Providence research from Washington locations.

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Submissions from 2020

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Not following the rules in guideline care for lung cancer diagnosis and staging has negative impact., Candice L. Wilshire, Joshua R Rayburn, Shu-Ching Chang, Christopher R Gilbert, Brian Louie, Ralph W Aye, Alexander S Farivar, Adam J Bograd, Eric Vallières, and Jed A Gorden

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Siponimod enriches regulatory T and B lymphocytes in secondary progressive multiple sclerosis., Qi Wu, Elizabeth A Mills, Qin Wang, Catherine A Dowling, Caitlyn Fisher, Britany Kirch, Steven K Lundy, David A Fox, Yang Mao-Draayer, AMS04 Study Group, James Bowden, and Stanley Cohan

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SOSTDC1-producing follicular helper T cells promote regulatory follicular T cell differentiation., Xin Wu, Yun Wang, Rui Huang, Qujing Gai, Haofei Liu, Meimei Shi, Xiang Zhang, Yonglin Zuo, Longjuan Chen, Qiwen Zhao, Yu Shi, Fengchao Wang, Xiaowei Yan, Huiping Lu, Senlin Xu, Xiaohong Yao, Lin Chen, Xia Zhang, Qiang Tian, Ziyan Yang, Bo Zhong, Chen Dong, Yan Wang, Xiu-Wu Bian, and Xindong Liu

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Autocatalytic chemical networks at the origin of metabolism., Joana C Xavier, Wim Hordijk, Stuart Kauffman, Mike Steel, and William F Martin

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The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View., Joao B Xavier, Vincent B Young, Joseph Skufca, Fiona Ginty, Traci Testerman, Alexander T Pearson, Paul Macklin, Amir Mitchell, Ilya Shmulevich, Lei Xie, J Gregory Caporaso, Keith A Crandall, Nicole L Simone, Filipa Godoy-Vitorino, Timothy J Griffin, Katrine L Whiteson, Heather H Gustafson, Daniel J Slade, Thomas M Schmidt, Marina R S Walther-Antonio, Tal Korem, Bobbie-Jo M Webb-Robertson, Mark P Styczynski, W Evan Johnson, Christian Jobin, Jason M Ridlon, Andrew Y Koh, Michael Yu, Libusha Kelly, and Jennifer A Wargo

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Correction to: Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy., Ke Xu, Dongkyoo Park, Andrew T Magis, Jun Zhang, Wei Zhou, Gabriel L Sica, Suresh S Ramalingam, Walter J Curran, and Xingming Deng

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Epigenetic biotypes of post-traumatic stress disorder in war-zone exposed veteran and active duty males., Ruoting Yang, Aarti Gautam, Derese Getnet, Bernie J Daigle, Stacy Miller, Burook Misganaw, Kelsey R Dean, Raina Kumar, Seid Muhie, Kai Wang, Inyoul Lee, Duna Abu-Amara, Janine D Flory, PTSD Systems Biology Consortium, Leroy Hood, Owen M Wolkowitz, Synthia H Mellon, Francis J Doyle, Rachel Yehuda, Charles R Marmar, Kerry J Ressler, Rasha Hammamieh, and Marti Jett

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Correction: A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD., Ruoting Yang, Gwyneth W Y Wu, Josine E Verhoeven, Aarti Gautam, Victor I Reus, Jee In Kang, Janine D Flory, Duna Abu-Amara, PTSD Systems Biology Consortium, Leroy Hood, Francis J Doyle, Rachel Yehuda, Charles R Marmar, Marti Jett, Rasha Hammamieh, Synthia H Mellon, and Owen M Wolkowitz

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Combining deep learning with token selection for patient phenotyping from electronic health records., Zhen Yang, Matthias Dehmer, Olli Yli-Harja, and Frank Emmert-Streib

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Diagnosing spinal cord ischemia: Are we doing enough catheter angiography?, Robert J Young, Jason H Huang, and Ruth Thiex

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Predictors of survival following surgical resection of limited-stage small cell lung cancer., Nicolas Zhou, Matthew Bott, Bernard J Park, Eric Vallieres, Candice L. Wilshire, Kazuhiro Yasufuku, Jonathan D Spicer, David R Jones, Boris Sepesi, and Small Cell Lung Cancer Working Group

Predictors of overall survival following surgical resection of small cell lung cancer, N Zhou, KG Mitchell, EM Corsini, DR Jones, MJ Bott, Candice L. Wilshire, SG Swisher, MB Antonoff, DC Rice, GL Walsh, RJ Mehran, WL Hofstetter, JA Roth, and See additional authors in comments

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Measurement of Organ-Specific and Acute-Phase Blood Protein Levels in Early Lyme Disease., Yong Zhou, Shizhen Qin, Mingjuan Sun, Li Tang, Xiaowei Yan, Taek-Kyun Kim, Juan Caballero, Gustavo Glusman, Mary E Brunkow, Mark J Soloski, Alison W Rebman, Carol Scavarda, Denise Cooper, Gilbert S Omenn, Robert L Moritz, Gary P Wormser, Nathan D Price, John N Aucott, and Leroy Hood

Submissions from 2019

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Protein-Catalyzed Capture Agents., Heather D Agnew, Matthew B Coppock, Matthew N Idso, Bert T Lai, JingXin Liang, Amy M McCarthy-Torrens, Carmen M Warren, and James R Heath

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Clinical Data: Sources and Types, Regulatory Constraints, Applications., Stanley C Ahalt, Christopher G Chute, Karamarie Fecho, Gustavo Glusman, Jennifer Hadlock, Casey Overby Taylor, Emily R Pfaff, Peter N Robinson, Harold Solbrig, Casey Ta, Nicholas Tatonetti, and Chunhua Weng

Incidence of incidental findings and the rate of downstream interventions in lung cancer screening: A multistate, community-based healthcare network experience, SE Anton, LC Horslen, CA Henson, Candice L. Wilshire, CR Gilbert, KM Spiegel, JR Rayburn, AS Carlson, CC Fuller, and M Bretta

High variability in radiologist reporting of incidental findings during lung cancer screening in a community-based healthcare network The American, SE Anton, Candice L. Wilshire, See all authors in comments, and CR Gilbert

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Personalized Nutrition: Translating the Science of NutriGenomics Into Practice: Proceedings From the 2018 American College of Nutrition Meeting., Okezie I Aruoma, Sharon Hausman-Cohen, Jessica Pizano, Michael A Schmidt, Deanna M Minich, Yael Joffe, Sebastian Brandhorst, Simon J Evans, and David M Brady

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Genome-scale metabolic model of the rat liver predicts effects of diet restriction., Priyanka Baloni, Vineet Sangar, James T Yurkovich, Max Robinson, Scott Taylor, Christine M Karbowski, Hisham K Hamadeh, Yudong D He, and Nathan D Price

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Incidence, associated risk factors, and impact of conversion to laparotomy in elective minimally invasive sigmoidectomy for diverticular disease., Amir Bastawrous, Ron G Landmann, Yuki Liu, Emelline Liu, and Robert K Cleary

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Minimally invasive sigmoidectomy for diverticular disease decreases inpatient opioid use: Results of a propensity score-matched study., Amir Bastawrous, I-Fan Shih, Yanli Li, and Robert K Cleary

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Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop., Davide Bedognetti, Michele Ceccarelli, Lorenzo Galluzzi, Rongze Lu, Karolina Palucka, Josue Samayoa, Stefani Spranger, Sarah Warren, Kwok-Kin Wong, Elad Ziv, Diego Chowell, Lisa M Coussens, Daniel D De Carvalho, David G DeNardo, Jérôme Galon, Howard L Kaufman, Tomas Kirchhoff, Michael T Lotze, Jason J Luke, Andy J Minn, Katerina Politi, Leonard D Shultz, Richard Simon, Vésteinn Thórsson, Joanne B Weidhaas, Maria Libera Ascierto, Paolo Antonio Ascierto, James M Barnes, Valentin Barsan, Praveen K Bommareddy, Adrian Bot, Sarah E Church, Gennaro Ciliberto, Andrea De Maria, Dobrin Draganov, Winson S Ho, Heather M McGee, Anne Monette, Joseph F Murphy, Paola Nisticò, Wungki Park, Maulik Patel, Michael Quigley, Laszlo Radvanyi, Harry Raftopoulos, Nils-Petter Rudqvist, Alexandra Snyder, Randy F Sweis, Sara Valpione, Lisa H Butterfield, Mary L Disis, Bernard A Fox, Alessandra Cesano, and Francesco M Marincola

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Proteomics Standards Initiative Extended FASTA Format., Pierre-Alain Binz, Jim Shofstahl, Juan Antonio Vizcaíno, Harald Barsnes, Robert J Chalkley, Gerben Menschaert, Emanuele Alpi, Karl Clauser, Jimmy K Eng, Lydie Lane, Sean L Seymour, Luis Francisco Hernández Sánchez, Gerhard Mayer, Martin Eisenacher, Yasset Perez-Riverol, Eugene A Kapp, Luis Mendoza, Peter R Baker, Andrew Collins, Tim Van Den Bossche, and Eric W Deutsch

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Author Correction: Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2., Evan Bolyen, Jai Ram Rideout, Matthew R Dillon, Nicholas A Bokulich, Christian C Abnet, Gabriel A Al-Ghalith, Harriet Alexander, Eric J Alm, Manimozhiyan Arumugam, Francesco Asnicar, Yang Bai, Jordan E Bisanz, Kyle Bittinger, Asker Brejnrod, Colin J Brislawn, C Titus Brown, Benjamin J Callahan, Andrés Mauricio Caraballo-Rodríguez, John Chase, Emily K Cope, Ricardo Da Silva, Christian Diener, Pieter C Dorrestein, Gavin M Douglas, Daniel M Durall, Claire Duvallet, Christian F Edwardson, Madeleine Ernst, Mehrbod Estaki, Jennifer Fouquier, Julia M Gauglitz, Sean M Gibbons, Deanna L Gibson, Antonio Gonzalez, Kestrel Gorlick, Jiarong Guo, Benjamin Hillmann, Susan Holmes, Hannes Holste, Curtis Huttenhower, Gavin A Huttley, Stefan Janssen, Alan K Jarmusch, Lingjing Jiang, Benjamin D Kaehler, Kyo Bin Kang, Christopher R Keefe, Paul Keim, Scott T Kelley, Dan Knights, Irina Koester, Tomasz Kosciolek, Jorden Kreps, Morgan G I Langille, Joslynn Lee, Ruth Ley, Yong-Xin Liu, Erikka Loftfield, Catherine Lozupone, Massoud Maher, Clarisse Marotz, Bryan D Martin, Daniel McDonald, Lauren J McIver, Alexey V Melnik, Jessica L Metcalf, Sydney C Morgan, Jamie T Morton, Ahmad Turan Naimey, Jose A Navas-Molina, Louis Felix Nothias, Stephanie B Orchanian, Talima Pearson, Samuel L Peoples, Daniel Petras, Mary Lai Preuss, Elmar Pruesse, Lasse Buur Rasmussen, Adam Rivers, Michael S Robeson, Patrick Rosenthal, Nicola Segata, Michael Shaffer, Arron Shiffer, Rashmi Sinha, Se Jin Song, John R Spear, Austin D Swafford, Luke R Thompson, Pedro J Torres, Pauline Trinh, Anupriya Tripathi, Peter J Turnbaugh, Sabah Ul-Hasan, Justin J J van der Hooft, Fernando Vargas, Yoshiki Vázquez-Baeza, Emily Vogtmann, Max von Hippel, William Walters, Yunhu Wan, Mingxun Wang, Jonathan Warren, Kyle C Weber, Charles H D Williamson, Amy D Willis, Zhenjiang Zech Xu, Jesse R Zaneveld, Yilong Zhang, Qiyun Zhu, Rob Knight, and J Gregory Caporaso

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Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2., Evan Bolyen, Jai Ram Rideout, Matthew R Dillon, Nicholas A Bokulich, Christian C Abnet, Gabriel A Al-Ghalith, Harriet Alexander, Eric J Alm, Manimozhiyan Arumugam, Francesco Asnicar, Yang Bai, Jordan E Bisanz, Kyle Bittinger, Asker Brejnrod, Colin J Brislawn, C Titus Brown, Benjamin J Callahan, Andrés Mauricio Caraballo-Rodríguez, John Chase, Emily K Cope, Ricardo Da Silva, Christian Diener, Pieter C Dorrestein, Gavin M Douglas, Daniel M Durall, Claire Duvallet, Christian F Edwardson, Madeleine Ernst, Mehrbod Estaki, Jennifer Fouquier, Julia M Gauglitz, Sean M Gibbons, Deanna L Gibson, Antonio Gonzalez, Kestrel Gorlick, Jiarong Guo, Benjamin Hillmann, Susan Holmes, Hannes Holste, Curtis Huttenhower, Gavin A Huttley, Stefan Janssen, Alan K Jarmusch, Lingjing Jiang, Benjamin D Kaehler, Kyo Bin Kang, Christopher R Keefe, Paul Keim, Scott T Kelley, Dan Knights, Irina Koester, Tomasz Kosciolek, Jorden Kreps, Morgan G I Langille, Joslynn Lee, Ruth Ley, Yong-Xin Liu, Erikka Loftfield, Catherine Lozupone, Massoud Maher, Clarisse Marotz, Bryan D Martin, Daniel McDonald, Lauren J McIver, Alexey V Melnik, Jessica L Metcalf, Sydney C Morgan, Jamie T Morton, Ahmad Turan Naimey, Jose A Navas-Molina, Louis Felix Nothias, Stephanie B Orchanian, Talima Pearson, Samuel L Peoples, Daniel Petras, Mary Lai Preuss, Elmar Pruesse, Lasse Buur Rasmussen, Adam Rivers, Michael S Robeson, Patrick Rosenthal, Nicola Segata, Michael Shaffer, Arron Shiffer, Rashmi Sinha, Se Jin Song, John R Spear, Austin D Swafford, Luke R Thompson, Pedro J Torres, Pauline Trinh, Anupriya Tripathi, Peter J Turnbaugh, Sabah Ul-Hasan, Justin J J van der Hooft, Fernando Vargas, Yoshiki Vázquez-Baeza, Emily Vogtmann, Max von Hippel, William Walters, Yunhu Wan, Mingxun Wang, Jonathan Warren, Kyle C Weber, Charles H D Williamson, Amy D Willis, Zhenjiang Zech Xu, Jesse R Zaneveld, Yilong Zhang, Qiyun Zhu, Rob Knight, and J Gregory Caporaso

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Ensembles, dynamics, and cell types: Revisiting the statistical mechanics perspective on cellular regulation., Stefan Bornholdt and Stuart Kauffman

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Rib plating offers favourable outcomes in patients with chronic non-union of prior rib fractures, KE Buehler, Candice L. Wilshire, AJ Bograd, and E Vallières

USING MI TO ADDRESS AMBIVALENCE IN TAKING MAT, Amy Burns

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Incidence, Management, and Outcomes of Intraoperative Catastrophes During Robotic Pulmonary Resection., Christopher Cao, Robert J Cerfolio, Brian Louie, Franca Melfi, Giulia Veronesi, Rene Razzak, Gaetano Romano, Pierluigi Novellis, Savan Shah, Neel Ranganath, and Bernard J Park

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Outcomes of major complications after robotic anatomic pulmonary resection., Christopher Cao, Brian Louie, Franca Melfi, Giulia Veronesi, Rene Razzak, Gaetano Romano, Pierluigi Novellis, Neel K Ranganath, and Bernard J Park

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Use and abuse of correlation analyses in microbial ecology., Alex Carr, Christian Diener, Nitin Baliga, and Sean M Gibbons

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Sublobar resection of typical carcinoid tumors of the lung (Reply)., Maria Cattoni, Farhood Farjah, and Brian E Louie

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Mcl-1 Interacts with Akt to Promote Lung Cancer Progression., Guo Chen, Dongkyoo Park, Andrew T Magis, Madhusmita Behera, Suresh S Ramalingam, Taofeek K Owonikoko, Gabriel L Sica, Keqiang Ye, Chao Zhang, Zhengjia Chen, Walter J Curran, and Xingming Deng

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Mcl-1 Interacts with Akt to Promote Lung Cancer Progression., Guo Chen, Dongkyoo Park, Andrew T Magis, Madhusmita Behera, Suresh S Ramalingam, Taofeek K Owonikoko, Gabriel L Sica, Keqiang Ye, Chao Zhang, Zhengjia Chen, Walter J Curran, and Xingming Deng

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Commentary: Adherence with a low-FODMAP diet in irritable bowel syndrome: are eating disorders the missing link?, Bruno P Chumpitazi, Ligia Alfaro-Cruz, Jasmine K Zia, Robert J Shulman, and Margaret M Heitkemper

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Dieulafoy Lesion: An Unusual Cause of Excessive Gastric Bleeding in a Neonate., Alison Kirse Coit, Uma Pisharody, and Michael Kamitsuka

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Predicting drug synergy for precision medicine using network biology and machine learning., Ali Cuvitoglu, Joseph X Zhou, Sui Huang, and Zerrin Isik

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ADAPTS: Automated deconvolution augmentation of profiles for tissue specific cells., Samuel A Danziger, David L Gibbs, Ilya Shmulevich, Mark McConnell, Matthew W B Trotter, Frank Schmitz, David J Reiss, and Alexander V Ratushny

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Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder., Kelsey R Dean, Rasha Hammamieh, Synthia H Mellon, Duna Abu-Amara, Janine D Flory, Guia Guffanti, Kai Wang, Bernie J Daigle, Aarti Gautam, Inyoul Lee, Ruoting Yang, Lynn M Almli, F Saverio Bersani, Nabarun Chakraborty, Duncan Donohue, Kimberly Kerley, Taek-Kyun Kim, Eugene Laska, Min Young Lee, Daniel Lindqvist, Adriana Lori, Liangqun Lu, Burook Misganaw, Seid Muhie, Jennifer Newman, Nathan D Price, Shizhen Qin, Victor I Reus, Carole Siegel, Pramod R Somvanshi, Gunjan S Thakur, Yong Zhou, Leroy Hood, Kerry J Ressler, Owen M Wolkowitz, Rachel Yehuda, Marti Jett, Francis J Doyle, and Charles Marmar

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The ProteomeXchange consortium in 2020: enabling 'big data' approaches in proteomics., Eric W Deutsch, Nuno Bandeira, Vagisha Sharma, Yasset Perez-Riverol, Jeremy J Carver, Deepti J Kundu, David García-Seisdedos, Andrew F Jarnuczak, Suresh Hewapathirana, Benjamin S Pullman, Julie Wertz, Zhi Sun, Shin Kawano, Shujiro Okuda, Yu Watanabe, Henning Hermjakob, Brendan MacLean, Michael J MacCoss, Yunping Zhu, Yasushi Ishihama, and Juan A Vizcaíno

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Human Proteome Project Mass Spectrometry Data Interpretation Guidelines 3.0., Eric W Deutsch, Lydie Lane, Christopher M Overall, Nuno Bandeira, Mark S Baker, Charles Pineau, Robert L Moritz, Fernando Corrales, Sandra Orchard, Jennifer E Van Eyk, Young-Ki Paik, Susan T Weintraub, Yves Vandenbrouck, and Gilbert S Omenn

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Human Proteome Project Mass Spectrometry Data Interpretation Guidelines 3.0., Eric W Deutsch, Lydie Lane, Christopher M Overall, Nuno Bandeira, Mark S Baker, Charles Pineau, Robert L Moritz, Fernando Corrales, Sandra Orchard, Jennifer E Van Eyk, Young-Ki Paik, Susan T Weintraub, Yves Vandenbrouck, and Gilbert S Omenn

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Outcomes following early versus delayed cholecystectomy performed for acute cholangitis., Andrew Discolo, Shelby Reiter, Bryce French, Danielle Hayes, Gary Lucas, Lancy Tan, James M Scanlan, and Ryan Martinez

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Alkylaminophenol Induces G1/S Phase Cell Cycle Arrest in Glioblastoma Cells Through p53 and Cyclin-Dependent Kinase Signaling Pathway., Phuong Doan, Aliyu Musa, Nuno R Candeias, Frank Emmert-Streib, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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Multi-Omic Biological Age Estimation and Its Correlation With Wellness and Disease Phenotypes: A Longitudinal Study of 3,558 Individuals., John C Earls, Noa Rappaport, Laura M Heath, Tomasz Wilmanski, Andrew T Magis, Nicholas J Schork, Gilbert S Omenn, Jennifer Lovejoy, Leroy Hood, and Nathan D Price

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Ensuring Quality Standards and Reproducible Research for Data Analysis Services in Oncology: A Cooperative Service Model., Frank Emmert-Streib, Matthias Dehmer, and Olli Yli-Harja

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Before and After: Comparison of Legacy and Harmonized TCGA Genomic Data Commons' Data., Galen F Gao, Joel S Parker, Sheila M Reynolds, Tiago C Silva, Liang-Bo Wang, Wanding Zhou, Rehan Akbani, Matthew Bailey, Saianand Balu, Benjamin P Berman, Denise Brooks, Hu Chen, Andrew D Cherniack, John A Demchok, Li Ding, Ina Felau, Sharon Gaheen, Daniela S Gerhard, David I Heiman, Kyle M Hernandez, Katherine A Hoadley, Reyka Jayasinghe, Anab Kemal, Theo A Knijnenburg, Peter W Laird, Michael K A Mensah, Andrew J Mungall, A Gordon Robertson, Hui Shen, Roy Tarnuzzer, Zhining Wang, Matthew Wyczalkowski, Liming Yang, Jean C Zenklusen, Zhenyu Zhang, Han Liang, and Michael S Noble

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Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor., Allison Gartung, Jun Yang, Vikas P Sukhatme, Diane R Bielenberg, Djanira Fernandes, Jaimie Chang, Birgitta A Schmidt, Sung Hee Hwang, David Zurakowski, Sui Huang, Mark W Kieran, Bruce D Hammock, and Dipak Panigrahy

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Extracellular Vesicle Encapsulated MicroRNAs in Patients with Type 2 Diabetes Are Affected by Metformin Treatment., Vikas Ghai, Taek-Kyun Kim, Alton Etheridge, Trine Nielsen, Torben Hansen, Oluf Pedersen, David Galas, and Kai Wang

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Defining Microbiome Health through a Host Lens., Sean M Gibbons

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Particle size, distribution, and behavior of talc preparations: within the United States and beyond., Christopher R Gilbert and Philippe Haouzi

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A Prospective, Ex Vivo Trial of Endobronchial Blockade Management Utilizing 3 Commonly Available Bronchial Blockers., Christopher R Gilbert, Christopher Mallow, Candice L. Wilshire, Shu-Ching Chang, Lonny B Yarmus, Eric Vallières, Katherine Haeck, and Jed A Gorden

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A Prospective, Ex Vivo Trial of Endobronchial Blockade Management Utilizing 3 Commonly Available Bronchial Blockers., Christopher R Gilbert, Christopher Mallow, Candice L. Wilshire, Shu-Ching Chang, Lonny B Yarmus, Eric Vallières, Katherine Haeck, and Jed A Gorden

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Aspirin-triggered proresolving mediators stimulate resolution in cancer., Molly M Gilligan, Allison Gartung, Megan L Sulciner, Paul C Norris, Vikas P Sukhatme, Diane R Bielenberg, Sui Huang, Mark W Kieran, Charles N Serhan, and Dipak Panigrahy

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Alterations in Phosphorylation of Hepatocyte Ribosomal Protein S6 Control Plasmodium Liver Stage Infection., Elizabeth K K Glennon, Laura S Austin, Nadia Arang, Heather S Kain, Fred D Mast, Kamalakannan Vijayan, John D Aitchison, Stefan H I Kappe, and Alexis Kaushansky

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Epidemiology of Colorectal Cancer in Average Risk Adults 20-39 Years of Age: A Population-Based National Study., Michael Glover, Emad Mansoor, Muhammed Panhwar, Sravanthi Parasa, and Gregory S Cooper

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Fe limitation decreases transcriptional regulation over the diel cycle in the model diatom Thalassiosira pseudonana., Johanna A L Goldman, Megan J Schatz, Chris T Berthiaume, Sacha N Coesel, Mónica V Orellana, and E Virginia Armbrust

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Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors., Jennifer L Guida, Tim A Ahles, Daniel Belsky, Judith Campisi, Harvey Jay Cohen, James DeGregori, Rebecca Fuldner, Luigi Ferrucci, Lisa Gallicchio, Leonid Gavrilov, Natalia Gavrilova, Paige A Green, Chamelli Jhappan, Ronald Kohanski, Kevin Krull, Jeanne Mandelblatt, Kirsten K Ness, Ann O'Mara, Nathan D Price, Jennifer Schrack, Stephanie Studenski, Olga Theou, Russell P Tracy, and Arti Hurria

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Histone Octamer Structure Is Altered Early in ISW2 ATP-Dependent Nucleosome Remodeling., Arjan Hada, Swetansu K Hota, Jie Luo, Yuan-Chi Lin, Seyit Kale, Alexey K Shaytan, Saurabh K Bhardwaj, Jim Persinger, Jeff Ranish, Anna R Panchenko, and Blaine Bartholomew

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Lymphatic Migration of Immune Cells., Henry R Hampton and Tatyana Chtanova

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Investigation of lipid metabolism dysregulation and the effects on immune microenvironments in pan-cancer using multiple omics data., Yang Hao, Daixi Li, Yong Xu, Jian Ouyang, Yongkun Wang, Yuqi Zhang, Baoguo Li, Lu Xie, and Guangrong Qin

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Framing technology challenges associated with improving cancer immunotherapies., James R Heath

The national distribution of American College of Radiology certified lung cancer screening sites in relation to high-risk individuals: The issue is access, CA Henson, Candice L. Wilshire, ST Chiu, CR Gilbert, E Vallières, and JA Gorden

Average Fitness Differences on NK Landscapes., Wim Hordijk, Stuart A Kauffman, and Peter F Stadler

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Molecular Diversity Required for the Formation of Autocatalytic Sets., Wim Hordijk, Mike Steel, and Stuart A Kauffman

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Minority and socioeconomically disadvantaged high-risk populations are underrepresented in a multistate, community-based network of lung cancer screening programs, LC Horslen, CA Henson, SE Anton, Candice L. Wilshire, Christopher R Gilbert, CC Fuller, BM McCall, KM Spiegel, JR Rayburn, AS Carlson, Roshanthi Weerasignhe, Eric Vallieres, and Jed A Gorden

Multicenter review of complex pleural space infection management reveals high frequency of imaging and subsequent high cumulative effective dose of radiation, LC Horslen, AS Jackson, Candice L. Wilshire, CC Fuller, JR Rayburn, CR Gilbert, RK Weerasinghe, AJ Bograd, E Vallières, and JA Gorden

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A Blueprint for Systems Biology., Trey Ideker and Leroy Hood

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Mass Spectrometry-Based Plasma Proteomics: Considerations from Sample Collection to Achieving Translational Data., Vera Ignjatovic, Philipp E Geyer, Krishnan K Palaniappan, Jessica E Chaaban, Gilbert S Omenn, Mark S Baker, Eric W Deutsch, and Jochen M Schwenk

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Data-driven multiscale modeling reveals the role of metabolic coupling for the spatio-temporal growth dynamics of yeast colonies., Jukka Intosalmi, Adrian C Scott, Michelle Hays, Nicholas Flann, Olli Yli-Harja, Harri Lähdesmäki, Aimée M Dudley, and Alexander Skupin

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Does Treatment of the Hiatus Influence the Outcomes of Magnetic Sphincter Augmentation for Chronic GERD?, Matías Mihura Irribarra, Sandra Blitz, Candice L. Wilshire, Anee Sophia Jackson, Alexander S Farivar, Ralph W Aye, Christy M Dunst, and Brian Louie

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Brain Health Strategies to Manage Stroke and Dementia Risks, Nancy B. Isenberg

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A Staging System for Neuroendocrine Tumors of the Lung Needs to Incorporate Histological Grade., Anee Sophia Jackson, Adam Rosenthal, Maria Cattoni, Adam J Bograd, Alexander S Farivar, Ralph W Aye, Eric Vallières, and Brian Louie

The quality elements for lung cancer screening programs: The struggle for implementation in the community The American Thoracic Society Dallas, Texas, AS Jackson, Candice L. Wilshire, and See all authors in comments

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Octogenarians exhibit quality of life improvement but increased morbidity after paraesophageal hernia repair., Anahita D Jalilvand, Edward L Jones, Sara E Martin Del Campo, and Kyle A Perry

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Six Month Abstinence Heterogeneity in the Best Quit Study., Harold S Javitz, Terry M Bush, Jennifer C Lovejoy, Alula J Torres, Tallie Wetzel, Ken P Wassum, Marcia M Tan, Nabil Alshurafa, and Bonnie Spring

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Cancer cell population growth kinetics at low densities deviate from the exponential growth model and suggest an Allee effect., Kaitlyn E Johnson, Grant Howard, William Mo, Michael K Strasser, Ernesto A B F Lima, Sui Huang, and Amy Brock

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Cancer cell population growth kinetics at low densities deviate from the exponential growth model and suggest an Allee effect., Kaitlyn E Johnson, Grant Howard, William Mo, Michael K Strasser, Ernesto A B F Lima, Sui Huang, and Amy Brock

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Assessing protein sequence database suitability using de novo sequencing., Richard Johnson, Brian C Searle, Brook L Nunn, Jason M Gilmore, Molly Phillips, Chris T Amemiya, Michelle Heck, and Michael J MacCoss

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An Inflammatory Landscape for Preoperative Neurologic Deficits in Glioblastoma., Amal Katrib, Hyun-Hwan Jeong, Nina L Fransen, Kristin S Henzel, and Jeremy A Miller

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Genomic and molecular characterization of preterm birth., Theo A Knijnenburg, Joseph G Vockley, Nyasha Chambwe, David L Gibbs, Crystal Humphries, Kathi C Huddleston, Elisabeth Klein, Prachi Kothiyal, Ryan Tasseff, Varsha Dhankani, Dale L Bodian, Wendy S W Wong, Gustavo Glusman, Denise E Mauldin, Michael Miller, Joseph Slagel, Summer Elasady, Jared C Roach, Roger Kramer, Kalle Leinonen, Jasper Linthorst, Rajiv Baveja, Robin Baker, Benjamin D Solomon, Greg Eley, Ramaswamy K Iyer, George L Maxwell, Brady Bernard, Ilya Shmulevich, Leroy Hood, and John E Niederhuber

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Underestimation of Liver Transplantation for Alcoholic Hepatitis in the National Transplant Database., Brian P Lee, Gene Y Im, John P Rice, Ethan Weinberg, Christine Hsu, Oren K Fix, George Therapondos, Hyosun Han, David W Victor, Sheila Eswaran, Haripriya Maddur, and Norah A Terrault

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Model to Calculate Harms and Benefits of Early vs Delayed Liver Transplantation for Patients with Alcohol-Associated Hepatitis., Brian P Lee, Sumeyye Samur, Ozden O Dalgic, Emily D Bethea, Michael R Lucey, Ethan Weinberg, Christine Hsu, Mary E Rinella, Gene Y Im, Oren K Fix, George Therapondos, Hyosun Han, David W Victor, Michael D Voigt, Sheila Eswaran, Norah A Terrault, and Jagpreet Chhatwal

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The Impact of Moyamoya Disease and, Ming-Jen Lee, Shannon Fallen, Yong Zhou, David Baxter, Kelsey Scherler, Meng-Fai Kuo, and Kai Wang

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Distinct Profiles of Cell-Free MicroRNAs in Plasma of Veterans with Post-Traumatic Stress Disorder., Min Young Lee, David Baxter, Kelsey Scherler, Taek-Kyun Kim, Xiaogang Wu, Duna Abu-Amara, Janine Flory, Rachel Yehuda, Charles Marmar, Marti Jett, Inyoul Lee, Kai Wang, and Leroy Hood

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A biological function based biomarker panel optimization process., Min Young Lee, Taek-Kyun Kim, Kathie-Anne Walters, and Kai Wang

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Characterizing the cancer-associated microbiome with small RNA sequencing data., Wei-Hao Lee, Kai-Pu Chen, Kai Wang, Hsuan-Cheng Huang, and Hsueh-Fen Juan

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Synthesis and preclinical validation of novel P2Y1 receptor ligands as a potent anti-prostate cancer agent., Hien Thi Thu Le, Tatu Rimpilainen, Saravanan Konda Mani, Akshaya Murugesan, Olli Yli-Harja, Nuno R Candeias, and Meenakshisundaram Kandhavelu

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The Impact of Gravity vs Suction-driven Therapeutic Thoracentesis on Pressure-related Complications: The GRAVITAS Multicenter Randomized Controlled Trial., Robert J Lentz, Samira Shojaee, Horiana B Grosu, Otis B Rickman, Lance Roller, Jasleen K Pannu, Zachary S DePew, Labib G Debiane, Joseph C Cicenia, Jason Akulian, Charla Walston, Trinidad M Sanchez, Kevin R Davidson, Nikhil Jagan, Sahar Ahmad, Christopher R Gilbert, John T Huggins, Heidi Chen, Richard W Light, Lonny Yarmus, David Feller-Kopman, Hans Lee, Najib M Rahman, and Fabien Maldonado

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Inhibition of heme sequestration of histidine-rich protein 2 using multiple epitope-targeted peptides., JingXin Liang, David N Bunck, Anvita Mishra, Sunga Hong, Matthew N Idso, and James R Heath

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Inhibition of heme sequestration of histidine-rich protein 2 using multiple epitope-targeted peptides., JingXin Liang, David N Bunck, Anvita Mishra, Sunga Hong, Matthew N Idso, and James R Heath

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Time-dependent saddle-node bifurcation: Breaking time and the point of no return in a non-autonomous model of critical transitions., Jeremiah H Li, Felix X-F Ye, Hong Qian, and Sui Huang

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Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites., Scott E Lindner, Kristian E Swearingen, Melanie J Shears, Michael P Walker, Erin N Vrana, Kevin J Hart, Allen M Minns, Photini Sinnis, Robert L Moritz, and Stefan H I Kappe

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Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction., Xindong Liu, Yun Wang, Huiping Lu, Jing Li, Xiaowei Yan, Minglu Xiao, Jing Hao, Andrei Alekseev, Hiep Khong, Tenghui Chen, Rui Huang, Jin Wu, Qiwen Zhao, Qi Wu, Senlin Xu, Xiaohu Wang, Wei Jin, Shicang Yu, Yan Wang, Lai Wei, Aibo Wang, Bo Zhong, Ling Ni, Xiaolong Liu, Roza Nurieva, Lilin Ye, Qiang Tian, Xiu-Wu Bian, and Chen Dong

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Liquid biopsy-based single-cell metabolic phenotyping of lung cancer patients for informative diagnostics., Ziming Li, Zhuo Wang, Yin Tang, Xiang Lu, Jie Chen, Yu Dong, Baojun Wu, Chunying Wang, Liu Yang, Zhili Guo, Min Xue, Shun Lu, Wei Wei, and Qihui Shi

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Objective Evidence of Reflux Control After Magnetic Sphincter Augmentation: One Year Results From a Post Approval Study., Brian Louie, C Daniel Smith, Christopher C Smith, Reginald C W Bell, George Kevin Gillian, Jeffrey S Mandel, Kyle A Perry, Walter Kurt Birkenhagen, Paul A Taiganides, Christy M Dunst, Howard M McCollister, John C Lipham, Leena K Khaitan, Shawn T Tsuda, Blair A Jobe, Shanu N Kothari, and Jon C Gould

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Precision Medicine in Pancreatic Disease-Knowledge Gaps and Research Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop., Mark E Lowe, Dana K Andersen, Richard M Caprioli, Jyoti Choudhary, Zobeida Cruz-Monserrate, Anil K Dasyam, Christopher E Forsmark, Fred S Gorelick, Joe W Gray, Mark Haupt, Kimberly A Kelly, Kenneth P Olive, Sylvia K Plevritis, Noa Rappaport, Holger R Roth, Hanno Steen, S Joshua Swamidass, Temel Tirkes, Aliye Uc, Kirill Veselkov, David C Whitcomb, and Aida Habtezion

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Precision Medicine in Pancreatic Disease-Knowledge Gaps and Research Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop., Mark E Lowe, Dana K Andersen, Richard M Caprioli, Jyoti Choudhary, Zobeida Cruz-Monserrate, Anil K Dasyam, Christopher E Forsmark, Fred S Gorelick, Joe W Gray, Mark Haupt, Kimberly A Kelly, Kenneth P Olive, Sylvia K Plevritis, Noa Rappaport, Holger R Roth, Hanno Steen, S Joshua Swamidass, Temel Tirkes, Aliye Uc, Kirill Veselkov, David C Whitcomb, and Aida Habtezion

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Identification of Cross-linked Peptides Using Isotopomeric Cross-linkers., Jie Luo, Jacob Bassett, and Jeff Ranish

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4D electron microscopy of T cell activation., Yue Lu, Byung-Kuk Yoo, Alphonsus H C Ng, Jungwoo Kim, Sinchul Yeom, Jau Tang, Milo M Lin, Ahmed H Zewail, and James R Heath