey, Merit E Cudkowicz, Robin A Conwit, Anna L Gudjonsdottir, Dixie J Ecklund, Janel K Fedler, Tina M Neill-Hudson, Louis B Nabors, Melanie Benge, James R Hackney, Marianne Chase, Timothy P Leonard, Toral Patel, Howard Colman, Macarena de la Fuente, Rekha Chaudhary, Karen Marder, Teri Kreisl, Nimish Mohile, Milan G Chheda, Katharine McNeill, Priya Kumthekar, Aclan Dogan, Jan Drappatz, Vinay Puduvalli, Agnes Kowalska, Jerome J Graber, Elizabeth Gerstner, Stephen Clark, Michael Salacz, and James Markert

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Clinical Course of Two Patients with COVID-19 Respiratory Failure After Administration of the Anticancer Small Molecule, RRx-001., Terese Catherine Hammond, Raymond C Lee, Bryan Oronsky, Tony R Reid, Scott Caroen, Tiffany M Juarez, Jaya Gill, Annie Heng, and Santosh Kesari

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Is It Time to Create Training Pathways Allowing Earlier Subspecialization within the "House of Orthopaedics"?: AOA Critical Issues., Robert A Hart, Alan H Daniels, Kalpit Shah, A Annunziato Amendola, Christopher D Harner, L Lawrence Marsh, Keith Kenter, and Serena Hu

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Manifestations of Alzheimer's disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90., Laura M Heath, John C Earls, Andrew T Magis, Sergey A Kornilov, Jennifer C Lovejoy, Cory C Funk, Noa Rappaport, Benjamin A Logsdon, Lara M Mangravite, Brian W Kunkle, Eden R Martin, Adam C Naj, Nilüfer Ertekin-Taner, Todd E Golde, Leroy Hood, Nathan D Price, and Alzheimer’s Disease Genetics Consortium

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Clinical Experiences of 3-Dimensional Biportal Endoscopic Spine Surgery for Lumbar Degenerative Disease., Dong Hwa Heo, Ji Yeon Kim, Jeong-Yoon Park, Jin Sung Kim, Hyeun Sung Kim, Jeffrey R Roh, Choon Keun Park, and Hungtae Chung

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P4 Medicine & What 21st Century Medicine Should Be, Leroy Hood

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Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways., Kristen R Ibanez, Karen N McFarland, Jennifer Phillips, Mariet Allen, Christian B Lessard, Lillian Zobel, Elsa Gonzalez De La Cruz, Shivani Shah, Quan Vo, Xue Wang, Zachary Quicksall, Daniel Ryu, Cory C Funk, Nilüfer Ertekin-Taner, Stefan Prokop, Todd E Golde, and Paramita Chakrabarty

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Perceived utility of electrodiagnostic testing in critical illness myopathy and polyneuropathy: A survey of intensive care unit providers., Michael Isfort, Bryan J McVerry, Lori Shutter, Minji Kim, and David Lacomis

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Vasoplegia Following Complex Spine Surgery: Incidence and Risk., Basem Ishak, Juan N Pulido, Alexander von Glinski, Darius Ansari, Rod J Oskouian, and Jens R Chapman

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How to Give Less Bad News: A Guide to ALS Mimics - David Ivanick, MD, David Ivanick

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Cervical Spine Research Society-Cervical Stiffness Disability Index (CSRS-CSDI): Validation of a Novel Scoring System Quantifying the Effect of Postarthrodesis Cervical Stiffness on Patient Quality of Life., Andrew S Jack, Erik Hayman, Clifford Pierre, Wyatt L Ramey, Christopher D Witiw, Rod J Oskouian, Alan H Daniels, Andrew Pugley, Kojo Hamilton, Christopher P Ames, Jens R Chapman, Zoher Ghogawala, and Robert A Hart

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Agent-based computational modeling of glioblastoma predicts that stromal density is central to oncolytic virus efficacy., Adrianne L Jenner, Munisha Smalley, David Goldman, William F Goins, Charles Cobbs, Ralph B Puchalski, E Antonio Chiocca, Sean Lawler, Paul Macklin, Aaron Goldman, and Morgan Craig

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Health Equity: What the Neuroradiologist Needs to Know., J E Jordan and G B McGinty

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The validity, responsiveness, and score interpretation of the PROMISnq Physical Function - Multiple Sclerosis 15a short form in multiple sclerosis., Paul Kamudoni, Dagmar Amtmann, Jeffrey Johns, Karon F Cook, Rana Salem, Sam Salek, Jana Raab, Rod Middleton, P Repovic, Kevin N Alschuler, Gloria von Geldern, Annette Wundes, Amy Barrett, Oyebimpe Olayinka-Amao, and Christian Henke

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Treatment of nonsurgical refractory back pain with high-frequency spinal cord stimulation at 10 kHz: 12-month results of a pragmatic, multicenter, randomized controlled trial., Leonardo Kapural, Jessica Jameson, Curtis Johnson, Daniel Kloster, Aaron Calodney, Peter Kosek, Julie Pilitsis, Markus Bendel, Erika Petersen, Chengyuan Wu, Taissa Cherry, Shivanand P Lad, Cong Yu, Dawood Sayed, Johnathan Goree, Mark K Lyons, Andrew Sack, Diana Bruce, Frances Rubenstein, Rose Province-Azalde, David Caraway, and Naresh P Patel

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A Case Report: Splenium of the Corpus Callosum Infarct Associated With COVID-19., David A Karp, Gabriel Beaudoin, and Robert A Egan

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Tenecteplase implementation for ischemic stroke at a large tertiary medical center, Laura Kays, Bryce Winn, and Aimee Doyle

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Psychedelic-Assisted Therapy and Psychedelic Science: A Review and Perspective on Opportunities in Neurosurgery and Neuro-Oncology., Daniel F Kelly, Keith Heinzerling, Akanksha Sharma, Shanthi Gowrinathan, Karina Sergi, and Regin Jay Mallari

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A preliminary safety assessment of vertebral augmentation with 32 P brachytherapy bone cement, Joyce H Keyak, Mando L Eijansantos, Katherine G Rosecrance, Daniel Wong, Sayeh Feizi, Aleen L Meldosian, Pranav Peddinti, Clifford M Les, Harry B Skinner, and Varun Sehgal

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Clinical and Economic Profile of Homeless Young Adults with Stroke in the United States, 2002-2017., Safi U Khan, Siva H Yedlapati, Muhammad Zia Khan, Salim S Virani, Michael J Blaha, Garima Sharma, John E Jordan, Bita A Kash, Farhaan S Vahidy, Adeel Arshad, Elias Mossialos, and Khurram Nasir

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An atypical clinical course of a 71-year-old man with right arm weakness and ataxia., Pravin Khemani, Michael Elliott, and Todd Levine

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Quality of life after long-term biochemical control of acromegaly., Allison Kimball, Laura E Dichtel, Kevin C J Yuen, Whitney W Woodmansee, Melanie S Haines, Lisa B Nachtigall, Brooke Swearingen, Pamela Jones, Nicholas A Tritos, Julie L Sharpless, Ursula B Kaiser, Anu Gerweck, and Karen K Miller

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Minimally Invasive Techniques for Facial Rejuvenation Utilizing Polydioxanone Threads., Amit Kochhar, Parvesh Kumar, and Kian Karimi

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The timed 25-foot walk is a more sensitive outcome measure than the EDSS for PPMS trials: an analysis of the PROMISE clinical trial dataset., Marcus W Koch, Jop Mostert, P Repovic, J D Bowen, Jacynthe Comtois, Eva Strijbis, Bernard Uitdehaag, and Gary Cutter

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The nine hole peg test as an outcome measure in progressive MS trials., Marcus W Koch, P Repovic, Jop Mostert, J D Bowen, Jacynthe Comtois, Eva Strijbis, Bernard Uitdehaag, and Gary Cutter