Providence research from Washington locations.

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Submissions from 2018

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Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy., Mariet Allen, Xue Wang, Daniel J Serie, Samantha L Strickland, Jeremy D Burgess, Shunsuke Koga, Curtis S Younkin, Thuy T Nguyen, Kimberly G Malphrus, Sarah J Lincoln, Melissa Alamprese, Kuixi Zhu, Rui Chang, Minerva M Carrasquillo, Naomi Kouri, Melissa E Murray, Joseph S Reddy, Cory Funk, Nathan D Price, Todd E Golde, Steven G Younkin, Yan W Asmann, Julia E Crook, Dennis W Dickson, and Nilüfer Ertekin-Taner

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Transcriptional regulatory networks underlying gene expression changes in Huntington's disease., Seth A Ament, Jocelynn R Pearl, Jeffrey P Cantle, Robert M Bragg, Peter J Skene, Sydney R Coffey, Dani E Bergey, Vanessa C Wheeler, Marcy E MacDonald, Nitin S Baliga, Jim Rosinski, Leroy E Hood, Jeffrey B Carroll, and Nathan D Price

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The Micronemal, Silvia A Arredondo, Kristian E Swearingen, Thomas Martinson, Ryan Steel, Dorender A Dankwa, Anke Harupa, Nelly Camargo, William Betz, Vladimir Vigdorovich, Brian G Oliver, Niwat Kangwanrangsan, Tomoko Ishino, Noah Sather, Sebastian Mikolajczak, Ashley M Vaughan, Motomi Torii, Robert L Moritz, and Stefan H I Kappe

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A Single Center Retrospective Study of Real World Relapsed/Refractory DLBCL Patients Eligible for CAR T-Cell Therapy: Patient Characteristics and Outcomes, Neil Bailey, John M Pagel, William Bensinger, Livia Hegerova, Raya Mawad, Michael Milder, Jennie Szeto, Ngan Trinh, Tenzin Tsomo, Paul Wisnewski, Clarisse M. Zayas, and Krish Patel

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Efficient region-based test strategy uncovers genetic risk factors for functional outcome in bipolar disorder., Monika Budde, Stefanie Friedrichs, Ney Alliey-Rodriguez, Seth Ament, Judith A Badner, Wade H Berrettini, Cinnamon S Bloss, William Byerley, Sven Cichon, Ashley L Comes, William Coryell, David W Craig, Franziska Degenhardt, Howard J Edenberg, Tatiana Foroud, Andreas J Forstner, Josef Frank, Elliot S Gershon, Fernando S Goes, Tiffany A Greenwood, Yiran Guo, Maria Hipolito, Leroy Hood, Brendan J Keating, Daniel L Koller, William B Lawson, Chunyu Liu, Pamela B Mahon, Melvin G McInnis, Francis J McMahon, Sandra M Meier, Thomas W Mühleisen, Sarah S Murray, Caroline M Nievergelt, John I Nurnberger, Evaristus A Nwulia, James B Potash, Danjuma Quarless, John Rice, Jared C Roach, William A Scheftner, Nicholas J Schork, Tatyana Shekhtman, Paul D Shilling, Erin N Smith, Fabian Streit, Jana Strohmaier, Szabolcs Szelinger, Jens Treutlein, Stephanie H Witt, Peter P Zandi, Peng Zhang, Sebastian Zöllner, Heike Bickeböller, Peter G Falkai, John R Kelsoe, Markus M Nöthen, Marcella Rietschel, Thomas G Schulze, and Dörthe Malzahn

POSTER: MI SKILLS ACQUISITION: PREPARING PSYCHIATRY RESIDENTS FOR THE FUTURE, Amy Burns

PHQ9: WHERE TO GO FROM HERE?, Amy Burns and Kelly Wurzel

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Simultaneous vs. sequential treatment for smoking and weight management in tobacco quitlines: 6 and 12 month outcomes from a randomized trial., Terry Bush, Jennifer Lovejoy, Harold Javitz, Alula Jimenez Torres, Ken Wassum, Marcia M Tan, and Bonnie Spring

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Niche emergence as an autocatalytic process in the evolution of ecosystems., Roberto Cazzolla Gatti, Brian Fath, Wim Hordijk, Stuart Kauffman, and Robert Ulanowicz

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TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease., Paramita Chakrabarty, Andrew Li, Thomas B Ladd, Michael R Strickland, Emily J Koller, Jeremy D Burgess, Cory C Funk, Pedro E Cruz, Mariet Allen, Mariya Yaroshenko, Xue Wang, Curtis Younkin, Joseph Reddy, Benjamin Lohrer, Leonie Mehrke, Brenda D Moore, Xuefei Liu, Carolina Ceballos-Diaz, Awilda M Rosario, Christopher Medway, Christopher Janus, Hong-Dong Li, Dennis W Dickson, Benoit I Giasson, Nathan D Price, Steven G Younkin, Nilüfer Ertekin-Taner, and Todd E Golde

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Chemotherapy-generated cell debris stimulates colon carcinoma tumor growth via osteopontin., Jaimie Chang, Swati S Bhasin, Diane R Bielenberg, Vikas P Sukhatme, Manoj Bhasin, Sui Huang, Mark W Kieran, and Dipak Panigrahy

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Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy., Guo Chen, Andrew T Magis, Ke Xu, Dongkyoo Park, David S Yu, Taofeek K Owonikoko, Gabriel L Sica, Sarah W Satola, Suresh S Ramalingam, Walter J Curran, Paul W Doetsch, and Xingming Deng

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Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease., Jaeyoon Chung, Xiaoling Zhang, Mariet Allen, Xue Wang, Yiyi Ma, Gary Beecham, Thomas J Montine, Steven G Younkin, Dennis W Dickson, Todd E Golde, Nathan D Price, Nilüfer Ertekin-Taner, Kathryn L Lunetta, Jesse Mez, Richard Mayeux, Jonathan L Haines, Margaret A Pericak-Vance, Gerard Schellenberg, Gyungah R Jun, and Lindsay A Farrer

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Intracorporeal versus extracorporeal anastomosis for minimally invasive right colectomy: A multi-center propensity score-matched comparison of outcomes., Robert K Cleary, Andrew Kassir, Craig S Johnson, Amir L Bastawrous, Mark K Soliman, Daryl S Marx, Luca Giordano, Tobi J Reidy, Eduardo Parra-Davila, Vincent J Obias, Joseph C Carmichael, Darren Pollock, and Alessio Pigazzi

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Criticality Distinguishes the Ensemble of Biological Regulatory Networks., Bryan C Daniels, Hyunju Kim, Douglas Moore, Siyu Zhou, Harrison B Smith, Bradley Karas, Stuart A Kauffman, and Sara I Walker

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The Cytoscape Automation app article collection., Barry Demchak, David Otasek, Alexander R Pico, Gary D Bader, Keiichiro Ono, Brett Settle, Eric Sage, John H Morris, William Longabaugh, Christian Lopes, Michael Kucera, Adam Treister, Benno Schwikowski, Piet Molenaar, and Trey Ideker

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Expanding the Use of Spectral Libraries in Proteomics., Eric W Deutsch, Yasset Perez-Riverol, Robert J Chalkley, Mathias Wilhelm, Stephen Tate, Timo Sachsenberg, Mathias Walzer, Lukas Käll, Bernard Delanghe, Sebastian Böcker, Emma L Schymanski, Paul Wilmes, Viktoria Dorfer, Bernhard Kuster, Pieter-Jan Volders, Nico Jehmlich, Johannes P C Vissers, Dennis W Wolan, Ana Y Wang, Luis Mendoza, Jim Shofstahl, Andrew W Dowsey, Johannes Griss, Reza M Salek, Steffen Neumann, Pierre-Alain Binz, Henry Lam, Juan Antonio Vizcaíno, Nuno Bandeira, and Hannes Röst

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Digitizing omics profiles by divergence from a baseline., Wikum Dinalankara, Qian Ke, Yiran Xu, Lanlan Ji, Nicole Pagane, Anching Lien, Tejasvi Matam, Elana J Fertig, Nathan D Price, Laurent Younes, Luigi Marchionni, and Donald Geman

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In vitro characterization of alkylaminophenols-induced cell death., Phuong Doan, Olga Anufrieva, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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Single cell analyses demonstrate that a heme - GATA1 feedback loop regulates red cell differentiation., Raymond T Doty, Xiaowei Yan, Christopher Lausted, Adam D Munday, Zhantao Yang, Danielle Yi, Neda Jabbari, Li Liu, Siobán B Keel, Qiang Tian, and Janis L Abkowitz

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Preparation of Small RNA NGS Libraries from Biofluids., Alton Etheridge, Kai Wang, David Baxter, and David Galas

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Extracellular vesicle RNAs reflect placenta dysfunction and are a biomarker source for preterm labour., Shannon Fallen, David Baxter, Xiaogang Wu, Taek-Kyun Kim, Oksana Shynlova, Min Young Lee, Kelsey Scherler, Stephen Lye, Leroy Hood, and Kai Wang

Defining recurrence surveillance in typical and atypical pulmonary carcinoid, AF Feczko, CL Wilshire, and See all authors in comments

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The BCGΔBCG1419c Vaccine Candidate Reduces Lung Pathology, IL-6, TNF-α, and IL-10 During Chronic TB Infection., Mario A Flores-Valdez, César Pedroza-Roldán, Michel de Jesús Aceves-Sánchez, Eliza J R Peterson, Nitin S Baliga, Rogelio Hernández-Pando, JoLynn Troudt, Elizabeth Creissen, Linda Izzo, Helle Bielefeldt-Ohmann, Thomas Bickett, and Angelo A Izzo

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Constraint-based modelling captures the metabolic versatility of Desulfovibrio vulgaris., Jason J Flowers, Matthew A Richards, Nitin Baliga, Birte Meyer, and David A Stahl

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Genome-wide Profiling of Urinary Extracellular Vesicle microRNAs Associated With Diabetic Nephropathy in Type 1 Diabetes., Vikas Ghai, Xiaogang Wu, Anjalei Bheda-Malge, Christos P Argyropoulos, José F Bernardo, Trevor Orchard, David Galas, and Kai Wang

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Droplet Digital PCR for Absolute Quantification of Extracellular MicroRNAs in Plasma and Serum: Quantification of the Cancer Biomarker hsa-miR-141., Maria D Giraldez, John R Chevillet, and Muneesh Tewari

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Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling., Maria D Giraldez, Ryan M Spengler, Alton Etheridge, Paula M Godoy, Andrea J Barczak, Srimeenakshi Srinivasan, Peter L De Hoff, Kahraman Tanriverdi, Amanda Courtright, Shulin Lu, Joseph Khoory, Renee Rubio, David Baxter, Tom A P Driedonks, Henk P J Buermans, Esther N M Nolte-'t Hoen, Hui Jiang, Kai Wang, Ionita Ghiran, Yaoyu E Wang, Kendall Van Keuren-Jensen, Jane E Freedman, Prescott G Woodruff, Louise C Laurent, David J Erle, David J Galas, and Muneesh Tewari

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Author Correction: Parent-of-origin-specific signatures of de novo mutations., Jakob M Goldmann, Wendy S W Wong, Michele Pinelli, Terry Farrah, Dale Bodian, Anna B Stittrich, Gustavo Glusman, Lisenka E L M Vissers, Alexander Hoischen, Jared C Roach, Joseph G Vockley, Joris A Veltman, Benjamin D Solomon, Christian Gilissen, and John E Niederhuber

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RAD54 N-terminal domain is a DNA sensor that couples ATP hydrolysis with branch migration of Holliday junctions., Nadish Goyal, Matthew J Rossi, Olga M Mazina, Yong Chi, Robert L Moritz, Bruce E Clurman, and Alexander V Mazin

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Loss of inter-cellular cooperation by complete epithelial-mesenchymal transition supports favorable outcomes in basal breast cancer patients., Anne Grosse-Wilde, Rolf E Kuestner, Stephanie M Skelton, Ellie MacIntosh, Aymeric Fouquier d'Hérouël, Gökhan Ertaylan, Antonio Del Sol, Alexander Skupin, and Sui Huang

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A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease., Daniela Hartl, Patrick May, Wei Gu, Manuel Mayhaus, Sabrina Pichler, Christian Spaniol, Enrico Glaab, Dheeraj Reddy Bobbili, Paul Antony, Sandra Koegelsberger, Alexander Kurz, Timo Grimmer, Kevin Morgan, Badri N Vardarajan, Christiane Reitz, John Hardy, Jose Bras, Rita Guerreiro, Rudi Balling, Jochen G Schneider, and Matthias Riemenschneider

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Integrative Molecular Characterization of Malignant Pleural Mesothelioma., Julija Hmeljak, Francisco Sanchez-Vega, Katherine A Hoadley, Juliann Shih, Chip Stewart, David Heiman, Patrick Tarpey, Ludmila Danilova, Esther Drill, Ewan A Gibb, Reanne Bowlby, Rupa Kanchi, Hatice U Osmanbeyoglu, Yoshitaka Sekido, Jumpei Takeshita, Yulia Newton, Kiley Graim, Manaswi Gupta, Carl M Gay, Lixia Diao, David L Gibbs, Vesteinn Thorsson, Lisa Iype, Havish Kantheti, David T Severson, Gloria Ravegnini, Patrice Desmeules, Achim A Jungbluth, William D Travis, Sanja Dacic, Lucian R Chirieac, Françoise Galateau-Sallé, Junya Fujimoto, Aliya N Husain, Henrique C Silveira, Valerie W Rusch, Robert C Rintoul, Harvey Pass, Hedy Kindler, Marjorie G Zauderer, David J Kwiatkowski, Raphael Bueno, Anne S Tsao, Jenette Creaney, Tara Lichtenberg, Kristen Leraas, Jay Bowen, Ina Felau, Jean Claude Zenklusen, Rehan Akbani, Andrew D Cherniack, Lauren A Byers, Michael S Noble, Jonathan A Fletcher, A Gordon Robertson, Ronglai Shen, Hiroyuki Aburatani, Bruce W Robinson, Peter Campbell, and Marc Ladanyi

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Involvement in surface antigen expression by a moonlighting FG-repeat nucleoporin in trypanosomes., Jennifer M Holden, Ludek Koreny, Samson Obado, Alexander V Ratushny, Wei-Ming Chen, Jean-Mathieu Bart, Miguel Navarro, Brian T Chait, John D Aitchison, Michael P Rout, and Mark C Field

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Lessons Learned as President of the Institute for Systems Biology (2000-2018)., Leroy E Hood

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StPeter: Seamless Label-Free Quantification with the Trans-Proteomic Pipeline., Michael R Hoopmann, Jason M Winget, Luis Mendoza, and Robert L Moritz

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Author Correction: A population-specific reference panel empowers genetic studies of Anabaptist populations., Liping Hou, Rachel L Kember, Jared C Roach, Jeffrey R O'Connell, David W Craig, Maja Bucan, William K Scott, Margaret Pericak-Vance, Jonathan L Haines, Michael H Crawford, Alan R Shuldiner, and Francis J McMahon

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Whole genome sequence and comparative analysis of Borrelia burgdorferi MM1., Neda Jabbari, Gustavo Glusman, Lena M Joesch-Cohen, Panga Jaipal Reddy, Robert L Moritz, Leroy Hood, and Christopher G Lausted

Management of complex pleural space infections: as the pendulum swings European Respiratory Society International Congress 2018 Paris, France, AS Jackson, CL Wilshire, and See all authors in comments

Treatment of surveillance detected disease after resection of primary non-small cell lung cancer The 26th European Conference on General Thoracic Surgery Ljubljana, Slovenia, AS Jackson, CL Wilshire, and See all authors in comments

Variable adoption of intrapleural fibrinolytic therapy for pleural space infections European Respiratory Society International Congress 2018 Paris, France, AS Jackson, CL Wilshire, and See all authors in comments

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Systematic Analysis of Splice-Site-Creating Mutations in Cancer., Reyka G Jayasinghe, Song Cao, Qingsong Gao, Michael C Wendl, Nam Sy Vo, Sheila M Reynolds, Yanyan Zhao, Héctor Climente-González, Shengjie Chai, Fang Wang, Rajees Varghese, Mo Huang, Wen-Wei Liang, Matthew A Wyczalkowski, Sohini Sengupta, Zhi Li, Samuel H Payne, David Fenyö, Jeffrey H Miner, Matthew J Walter, Benjamin Vincent, Eduardo Eyras, Ken Chen, Ilya Shmulevich, Feng Chen, and Li Ding

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Novel metrics for quantifying bacterial genome composition skews., Lena M Joesch-Cohen, Max Robinson, Neda Jabbari, Christopher G Lausted, and Gustavo Glusman

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Determining Relative Dynamic Stability of Cell States Using Boolean Network Model., Jae Il Joo, Joseph X Zhou, Sui Huang, and Kwang-Hyun Cho

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An RNAi screen in human cell lines reveals conserved DNA damage repair pathways that mitigate formaldehyde sensitivity., Eleonora Juarez, Nyasha Chambwe, Weiliang Tang, Asia D Mitchell, Nichole Owen, Anuradha Kumari, Raymond J Monnat, and Amanda K McCullough

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Emergence of diversity in homogeneous coupled Boolean networks., Chris Kang, Boris Aguilar, and Ilya Shmulevich

Management of complex pleural space infections: as the pendulum swings The American Association for Thoracic Surgery 98th Annual Meeting Resident Poster Competition San Diego, California, NM Kanodra, CL Wilshire, and See all authors in comments

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MAMMOTh: A new database for curated mathematical models of biomolecular systems., Fedor Kazantsev, Ilya Akberdin, Sergey Lashin, Natalia Ree, Vladimir Timonov, Alexander Ratushny, Tamara Khlebodarova, and Vitaly Likhoshvai

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The building blocks of successful translation of proteomics to the clinic., Paul Kearney, J Jay Boniface, Nathan D Price, and Leroy Hood

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Serum lipidomic analysis for the discovery of biomarkers for major depressive disorder in drug-free patients., Eun Young Kim, Jae Won Lee, Min Young Lee, Se Hyun Kim, Hyuck Jun Mok, Kyooseob Ha, Yong Min Ahn, and Kwang Pyo Kim

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Integrative structure and functional anatomy of a nuclear pore complex., Seung Joong Kim, Javier Fernandez-Martinez, Ilona Nudelman, Yi Shi, Wenzhu Zhang, Barak Raveh, Thurston Herricks, Brian D Slaughter, Joanna A Hogan, Paula Upla, Ilan E Chemmama, Riccardo Pellarin, Ignacia Echeverria, Manjunatha Shivaraju, Azraa S Chaudhury, Junjie Wang, Rosemary Williams, Jay R Unruh, Charles H Greenberg, Erica Y Jacobs, Zhiheng Yu, M Jason de la Cruz, Roxana Mironska, David L Stokes, John D Aitchison, Martin F Jarrold, Jennifer L Gerton, Steven J Ludtke, Christopher W Akey, Brian T Chait, Andrej Sali, and Michael P Rout

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ProbAnnoWeb and ProbAnnoPy: probabilistic annotation and gap-filling of metabolic reconstructions., Brendan King, Terry Farrah, Matthew A Richards, Michael Mundy, Evangelos Simeonidis, and Nathan D Price

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Molecular structure of promoter-bound yeast TFIID., Olga Kolesnikova, Adam Ben-Shem, Jie Luo, Jeff Ranish, Patrick Schultz, and Gabor Papai

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Selected reaction monitoring mass spectrometry of mastitis milk reveals pathogen-specific regulation of bovine host response proteins., Ulrike Kusebauch, Lorenzo E Hernández-Castellano, Stine L Bislev, Robert L Moritz, Christine M Røntved, and Emøke Bendixen

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Predicting Low-Risk for Sustained Alcohol Use After Early Liver Transplant for Acute Alcoholic Hepatitis: The SALT Score., Brian P Lee, Eric Vittinghoff, Christine Hsu, Hyosun Han, George Therapondos, Oren K Fix, David W Victor, Deepti Dronamraju, Gene Y Im, Michael D Voigt, John P Rice, Michael R Lucey, Sheila Eswaran, Po-Hung Chen, Zhiping Li, Haripriya Maddur, and Norah A Terrault

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ABRF Proteome Informatics Research Group (iPRG) 2016 Study: Inferring Proteoforms from Bottom-up Proteomics Data., Joon-Yong Lee, Hyungwon Choi, Christopher M Colangelo, Darryl Davis, Michael R Hoopmann, Lukas Käll, Henry Lam, Samuel H Payne, Yasset Perez-Riverol, Matthew The, Ryan Wilson, Susan T Weintraub, and Magnus Palmblad

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Surface Immobilization of Redox-Labile Fluorescent Probes: Enabling Single-Cell Co-Profiling of Aerobic Glycolysis and Oncogenic Protein Signaling Activities., Zhonghan Li, Hanjun Cheng, Shiqun Shao, Xiang Lu, Li Mo, Jonathan Tsang, Pu Zeng, Zhili Guo, Siwen Wang, David A Nathanson, James R Heath, Wei Wei, and Min Xue

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Reply to "Precision medicine in the clouds"., Andrew T Magis, John C Earls, Gustavo Glusman, Gilbert S Omenn, Jennifer C Lovejoy, Nathan D Price, and Leroy Hood

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The Iceman's Last Meal Consisted of Fat, Wild Meat, and Cereals., Frank Maixner, Dmitrij Turaev, Amaury Cazenave-Gassiot, Marek Janko, Ben Krause-Kyora, Michael R Hoopmann, Ulrike Kusebauch, Mark Sartain, Gea Guerriero, Niall O'Sullivan, Matthew Teasdale, Giovanna Cipollini, Alice Paladin, Valeria Mattiangeli, Marco Samadelli, Umberto Tecchiati, Andreas Putzer, Mine Palazoglu, John Meissen, Sandra Lösch, Philipp Rausch, John F Baines, Bum Jin Kim, Hyun-Joo An, Paul Gostner, Eduard Egarter-Vigl, Peter Malfertheiner, Andreas Keller, Robert W Stark, Markus Wenk, David Bishop, Daniel G Bradley, Oliver Fiehn, Lars Engstrand, Robert L Moritz, Philip Doble, Andre Franke, Almut Nebel, Klaus Oeggl, Thomas Rattei, Rudolf Grimm, and Albert Zink

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mRNA transcript distribution bias between Borrelia burgdorferi bacteria and their outer membrane vesicles., Anjali Malge, Vikas Ghai, Panga Jaipal Reddy, David Baxter, Taek-Kyun Kim, Robert L Moritz, and Kai Wang

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A Multi-omic Association Study of Trimethylamine N-Oxide., Ohad Manor, Niha Zubair, Matthew P Conomos, Xiaojing Xu, Jesse E Rohwer, Cynthia E Krafft, Jennifer C Lovejoy, and Andrew T Magis

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Anticancer activity study of A, Gabriella Marucci, Claudia Santinelli, Michela Buccioni, Aleix Martí Navia, Catia Lambertucci, Anastasia Zhurina, Olli Yli-Harja, Rosaria Volpini, and Meenakshisundaram Kandhavelu

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Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes., Nazar Mashtalir, Andrew R D'Avino, Brittany C Michel, Jie Luo, Joshua Pan, Jordan E Otto, Hayley J Zullow, Zachary M McKenzie, Rachel L Kubiak, Roodolph St Pierre, Alfredo M Valencia, Steven J Poynter, Seth H Cassel, Jeffrey A Ranish, and Cigall Kadoch

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Characterization of Peroxisomal Regulation Networks., Fred D Mast and John D Aitchison

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ESCRT-III is required for scissioning new peroxisomes from the endoplasmic reticulum., Fred D Mast, Thurston Herricks, Kathleen M Strehler, Leslie R Miller, Ramsey A Saleem, Richard A Rachubinski, and John D Aitchison

Does treatment of the hiatus influence the outcomes of magnetic sphincter augmentation for chronic GERD? The Society of Surgery of the Alimentary Tract, 59th Annual Meeting Digestive Diseases Week, M Matias, S Blitz, CL Wilshire, AS Jackson, AS Farivar, RW Aye, CM Dunst, and BE Louie

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Venetoclax As Monotherapy or in Combination: Patterns of Use and Predictors of Outcomes in an International Multicenter Study of CLL Patients, Anthony R. Mato, John M Pagel, Neil Bailey, and See all authors in comments

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Allosteric Inhibitor of KRas Identified Using a Barcoded Assay Microchip Platform., Amy M McCarthy, Jungwoo Kim, A Katrine Museth, Ryan K Henning, John E Heath, Emma Winson, Joseph J Oh, Jingxin Liang, Sunga Hong, and James R Heath

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Analysis and visualization of linked molecular and clinical cancer data by using Oncoscape., Lisa G McFerrin, Michael Zager, Jianan Zhang, Gretchen Krenn, Robert McDermott, Desert Horse-Grant, Emily Silgard, Kara Colevas, Paul Shannon, Hamid Bolouri, and Eric C Holland

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Flexible and Fast Mapping of Peptides to a Proteome with ProteoMapper., Luis Mendoza, Eric W Deutsch, Zhi Sun, David S Campbell, David Shteynberg, and Robert L Moritz

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The proBAM and proBed standard formats: enabling a seamless integration of genomics and proteomics data., Gerben Menschaert, Xiaojing Wang, Andrew R Jones, Fawaz Ghali, David Fenyö, Volodimir Olexiouk, Bing Zhang, Eric W Deutsch, Tobias Ternent, and Juan Antonio Vizcaíno

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Targeting TWIST1 through loss of function inhibits tumorigenicity of human glioblastoma., Andrei M Mikheev, Svetlana A Mikheeva, Liza J Severs, Cory C Funk, Lei Huang, José L McFaline-Figueroa, Jeanette Schwensen, Cole Trapnell, Nathan D Price, Stephen Wong, and Robert C Rostomily

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Partnership Between Islam and Palliative Care at Swedish Health Services, Hodo Mohamud, Renee Rassilyer-Bomers, Samantha Bohn, Greg Malone, Hilaire Thompson (Faculty Capstone Project Committee Chair), Eeeseung Byun (Committee Member), and Margaret Heitkemper (Committee Member)

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Simulation Study of cDNA Dataset to Investigate Possible Association of Differentially Expressed Genes of Human THP1-Monocytic Cells in Cancer Progression Affected by Bacterial Shiga Toxins., Syed A Muhammad, Jinlei Guo, Thanh M Nguyen, Xiaogang Wu, Baogang Bai, X Frank Yang, and Jake Y Chen

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Increased levels of RECQ5 shift DNA repair from canonical to alternative pathways., Henry C Olson, Luther Davis, Kostantin Kiianitsa, Kevin J Khoo, Yilun Liu, Theo A Knijnenburg, and Nancy Maizels

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Progress on Identifying and Characterizing the Human Proteome: 2018 Metrics from the HUPO Human Proteome Project., Gilbert S Omenn, Lydie Lane, Christopher M Overall, Fernando J Corrales, Jochen M Schwenk, Young-Ki Paik, Jennifer E Van Eyk, Siqi Liu, Michael Snyder, Mark S Baker, and Eric W Deutsch

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Systems biology approaches towards predictive microbial ecology., Anne E Otwell, Adrián López García de Lomana, Sean M Gibbons, Mónica V Orellana, and Nitin S Baliga

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Transcription Activation Domains of the Yeast Factors Met4 and Ino2: Tandem Activation Domains with Properties Similar to the Yeast Gcn4 Activator., Derek Pacheco, Linda Warfield, Michelle Brajcich, Hannah Robbins, Jie Luo, Jeff Ranish, and Steven Hahn

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Toward Completion of the Human Proteome Parts List: Progress Uncovering Proteins That Are Missing or Have Unknown Function and Developing Analytical Methods., Young-Ki Paik, Christopher M Overall, Fernando Corrales, Eric W Deutsch, Lydie Lane, and Gilbert S Omenn

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Temporal Transcriptomic Analysis of Metabolic Genes in Maternal Organs and Placenta During Murine Pregnancy., Alison Paquette, Priyanka Baloni, Anisa Holloman, Sanjay Nigam, Theo Bammler, Qingcheng Mao, and Nathan D Price

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Comparative transcriptomic analysis of human placentae at term and preterm delivery., Alison G Paquette, Heather M Brockway, Nathan D Price, and Louis J Muglia

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Distinct communication patterns of trophoblastic miRNA among the maternal-placental-fetal compartments., Alison G Paquette, Tianjiao Chu, Xiaogang Wu, Kai Wang, Nathan D Price, and Yoel Sadovsky

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Comparative analysis of gene expression in maternal peripheral blood and monocytes during spontaneous preterm labor., Alison G Paquette, Oksana Shynlova, Mark Kibschull, Nathan D Price, and Stephen J Lye

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Reply., Alison Paquette, Nathan D Price, and Stephen J Lye

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Structure of human TFIID and mechanism of TBP loading onto promoter DNA., Avinash B Patel, Robert K Louder, Basil J Greber, Sebastian Grünberg, Jie Luo, Jie Fang, Yutong Liu, Jeff Ranish, Steve Hahn, and Eva Nogales

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Effects of Delivering SLCO1B1 Pharmacogenetic Information in Randomized Trial and Observational Settings., Bruce Peyser, Emily P Perry, Kavisha Singh, Rosalynn D Gill, Michael R Mehan, Susanne B Haga, Michael D Musty, Nicholas A Milazzo, Dillon Savard, Yi-Ju Li, Gloria Trujilio, and Deepak Voora

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Editorial overview: Systems biology: Data, discovery, delivery., Nathan D Price and Eran Segal

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Stress response of a marine ammonia-oxidizing archaeon informs physiological status of environmental populations., Wei Qin, Shady A Amin, Rachel A Lundeen, Katherine R Heal, Willm Martens-Habbena, Serdar Turkarslan, Hidetoshi Urakawa, Kyle C Costa, Erik L Hendrickson, Tony Wang, David Ac Beck, Sonia M Tiquia-Arashiro, Fred Taub, Andrew D Holmes, Neeraja Vajrala, Paul M Berube, Todd M Lowe, James W Moffett, Allan H Devol, Nitin S Baliga, Daniel J Arp, Luis A Sayavedra-Soto, Murray Hackett, E Virginia Armbrust, Anitra E Ingalls, and David A Stahl

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The Integrated Genomic Landscape of Thymic Epithelial Tumors., Milan Radovich, Curtis R Pickering, Ina Felau, Gavin Ha, Hailei Zhang, Heejoon Jo, Katherine A Hoadley, Pavana Anur, Jiexin Zhang, Mike McLellan, Reanne Bowlby, Thomas Matthew, Ludmila Danilova, Apurva M Hegde, Jaegil Kim, Mark D M Leiserson, Geetika Sethi, Charles Lu, Michael Ryan, Xiaoping Su, Andrew D Cherniack, Gordon Robertson, Rehan Akbani, Paul Spellman, John N Weinstein, D Neil Hayes, Ben Raphael, Tara Lichtenberg, Kristen Leraas, Jean Claude Zenklusen, Junya Fujimoto, Cristovam Scapulatempo-Neto, Andre L Moreira, David Hwang, James Huang, Mirella Marino, Robert Korst, Giuseppe Giaccone, Yesim Gokmen-Polar, Sunil Badve, Arun Rajan, Philipp Ströbel, Nicolas Girard, Ming S Tsao, Alexander Marx, Anne S Tsao, and Patrick J Loehrer

Referrals for palliative care and hospice are underutilized in patients with advanced non-small cell lung cancer, JR Rayburn, CL Wilshire, CR Gilbert, BE Louie, RW Aye, AS Farivar, E Vallières, and JA Gorden

Multistate healthcare network underutilizes valuable end-of-life resources in stage IV non-small cell lung cancer, JR Rayburn, CL Wilshire, CR Gilbert, RK Weerasinghe, BE Louie, RW Aye, AS Farivar, E Vallières, and JA Gorden

Patterns of multidisciplinary tumor board utilization in the management of non-small cell lung cancer The American Thoracic Society San Diego, California, JR Rayburn, CL Wilshire, and See all authors in comments

Reducing the use of catheters, tubes and imaging after hiatal hernia surgery significantly reduces length of hospital stay Society of American Gastrointestinal and Endoscopic Surgeons Annual Meeting Seattle, Washington, JR Rayburn, CL Wilshire, and See all authors in comments

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Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus., Ben Readhead, Jean-Vianney Haure-Mirande, Cory C Funk, Matthew A Richards, Paul Shannon, Vahram Haroutunian, Mary Sano, Winnie S Liang, Noam D Beckmann, Nathan D Price, Eric M Reiman, Eric E Schadt, Michelle E Ehrlich, Sam Gandy, and Joel T Dudley

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Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience., Perry G Ridge, Celeste M Karch, Simon Hsu, Ivan Arano, Craig C Teerlink, Mark T W Ebbert, Josue D Gonzalez Murcia, James M Farnham, Anna R Damato, Mariet Allen, Xue Wang, Oscar Harari, Victoria M Fernandez, Rita Guerreiro, Jose Bras, John Hardy, Ronald Munger, Maria Norton, Celeste Sassi, Andrew Singleton, Steven G Younkin, Dennis W Dickson, Todd E Golde, Nathan D Price, Nilüfer Ertekin-Taner, Carlos Cruchaga, Alison M Goate, Christopher Corcoran, JoAnn Tschanz, Lisa A Cannon-Albright, and John S K Kauwe

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Abstract 15297: High-Density Lipoprotein Function Associates With GlycA, a Novel Inflammation Marker, but Does Not Explain the Association Between GlycA and Incident Cardiovascular Events, Kayla A. Riggs, Parag H. Joshi, Amit Khera, Kavisha Singh, Oludamilola Akinmolayemi, Colby R. Ayers, and Anand Rohatgi

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Genotype Fingerprints Enable Fast and Private Comparison of Genetic Testing Results for Research and Direct-to-Consumer Applications., Max Robinson and Gustavo Glusman

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The Microbiome Stress Project: Toward a Global Meta-Analysis of Environmental Stressors and Their Effects on Microbial Communities., Jennifer D Rocca, Marie Simonin, Joanna R Blaszczak, Jessica G Ernakovich, Sean M Gibbons, Firas S Midani, and Alex D Washburne

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Adverse Events, Patterns of Tumor Lysis Syndrome Prophylaxis and Management, and Dosing Patterns in a Large Cohort of Venetoclax Treated CLL Patients in Community and Academic Settings, Lindsey E. Roeker, Neil Bailey, and See full list of authors in comments

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Extracellular vesicles in DLBCL provide abundant clues to aberrant transcriptional programming and genomic alterations., Sarah C Rutherford, Angela A Fachel, Sheng Li, Seema Sawh, Ashlesha Muley, Jennifer Ishii, Ashish Saxena, Pilar M Dominguez, Eloisi Caldas Lopes, Xabier Agirre, Nyasha Chambwe, Fabian Correa, Yanwen Jiang, Kristy L Richards, Doron Betel, and Rita Shaknovich