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Submissions from 2022

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Evolution of the AO Spine Sacral and Pelvic Classification System: a systematic review., Barry Ting Sheen Kweh, Jin W Tee, F Cumhur Oner, Klaus J Schnake, Emiliano N Vialle, Frank Kanziora, Shanmuganathan Rajasekaran, Marcel Dvorak, Jens R Chapman, Lorin M Benneker, Gregory Schroeder, and Alexander R Vaccaro

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The AO spine upper cervical injury classification system: Do work setting or trauma center affiliation affect classification accuracy or reliability?, Mark J Lambrechts, Gregory D Schroeder, Brian A Karamian, Jose A Canseco, Richard Bransford, Cumhur Oner, Lorin M Benneker, Frank Kandziora, Rajasekaran Shanmuganathan, Rishi Kanna, Andrei F Joaquim, Jens R Chapman, Emiliano Vialle, Mohammad El-Sharkawi, Marcel Dvorak, Klaus Schnake, Christopher K Kepler, and Alexander R Vaccaro

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Global Validation of the AO Spine Upper Cervical Injury Classification: Geographic Region Affects Reliability and Reproducibility., Mark J Lambrechts, Gregory D Schroeder, Brian A Karamian, Jose A Canseco, Richard Bransford, Cumhur Oner, Lorin M Benneker, Frank Kandziora, Rajasekaran Shanmuganathan, Rishi Kanna, Andrei F Joaquim, Jens R Chapman, Emiliano Vialle, Mohammad El-Sharkawi, Marcel Dvorak, Klaus Schnake, Christopher K Kepler, Alexander R Vaccaro, and AO Spine Upper Cervical Injury Classification International Members

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Recent Advances in RNA Therapy and Its Carriers to Treat the Single-Gene Neurological Disorders., Ming-Jen Lee, Inyoul Lee, and Kai Wang

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Radiological Features in Type II Odontoid Fractures in Older Adults After High- and Low-Energy Trauma., Pavlina Lenga, Mohammed Issa, Lennart Krull, Karl Kiening, Andreas W Unterberg, Till Schneider, Rod J Oskouian, Jens R Chapman, and Basem Ishak

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Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma: A Phase 3 Prospective Externally Controlled Cohort Trial., Linda M Liau, Keyoumars Ashkan, Steven Brem, Jian L Campian, John E Trusheim, Fabio M Iwamoto, David D Tran, George Ansstas, Charles S Cobbs, Jason A Heth, Michael E Salacz, Stacy D'Andre, Robert D Aiken, Yaron A Moshel, Joo Y Nam, Clement P Pillainayagam, Stephanie A Wagner, Kevin A Walter, Rekha Chaudary, Samuel A Goldlust, Ian Y Lee, Daniela A Bota, Heinrich Elinzano, Jai Grewal, Kevin Lillehei, Tom Mikkelsen, Tobias Walbert, Steven Abram, Andrew J Brenner, Matthew G Ewend, Simon Khagi, Darren S Lovick, Jana Portnow, Lyndon Kim, William G Loudon, Nina L Martinez, Reid C Thompson, David E Avigan, Karen L Fink, Francois J Geoffroy, Pierre Giglio, Oleg Gligich, Dietmar Krex, Scott M Lindhorst, Jose Lutzky, Hans-Jörg Meisel, Minou Nadji-Ohl, Lhagva Sanchin, Andrew Sloan, Lynne P Taylor, Julian K Wu, Erin M Dunbar, Arnold B Etame, Santosh Kesari, David Mathieu, David E Piccioni, David S Baskin, Michel Lacroix, Sven-Axel May, Pamela Z New, Timothy J Pluard, Steven A Toms, Victor Tse, Scott Peak, John L Villano, James D Battiste, Paul J Mulholland, Michael L Pearlman, Kevin Petrecca, Michael Schulder, Robert M Prins, Alton L Boynton, and Marnix L Bosch

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Vagus nerve stimulation paired with rehabilitation for stroke: Implantation experience from the VNS-REHAB trial., Charles Y Liu, Jonathan Russin, David P Adelson, Alistair Jenkins, Omar Hilmi, Benjamin Brown, Bradley Lega, Tony Whitworth, Dev Bhattacharyya, Theodore H Schwartz, Vibhor Krishna, Ziv Williams, Christopher Uff, Jon Willie, Caitlin Hoffman, William A Vandergrift, Achal Singh Achrol, Rushna Ali, Peter Konrad, Joseph Edmonds, Daniel Kim, Pragnesh Bhatt, Brent W Tarver, David Pierce, Ravi Jain, Chester Burress, Reema Casavant, Cecília N Prudente, and Navzer D Engineer

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Treatment of Cushing's Disease with Pituitary-Targeting Seliciclib., Ning Ai Liu, Anat Ben-Shlomo, John D Carmichael, Christina Wang, Ronald S Swerdloff, Anthony P Heaney, Garni Barkhoudarian, Daniel Kelly, Mazen Noureddin, Lin Lu, Manish Desai, Yana Stolyarov, Kevin Yuen, Adam N Mamelak, James Mirocha, Mourad Tighiouart, and Shlomo Melmed

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A scalable and modular automated pipeline for stitching of large electron microscopy datasets., Gayathri Mahalingam, Russel Torres, Daniel Kapner, Eric T Trautman, Tim Fliss, Shamishtaa Seshamani, Eric Perlman, Rob Young, Samuel Kinn, JoAnn Buchanan, Marc M Takeno, Wenjing Yin, Daniel J Bumbarger, Ryder P Gwinn, Julie Nyhus, Ed Lein, Steven J Smith, R Clay Reid, Khaled A Khairy, Stephan Saalfeld, Forrest Collman, and Nuno Macarico da Costa

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Disruption of cellular iron homeostasis by, Nunziata Maio, Russell P Saneto, Richard Steet, Márcio A Sotero de Menezes, Cindy Skinner, and Tracey A Rouault

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Handgrip Strength Is Related to Hippocampal and Lobar Brain Volumes in a Cohort of Cognitively Impaired Older Adults with Confirmed Amyloid Burden., Somayeh Meysami, Cyrus A Raji, Ryan M. Glatt, Emily S Popa, Aarthi Ganapathi, Tess Bookheimer, Colby B Slyapich, Kyron P Pierce, Casey J Richards, Melanie G Lampa, Jaya Mini Gill, Molly Rapozo, John F Hodes, Ynez M Tongson, Claudia L Wong, Mihae Kim, Verna R Porter, Scott Kaiser, Stella Panos, Richelin V Dye, Karen J Miller, Susan Y Bookheimer, Neil A Martin, Santosh Kesari, Daniel F Kelly, Jennifer Bramen, Prabha Siddarth, and David A Merrill

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Predicting poor response to anti-coagulation therapy in cerebral venous thrombosis using a simple clinical-radiological score., Victor Montalvan, Gabriel Neves, Tulio Bueso, Riichi Ota, Saji Bushnaq, Thomas Windisch, and Saif Bushnaq

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Patient-Reported Outcomes and Predictive Factors following Focused Ultrasound Thalamotomy for Essential Tremor., Shayan Moosa, Andrew Craver, David Asuzu, Matthew Eames, Tony R Wang, and William Jeffrey Elias

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Cerebral Regional Tissue Oxygenation as Surrogate for Blood Loss in Nonhuman Primate Models of Shock., Clifford G Morgan, Leslie E Neidert, Emily N Hathaway, Michael M Tiller, Sylvain Cardin, and Jacob J Glaser

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Spontaneous Resolution of Aberrant Cerebellar Tonsil Movement in a Patient with Improving Chiari I Malformation., Ryan Morgan, Reagan A Collins, Taha Hassan, Roy Jacob, and Laszlo Nagy

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GPR17 Signaling Activation by CHBC Agonist Induced Cell Death via Modulation of MAPK Pathway in Glioblastoma., Phung Nguyen, Phuong Doan, Akshaya Murugesan, Thiyagarajan Ramesh, Tatu Rimpilainen, Nuno R Candeias, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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Anterior vs Posterior Approach in Multilevel Cervical Spondylotic Myelopathy: A Nationwide Propensity-Matched Analysis of Complications, Outcomes, and Narcotic Use., Ravi S Nunna, Syed Khalid, Ryan G Chiu, Rown Parola, Richard G Fessler, Owoicho Adogwa, and Ankit I Mehta

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Advancing Care and Outcomes for African American Patients With Multiple Sclerosis., Annette F Okai, Annette M Howard, Mitzi J Williams, Justine Brink, Chiayi Chen, tamela stuchiner, Elizabeth Baraban, Grace Jeong, and Stanley Cohan

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Dimethyl Fumarate Delays Multiple Sclerosis in Radiologically Isolated Syndrome., Darin T Okuda, Orhun Kantarci, Christine Lebrun-Frénay, Maria Pia Sormani, Christina J Azevedo, Francesca Bovis, Le H Hua, Lilyana Amezcua, Ellen M Mowry, Christophe Hotermans, Jason Mendoza, John S Walsh, Christian von Hehn, Wendy S Vargas, Stacy Donlon, Robert T Naismith, Annette Okai, Gabriel Pardo, Pavle Repovic, Olaf Stüve, Aksel Siva, and Daniel Pelletier

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Minimally invasive pericranial flap harvest through a supraorbital eyebrow craniotomy: Technical note in salvage skull base reconstruction., Madeline G Olson, Michael B Avery, Shauna Javaherian, Walavan Sivakumar, Daniel F Kelly, Chester Griffiths, and Garni Barkhoudarian

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Cerebral blood flow dynamics before, during, and after seizures from epilepsy and the periictal state., Kalarickal Oommen and Jonathan Kopel

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The Role of Parenteral Dantrolene in the Contemporary Management of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage: A Systematic Review., Michael Ortiz, Ravi S Nunna, Kaushik Ravipati, Angela Tran, Adnan I Qureshi, and Farhan Siddiq

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Effect of sodium phenylbutyrate/taurursodiol on tracheostomy/ventilation-free survival and hospitalisation in amyotrophic lateral sclerosis: long-term results from the CENTAUR trial., Sabrina Paganoni, Suzanne Hendrix, Samuel P Dickson, Newman Knowlton, James D Berry, Michael Elliott, Samuel Maiser, Chafic Karam, James B Caress, Margaret Ayo Owegi, Adam Quick, James Wymer, Stephen A Goutman, Daragh Heitzman, Terry D Heiman-Patterson, Carlayne Jackson, Colin Quinn, Jeffrey D Rothstein, Edward J Kasarskis, Jonathan Katz, Liberty Jenkins, Shafeeq S Ladha, Timothy M Miller, Stephen N Scelsa, Tuan H Vu, Christina Fournier, Kristin M Johnson, Andrea Swenson, Namita Goyal, Gary L Pattee, Suma Babu, Marianne Chase, Derek Dagostino, Meghan Hall, Gale Kittle, Mathew Eydinov, Joseph Ostrow, Lindsay Pothier, Rebecca Randall, Jeremy M Shefner, Alexander V Sherman, Eric Tustison, Prasha Vigneswaran, Hong Yu, Joshua Cohen, Justin Klee, Rudolph Tanzi, Walter Gilbert, Patrick Yeramian, and Merit Cudkowicz

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Molecular alterations associated with improved outcome in patients with glioblastoma treated with Tumor-Treating Fields., Manjari Pandey, Joanne Xiu, Sandeep Mittal, Jia Zeng, Michelle Saul, Santosh Kesari, Amir Azadi, Herbert Newton, Karina Deniz, Katherine Ladner, Ashley Sumrall, W Michael Korn, and Emil Lou

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Examination of the Economic Burden of Frailty in Patients With Adult Spinal Deformity Undergoing Surgical Intervention., Peter G Passias, Waleed Ahmad, Nicholas Kummer, Renaud Lafage, Virginie Lafage, Khaled Kebaish, Alan Daniels, Eric Klineberg, Alex Soroceanu, Jeffrey Gum, Breton Line, Robert A Hart, Douglas Burton, Robert Eastlack, Amit Jain, Justin S Smith, Christopher P Ames, Christopher Shaffrey, Frank Schwab, Richard Hostin, and Shay Bess

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Development of Risk Stratification Predictive Models for Cervical Deformity Surgery., Peter G Passias, Waleed Ahmad, Cheongeun Oh, Bailey Imbo, Sara Naessig, Katherine Pierce, Virginie Lafage, Renaud Lafage, D Kojo Hamilton, Themistocles S Protopsaltis, Eric O Klineberg, Jeffrey Gum, Andrew J Schoenfeld, Breton Line, Robert A Hart, Douglas C Burton, Shay Bess, Frank J Schwab, Justin S Smith, Christopher I Shaffrey, Christopher P Ames, and International Spine Study Group

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Changes in health-related quality of life measures associated with degree of proximal junctional kyphosis., Peter G Passias, Nicholas J Frangella, Tyler K Williamson, Kevin A Moattari, Renaud Lafage, Virginie Lafage, Justin S Smith, Khaled M Kebaish, Douglas C Burton, Robert A Hart, Christopher P Ames, Shay Bess, Christopher I Shaffrey, and Frank J Schwab

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Evolution of Adult Cervical Deformity Surgery Clinical and Radiographic Outcomes Based on a Multicenter Prospective Study: Are Behaviors and Outcomes Changing with Experience?, Peter G Passias, Oscar Krol, Kevin Moattari, Tyler K Williamson, Virginie Lafage, Renaud Lafage, Han Jo Kim, Alan Daniels, Bassel Diebo, Themistocles Protopsaltis, Gregory Mundis, Khaled Kebaish, Alexandra Soroceanu, Justin Scheer, D Kojo Hamilton, Eric Klineberg, Andrew J Schoenfeld, Shaleen Vira, Breton Line, Robert Hart, Douglas C Burton, Frank A Schwab, Christopher Shaffrey, Shay Bess, Justin S Smith, Christopher P Ames, and International Spine Study Group

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The Benefit of Addressing Malalignment In Revision Surgery for Proximal Junctional Kyphosis Following ASD Surgery., Peter G Passias, Oscar Krol, Tyler K Williamson, Virginie Lafage, Renaud Lafage, Justin S Smith, Breton Line, Shaleen Vira, Shaina Lipa, Alan Daniels, Bassel Diebo, Andrew Schoenfeld, Jeffrey Gum, Khaled Kebaish, Paul Park, Gregory Mundis, Richard Hostin, Manush Gupta, Robert Eastlack, Neel Anand, Christopher Ames, Robert A Hart, Douglas Burton, Frank J Schwab, Christopher Shaffrey, Eric Klineberg, and Shay Bess

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Improvements in Outcomes and Cost after Adult Spinal Deformity Corrective Surgery between 2008 and 2019., Peter G Passias, Nicholas Kummer, Bailey Imbo, Virginie Lafage, Renaud Lafage, Justin S Smith, Breton Line, Shaleen Vira, Andrew J Schoenfeld, Jeffrey L Gum, Alan H Daniels, Eric O Klineberg, Munish C Gupta, Khaled M Kebaish, Amit Jain, Brian J Neuman, Dean Chou, Leah Y Carreon, Robert A Hart, Douglas C Burton, Christopher I Shaffrey, Christopher P Ames, Frank J Schwab, Richard A Hostin, Shay Bess, and International Spine Study Group

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The Additional Economic Burden of Frailty in Adult Cervical Deformity Patients Undergoing Surgical Intervention., Peter G Passias, Nicholas Kummer, Tyler K Williamson, Waleed Ahmad, Jordan Lebovic, Virginie Lafage, Renaud Lafage, Han Jo Kim, Alan H Daniels, Jeffrey L Gum, Bassel G Diebo, Munish C Gupta, Alexandra Soroceanu, Justin K Scheer, D Kojo Hamilton, Eric O Klineberg, Breton Line, Andrew J Schoenfeld, Robert A Hart, Douglas C Burton, Robert K Eastlack, Gregory M Mundis, Praveen Mummaneni, Dean Chou, Paul Park, Frank J Schwab, Christopher I Shaffrey, Shay Bess, Christopher P Ames, Justin S Smith, and International Spine Study Group

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Highest Achievable Outcomes for Patients Undergoing Cervical Deformity Corrective Surgery by Frailty., Peter G Passias, Nicholas Kummer, Tyler K Williamson, Kevin Moattari, Virginie Lafage, Renaud Lafage, Han Jo Kim, Alan H Daniels, Jeffrey L Gum, Bassel G Diebo, Themistocles S Protopsaltis, Gregory M Mundis, Robert K Eastlack, Alexandra Soroceanu, Justin K Scheer, D Kojo Hamilton, Eric O Klineberg, Breton Line, Robert A Hart, Douglas C Burton, Praveen Mummaneni, Dean Chou, Paul Park, Frank J Schwab, Christopher I Shaffrey, Shay Bess, Christopher P Ames, and Justin S Smith

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Establishment of an Individualized Distal Junctional Kyphosis Risk Index following the Surgical Treatment of Adult Cervical Deformities., Peter G Passias, Sara Naessig, Navraj Sagoo, Lara Passfall, Waleed Ahmad, Renaud Lafage, Virginie Lafage, Shaleen Vira, Andrew J Schoenfeld, Cheongeun Oh, Themistocles Protopsaltis, Han Jo Kim, Alan Daniels, Robert A Hart, Douglas Burton, Eric O Klineberg, Shay Bess, Frank Schwab, Christopher Shaffrey, Christopher P Ames, Justin S Smith, and International Spine Study Group

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Pelvic Non-Response Following Treatment of Adult Spinal Deformity: Influence of Realignment Strategies on Occurrence., Peter G Passias, Katherine E Pierce, Tyler K Williamson, Oscar Krol, Renaud Lafage, Virginie Lafage, Andrew J Schoenfeld, Themistocles S Protopsaltis, Shaleen Vira, Breton Line, Bassel G Diebo, Christopher P Ames, Han Jo Kim, Justin S Smith, Dean Chou, Alan H Daniels, Jeffrey L Gum, Christopher I Shaffrey, Douglas C Burton, Michael P Kelly, Eric O Klineberg, Robert A Hart, Shay Bess, Frank J Schwab, and Munish C Gupta

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Predictive Analytics for Determining Extended Operative Time in Corrective Adult Spinal Deformity Surgery., Peter G Passias, Gregory W Poorman, Dennis Vasquez-Montes, Nicholas Kummer, Gregory Mundis, Neel Anand, Samantha R Horn, Frank A Segreto, Lara Passfall, Oscar Krol, Bassel Diebo, Doug Burton, Aaron Buckland, Michael Gerling, Alex Soroceanu, Robert Eastlack, D Kojo Hamilton, Robert A Hart, Frank Schwab, Virginie Lafage, Christopher Shaffrey, Daniel Sciubba, Shay Bess, Christopher Ames, Eric Klineberg, and International Spine Study Group

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Is frailty responsive to surgical correction of adult spinal deformity? An investigation of sagittal re-alignment and frailty component drivers of postoperative frailty status., Peter G Passias, Frank A Segreto, Kevin A Moattari, Renaud Lafage, Justin S Smith, Breton G Line, Robert K Eastlack, Douglas C Burton, Robert A Hart, Shay Bess, Christopher I Shaffrey, Christopher P Ames, Virginie Lafage, and International Spine Study Group

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Posterior Ischemic Optic Neuropathy Because of Hematologic Malignancy., Ankush U Patel, Uresh S Patel, and Eugene F May

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Clinical and radiographic benefits of skipping C7 instrumentation in posterior cervicothoracic fusion: a retrospective analysis., Saavan Patel, Morteza Sadeh, Matthew K Tobin, Nauman S Chaudhry, C Gragnaniello, and Sergey Neckrysh

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MTAP loss: a possible therapeutic approach for glioblastoma., C Pawan K Patro, Nupur Biswas, Sandeep C Pingle, Feng Lin, Misa Anekoji, Lawrence D Jones, Santosh Kesari, Feng Wang, and Shashaanka Ashili

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Normothermic Regional Perfusion Requires Careful Ethical Analysis Before Adoption Into Donation After Circulatory Determination of Death., Harry Peled, Sajen Mathews, David Rhodes, and James L Bernat

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Correction: Phase 1 First-in-Human Dose Escalation and Dose Expansion Study of KLS-1 (64Zinc Aspartate) in Patients With Cancer and Neurodegenerative Diseases., Jesus A Perez, Javier J Lopez, Claudia C Torres Badillo, Jaya Gill, Santosh Kesari, Peter Novak, Max Temnikov, Roman Byshovets, and Oleg Bychkov

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Phase 1 First-in-Human Dose Escalation and Dose Expansion Study of KLS-1 (64Zinc Aspartate) in Patients With Cancer and Neurodegenerative Diseases., Jesus A Perez, Javier J Lopez, Claudia C Torres Badillo, Jaya Gill, Santosh Kesari, Peter Novak, Max Temnikov, Roman Byshovets, and Oleg Bychkov

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Durability of High-Frequency 10-kHz Spinal Cord Stimulation for Patients With Painful Diabetic Neuropathy Refractory to Conventional Treatments: 12-Month Results From a Randomized Controlled Trial., Erika A Petersen, Thomas G Stauss, James A Scowcroft, Elizabeth S Brooks, Judith L White, Shawn M Sills, Kasra Amirdelfan, Maged N Guirguis, Jijun Xu, Cong Yu, Ali Nairizi, Denis G Patterson, Kostandinos C Tsoulfas, Michael J Creamer, Vincent Galan, Richard H Bundschu, Neel D Mehta, Dawood Sayed, Shivanand P Lad, David J DiBenedetto, Khalid A Sethi, Johnathan H Goree, Matthew T Bennett, Nathan J Harrison, Atef F Israel, Paul Chang, Paul W Wu, Charles E Argoff, Christian E Nasr, Rod S Taylor, David L Caraway, and Nagy A Mekhail

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High-Frequency 10-kHz Spinal Cord Stimulation Improves Health-Related Quality of Life in Patients With Refractory Painful Diabetic Neuropathy: 12-Month Results From a Randomized Controlled Trial., Erika A Petersen, Thomas G Stauss, James A Scowcroft, Elizabeth S Brooks, Judith L White, Shawn M Sills, Kasra Amirdelfan, Maged N Guirguis, Jijun Xu, Cong Yu, Ali Nairizi, Denis G Patterson, Kostandinos C Tsoulfas, Michael J Creamer, Vincent Galan, Richard H Bundschu, Neel D Mehta, Dawood Sayed, Shivanand P Lad, David J DiBenedetto, Khalid A Sethi, Johnathan H Goree, Matthew T Bennett, Nathan J Harrison, Atef F Israel, Paul Chang, Paul W Wu, Charles E Argoff, Christian E Nasr, Rod S Taylor, David L Caraway, and Nagy A Mekhail

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ALSUntangled #66: antimycobacterial antibiotics., Ellen S Pierce, Paul Barkhaus, Morgan Beauchamp, Mark Bromberg, Gregory T Carter, Jill Goslinga, David Greeley, Sky Kihuwa-Mani, Gleb Levitsky, Isaac Lund, Christopher McDermott, Gary Pattee, Kaitlyn Pierce, Meraida Polak, Dylan Ratner, Paul Wicks, and Richard Bedlack

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An Assessment of the Safety of Surgery and Hardware Placement in de-novo Spinal Infections. A Systematic Review and Meta-Analysis of the Literature., Jonathan Pluemer, Yevgeniy Freyvert, Nathan Pratt, Jerry E Robinson, Jared A Cooke, Zachary L Tataryn, Periklis Godolias, Zeyad A Daher, Rod J Oskouian, and Jens R Chapman

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Mutations of FH and IDH may induce gliomagenesis by similar mechanisms., Aditya Raghunathan, Cristiane M Ida, Erick M Westbroek, Sounak Gupta, Robert B Jenkins, Caterina Giannini, and Kenneth D Aldape

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The Coaching for Cognition in Alzheimer's (COCOA) trial: Study design., Jared C Roach, Junko Hara, Deborah Fridman, Jennifer C Lovejoy, Kathleen Jade, Laura Heim, Rachel Romansik, Adrienne Swietlikowski, Sheree Phillips, Molly Rapozo, Maria A Shay, Dan Fischer, Cory C Funk, Lauren Dill, Michael Brant-Zawadzki, Leroy Hood, and William R Shankle

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Dense data enables 21th century clinical trials., Jared C Roach, John F Hodes, Cory C Funk, William R Shankle, David A Merrill, Leroy Hood, and Jennifer Bramen

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Evidence of neuroinflammation and immunotherapy responsiveness in individuals with down syndrome regression disorder., Jonathan D Santoro, Rebecca Partridge, Runi Tanna, Dania Pagarkar, Mellad Khoshnood, Mustafa Rehmani, Ryan M Kammeyer, Grace Y Gombolay, Kristen Fisher, Allison Conravey, Jane El-Dahr, Alison Christy, Lina Patel, Melanie A Manning, Heather Van Mater, Michael S Rafii, and Eileen A Quinn

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Assessment and Diagnosis of Down Syndrome Regression Disorder: International Expert Consensus., Jonathan D Santoro, Lina Patel, Ryan Kammeyer, Robyn A Filipink, Grace Y Gombolay, Kathleen M Cardinale, Diego Real de Asua, Shahid Zaman, Stephanie L Santoro, Sammer M Marzouk, Mellad Khoshnood, Benjamin N Vogel, Runi Tanna, Dania Pagarkar, Sofia Dhanani, Maria Del Carmen Ortega, Rebecca Partridge, Maria A Stanley, Jessica S Sanders, Alison Christy, Elise M Sannar, Ruth Brown, Andrew A McCormick, Heather Van Mater, Cathy Franklin, Gordon Worley, Eileen A Quinn, George T Capone, Brian Chicoine, Brian G Skotko, and Michael S Rafii

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Best Practice Guidelines for Assessment and Management of Osteoporosis in Adult Patients Undergoing Elective Spinal Reconstruction., Zeeshan M Sardar, Josephine R Coury, Meghan Cerpa, Christopher J DeWald, Christopher P Ames, Christopher Shuhart, Colleen Watkins, David W Polly, Douglas R Dirschl, Eric O Klineberg, John R Dimar, Kelly D Krohn, Khaled M Kebaish, Laura L Tosi, Michael Kelly, Nancy E Lane, Neil C Binkley, Sigurd H Berven, Nathan J Lee, Paul Anderson, Peter D Angevine, Ronald A Lehman, and Lawrence G Lenke

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Detection of perillyl alcohol and its metabolite perillic acid in postsurgical glioblastoma tissue after intranasal administration of NEO100: illustrative case., Axel H Schönthal, Steve Swenson, Phillip A Bonney, Naveed Wagle, Vincent F Simmon, Anna J Mathew, Kyle M Hurth, and Thomas C Chen

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The impact of mentoring on early career faculty: Assessment of a virtual mentoring program., Akanksha Sharma, Heather Leeper, Soo Bang, Donna Molaie, and Alyx B. Porter

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Advances in the Diagnosis and Treatment of Leptomeningeal Disease., Akanksha Sharma, Justin T Low, and Priya Kumthekar

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Trends and Long-term Health Care Utilization of Computer-assisted Neuronavigation in Spine Fusions: An Exact Matched Analysis of National Administrative Database., Mayur Sharma, Syed Abdullah Uddin, George Hanna, Beatrice Ugiliweneza, Terrence T Kim, J Patrick Johnson, Maxwell Boakye, and Doniel Drazin

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Podcast on B Cell-Targeting Therapies and Other Multiple Sclerosis Concerns During COVID-19., Robert K Shin, P Repovic, and Joseph R Berger

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The Committee on Advanced Subspecialty Training-accredited postgraduate neurosurgery fellowship application experience: a national survey., Nathan A Shlobin, Christopher S Graffeo, David L Dornbos, Debraj Mukherjee, Walavan Sivakumar, and Jeremiah Johnson

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Transient Opening of the Blood-Brain Barrier by Vasoactive Peptides to Increase CNS Drug Delivery: Reality Versus Wishful Thinking?, Matthew A Smith-Cohn, Nicholas B Burley, and Stuart A Grossman

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The MSIS-29 and SF-36 as outcomes in secondary progressive MS trials., Eva Mm Strijbis, Pavle Repovic, Jop Mostert, James D Bowen, Bernard Mj Uitdehaag, Gary Cutter, and Marcus W Koch

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Critical appraisal of minimally invasive keyhole surgery for intracranial meningioma in a large case series., Jai Deep Thakur, Regin Jay Mallari, Alex Corlin, Samantha Yawitz, Amy Eisenberg, John Rhee, Walavan Sivakumar, Howard Krauss, Neil A Martin, Chester Griffiths, Garni Barkhoudarian, and Daniel F Kelly

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Acute Spinal Cord Injury: Using Evidence in the Critical Care Unit for Optimal Outcomes, Rosemary Timmerman

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Prevalence and Outcomes of Bicuspid Aortic Valve in Patients With Aneurysmal Sub-Arachnoid Hemorrhage: A Prospective Neurology Registry Report., Saarwaani Vallabhajosyula, Li-Tan Yang, Sarah C Thomas, Joseph J Maleszewski, Amber N Boler, Prabin Thapa, Maurice Enriquez-Sarano, Alejandro A Rabinstein, and Hector I Michelena

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Clinical application of the "sellar barrier's concept" for predicting intraoperative CSF leak in endoscopic endonasal surgery for pituitary adenomas with a machine learning analysis., J F Villalonga, D Solari, R Cuocolo, V De Lucia, L Ugga, C Gragnaniello, J I Pailler, A Cervio, A Campero, L M Cavallo, and P Cappabianca

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CTNI-51. FEASIBILITY AND SAFETY OF NEUROSURGICAL RESECTION AND INTRA-OPERATIVE RADIATION THERAPY USING THE XOFT AXXENT ELECTRONIC BRACHYTHERAPY SYSTEM AND BEVACIZUMAB IN RECURRENT GLIOBLASTOMA, Naveed Wagle, Garni Barkhoudarian, Lisa Chaiken, Robert Wollman, Akanksha Sharma, Jose Carrillo, Minhdan Nguyen, Judy D Truong, Jared Chow, Emma Chacon, and Santosh Kesari

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Another Year Has Come to an End., Jeffrey C Wang, Jens R Chapman, and Karsten Wiechert

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"Special Collections: Creating Order in the Chaos"., Jeffrey C Wang, Karsten Wiechert, and Jens R Chapman

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Germline biomarkers predict toxicity to anti-PD1/PDL1 checkpoint therapy., Joanne Weidhaas, Nicholas Marco, Aaron W Scheffler, Anusha Kalbasi, Kirk Wilenius, Emily Rietdorf, Jaya Mini Gill, Mara Heilig, Caroline Desler, Robert K Chin, Tania Kaprealian, Susan McCloskey, Ann Raldow, Naga P Raja, Santosh Kesari, Jose Carrillo, Alexandra Drakaki, Mark Scholz, and Donatello Telesca

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Predicting Long-term Disability in Multiple Sclerosis: A Narrative Review of Current Evidence and Future Directions., Bianca Weinstock-Guttman, Maria Pia Sormani, and P Repovic

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Spine Apps: Creating Order in the Chaos?, Karsten Wiechert, Jens R Chapman, and Jeffrey C Wang

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Spine Surgery has Always had Multi-Specialty Roots: Time for Nonoperative Spine Care to Catch up and Join the Club., Karsten Wiechert, Jens R Chapman, and Jeffrey C Wang

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Efficacy and Safety Outcomes with Diroximel Fumarate After Switching from Prior Therapies or Continuing on DRF: Results from the Phase 3 EVOLVE-MS-1 Study., Sibyl Wray, Florian Then Bergh, Annette Wundes, Douglas L Arnold, Jelena Drulovic, Elzbieta Jasinska, J D Bowen, Donald Negroski, Robert T Naismith, Samuel F Hunter, Mark Gudesblatt, Hailu Chen, Jennifer Lyons, Sai L Shankar, Shivani Kapadia, Jason P Mendoza, and Barry A Singer

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The role of BAG3 in dilated cardiomyopathy and its association with Charcot-Marie-Tooth disease type 2., Nitya Yerabandi, Valentina L Kouznetsova, Santosh Kesari, and Igor F Tsigelny

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The landscape of brain tumor mimics in neuro-oncology practice., Lalanthica V Yogendran, Tuba Kalelioglu, Joseph H Donahue, Haroon Ahmad, Kester A Phillips, Nicole M Calautti, Maria-Beatriz Lopes, Ashok R Asthagiri, Benjamin Purow, David Schiff, Sohil H Patel, and Camilo E Fadul

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An Evaluation of Oral Anticoagulation Initiation after Ischemic Stroke in Patients with Atrial fibrillation/Atrial Flutter at Hospital Discharge, Jessica Zhao, Meri Slavica, Vanessa Jenkins, and Natalie Swearingen

Submissions from 2021

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Quality of life in individuals newly diagnosed with multiple sclerosis or clinically isolated syndrome., Kevin N Alschuler, Daniel Whibley, Anna L Kratz, Mark P Jensen, Annette Wundes, Gloria von Geldern, Peiqing Qian, Charles H Bombardier, and Dawn M Ehde

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Predictors of Extended Hospitalization and Early Reoperation After Elective Lumbar Disc Arthroplasty., Darius Ansari, Justin T DesLaurier, Saavan Patel, Jens R Chapman, and Rod J Oskouian

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Three-stage revision arthroplasty for the treatment of fungal periprosthetic joint infection: outcome analysis of a novel treatment algorithm : a prospective study., Hinnerk Baecker, Sven Frieler, Jan Geßmann, Stephan Pauly, Thomas A Schildhauer, and Yannik Hanusrichter

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Systems modeling of metabolic dysregulation in neurodegenerative diseases., Priyanka Baloni, Cory C Funk, Ben Readhead, and Nathan D Price

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Evaluation of FKBP5 as a cortisol activity biomarker in patients with ACTH-dependent Cushing syndrome., Irina Bancos, Betul Ayse Hatipoglu, Kevin C J Yuen, Lakshmi Chandramohan, Sandeep Chaudhari, and Andreas G Moraitis

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Creating Clinically Relevant Aneurysm Sizes in the Rabbit Surgical Elastase Model., Brooke L Belanger, Michael B Avery, Arindom Sen, Muneer Eesa, and Alim P Mitha

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Human neocortical expansion involves glutamatergic neuron diversification., Jim Berg, Staci A Sorensen, Jonathan T Ting, Jeremy A Miller, Thomas Chartrand, Anatoly Buchin, Trygve E Bakken, Agata Budzillo, Nick Dee, Song-Lin Ding, Nathan W Gouwens, Rebecca D Hodge, Brian Kalmbach, Changkyu Lee, Brian R Lee, Lauren Alfiler, Katherine Baker, Eliza Barkan, Allison Beller, Kyla Berry, Darren Bertagnolli, Kris Bickley, Jasmine Bomben, Thomas Braun, Krissy Brouner, Tamara Casper, Peter Chong, Kirsten Crichton, Rachel Dalley, Rebecca de Frates, Tsega Desta, Samuel Dingman Lee, Florence D'Orazi, Nadezhda Dotson, Tom Egdorf, Rachel Enstrom, Colin Farrell, David Feng, Olivia Fong, Szabina Furdan, Anna A Galakhova, Clare Gamlin, Amanda Gary, Alexandra Glandon, Jeff Goldy, Melissa Gorham, Natalia A Goriounova, Sergey Gratiy, Lucas Graybuck, Hong Gu, Kristen Hadley, Nathan Hansen, Tim S Heistek, Alex M Henry, Djai B Heyer, DiJon Hill, Chris Hill, Madie Hupp, Tim Jarsky, Sara Kebede, Lisa Keene, Lisa Kim, Mean-Hwan Kim, Matthew Kroll, Caitlin Latimer, Boaz P Levi, Katherine E Link, Matthew Mallory, Rusty Mann, Desiree Marshall, Michelle Maxwell, Medea McGraw, Delissa McMillen, Erica Melief, Eline J Mertens, Leona Mezei, Norbert Mihut, Stephanie Mok, Gabor Molnar, Alice Mukora, Lindsay Ng, Kiet Ngo, Philip R Nicovich, Julie Nyhus, Gaspar Olah, Aaron Oldre, Victoria Omstead, Attila Ozsvar, Daniel Park, Hanchuan Peng, Trangthanh Pham, Christina A Pom, Lydia Potekhina, Ramkumar Rajanbabu, Shea Ransford, David Reid, Christine Rimorin, Augustin Ruiz, David Sandman, Josef Sulc, Susan M Sunkin, Aaron Szafer, Viktor Szemenyei, Elliot R Thomsen, Michael Tieu, Amy Torkelson, Jessica Trinh, Herman Tung, Wayne Wakeman, Femke Waleboer, Katelyn Ward, René Wilbers, Grace Williams, Zizhen Yao, Jae-Guen Yoon, Costas Anastassiou, Anton Arkhipov, Pal Barzo, Amy Bernard, Charles Cobbs, Philip C de Witt Hamer, Richard G Ellenbogen, Luke Esposito, Manuel Ferreira, Ryder P Gwinn, Michael J Hawrylycz, Patrick R Hof, Sander Idema, Allan R Jones, C Dirk Keene, Andrew L Ko, Gabe J Murphy, Lydia Ng, Jeffrey G Ojemann, Anoop P Patel, John W Phillips, Daniel L Silbergeld, Kimberly Smith, Bosiljka Tasic, Rafael Yuste, Idan Segev, Christiaan P J de Kock, Huibert D Mansvelder, Gabor Tamas, Hongkui Zeng, Christof Koch, and Ed S Lein

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Safety evaluation of shorter infusion for ocrelizumab in a substudy of the Phase IIIb CHORDS trial., Robert A Bermel, Emmanuelle Waubant, Gabriel Pardo, Ann Bass, P Repovic, Scott Newsome, John W Lindsey, Deidre Kile, Ashish Pradhan, Bruno Musch, and Aram Zabeti

Extent of Hippocampal Ablation Influences Seizure Outcomes Following Laser Amygdalohippocampotomy Poster Presented at the American Association of Neurology, online, A Bhatt, A Lesko, A Kansara, E Baraban, and See full citation in comments

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COVID-19 in Patients With Pre-existing Neurologic Disorders: Clinical Course and Outcomes (2608), Svetlana Blitshteyn, Akanksha Sharma, and See full list of authors in comments

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Exercise training and cognition in multiple sclerosis: The GET Smart trial protocol., Charles H Bombardier, Robert W Motl, Ralph H B Benedict, Nancy Temkin, P Qian, Katharine Alexander, Annabeth Evans, Andrea Thomas, Kristin Toms, Cathea M Carey, and George H Kraft

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DNA Damage Response in Glioblastoma: Mechanism for Treatment Resistance and Emerging Therapeutic Strategies., Alipi Bonm and Santosh Kesari

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The anatomy of the peridural membrane of the human spine., Hemmo A Bosscher, Petar N Grozdanov, Irfan I Warraich, Clinton C MacDonald, and Miles R Day

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The peridural membrane of the spine has characteristics of synovium., Hemmo A Bosscher, Petar N Grozdanov, Irfan I Warraich, Clinton C MacDonald, and Miles R Day

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Marizomib alone or in combination with bevacizumab in patients with recurrent glioblastoma: Phase I/II clinical trial data., Daniela A Bota, Warren Mason, Santosh Kesari, Rajiv Magge, Benjamin Winograd, Ileana Elias, Steven D Reich, Nancy Levin, Mohit Trikha, and Annick Desjardins

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Structural and Functional Imaging in Glioma Management., Bledi C Brahimaj, Ryan B Kochanski, John J Pearce, Melike Guryildirim, Carter S Gerard, Mehmet Kocak, Sepehr Sani, and Richard W Byrne

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Examining Delayed Recall in Cochlear Implant Users Using the Montreal Cognitive Assessment, California Verbal Learning Test, Third Edition, and Item Specific Deficit Approach: Preliminary Results., Nadav Brumer, Elizabeth Elkins, Jennifer Parada, Jake Hillyer, and Alexandra Parbery-Clark

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Multicenter assessment of outcomes and complications associated with transforaminal versus anterior lumbar interbody fusion for fractional curve correction., Thomas J Buell, Christopher I Shaffrey, Shay Bess, Han Jo Kim, Eric O Klineberg, Virginie Lafage, Renaud Lafage, Themistocles S Protopsaltis, Peter G Passias, Gregory M Mundis, Robert K Eastlack, Vedat Deviren, Michael P Kelly, Alan H Daniels, Jeffrey L Gum, Alex Soroceanu, D Kojo Hamilton, Munish C Gupta, Douglas C Burton, Richard A Hostin, Khaled M Kebaish, Robert A Hart, Frank J Schwab, Christopher P Ames, Justin S Smith, and International Spine Study Group

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Global coronal decompensation and adult spinal deformity surgery: comparison of upper-thoracic versus lower-thoracic proximal fixation for long fusions., Thomas J Buell, Christopher I Shaffrey, Han Jo Kim, Eric O Klineberg, Virginie Lafage, Renaud Lafage, Themistocles S Protopsaltis, Peter G Passias, Gregory M Mundis, Robert K Eastlack, Vedat Deviren, Michael P Kelly, Alan H Daniels, Jeffrey L Gum, Alex Soroceanu, D Kojo Hamilton, Munish C Gupta, Douglas C Burton, Richard A Hostin, Khaled M Kebaish, Robert A Hart, Frank J Schwab, Shay Bess, Christopher P Ames, Justin S Smith, and International Spine Study Group (ISSG)

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Operative Treatment of Severe Scoliosis in Symptomatic Adults: Multicenter Assessment of Outcomes and Complications With Minimum 2-Year Follow-up., Thomas J Buell, Justin S Smith, Christopher I Shaffrey, Han Jo Kim, Eric O Klineberg, Virginie Lafage, Renaud Lafage, Themistocles S Protopsaltis, Peter G Passias, Gregory M Mundis, Robert K Eastlack, Vedat Deviren, Michael P Kelly, Alan H Daniels, Jeff L Gum, Alex Soroceanu, D Kojo Hamilton, Munish C Gupta, Douglas C Burton, Richard A Hostin, Khaled M Kebaish, Robert A Hart, Frank J Schwab, Shay Bess, and Christopher P Ames

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Theoretical impact of the AT(N) framework on dementia using a community autopsy sample., Bridget Teevan Burke, Caitlin Latimer, C Dirk Keene, Joshua A Sonnen, Wayne McCormick, J D Bowen, Susan M McCurry, Eric B Larson, and Paul K Crane

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Essentialism and Spine Surgery in Times of Pandemia: With Reflections on the Contributions of the Late Friedrich P. Magerl., Jens R Chapman, Jeffrey C Wang, and Karsten Wiechert

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Claiming the Scientific High Ground: New Frontiers and Ancient Wisdoms in the Age of COVID-19., Jens R Chapman, Karsten Wiechert, and Jeffrey C Wang

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Gamified Dual-Task Training for Individuals with Parkinson Disease: An Exploratory Study on Feasibility, Safety, and Efficacy., Lee-Kuen Chua, Yu-Chen Chung, David Bellard, Laura Swan, Nicole Gobreial, Amanda Romano, Ryan M. Glatt, Michael A Bonaguidi, Darrin J Lee, Yi Jin, Charles Y Liu, and Beth E Fisher

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SNO 2020 diversity survey: defining demographics, racial biases, career success metrics and a path forward for the field of neuro-oncology., Ugonma N Chukwueke, Elizabeth Vera, Alvina Acquaye, Shawn L Hervey-Jumper, Yazmin Odia, Laura J Klesse, Erin Dunbar, Akanksha Sharma, Ekokobe Fonkem, Alissa A Thomas, Tamra E Werbowetski-Ogilvie, Sandra Camelo-Piragua, Na Tosha N Gatson, Macarena I de la Fuente, Terri S Armstrong, Alyx B Porter, and Sadhana Jackson