The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2020

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Effects of YOCAS yoga, cognitive behavioral therapy, and survivorship health education on insomnia: A URCC NCORP Research Base Phase III RCT in 740 cancer survivors., Karen Michelle Mustian, Po-Ju Lin, Eva Culakova, Javier Bautista, Huiwen Xu, Supriya Gupta Mohile, Michelle Christine Janelsins, Luke Joseph Peppone, Amber Kleckner, Ian Kleckner, Kah Poh Loh, Richard Francis Dunne, Nikesha Gilmore, Alison Conlin, Kim Ong Gococo, and Anthony John Jaslowski

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A first-in-human phase 1 dose escalation study of spartalizumab (PDR001), an anti-PD-1 antibody, in patients with advanced solid tumors., Aung Naing, Justin F Gainor, Hans Gelderblom, Patrick M Forde, Marcus O Butler, Chia-Chi Lin, Sunil Sharma, Maria Ochoa de Olza, Andrea Varga, Matthew H Taylor, Jan H M Schellens, Hongqian Wu, Haiying Sun, Antonio P Silva, Jason Faris, Jennifer Mataraza, Scott Cameron, and Todd M Bauer

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Effect of Pembrolizumab Plus Neoadjuvant Chemotherapy on Pathologic Complete Response in Women With Early-Stage Breast Cancer: An Analysis of the Ongoing Phase 2 Adaptively Randomized I-SPY2 Trial., Rita Nanda, Minetta C Liu, Christina Yau, Rebecca Shatsky, Lajos Pusztai, Anne Wallace, A Jo Chien, Andres Forero-Torres, Erin D Ellis, Heather Han, Amy Clark, Kathy Albain, Judy C Boughey, Nora T Jaskowiak, Anthony Elias, Claudine Isaacs, Kathleen Kemmer, Teresa Helsten, Melanie Majure, Erica Stringer-Reasor, Catherine Parker, Marie C Lee, Tufia Haddad, Ronald N Cohen, Smita Asare, Amy Wilson, Gillian L Hirst, Ruby Singhrao, Katherine Steeg, Adam Asare, Jeffrey B Matthews, Scott Berry, Ashish Sanil, Richard Schwab, W Fraser Symmans, Laura van 't Veer, Douglas Yee, Angela DeMichele, Nola M Hylton, Michelle Melisko, Jane Perlmutter, Hope S Rugo, Donald A Berry, and Laura J Esserman

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Phenobarbital for Acute Alcohol Withdrawal Management in Surgical Trauma Patients-A Retrospective Comparison Study., Shamim H Nejad, Mladen Nisavic, Andreas Larentzakis, Suzan Dijkink, Yuchiao Chang, Alexander R Levine, Marc de Moya, and George Velmahos

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Development of a Risk Score and Nomogram to Predict Individual Benefit Attained from the Addition of Adjuvant Chemotherapy in the Treatment of Stage II Colon Cancer., Daniel W Nelson, Clay Merritt, Shu-Ching Chang, Gary Grunkemeier, Scott R Steele, and Melanie Goldfarb

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Atezolizumab Plus Chemotherapy for First-Line Treatment of Non-Squamous Non-Small Cell Lung Cancer: Results From the Randomized Phase III IMpower132 Trial., Makoto Nishio, Fabrice Barlesi, Howard West, Simon Ball, Rodolfo Bordoni, Manuel Cobo, Pascale Dubray Longeras, Jerome Goldschmidt, Silvia Novello, Francisco Orlandi, Rachel E Sanborn, Zsuzsanna Szalai, Grigoriy Ursol, Diana Mendus, Lijia Wang, Xiaohui Wen, Mark McCleland, Tien Hoang, See Phan, and Mark A Socinski

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375O Final efficacy results from IMpower132: First-line atezolizumab + chemotherapy in patients with stage IV non-squamous NSCLC, M Nishio, F Barlesi, S Ball, R Bordoni, M Cobo, P Dubray-Longeras, J Goldschmidt, S Novello, FJ Orlandi, Rachel E Sanborn, Z Szalai, G Ursol, D Mendus, L Wang, X Wen, M McCleland, T Hoang, S Phan, and M Socinski

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375O - Final efficacy results from IMpower132: First-line atezolizumab + chemotherapy in patients with stage IV non-squamous NSCLC, M Nishio (presenter), F Barlesi, S Ball, R Bordoni, M Cobo, P Dubray-Longeras, J Goldschmidt, S Novello, FJ Orlandi, Rachel E Sanborn, Z Szalai, G Ursol, D Mendus, L Wang, X Wen, M McCleland, T Hoang, S Phan, and M Socinski

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Management of adverse events in patients with HER2+ metastatic breast cancer treated with tucatinib, trastuzumab, and capecitabine (HER2CLIMB)., Alicia Frances Claire Okines, Elisavet Paplomata, Tanya Wahl, Gail Lynn Shaw Wright, Stephanie Sutherland, Erik Jakobsen, Frances Valdes, Arlene Chan, Amy Sanders Clark, Alison Conlin, Maryam B. Lustberg, Jennifer M. Specht, Timothy J. Pluard, Xiaofu Zhu, Ian E. Krop, Karen A. Gelmon, Dennis J. Slamon, Jorge Ramos, Grace An, and Erika Paige Hamilton

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The Impact of Replacing Peripheral Intravenous Catheters when Clinically Indicated on Infection Rate, Nurse Satisfaction, and Costs in CCU, Step-Down, and Oncology Units., Rosemary C Olivier, Mary Wickman, Claudia Skinner, and Lilian Ablir

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Therapy of Myeloid Leukemia using Novel Bispecific Fusion Proteins Targeting CD45 and 90Y-DOTA., Johnnie J Orozco, Aimee L Kenoyer, Yukang Lin, Shyril O'Steen, Rosario Guel, Margaret E Nartea, Alexandra H Hernandez, Mark D Hylarides, Darrell R Fisher, Ethan R Balkin, Donald K Hamlin, D Scott Wilbur, Kelly D Orcutt, K Dane Wittrup, Damian J Green, Ajay K Gopal, Brian G Till, Brenda Sandmaier, Oliver W Press, and John M Pagel

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Navigating the Paradox of Scarcity: The Case for Radiologist-Driven Care., Daniel A Ortiz, Kevin M Cregan, Join Y Luh, and Taj M Kattapuram

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Primary CNS lymphoma commonly expresses immune response biomarkers., Alexander Ou, Ashley Sumrall, Surasak Phuphanich, David Spetzler, Zoran Gatalica, Joanne Xiu, Sharon Michelhaugh, Andrew Brenner, Manjari Pandey, Santosh Kesari, W Michael Korn, Sandeep Mittal, Jason Westin, and Amy B Heimberger

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Response to radiotherapy in pancreatic ductal adenocarcinoma is enhanced by inhibition of myeloid-derived suppressor cells using STAT3 anti-sense oligonucleotide., Ayman J Oweida, Adam C Mueller, Miles Piper, Dallin Milner, Benjamin Van Court, Shilpa Bhatia, Andy Phan, Thomas Bickett, Kimberly Jordan, Theresa Proia, Richard Schulick, Wells A Messersmith, Marco Del Chiaro, Eric Clambey, Michael J. Gough, Jason Williams, Kirk Hansen, Karyn Goodman, and Sana D Karam

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Prevalence of class I-III BRAF mutations among 114,662 cancer patients in a large genomic database., Jeff Owsley, Matthew K Stein, Jason Porter, Gino K In, Mohamed Salem, Steven O'Day, Andrew Elliott, Kelsey Poorman, Geoffrey Gibney, and Ari VanderWalde

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Improving Breast Cancer Detection Accuracy of Mammography with the Concurrent Use of an Artificial Intelligence Tool., Serena Pacilè, January Lopez, Pauline Chone, Thomas Bertinotti, Jean Marie Grouin, and Pierre Fillard

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Treatment selection in patients with relapsed or refractory follicular lymphoma., John M Pagel

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Refining the management of relapsed or refractory follicular lymphoma., John M Pagel, John M Burke, and Lori A Leslie

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Refining the management of relapsed or refractory follicular lymphoma: case scenarios., John M Pagel, John M Burke, and Lori A Leslie

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Rapid Donor Identification Improves Survival in High-Risk First-Remission Patients With Acute Myeloid Leukemia., John M Pagel, Megan Othus, Guillermo Garcia-Manero, Min Fang, Jerald P Radich, David A Rizzieri, Guido Marcucci, Stephen A Strickland, Mark R Litzow, M Lynn Savoie, Stephen R Spellman, Dennis L Confer, Jeffrey W Chell, Maria Brown, Bruno C Medeiros, Mikkael A Sekeres, Tara L Lin, Geoffrey L Uy, Bayard L Powell, Ruthee-Lu Bayer, Richard A Larson, Richard M Stone, David Claxton, James Essell, Selina M Luger, Sanjay R Mohan, Anna Moseley, Harry P Erba, and Frederick R Appelbaum

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Antiproliferative and apoptotic effects of indole derivative, N-(2-hydroxy-5-nitrophenyl (4'-methylphenyl) methyl) indoline in breast cancer cells., Suresh Palanivel, Akshaya Murugesan, Kumar Subramanian, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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Anticancer activity of THMPP: Downregulation of PI3K/ S6K1 in breast cancer cell line., Suresh Palanivel, Akshaya Murugesan, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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Alkylamino Phenol Derivative Induces Apoptosis by Inhibiting EGFR Signaling Pathway in Breast Cancer Cells., Suresh Palanivel, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?, Dipak Panigrahy, Molly M Gilligan, Sui Huang, Allison Gartung, Irene Cortés-Puch, Patricia J Sime, Richard P Phipps, Charles N Serhan, and Bruce D Hammock

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Massive cotyledenoid leiomyoma treated with uterine-conserving surgery., William H Parker, Roderick Turner, Stanford Schwimer, and Lee Foshag

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A Phase 2, Open-Label, Multicenter Study of Tazemetostat in Combination with Rituximab for the Treatment of Relapsed or Refractory Follicular Lymphoma, Krish Patel, Neil Bailey, and John M Pagel

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Real World Observational Study Using Clonoseq® Next Generation Sequencing in Hematologic Malignancies: The 'Watch' Registry, Krish Patel, Neil Bailey, John M Pagel, and See all authors in comments

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Use of the IL-6R Antagonist Tocilizumab in Hospitalized COVID-19 Patients., Krish Patel, Ted A Gooley, Neil Bailey, Megumi Bailey, Livia Hegerova, Ami Batchelder, Heather Holdread, Vanessa Dunleavy, Tyler Downey, Jens Frisvold, Samantha Megrath, Krystle Pagarigan, Jennie Szeto, Justin Rueda, Adel Islam, Cynthia L Maree, Sonam Nyatsatsang, Sarah E Bork, Anne B Lipke, D Shane O'Mahony, Teresa E Wagner, Juan Pulido, John Mignone, Samuel Youssef, Matthew Hartman, Jason D Goldman, and John M Pagel

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Health Care Coach Support in Reducing Acute Care Use in Patients With Cancer, Manali I. Patel, Kim Smith, Etsegenet Sisay, and David J. Park

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Progesterone receptor membrane component 1 promotes the growth of breast cancers by altering the phosphoproteome and augmenting EGFR/PI3K/AKT signalling., Diego A Pedroza, Venkatesh Rajamanickam, Ramadevi Subramani, Alejandra Bencomo, Adriana Galvez, and Rajkumar Lakshmanaswamy

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Neoantigen-specific CD4(+) T-cell response is critical for the therapeutic efficacy of cryo-thermal therapy, Peng Peng, Hong-Ming Hu, Ping Liu, and Lisa X Xu

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Discrimination of benign from malignant breast lesions in dense breasts with model-based analysis of regions-of-interest using directional diffusion-weighted images., Alan I Penn, Milica Medved, Vandana Dialani, Etta D Pisano, Elodia B Cole, David Brousseau, Gregory S Karczmar, Guimin Gao, Barry D Reich, and Hiroyuki Abe

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Pixantrone plus rituximab versus gemcitabine plus rituximab in patients with relapsed aggressive B-cell non-Hodgkin lymphoma not eligible for stem cell transplantation: a phase 3, randomized, multicentre trial (PIX306)., Ruth Pettengell, Monika Długosz-Danecka, David Andorsky, David Belada, Pencho Georgiev, Donald Quick, Jack W Singer, Simran B Singh, Athanasios Pallis, Anton Egorov, and Gilles Salles

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Enabling Scalable Comprehensive Genomic Profiling from FFPE Samples, Brian D. Piening

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Ageotypes: Distinct Biomolecular Trajectories in Human Aging., Brian D. Piening, Jennifer Lovejoy, and John C Earls

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AML risk stratification models utilizing ELN-2017 guidelines and additional prognostic factors: a SWOG report., Era L Pogosova-Agadjanyan, Anna Moseley, Megan Othus, Frederick R Appelbaum, Thomas R Chauncey, I-Ming L Chen, Harry P Erba, John E Godwin, Isaac C Jenkins, Min Fang, Mike Huynh, Kenneth J Kopecky, Alan F List, Jasmine Naru, Jerald P Radich, Emily Stevens, Brooke E Willborg, Cheryl L Willman, Brent L Wood, Qing Zhang, Soheil Meshinchi, and Derek L Stirewalt

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Comprehensive Immune Profiling of Medullary Thyroid Cancer., Nikita Pozdeyev, Timothy A Erickson, Lian Zhang, Kim Ellison, Christopher J Rivard, Sharon Sams, Fred R Hirsch, Bryan R Haugen, and Jena D French

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Association of BRAF V600E/K Mutation Status and Prior BRAF/MEK Inhibition With Pembrolizumab Outcomes in Advanced Melanoma: Pooled Analysis of 3 Clinical Trials., Igor Puzanov, Antoni Ribas, Caroline Robert, Jacob Schachter, Marta Nyakas, Adil Daud, Ana Arance, Matteo S Carlino, Steven J O'Day, Georgina V Long, Kim A Margolin, Reinhard Dummer, Dirk Schadendorf, Jose Lutzky, Paolo A Ascierto, Ahmad Tarhini, Jianxin Lin, Robin Mogg, Blanca Homet Moreno, Nageatte Ibrahim, and Omid Hamid

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Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma., Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary E Goodman, Stig E Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J Hung, Angeline Andrew, Lambertus A Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Victoria L Stevens, Guangfu Jin, David C Christiani, Zhibin Hu, Christopher I Amos, Hongxia Ma, and Hongbing Shen

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Brain Structure in Bilingual Compared to Monolingual Individuals with Alzheimer's Disease: Proof of Concept., Cyrus A Raji, Somayeh Meysami, David A Merrill, Verna R Porter, and Mario F Mendez

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Upregulation of Cell Surface GD3 Ganglioside Phenotype is Associated with Human Melanoma Brain Metastasis., Romela Irene Ramos, Matias Bustos, Jinfeng Wu, Peter Jones, Shu-Ching Chang, Eiji Kiyohara, Kevin Tran, Xiaoqing Zhang, Stacey L Stern, Sivan Izraely, Orit Sagi-Assif, Isaac P Witz, Michael A Davies, Gordon B Mills, Daniel F Kelly, Reiko F Irie, and Dave S B Hoon

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Genetic Variants in Immune Related Genes as Predictors of Responsiveness to BCG Immunotherapy in Metastatic Melanoma Patients., Romela Irene Ramos, Misa A Shaw, Leland J Foshag, Stacey L Stern, Negin Rahimzadeh, David Elashoff, and Dave Hoon

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Genetic Variants in Immune Related Genes as Predictors of Responsiveness to BCG Immunotherapy in Metastatic Melanoma Patients., Romela Irene Ramos, Misa A Shaw, Leland Foshag, Stacey L Stern, Negin Rahimzadeh, David Elashoff, and Dave Hoon

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Nivolumab Monotherapy and Nivolumab Plus Ipilimumab in Recurrent Small Cell Lung Cancer: Results From the CheckMate 032 Randomized Cohort., Neal E Ready, Patrick A Ott, Matthew D Hellmann, Jon Zugazagoitia, Christine L Hann, Filippo de Braud, Scott J Antonia, Paolo A Ascierto, Victor Moreno, Akin Atmaca, Stefania Salvagni, Matthew H Taylor, Asim Amin, D Ross Camidge, Leora Horn, Emiliano Calvo, Ang Li, Wen Hong Lin, Margaret K Callahan, and David R Spigel

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Confirmatory Tissue Sampling in Clinical Stage I Sarcoidosis., Jerome M Reich

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Response to Grannis FW. Current Controversies in Cardiothoracic Imaging: Overdiagnosis at Lung Cancer Screening-No So Bad After All-Counterpoint., Jerome M Reich and Jong S Kim

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Birds of a Feather? Genetic Counseling, Genetic Testing, and Humanism., Robert Resta

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Gemogenovatucel-T (Vigil) immunotherapy as maintenance in frontline stage III/IV ovarian cancer (VITAL): a randomised, double-blind, placebo-controlled, phase 2b trial., Rodney P Rocconi, Elizabeth A Grosen, Sharad A Ghamande, John K Chan, Minal A Barve, Jonathan Oh, Devansu Tewari, Peter C Morris, Erin E Stevens, Justin N Bottsford-Miller, Min Tang, Phylicia Aaron, Laura Stanbery, Staci Horvath, Gladice Wallraven, Ernest Bognar, Luisa Manning, John Nemunaitis, David Shanahan, Brian M Slomovitz, Thomas J Herzog, Bradley J Monk, and Robert L Coleman

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P0357 (S1601). - Malignant Melanoma of the Gallbladder Masquerading as Cholangitis and Cholecystitis, Medora Rodrigues, Sanjay Logani, Juan Mejia, Wichit Srikureja, and Nishant Puri

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Worldwide Examination of Patients with CLL Hospitalized for COVID-19, Lindsey E. Roeker, Neil Bailey, and See full list of authors in comments

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451 Combining Bempegaldesleukin (CD122-preferential IL-2 pathway agonist) and NKTR-262 (TLR7/8 agonist) pairs local innate activation with systemic CD8+ T cell expansion to enhance anti-tumor immunity, Annah S Rolig, Daniel Rose, Saul Kivimae, Werner Rubas, and William L. Redmond

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451 Combining Bempegaldesleukin (CD122-preferential IL-2 pathway agonist) and NKTR-262 (TLR7/8 agonist) pairs local innate activation with systemic CD8+ T cell expansion to enhance anti-tumor immunity, Annah S Rolig, Daniel Rose, Saul Kivimae, Werner Rubas, and William L. Redmond

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A Multi-Institutional Analysis of the Effect of Positive Surgical Margins Following Robot-Assisted Partial Nephrectomy on Oncologic Outcomes., Michael Rothberg, David J Paulucci, Kennedy E Okhawere, Christopher Reynolds, Ketan K Badani, Ronney Abaza, Daniel Eun, Akshay Bhandari, James R Porter, and Ashok Hemal

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Assessing Time from Door-to-Antibiotic Administration for Adult Cancer Patients with Neutropenic Fever in the Emergency Department, Sarah Roy and Tina Magsarili

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Assessing Time from Door-to-Antibiotic Administration for Adult Cancer Patients with Neutropenic Fever in the Emergency Department, Sarah Roy and Tina Magsarili

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Part Two: 24. Skin Cancer, Krista M. Rubin Ed. and Christine Boley Ed.

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Facebook Live: Lung Cancer awareness and da Vinci robotic surgery, Cheri Russum, Kimberly E Costas, and Luis F Alberton

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Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume I-conceptual challenges., Sergio Rutella, Michael A Cannarile, Sacha Gnjatic, Bruno Gomes, Justin Guinney, Vaios Karanikas, Mohan Karkada, John M Kirkwood, Beatrix Kotlan, Giuseppe V Masucci, Els Meeusen, Anne Monette, Aung Naing, Vésteinn Thorsson, Nicholas Tschernia, Ena Wang, Daniel K Wells, Timothy L Wyant, and Alessandra Cesano

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Parathyroidectomy and Hypertension-Reply., Meena Said

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Complex Oncological Decision-Making Utilizing Fast-and-Frugal Trees in a Community Setting-Role of Academic and Hybrid Modeling., Ravi Salgia, Isa Mambetsariev, Tingting Tan, Amanda Schwer, Daryl Pearlstein, Hazem Chehabi, Angel Baroz, Jeremy Fricke, Rebecca Pharaon, Hannah Romo, Thomas Waddington, Razmig Babikian, Linda Buck, Prakash Kulkarni, Mary Cianfrocca, Benjamin Djulbegovic, and Sumanta K Pal

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405 CDX1140–01, a phase 1 dose-escalation/expansion study of CDX-1140 alone (Part 1) and in combination with CDX-301 (Part 2) or pembrolizumab (Part 3), Rachel E Sanborn, Ralph Hauke, Nashat Gabrail, Mark O'Hara, Nina Bhardwaj, Rodolfo Bordoni, Michael Gordon, Danny Khalil, Maen Abdelrahim, Thomas Marron, Thomas Hawthorne, Lawrence Thomas, Tracey Rawls, Diego Alavardo, Laura Vitale, Tibor Keler, and Michael Yellin

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405 CDX1140–01, a phase 1 dose-escalation/expansion study of CDX-1140 alone (Part 1) and in combination with CDX-301 (Part 2) or pembrolizumab (Part 3), Rachel E Sanborn, Ralph Hauke, Nashat Gabrail, Mark O'Hara, Nina Bhardwaj, Rodolfo Bordoni, Michael Gordon, Danny Khalil, Maen Abdelrahim, Thomas Marron, Thomas Hawthorne, Lawrence Thomas, Tracey Rawls, Mark Rogalski, Diego Alvarado, Laura Vitale, Tibor Keler, and Michael Yellin

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Concordance of multispectral immunofluorescence (mIF) with programmed death ligand 1 (PD-L1) and stromal tumor infiltrating lymphocyte (sTILs) clinical assays in early-stage breast cancer (BC)., Katherine Sanchez, Shu-Ching Chang, Isaac Kim, Maritza Martel, Yaping Wu, William L. Redmond, Zhaoyu Sun, Dottie Waddell, Deborah R. Laxague, Brady Bernard, Monil Shah, Walter Urba, and David B. Page

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Part One: 11. Clinical Trials and Research Protocols, Marlon G Saria Ed. and Santosh Kesari Ed.

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Part Two: 9. Precision Medicine, Marlon G Saria Ed. and Santosh Kesari Ed.

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Complementary and Alternative Medicine Attitudes and Use in Caregivers of Patients with Lung Cancer, Trisha Saul, Lorraine Evangelista, Jung-Ah Lee, Sangyhuk Shin, and Michelle Fortier

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Inaccurate pretreatment staging can impact survival in early stage esophageal adenocarcinoma., Anthony J Scholer, Abhineet Uppal, Shu-Ching Chang, Debopriya Ghosh, Mary Garland-Kledzik, Juan A Santamaria-Barria, Adam Khader, Ahmed Dehal, Trevan D Fischer, and Melanie Goldfarb

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Clinical application of next generation sequencing in lymphoma., Anthony J Scott, Molly C Tokaz, Maryann M Shango, Sumana Devata, Shannon A Carty, Mark S Kaminski, Arul M Chinnaiyan, Tycel J Phillips, and Ryan A Wilcox

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Lisocabtagene maraleucel (liso-cel) for treatment of second-line (2L) transplant noneligible (TNE) relapsed/refractory (R/R) aggressive large B-cell non-Hodgkin lymphoma (NHL): Updated results from the PILOT study., Alison R. Sehgal, Gerhard Hildebrandt, Nilanjan Ghosh, John E Godwin, Nina D. Wagner-Johnston, Daanish Hoda, Edward J. Licitra, Javier Munoz, Nikolaus S. Trede, Lei Wang, Jerill Thorpe, and Leo I. Gordon

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Interim subgroup analysis for response by PD-L1 status of CLASSICAL-Lung, a phase Ib/II study of pepinemab (VX15/2503) in combination with avelumab in advanced NSCLC., Michael Rahman Shafique, Terrence Lee Fisher, Elizabeth E. Evans, John E. Leonard, Desa Rae Electa Pastore, Crystal L. Mallow, Ernest Smith, Andreas Schroder, Kevin M. Chin, Joseph Thaddeus Beck, Megan Ann Baumgart, Ramaswamy Govindan, Nashat Y. Gabrail, Rachel E Sanborn, Alexander I. Spira, Nagashree Seetharamu, Yanyan Lou, Aaron Scott Mansfield, Jonathan Wade Goldman, and Maurice Zauderer

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Interim results from a phase Ib/II study of pepinemab in combination with avelumab in advanced NSCLC patients following progression on prior systemic and/or anti-PDx therapies., Michael Rahman Shafique, Terrence Lee Fisher, Elizabeth E. Evans, John E. Leonard, Desa Rae Electa Pastore, Crystal L. Mallow, Ernest Smith, Andreas Schroder, Kevin M. Chin, J Thaddeus Beck, Megan Ann Baumgart, Ramaswamy Govindan, Nashat Y. Gabrail, Rachel E Sanborn, Alexander I. Spira, Nagashree Seetharamu, Yan Yan Lou, Aaron Scott Mansfield, Jonathan Wade Goldman, and Maurice Zauderer

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Interim results from a phase Ib/II study of pepinemab in combination with avelumab in advanced NSCLC patients following progression on prior systemic and/or anti-PDx therapies., Michael Rahman Shafique, Terrence Lee Fisher, Elizabeth E. Evans, John E. Leonard, Desa Rae Electa Pastore, Crystal L. Mallow, Ernest Smith, Andreas Schroder, Kevin M. Chin, J Thaddeus Beck, Megan Ann Baumgart, Ramaswamy Govindan, Nashat Y. Gabrail, Rachel E Sanborn, Alexander I. Spira, Nagashree Seetharamu, Yanyan Lou, Aaron Scott Mansfield, Jonathan Wade Goldman, and Maurice Zauderer

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A Pilot Study to Assess the Integration of a Unique PROQOL Tool and Early Palliative Care Intervention in the Care of High Grade Glioma Patients and their Caregivers (2633), Akanksha Sharma and See full list of authors in comments

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Longitudinal Perception of Prognosis of Patients with High Grade Glioma Compared to their Caregivers and Clinicians (2588), Akanksha Sharma and See full list of authors in comments

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1020O A phase I, first-in-human, open-label, dose escalation study of MGD019, an investigational bispecific PD-1 x CTLA-4 DART® molecule in patients with advanced solid tumours, M Sharma, Rachel E Sanborn, GM Cote, JC Bendell, S Kaul, F Chen, A Berezhnoy, P Moore, E Bonvini, BJ Sumrow, and JJ Luke

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Acalabrutinib with or without obinutuzumab versus chlorambucil and obinutuzmab for treatment-naive chronic lymphocytic leukaemia (ELEVATE TN): a randomised, controlled, phase 3 trial., Jeff P Sharman, Miklos Egyed, Wojciech Jurczak, Alan Skarbnik, John M Pagel, Ian W Flinn, Manali Kamdar, Talha Munir, Renata Walewska, Gillian Corbett, Laura Maria Fogliatto, Yair Herishanu, Versha Banerji, Steven Coutre, George Follows, Patricia Walker, Karin Karlsson, Paolo Ghia, Ann Janssens, Florence Cymbalista, Jennifer A Woyach, Gilles Salles, William G Wierda, Raquel Izumi, Veerendra Munugalavadla, Priti Patel, Min Hui Wang, Sofia Wong, and John C Byrd

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Use of a report card to evaluate outcomes of achalasia surgery: beyond the Eckardt score., Ealaf Shemmeri, Ralph W Aye, Alexander S Farivar, Adam J Bograd, and Brian E Louie

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Circulating MicroRNAs and Extracellular Vesicle-Containing MicroRNAs as Response Biomarkers of Anti-programmed Cell Death Protein 1 or Programmed Death-Ligand 1 Therapy in NSCLC., Takehito Shukuya, Vikas Ghai, Joseph M Amann, Tamio Okimoto, Konstantin Shilo, Taek-Kyun Kim, Kai Wang, and David P Carbone

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407 Preliminary safety, pharmacokinetics/pharmacodynamics, and antitumor activity of XmAb20717, a PD-1 x CTLA-4 bispecific antibody, in patients with advanced solid tumors, Elaine Shum, Adil Daud, Matthew Reilley, Yana Najjar, John Thompson, Joaquina Baranda, R Donald Harvey, Rom Leidner, Anthony Shields, Ezra Cohen, Roger Cohen, Alain Mita, Shubham Pant, Mark Stein, Bartosz Chmielowski, Siwen Hu-Lieskovan, Catherine Fleener, Ying Ding, Sowmya Chollate, Hector Avina, Jolene Shorr, Raphael Clynes, and Barbara Hickingbottom

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407 Preliminary safety, pharmacokinetics/pharmacodynamics, and antitumor activity of XmAb20717, a PD-1 x CTLA-4 bispecific antibody, in patients with advanced solid tumors, Elaine Shum, Adil Daud, Matthew Reilley, Yana Najjar, John Thompson, Joaquina Baranda, R Donald Harvey, Rom Leidner, Anthony Shields, Ezra Cohen, Alain Mita, Shubham Pant, Mark Stein, Bartosz Chmielowski, Siwen Hu-Lieskovan, Catherine Fleener, Ying Ding, Sowmya Chollate, Hector Avina, Jolene Shorr, Raphael Clynes, and Barbara Hickingbottom

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Pomalidomide, dexamethasone, and daratumumab in relapsed refractory multiple myeloma after lenalidomide treatment., David S Siegel, Gary J Schiller, Christy Samaras, Michael Sebag, Jesus Berdeja, Siddhartha Ganguly, Jeffrey Matous, Kevin Song, Christopher S Seet, Giampaolo Talamo, Mirelis Acosta-Rivera, Michael Bar, Donald Quick, Bertrand Anz, Gustavo Fonseca, Donna Reece, William E Pierceall, Weiyuan Chung, Faiza Zafar, Amit Agarwal, and Nizar J Bahlis

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Review of Procedures and Outcomes of Video-Assisted Thoracic Surgery for the Treatment of Non-Small Cell Lung Cancer in 45 Patients Undergoing Segmentectomy., Rachel Sier and Osita Onugha

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Elevating your breast program to the next level., Melvin J Silverstein

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Empowering Clinical Nurses: Decreasing Clostridium Difficile, Danielle N. Sloane and Michelle McSherry

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Low-dose adjuvant vaginal cylinder brachytherapy for early-stage non-endometrioid endometrial cancer: recurrence risk and survival outcomes., Alicia Smart, Daniela Buscariollo, Gabriela Alban, Ivan Buzurovic, Teresa Cheng, Jennifer Pretz, Betty Krechmer, Martin King, and Larissa Lee

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A phase 1/2 study of the oral FLT3 inhibitor pexidartinib in relapsed/refractory FLT3-ITD-mutant acute myeloid leukemia., Catherine C Smith, Mark J Levis, Olga Frankfurt, John M Pagel, Gail J Roboz, Richard M Stone, Eunice S Wang, Paul L Severson, Brian L West, Mai H Le, Sabine Kayser, Bao Lam, Henry H Hsu, Chao Zhang, Gideon Bollag, and Alexander E Perl

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The Cancer Rehabilitation Medicine Metrics Consortium: A Path to Enhanced, Multi-Site Outcome Assessment to Enhance Care and Demonstrate Value., Sean R Smith, Mary Vargo, David S Zucker, Maryanne Henderson, Samman Shahpar, Eric M Wisotzky, Christian Custodio, Jeffrey Basford, Gina Jay, Lynn Gerber, and Andrea Cheville

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Surgical Management of Non-Small Cell Lung Cancer Invading the Fissure: Less Is More?, Shane P Smith, Adam J Bograd, Gal Levy, Shu-Ching Chang, Alexander S Farivar, Ralph W Aye, Brian Louie, and Eric Vallieres

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Nanoparticle Albumin-bound Paclitaxel Plus Carboplatin Induction Followed by Nanoparticle Albumin-bound Paclitaxel Maintenance in Squamous Non-Small-cell Lung Cancer (ABOUND.sqm): A Phase III Randomized Clinical Trial., David R Spigel, Robert M Jotte, Santiago Ponce Aix, Laurent Gressot, Daniel Morgensztern, Michael McCleod, Mark A Socinski, Davey Daniel, Oscar Juan-Vidal, Kathryn F Mileham, Howard J. West, Ray Page, Niels Reinmuth, Jeanna Knoble, Tianlei Chen, Rafia Bhore, Marianne Wolfsteiner, Teng Jin Ong, Cesare Gridelli, and Michael Thomas

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What is the Cost-Effective Treatment for Melanoma Patients with a Positive Sentinel Node?, Hayley Standage, Alyssa R Hersh, Aaron Caughey, Matthew H Taylor, John Vetto, and Dale Han

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Hodgkin lymphoma arising in patients with chronic lymphocytic leukemia: outcomes from a large multi-center collaboration., Deborah M Stephens, Ken Boucher, Elizabeth Kander, Sameer A Parikh, Erin M Parry, Mazyar Shadman, John M Pagel, Jennifer Cooperrider, Joanna Rhodes, Anthony Mato, Allison Winter, Brian Hill, Sameh Gaballa, Alexey Danilov, Tycel Phillips, Danielle M Brander, Sonali M Smith, Matthew Davids, Kerry Rogers, Martha J Glenn, and John C Byrd

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An exercise oncology clinical pathway: Screening and referral for personalized interventions., Nicole L Stout, Justin C Brown, Anna L Schwartz, Timothy F Marshall, Anna M Campbell, Larissa Nekhlyudov, David S Zucker, Karen M Basen-Engquist, Grace Campbell, Jeffrey Meyerhardt, Andrea L Cheville, Kelley R Covington, Jennifer A Ligibel, Jonas M Sokolof, Kathryn H Schmitz, and Catherine M Alfano

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Response to anti-PD-1 and anti-LAG-3 immune checkpoint blockade (ICB) is associated with induction of pro-inflammatory Tregs, Elizabeth Sturgill, Courtney Mick, Johanna K. Kaufmann, and William L. Redmond

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Clinical activity of the RET inhibitor pralsetinib (BLU-667) in patients with RET fusion+ solid tumors., Vivek Subbiah, Mini I-Nan Hu, Justin F. Gainor, Aaron Scott Mansfield, Guzman Alonso, Matthew H Taylor, Viola Weijia Zhu, Pilar Garrido Lopez, Alessio Amatu, Robert C. Doebele, Philippe Alexandre Cassier, Bhumsuk Keam, Martin H. Schuler, Hui Zhang, Corinne Clifford, Michael Palmer, Jennifer Green, Christopher D. Turner, and Giuseppe Curigliano

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Demonstration of reciprocal diurnal variation in human serum T3 and rT3 concentration demonstrated by mass spectrometric analysis and establishment of thyroid hormone reference intervals., Qian Sun, Lívia Avallone, Brian Stolze, Katherine A Araque, Yesim Özarda, Jacqueline Jonklaas, Toral Parikh, Kerry Welsh, Likhona Masika, and Steven J Soldin

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Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer., Ryan Sun, Miao Xu, Xihao Li, Sheila Gaynor, Hufeng Zhou, Zilin Li, Yohan Bossé, Stephen Lam, Ming-Sound Tsao, Adonina Tardon, Chu Chen, Jennifer Doherty, Gary E Goodman, Stig E Bojesen, Maria T Landi, Mattias Johansson, John K Field, Heike Bickeböller, H-Erich Wichmann, Angela Risch, Gadi Rennert, Suzanne Arnold, Xifeng Wu, Olle Melander, Hans Brunnström, Loic Le Marchand, Geoffrey Liu, Angeline Andrew, Eric Duell, Lambertus A Kiemeney, Hongbing Shen, Aage Haugen, Mikael Johansson, Kjell Grankvist, Neil Caporaso, Penella Woll, M Dawn Teare, Ghislaine Scelo, Yun-Chul Hong, Jian-Min Yuan, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Demetrios Albanes, Raymond Mak, David Barbie, Paul Brennan, Rayjean J Hung, Christopher I Amos, David C Christiani, and Xihong Lin

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An introduction to the Cyrcadia Breast Monitor: A wearable breast health monitoring device., Vinitha Sree S, Rob Royea, Kevin J Buckman, Matt Benardis, Jim Holmes, Ronald L Fletcher, Ng Eyk, U Rajendra Acharya, and Joshua D I Ellenhorn

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Sequential Complications of Hypercalcemia, Necrotizing Granulomatous Vasculitis, and Aplastic Anemia Occurring in One Patient with Angioimmunoblastic T-cell Lymphoma., Sriman Swarup, Jonathan Kopel, Kyaw Zin Thein, Kaiser Tarafdar, Khatrina Swarup, Seshadri Thirumala, and Donald P Quick

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Spontaneous heparin induced thrombocytopenia (HIT) following curettage and bone graft of femur in a patient with monostotic fibrous dysplasia., Sriman Swarup, Jonathan Kopel, Rachana Yendala, Seshadri Thirumala, and Donald Quick

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560 Alpha-tocopheryloxyacetic acid induces apoptosis of murine rhabdomyosarcoma in vitro while modulating innate and adaptive immune responses in vivo, Fernanda Szewc, Longzhen Song, Sean Rinella, Christopher Dubay, Emmanuel Akporiaye, William L. Redmond, and Christian Capitini