The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2020

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Prior tonsillectomy is associated with an increased risk of esophageal adenocarcinoma., Katherine S Garman, Teminioluwa A Ajayi, Harold J Boutte, Shih-Ting Chiu, Richard J von Furstenberg, Benjamin R Lloyd, Cecelia Zhang, Mark W Onaitis, Shein-Chung Chow, and Shannon J McCall

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1074TiP SGNTGT-001: A phase I study of SGN-TGT, an effector-function enhanced monoclonal antibody (mAb), in advanced malignancies, E Garralda, Rachel E Sanborn, AR Minchom, D Davar, G Curigliano, V Ribrag, A Mehta, F Foss, P Garfin, and S Ansell

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Management of early hepatocellular carcinoma: results of the Delphi consensus process of the Americas Hepato-Pancreato-Biliary Association., Sepideh Gholami, Lauren M Perry, Jason W Denbo, Kenneth Chavin, Philippa H Newell, Quan Ly, Charles St Hill, Gareth Morris-Stiff, Jonathan Kessler, Timothy L Frankel, Neehar D Parikh, Prejesh Philips, George Salti, Toms Augustin, Federico Aucejo, Meelie Debroy, Natalie Coburn, and Susanne G Warner

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Life Is Really Simple, but We Insist on Making It Complicated-Lessons From Confucius on Ultrasound Use in the ICU., Christopher R Gilbert, Fabien Maldonado, Lonny B Yarmus, Jason A Akulian, Candice L. Wilshire, and Jed A Gorden

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Life Is Really Simple, but We Insist on Making It Complicated-Lessons From Confucius on Ultrasound Use in the ICU., Christopher R Gilbert, Fabien Maldonado, Lonny B Yarmus, Jason A Akulian, Candice L. Wilshire, and Jed A Gorden

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Poor Monitor Screen Height Positioning by Pulmonologists During Flexible Bronchoscopy: A Nested, Prospective Observational Trial., Christopher R Gilbert, Jeffrey Thiboutot, Alexander Chen, A Christine Argento, Nicholas J Pastis, Hans J Lee, Andrew D Lerner, and Lonny B Yarmus

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Assessment of Ergonomic Strain and Positioning During Bronchoscopic Procedures: A Feasibility Study., Christopher R Gilbert, Jeffrey Thiboutot, Christopher Mallow, Alexander Chen, Nicholas J Pastis, A Christine Argento, Jennifer Millar, Robert A Lavin, Andrew D Lerner, Diana H Yu, Ben Salwen, Daniel Lunz, Hans J Lee, and Lonny B Yarmus

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Management of Indwelling Tunneled Pleural Catheters: A Modified Delphi Consensus Statement., Christopher R Gilbert, Momen M Wahidi, Richard W Light, M Patricia Rivera, Daniel H Sterman, Rajesh Thomas, Samira Shojaee, Shmuel Shoham, Ionnis Psallidas, David E Ost, Daniela Molena, Nick Maskell, Fabien Maldonado, Moishe Liberman, Y C Gary Lee, Hans Lee, Felix J F Herth, Horiana Grosu, Jed A Gorden, Edward T H Fysh, John P Corcoran, A Christine Argento, Jason A Akulian, Najib M Rahman, and Lonny B Yarmus

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Part One: 2. Screening and Early Detection, Jaya M. Gill Ed.

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Disparities in the Occurrence of Late Effects following Treatment among Adolescent and Young Adult Melanoma Survivors., Alicia A Gingrich, Candice A M Sauder, Melanie Goldfarb, Qian Li, Ted Wun, and Theresa H M Keegan

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Safety and Clinical Activity of MEDI0562, a Humanized OX40 Agonist Monoclonal Antibody, in Adult Patients with Advanced Solid Tumors., Bonnie S Glisson, Rom Leidner, Robert L Ferris, John Powderly, Naiyer A Rizvi, Bhumsuk Keam, Reva Schneider, Sanjay Goel, James P Ohr, Jennifer Burton, Yanan Zheng, Steven Eck, Matthew Gribbin, Katie Streicher, Danielle M Townsley, and Sandip Pravin Patel

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Outcomes of Treatment with the Chimeric Antigen Receptor (CAR) T Cell Therapy Lisocabtagene Maraleucel (liso-cel) in the Nonuniversity Setting: Initial Results from the Outreach Study, John E Godwin, Cesar O. Freytes, Michael Maris, Don A. Stevens, Daanish Hoda, Bassam Mattar, Juan C. Varela, Mohamad Cherry, James Essell, Jay Courtright, Suzanne R. Fanning, Habte A. Yimer, Nikolaus S. Trede, Marina Youssef, James Lymp, and Carlos Bachier

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Blood test shows high accuracy in detecting stage I non-small cell lung cancer., Cherylle Goebel, Christopher L Louden, Robert McKenna, Osita Onugha, Andrew Wachtel, and Thomas Long

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Recent advances in the understanding and management of primary hyperparathyroidism., Melanie Goldfarb and Frederick R Singer

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Safety and tolerability of MEDI0562 in combination with durvalumab or tremelimumab in patients with advanced solid tumors., Jonathan Wade Goldman, Sarina Anne Piha-Paul, Brendan Curti, Katrina Pedersen, Todd Michael Bauer, Stefanie L. Groenland, Richard D. Carvajal, Vaishali Chhaya, Scott A. Hammond, Katie Streicher, Danielle Michelle Townsley, Young Kwang Chae, Jens Voortman, Aurelien Marabelle, and John D. Powderly

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Safety and tolerability of MEDI0562 in combination with durvalumab or tremelimumab in patients with advanced solid tumors., Jonathan Wade Goldman, Sarina Anne Piha-Paul, Brendan Curti, Katrina Pedersen, Todd Michael Bauer, Stefanie L. Groenland, Richard D. Carvajal, Vaishali Chhaya, Scott A. Hammond, Katie Streicher, Danielle Michelle Townsley, Young Kwang Chae, Jens Voortman, Aurelien Marabelle, and John D. Powderly

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CT191 - Interim results from CLASSICAL-Lung, phase 1b/2 study of pepinemab (VX15/2503) in combination with avelumab in advanced NSCLC, Jonathan W. Goldman, Terrence L. Fisher, Elizabeth Evans, John E. Leonard, Desa Rae Pastore, Crystal Mallow, Ernest Smith, Andreas Schroder, Kevin Chin, Michael Shafique, Thaddeus Beck, Megan A. Baumgart, Ramaswamy Govindan, Nashat Gabrail, Rachel E Sanborn, Alexander Spira, Nagashree Seetharamu, Yanyan Lou, Aaron S. Mansfield, and Maurice Zauderer

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Abstract CT191: Interim results from CLASSICAL-Lung, phase 1b/2 study of pepinemab (VX15/2503) in combination with avelumab in advanced NSCLC, Jonathan W. Goldman, Terrence L. Fisher, Elizabeth Evans, John E. Leonard, Desa Rae Pastore, Crystal Mallow, Ernest Smith, Andreas Schroeder, Kevin Chin, Michael Shafique, Thaddeaus Beck, Megan A. Baumgart, Ramaswamy Govindan, Nashat Gabrail, Rachel E Sanborn, Alexander I. Spira, Nagashree Seetharamu, Yanyan Lou, Aaron S. Mansfield, and Maurice Zauderer

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Utilization of Claims Data in Research: Are We Missing the Forest and the Trees?, Jed A Gorden, Candice L. Wilshire, and Christopher R Gilbert

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Using Preclinical Data to Design Combination Clinical Trials of Radiation Therapy and Immunotherapy., Michael J. Gough, Shay Sharon, Marka R Crittenden, and Kristina H Young

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Using Preclinical Data to Design Combination Clinical Trials of Radiation Therapy and Immunotherapy., Michael J. Gough, Shay Sharon, Marka R Crittenden, and Kristina H Young

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Prospective Study of Use of Edmonton Symptom Assessment Scale Versus Routine Symptom Management During Weekly Radiation Treatment Visits., Uma D Goyal, Kristen Riegert, Rajayogesh Davuluri, Shawn Ong, Sun K Yi, Shona T Dougherty, and Charles C Hsu

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Pembrolizumab immunotherapy for relapsed CNS Lymphoma., Jerome J Graber, Benjamin Plato, Raya Mawad, and Daniel J Moore

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A phase II single-arm study of pembrolizumab with enzalutamide in men with metastatic castration-resistant prostate cancer progressing on enzalutamide alone., Julie N Graff, Tomasz M Beer, Joshi J Alumkal, Rachel E Slottke, William L. Redmond, George V Thomas, Reid F Thompson, Mary A Wood, Yoshinobu Koguchi, Yiyi Chen, Emile Latour, Raymond C Bergan, Charles G Drake, and Amy E Moran

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Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma., Catherine S Grasso, Jennifer Tsoi, Mykola Onyshchenko, Gabriel Abril-Rodriguez, Petra Ross-Macdonald, Megan Wind-Rotolo, Ameya Champhekar, Egmidio Medina, Davis Y Torrejon, Daniel Sanghoon Shin, Phuong Tran, Yeon Joo Kim, Cristina Puig-Saus, Katie Campbell, Agustin Vega-Crespo, Michael Quist, Christophe Martignier, Jason J Luke, Jedd D Wolchok, Douglas B Johnson, Bartosz Chmielowski, F Stephen Hodi, Shailender Bhatia, William Sharfman, Walter Urba, Craig L Slingluff, Adi Diab, John B A G Haanen, Salvador Martin Algarra, Drew M Pardoll, Valsamo Anagnostou, Suzanne L Topalian, Victor E Velculescu, Daniel E Speiser, Anusha Kalbasi, and Antoni Ribas

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Comprehensive guidance on the diagnosis and management of primary mesenchymal tumours of the thyroid gland., Sriram Gubbi, Shilpa Thakur, Shirisha Avadhanula, Katherine A Araque, Armando C Filie, Mark Raffeld, James Welch, Jaydira Del Rivero, Electron Kebebew, Kenneth D Burman, Leonard Wartofsky, and Joanna Klubo-Gwiezdzinska

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Germinal centers in tertiary lymphoid structures distinguish long-term pancreatic cancer survivors associated with neoantigen expression and immune memory, Andrew J Gunderson

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TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking., Andrew J Gunderson, Tomoko Yamazaki, Kayla McCarty, Nathaniel E Fox, Michaela Phillips, Alejandro F Alice, Tiffany Blair, Mark Whiteford, David O'Brien, Rehan Ahmad, Maria X Kiely, Amanda Hayman, Todd Crocenzi, Michael J. Gough, Marka R. Crittenden, and Kristina H Young

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Novel application of vinylpolysiloxane hearing aid impression mold as patient-specific bolus for head and neck cancer radiotherapy., Anne Elizabeth Gunter, John Burgoyne, Min Park, Namou Kim, Daliang Cao, and Vivek Mehta

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Initial and Consolidation Therapy for Younger Patients with Mantle Cell Lymphoma., Daniel Guy and Brad S Kahl

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Surveillance for second breast cancer events in women with a personal history of breast cancer using breast MRI: a systematic review and meta-analysis., Cameron B Haas, Larissa Nekhlyudov, Janie M Lee, Sara H Javid, Mary Bush, Dianne Johnson, Timothy Gleason, Cary Kaufman, Jennifer Specht, Sean Stitham, and Karen J Wernli

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The importance of age as prognostic factor for the outcome of patients with hepatoblastoma: Analysis from the Children's Hepatic tumors International Collaboration (CHIC) database., Beate Haeberle, Arun Rangaswami, Mark Krailo, Piotr Czauderna, Eiso Hiyama, Rudolf Maibach, Dolores Lopez-Terrada, Daniel C Aronson, Rita Alaggio, Marc Ansari, Marcio H Malogolowkin, Giorgio Perilongo, Allison F O'Neill, Angela Trobaugh-Lotrario, Kenichiro Watanabe, Irene Schmid, Dietrich von Schweinitz, Sarangarajan Ranganathan, Kenichi Yoshimura, Tomoro Hishiki, Yukichi Tanaka, Jin Piao, Yurong Feng, Eugenia Rinaldi, Davide Saraceno, Marisa Derosa, and Rebecka L Meyers

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Organ Preservation in the Treatment of Stage II and III Rectal Cancer., Ed Hagen and Robert K Cleary

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Perianal basal cell carcinoma: a common cancer in an uncommon location., Ed Hagen, Nathan Hite, John A Griffin, and Rodney Kratz

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Laparoscopic Transhiatal Esophagectomy for Invasive Esophageal Adenocarcinoma., Kelly R Haisley, Walaa F Abdelmoaty, and Christy M Dunst

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Results of Lung Cancer Screening in the Community., John R Handy, Michael Skokan, Erika Rauch, Steven Zinck, Rachel E Sanborn, Svetlana Kotova, and Mansen Wang

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Results of Lung Cancer Screening in the Community., John R Handy, Michael Skokan, Erika Rauch, Steven Zinck, Rachel E Sanborn, Svetlana Kotova, and Mansen Wang

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How we treat left-sided vs right-sided colon cancer., Diana L Hanna and Heinz-Josef Lenz

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INDUCE-3: A randomized, double-blind study of GSK3359609 (GSK609), an inducible T-cell co-stimulatory (ICOS) agonist antibody, plus pembrolizumab (PE) versus placebo (PL) plus PE for first-line treatment of PD-L1-positive recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC)., Aaron Richard Hansen, Thomas Stanton, Min Hee Hong, Ezra EW Cohen, Hisham Mohamed Mehanna, Michael Jon Chisamore, David Turner, Sapna Yadavilli, Kelly Bell, Carlos Baccan, Rosalida Leone, Helen Chen, Helen Zhou, Catherine Elizabeth Ellis, Marc S. Ballas, Axel Hoos, and Danny Rischin

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Three-Dimensional Computer-Assisted Surgical Planning, Manufacturing, and Intraoperative Navigation in Oncologic Surgery., Phillip Harrison, Ashish Patel, Allen C Cheng, and Richard Bryan Bell

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The Effects of Music Medicine on Reducing Distress, Anxiety, and Pain During Bone Marrow Biopsy Procedures, Betsy Hartman, Sharon Mast, and Judy Delismon

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Use of Convalescent Plasma in Hospitalized Patients with Covid-19 - Case Series., Livia Hegerova, Ted Gooley, Kelly A Sweerus, Cynthia L Maree, Neil Bailey, Megumi Bailey, Vanessa Dunleavy, Krish Patel, Kirsten Alcorn, N Rebecca Haley, Jill M Johnsen, Barbara A Konkle, Annamarie C Lahti, Morgan L Alexander, Jason D Goldman, Anne B Lipke, Sun-Jung Lim, Mark David Sullivan, John S Pauk, and John M Pagel

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An atypical case of necrotizing fasciitis secondary to perforated cecal cancer., Laura S Heidelberg, Erica Pettke, Teresa E Wagner, and Lauren Angotti

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Simultaneously spatial and temporal Higher-Order Total Variations for noise suppression and motion reduction in DCE and IVIM., Renjie He, Yao Ding, Abdallah S R Mohamed, Sweet Ping Ng, Rachel B Ger, Hesham Elhalawani, Baher A Elgohari, Kristina H Young, Katherine A Hutcheson, Clifton D Fuller, and Stephen Y Lai

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Cellular thermal shift analysis for interrogation of CRISPR-assisted proteomic changes., Nam-Gu Her, Ivan Babic, Venkata Yenugonda, Santosh Kesari, and Elmar Nurmemmedov

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Thrombospondin-1 counteracts the p97 inhibitor CB-5083 in colon carcinoma cells., Nam-Gu Her, Santosh Kesari, and Elmar Nurmemmedov

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Stapled Diaphragmatic Plication: Is It Better Than Suture Plication?, Terra M Hill and Osita Onugha

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Allogeneic autophagosome-enriched composition for the treatment of disease, Traci Hilton, Sandra Aung, Rieneke van de Ven, Christopher Paustian, Tarsem Moudgil, Christopher Dubay, Christopher Twitty, Hong-Ming Hu, and Bernard A Fox

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Allogeneic autophagosome-enriched composition for the treatment of disease, Traci Hilton, Sandra Aung, Rieneke van de Ven, Christopher Paustian, Tarsem Moudgil, Christopher Dubay, Christopher Twitty, Hong-Ming Hu, and Bernard A Fox

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Allogeneic autophagosome-enriched composition for the treatment of disease, Traci Hilton, Sandra Aung, Rieneke van de Ven, Christopher Paustian, Tarsem Moudgil, Christopher Dubay, Christopher Twitty, Hong-Ming Hu, and Bernard A Fox

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Allogeneic autophagosome-enriched composition for the treatment of disease, Traci Hilton, Sandra Aung, Rieneke van de Ven, Christopher Paustian, Tarsem Moudgil, Christopher Dubay, Christopher Twitty, Hong-Ming Hu, and Bernard A Fox

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Simultaneous Isolation of Circulating Nucleic Acids and EV-Associated Protein Biomarkers From Unprocessed Plasma Using an AC Electrokinetics-Based Platform., Juan Pablo Hinestrosa, David J Searson, Jean M Lewis, Alfred Kinana, Orlando Perrera, Irina Dobrovolskaia, Kevin Tran, Robert Turner, Heath I Balcer, Iryna Clark, David Bodkin, Dave Hoon, and Rajaram Krishnan

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Breast cancer care during a pandemic: an opportune time for cryoablation?, Dennis R Holmes

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Patients With Natural Killer (NK) Cell Chronic Active Epstein-Barr Virus Have Immature NK Cells and Hyperactivation of PI3K/Akt/mTOR and STAT1 Pathways., Matthew K Howe, Kennichi Dowdell, Hye Sun Kuehn, Qingxue Li, Geoffrey T Hart, Doreen Garabedian, Kelly Liepshutz, Amy P Hsu, Hua Su, Julie E Niemela, Jennifer L Stoddard, Gulbu Uzel, Evan Shereck, Laura Schulz, Tatyana Feldman, Sergio D Rosenzweig, Eric O Long, Lesia Dropulic, and Jeffrey I Cohen

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Complete response with talimogene laherparepvec in recurrent melanoma of the ear: A case report., Ashley C Hsu, Niels C Kokot, Burton L Eisenberg, and Jacob S Thomas

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SITC cancer immunotherapy resource document: a compass in the land of biomarker discovery., Siwen Hu-Lieskovan, Srabani Bhaumik, Kavita Dhodapkar, Jean-Charles J B Grivel, Sumati Gupta, Brent A Hanks, Sylvia Janetzki, Thomas O Kleen, Yoshinobu Koguchi, Amanda W Lund, Cristina Maccalli, Yolanda D Mahnke, Ruslan D Novosiadly, Senthamil R Selvan, Tasha Sims, Yingdong Zhao, and Holden T Maecker

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Cumulative suppressive index as a predictor of relapse free survival and overall survival in Human Papilloma Virus-negative oral squamous cell carcinomas with negative resection margins., Lauren Hum, Daniel Bethmann, Zipei Feng, Shu-Ching Chang, Alexander Eckert, Carmen Ballesteros-Merino, Claudia Keschke, Matthias Kappler, Carlo Bifulco, Claudia Wickenhauser, Barbara Seliger, Bernard A Fox, and Richard Bryan Bell

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Survival with Olaparib in Metastatic Castration-Resistant Prostate Cancer., Maha Hussain, Joaquin Mateo, Karim Fizazi, Fred Saad, Neal Shore, Shahneen Sandhu, Kim N Chi, Oliver Sartor, Neeraj Agarwal, David Olmos, Antoine Thiery-Vuillemin, Przemyslaw Twardowski, Guilhem Roubaud, Mustafa Özgüroğlu, Jinyu Kang, Joseph Burgents, Christopher Gresty, Claire Corcoran, Carrie A Adelman, and Johann de Bono

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Building a circular RNA centered gene regulation network associated with cervical squamous cell carcinoma., Wei Hu, Qingqing Li, Xiaoyi He, Ming Gao, Zhanfu Zheng, Yuanlin Ding, Kai Wang, and Yuqing He

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Molecular profiling of melanoma brain metastases compared to primary cutaneous melanoma and to extracranial metastases., Gino K In, Kelsey Poorman, Michelle Saul, Steven O'Day, Jeffrey M Farma, Anthony J Olszanski, Michael S Gordon, Jacob S Thomas, Burton Eisenberg, Lawrence Flaherty, Amy Weise, Steven Daveluy, Geoffrey Gibney, Michael B Atkins, and Ari Vanderwalde

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Association of Event-Free and Distant Recurrence-Free Survival With Individual-Level Pathologic Complete Response in Neoadjuvant Treatment of Stages 2 and 3 Breast Cancer: Three-Year Follow-up Analysis for the I-SPY2 Adaptively Randomized Clinical Trial., I-SPY2 Trial Consortium, Douglas Yee, Angela M DeMichele, Christina Yau, Claudine Isaacs, W Fraser Symmans, Kathy S Albain, Yunn-Yi Chen, Gregor Krings, Shi Wei, Shuko Harada, Brian Datnow, Oluwole Fadare, Molly Klein, Stefan Pambuccian, Beiyun Chen, Kathi Adamson, Sharon Sams, Paulette Mhawech-Fauceglia, Anthony Magliocco, Mike Feldman, Mara Rendi, Husain Sattar, Jay Zeck, Idris T Ocal, Ossama Tawfik, Lauren Grasso LeBeau, Sunati Sahoo, Tuyethoa Vinh, A Jo Chien, Andres Forero-Torres, Erica Stringer-Reasor, Anne M Wallace, Lajos Pusztai, Judy C Boughey, Erin D Ellis, Anthony D Elias, Janice Lu, Julie E Lang, Hyo S Han, Amy S Clark, Rita Nanda, Donald W Northfelt, Qamar J Khan, Rebecca K Viscusi, David M Euhus, Kirsten K Edmiston, Stephen Y Chui, Kathleen Kemmer, John W Park, Minetta C Liu, Olufunmilayo Olopade, Brian Leyland-Jones, Debasish Tripathy, Stacy L Moulder, Hope S Rugo, Richard Schwab, Shelly Lo, Teresa Helsten, Heather Beckwith, Patricia Haugen, Nola M Hylton, Laura J Van't Veer, Jane Perlmutter, Michelle E Melisko, Amy Wilson, Garry Peterson, Adam L Asare, Meredith B Buxton, Melissa Paoloni, Julia L Clennell, Gillian L Hirst, Ruby Singhrao, Katherine Steeg, Jeffrey B Matthews, Smita M Asare, Ashish Sanil, Scott M Berry, Laura J Esserman, and Donald A Berry

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Determinant factors on differences in survival for gastric cancer between the US and Japan using nationwide databases., Yuri Ito, Isao Miyashiro, Takashi Ishikawa, Kohei Akazawa, Keisuke Fukui, Hitoshi Katai, Souya Nunobe, Ichiro Oda, Yoh Isobe, Shunichi Tsujitani, Hiroyuki Ono, Satoshi Tanabe, Takeo Fukagawa, Satoshi Suzuki, Yoshihiro Kakeji, Mitsuru Sasako, Anton J Bilchik, and Manabu Fujita

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The melanoma brain metastatic microenvironment: aldolase C partakes in shaping the malignant phenotype of melanoma cells - a case of inter-tumor heterogeneity., Sivan Izraely, Shlomit Ben-Menachem, Orit Sagi-Assif, Tsipi Meshel, Sapir Malka, Alona Telerman, Matias A Bustos, Romela Irene Ramos, Metsada Pasmanik-Chor, Dave Hoon, and Isaac P Witz

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Modulation of Immune Checkpoints by Chemotherapy in Human Colorectal Liver Metastases., Neda Jabbari, Heidi L Kenerson, Christopher Lausted, Xiaowei Yan, Changting Meng, Kevin M Sullivan, Priyanka Baloni, Dani E Bergey, Venu G Pillarisetty, Leroy Hood, Raymond S Yeung, and Qiang Tian

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Staging System for Neuroendocrine Tumors of the Lung Needs to Incorporate Histologic Grade., Anee Sophia Jackson, Adam Rosenthal, Maria Cattoni, Adam J Bograd, Alexander S Farivar, Ralph W Aye, Eric Vallières, and Brian Louie

Primary surgical management of complicated pleural space infections has superior outcomes when compared to intra-pleural fibrinolytic therapy, AS Jackson, Candice L. Wilshire, SC Chang, LC Horslen, JR Rayburn, CC Fuller, AS Farivar, AJ Bograd, RW Aye, BE Louie, E Vallières, CR Gilbert, and JA Gorden

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The role of antimicrobial prophylaxis in patients with head and neck cancer undergoing chemoradiation., Alina T Jaeger, James E Connelly, Ruyun Jin, Samuel N Jacobson, and Rom Leidner

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The effect of radiation therapy on post-prostatectomy urinary function., David Jenkins, Gregory P Swanson, Sameer G Jhavar, Kristofer R Wagner, Chul S Ha, and Wencong Chen

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480 Preliminary evaluation of a novel coronavirus vaccine (CORVax) using electroporation of plasmid DNA encoding a stabilized prefusion SARS-CoV-2 spike protein alone or with transfection of plasmid IL-12, Shawn M. Jensen, Christopher Twitty, Christopher Paustian, Madelein Laws, Glenna McDonnell, Keith W Wegman, Tarsem Moudgil, Michael E Afentoulis, Mia Han, Kellie Malloy Foerter, David Canton, Jack Lee, Bianca Nguyen, John Rodriguez, Kim Jaffe, Brian D. Piening, Carlo Bifulco, Daniel O'Connor, Walter Urba, Rom Leidner, Traci Hilton, Hong-Ming Hu, and Bernard A Fox

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480 Preliminary evaluation of a novel coronavirus vaccine (CORVax) using electroporation of plasmid DNA encoding a stabilized prefusion SARS-CoV-2 spike protein alone or with transfection of plasmid IL-12, Shawn M. Jensen, Christopher Twitty, Christopher Paustian, Madelein Laws, Glenna McDonnell, Keith W Wegmann, Tarsem Moudgil, Michael E Afentoulis, Mia Han, Kellie Malloy Foerter, David Canton, Jack Lee, Biance Nguyen, John Rodriguez, Kim Jaffe, Brian D. Piening, Carlo Bifulco, Daniel O'Connor, Walter Urba, Rom Leidner, Traci Hilton, Hong-Ming Hu, and Bernard A Fox

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The relationship between body-mass index and overall survival in non-small cell lung cancer by sex, smoking status, and race: A pooled analysis of 20,937 International lung Cancer consortium (ILCCO) patients., Mei Jiang, Aline F Fares, Daniel Shepshelovich, Ping Yang, David Christiani, Jie Zhang, Kouya Shiraishi, Brid M Ryan, Chu Chen, Ann G Schwartz, Adonina Tardon, Sanjay Shete, Matthew B Schabath, M Dawn Teare, Loic Le Marchand, Zuo-Feng Zhang, John K Field, Hermann Brenner, Nancy Diao, Juntao Xie, Takashi Kohno, Curtis C Harris, Angela S Wenzlaff, Guillermo Fernandez-Tardon, Yuanqing Ye, Fiona Taylor, Lynne R Wilkens, Michael Davies, Yi Liu, Matt J Barnett, Gary E Goodman, Hal Morgenstern, Bernd Holleczek, Sera Thomas, M Catherine Brown, Rayjean J Hung, Wei Xu, and Geoffrey Liu

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Protein-altering germline mutations implicate novel genes related to lung cancer development., Xuemei Ji, Semanti Mukherjee, Maria Teresa Landi, Yohan Bosse, Philippe Joubert, Dakai Zhu, Ivan Gorlov, Xiangjun Xiao, Younghun Han, Olga Gorlova, Rayjean J Hung, Yonathan Brhane, Robert Carreras-Torres, David C Christiani, Neil Caporaso, Mattias Johansson, Geoffrey Liu, Stig E Bojesen, Loic Le Marchand, Demetrios Albanes, Heike Bickeböller, Melinda C Aldrich, William S Bush, Adonina Tardon, Gad Rennert, Chu Chen, Jinyoung Byun, Konstantin H Dragnev, John K Field, Lambertus Fa Kiemeney, Philip Lazarus, Shan Zienolddiny, Stephen Lam, Matthew B Schabath, Angeline S Andrew, Pier A Bertazzi, Angela C Pesatori, Nancy Diao, Li Su, Lei Song, Ruyang Zhang, Natasha Leighl, Jakob S Johansen, Anders Mellemgaard, Walid Saliba, Christopher Haiman, Lynne Wilkens, Ana Fernandez-Somoano, Guillermo Fernandez-Tardon, Erik H F M van der Heijden, Jin Hee Kim, Michael P A Davies, Michael W Marcus, Hans Brunnström, Jonas Manjer, Olle Melander, David C Muller, Kim Overvad, Antonia Trichopoulou, Rosario Tumino, Gary E Goodman, Angela Cox, Fiona Taylor, Penella Woll, Erich Wichmann, Thomas Muley, Angela Risch, Albert Rosenberger, Kjell Grankvist, Mikael Johansson, Frances Shepherd, Ming-Sound Tsao, Susanne M Arnold, Eric B Haura, Ciprian Bolca, Ivana Holcatova, Vladimir Janout, Milica Kontic, Jolanta Lissowska, Anush Mukeria, Simona Ognjanovic, Tadeusz M Orlowski, Ghislaine Scelo, Beata Swiatkowska, David Zaridze, Per Bakke, Vidar Skaug, Lesley M Butler, Kenneth Offit, Preethi Srinivasan, Chaitanya Bandlamudi, Matthew D Hellmann, David B Solit, Mark E Robson, Charles M Rudin, Zsofia K Stadler, Barry S Taylor, Michael F Berger, Richard Houlston, John McLaughlin, Victoria Stevens, David C Nickle, Ma'en Obeidat, Wim Timens, María Soler Artigas, Sanjay Shete, Hermann Brenner, Stephen Chanock, Paul Brennan, James D McKay, and Christopher I Amos

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CX-2029, a PROBODY drug conjugate targeting CD71 (transferrin receptor): Results from a first-in-human study (PROCLAIM-CX-2029) in patients (Pts) with advanced cancer., Melissa Lynne Johnson, Anthony B. El-Khoueiry, Navid Hafez, Nehal J. Lakhani, Hirva Mamdani, Jordi Rodon Ahnert, Rachel E Sanborn, Thang Ho, Rachel Li, Jana Waldes, and Alexander I. Spira

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MIPS participation in radiation oncology practices-A simple survey., Ryan T Jones, Mary Jo Tarrant, Dominick Parris, Michael Ray, and Join Y Luh

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Nivolumab in Advanced Hepatocellular Carcinoma: Safety Profile and Select Treatment-Related Adverse Events From the CheckMate 040 Study., Karen Julien, Hiu Tung Leung, Carmen Fuertes, Megumi Mori, Miao-Jen Wang, Jocelyn Teo, Lisa Weiss, Sara Hamilton, Holly DiFebo, Yoon Jin Noh, Aralee Galway, Jane Koh, Edith Brutcher, Huanyu Zhao, Yun Shen, Marina Tschaika, and Yue-Yun To

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Comparative lipidomics of 5-Fluorouracil-sensitive and -resistant colorectal cancer cells reveals altered sphingomyelin and ceramide controlled by acid sphingomyelinase (SMPD1)., Jae Hun Jung, Kohei Taniguchi, Hyeong Min Lee, Min Young Lee, Raju Bandu, Kazumasa Komura, Kil Yeon Lee, Yukihiro Akao, and Kwang Pyo Kim

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National Cancer Institute Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions., Jacob Kagan, Robert L Moritz, Richard Mazurchuk, Je Hyuk Lee, Peter Vasili Kharchenko, Orit Rozenblatt-Rosen, Eytan Ruppin, Fredrik Edfors, Fiona Ginty, Yury Goltsev, James A Wells, John LaCava, Jessica L Riesterer, Ronald N Germain, Tujin Shi, Mark S Chee, Bogdan A Budnik, John R Yates, Brian T Chait, Jeffery R Moffitt, Richard D Smith, and Sudhir Srivastava

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Maximizing Breast Cancer Therapy with Awareness of Potential Treatment-Related Blood Disorders., Henry G Kaplan, Gregory S Calip, and Judith A Malmgren

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Pre/perimenopausal (preMeno) women receiving palbociclib (PAL) for hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2‒) advanced breast cancer (ABC) in a real-world setting: Treatment patterns from POLARIS, MS Karuturi, A Garrett, JL Blum, J Anderson, E Jensen, T Pluard, Thomas Stanton, K Manning, JC Cappelleri, F Beery, Y Wang, and D Tripathy

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MP70-07 TRANSPERINEAL FOCAL CRYOABLATION AS A TREATMENT FOR CLINICALLY SIGNIFICANT PROSTATE CANCER, Mark J. Kelly and Jonatan Torrez

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Tumor slice culture as a biologic surrogate of human cancer., Heidi L Kenerson, Kevin M Sullivan, Yongwoo D Seo, Kathryn M Stadeli, Cigdem Ussakli, Xiaowei Yan, Christopher G Lausted, Venu G Pillarisetty, James O Park, Kimberly J Riehle, Matthew Yeh, Qiang Tian, and Raymond S Yeung

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Delay in surgery is associated with axillary upstaging of clinically node negative breast cancer patients., Adam Khader, Shu-Ching Chang, Juan A Santamaria-Barria, Mary Garland-Kledzik, Anthony J Scholer, Melanie Goldfarb, Janie Grumley, and Trevan D Fischer

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BRAINSTORM: A Multi-Institutional Phase 1/2 Study of RRx-001 in Combination With Whole Brain Radiation Therapy for Patients With Brain Metastases., Michelle M Kim, Hemant A Parmar, Matthew Schipper, Theresa Devasia, Madhava P Aryal, Santosh Kesari, Steven J O'Day, Aki Morikawa, Daniel E Spratt, Larry Junck, Aaron Mammoser, James A Hayman, Theodore S Lawrence, Christina I Tsien, Robert Aiken, Sharad Goyal, Nacer Abrouk, Malcolm Trimble, Yue Cao, and Christopher D Lao

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Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis., Myoung Sook Kim, Ramkishore Gernapudi, Yessenia Cedeño Cedeño, Brian M Polster, Ramon Martinez, Paul Shapiro, Santosh Kesari, Elmar Nurmemmedov, and Antonino Passaniti

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"Chemotherapy-periodized" Exercise to Accommodate for Cyclical Variation in Fatigue., Amy A Kirkham, Kelcey A Bland, David S Zucker, Joshua Bovard, Tamara Shenkier, Donald C McKenzie, Margot K Davis, Karen A Gelmon, and Kristin L Campbell

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Inflammatory and clinical risk factors for chemotherapy-induced peripheral neuropathy (CIPN): A nationwide longitudinal study in 143 cancer patients during chemotherapy., Ian Kleckner, Todd Jusko, Eva Culakova, Amber Kleckner, Matthew Asare, Julia Ellen Inglis, Kah Poh Loh, Luke Joseph Peppone, Jeffrey L. Berenberg, Alison Conlin, Deborah J. Ossip, and Karen Michelle Mustian

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Primary chemoablation of low-grade upper tract urothelial carcinoma using UGN-101, a mitomycin-containing reverse thermal gel (OLYMPUS): an open-label, single-arm, phase 3 trial., Nir Kleinmann, Surena F Matin, Phillip M Pierorazio, John L Gore, Ahmad Shabsigh, Brian Hu, Karim Chamie, Guilherme Godoy, Scott Hubosky, Marcelino Rivera, Michael O'Donnell, Marcus Quek, Jay D Raman, John J Knoedler, Douglas Scherr, Joshua Stern, Christopher Weight, Alon Weizer, Michael Woods, Hristos Kaimakliotis, Angela B Smith, Jennifer M Linehan, Jonathan Coleman, Mitchell R Humphreys, Raymond Pak, David Lifshitz, Michael Verni, Mehrad Adibi, Mahul B Amin, Elyse Seltzer, Ifat Klein, Marina Konorty, Dalit Strauss-Ayali, Gil Hakim, Mark Schoenberg, and Seth P Lerner

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Management of CLL Patients Early in the COVID-19 Pandemic: An International Survey of CLL Experts, Brian Koffman, Anthony Mato, John C. Byrd, Alexey Danilov, Brad Hedrick, Chaitra Ujjani, Lindsey Roeker, Deborah M. Stephens, Matthew S. Davids, John M Pagel, and Mazyar Shadman

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760 Trough levels of ipilimumab in serum as a potential predictive biomarker of clinical outcomes for patients with advanced melanoma after treatment with ipilimumab, Yoshinobu Koguchi, Noriko Iwamoto, Takashi Shimada, Shu-Ching Chang, John Cha, Brian D. Piening, Brendan Curti, Walter Urba, and William L. Redmond

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760 Trough levels of ipilimumab in serum as a potential predictive biomarker of clinical outcomes for patients with advanced melanoma after treatment with ipilimumab, Yoshinobu Koguchi, Noriko Iwamoto, Takashi Shimada, Shu-Ching Chang, John Cha, Brian D. Piening, Brian Piening, Brendan Curti, Walter Urba, and William L. Redmond

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ANG1005, a brain penetrating peptide-drug conjugate, shows activity in patients with breast cancer with leptomeningeal carcinomatosis and recurrent brain metastases., Priya Kumthekar, Shou-Ching Tang, Andrew J Brenner, Santosh Kesari, David E Piccioni, Carey K Anders, Jose A Carrillo, Pavani Chalasani, Peter Kabos, Shannon L Puhalla, Katherine H R Tkaczuk, Agustin Garcia, Manmeet S Ahluwalia, Jeffrey S Wefel, Nehal Lakhani, and Nuhad K Ibrahim

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Ineffective esophageal motility is not a contraindication to total fundoplication., Anne-Sophie Laliberte, Brian Louie, Candice L. Wilshire, Alexander S Farivar, Adam J Bograd, and Ralph W Aye

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COVID-19 and cancer: A guide with suggested COVID-19 rule-out criteria to support clinical decision-making., Christopher Larson, Bryan Oronsky, Sharad Goyal, Carolyn Ray, Farah Hedjran, Terese C Hammond, Santosh Kesari, Scott Caroen, Michelle Lybeck, Vaughn E Dobalian, Arnold Oronsky, and Tony Reid

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Phase 1 study of CWP232291 in patients with relapsed or refractory acute myeloid leukemia and myelodysplastic syndrome., Je-Hwan Lee, Stefan Faderl, John M Pagel, Chul Won Jung, Sung-Soo Yoon, Animesh D Pardanani, Pamela S Becker, Howard Lee, Jeongeun Choi, Kyoungjune Lee, Minkyoung Kim, and Jorge E Cortes

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Characterizing the cancer-associated microbiome with small RNA sequencing data., Wei-Hao Lee, Kai-Pu Chen, Kai Wang, Hsuan-Cheng Huang, and Hsueh-Fen Juan

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386 Phase I/Ib first-in-human study of HEK-NIZ985, a recombinant IL-15/IL-15Rα heterodimer, alone and in combination with spartalizumab, in adults with advanced and metastatic solid tumors, Rom Leidner, Andrea Wang-Gillam, Sumati Gupta, Robert Wesolowski, Douglas McNeel, Kevin Conlon, Nehal Parikh, Jessica O'Keeffe, Niladri Roy Chowdhury, Xiaoli Wang, Ryan Sullivan, and John Thompson

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386 Phase I/Ib first-in-human study of HEK-NIZ985, a recombinant IL-15/IL-15Rα heterodimer, alone and in combination with spartalizumab, in adults with advanced and metastatic solid tumors, Rom Leidner, Andrea Wang-Gillam, Sumati Gupta, Robert Wesolowski, Douglas McNeel, Kevin Conlon, Nehal Parikh, Jessica O'Keeffe, Niladri Roy Chowdhury, Xiaoli Wang, Ryan Sullivan, and John Thompson

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Radiofrequency Ablation for the Palliative Treatment of Bone Metastases: Outcomes from the Multicenter OsteoCool Tumor Ablation Post-Market Study (OPuS One Study) in 100 Patients., Jason Levy, Thomas Hopkins, Jonathan Morris, Nam D Tran, Elizabeth David, Francesco Massari, Hamed Farid, Alexander Vogel, William G O'Connell, Peter Sunenshine, Robert Dixon, Afshin Gangi, Nicolas von der Höh, and Sandeep Bagla

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Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer., Ling Li, Lisa Hobson, Laura Perry, Bethany Clark, Susan Heavey, Aiman Haider, Ashwin Sridhar, Greg Shaw, John Kelly, Alex Freeman, Ian Wilson, Hayley Whitaker, Elmar Nurmemmedov, Sebastian Oltean, Sean Porazinski, and Michael Ladomery

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Complications Associated With Ureteroscopic Management of Upper Tract Urothelial Carcinoma., Jennifer M Linehan, Mark Schoenberg, Elyse Seltzer, Kim Thacker, and Angela B Smith