The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2025

Clinical and Multiomic Features Differentiate Young Black and White Breast Cancer Cohorts Derived by Machine Learning Approaches., Kawther Abdilleh, Boris Aguilar, and George Acquaah-Mensah

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Collaborating across sectors in service of open science, precision oncology, and patients: an overview of the AACR Project GENIE (Genomics Evidence Neoplasia Information Exchange) Biopharma Collaborative (BPC), A Acebedo, Brian D. Piening, and See full list of authors in comments

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Radiomics Combined with Transcriptomics Improves Prediction of Breast Cancer Recurrence, Molecular Subtype and Grade., George K Acquaah-Mensah, Boris Aguilar, and Kawther Abdilleh

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Evaluation of the use of convoluted neural network for detecting early gastric cancer and predicting its invasion depth: A systematic review and meta-analysis., Samagra Agarwal, Mahender Singh Rajput, Shivam Pandey, Daryl Ramai, James H Tabibian, Andrew Ofosu, Monique T Barakat, Mohit Girotra, and Soumya Jagannath Mahapatra

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Phase 2 trial of perioperative chemo-immunotherapy for gastro-esophageal adenocarcinoma: The role of M2 macrophage landscape in predicting response., Thierry Alcindor, James Tankel, Pierre-Olivier Fiset, Sanjima Pal, Touhid Opu, Michael Strasser, Mehrnoush Dehghani, Nicholas Bertos, Dongmei Zuo, Carmen Mueller, Jonathan Cools-Lartigue, Marc Hickeson, Victoria Marcus, Sophie Camilleri-Broet, Alan Spatz, Gertruda Evaristo, Mina Farag, Giovanni Artho, Arielle Elkrief, Ramy Saleh, Swneke Bailey, Morag Park, Sui Huang, Veena Sangwan, and Lorenzo Ferri

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Subcutaneous versus intravenous amivantamab, both in combination with lazertinib, in refractory EGFR-mutated non-small cell lung cancer: Patient satisfaction and resource utilization results from the PALOMA-3 study., Mariam Alexander, Ying Cheng, Se-Hoon Lee, Antonio Passaro, Alexander I Spira, Byoung Chul Cho, Sun Min Lim, Yuichiro Ohe, Adnan Nagrial, Jiunn Liang Tan, Vanina Wainsztein, Elisa Ramos, Maria Del Rosario Garcia Campelo, Hiroaki Akamatsu, Danny Nguyen, Alexis B Cortot, Alona Zer, Dilek Erdem, Rachel E Sanborn, Till-Oliver Emde, Anna R Minchom, Bogdan Zurawski, Maria Lurdes Ferreira, James Chih-Hsin Yang, Melina E Marmarelis, Julia Schuchard, Jefferson Alves, Debopriya Ghosh, Gregor Balaburski, Remy B Verheijen, Liliana Ribeiro, Mohamed Gamil, Joshua M Bauml, Mahadi Baig, and Natasha B Leighl

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A novel structural modeling magnitude and orientation radiomic descriptor for evaluating response to neoadjuvant therapy in rectal cancers via MRI., Charlems Alvarez-Jimenez, Jacob T Antunes, Thomas DeSilvio, Zhouping Wei, Marwa Ismail, Joseph E Willis, Emily Steinhagen, Andrei Purysko, David Liska, Smitha Krishnamurthi, Marka R Crittenden, Michael J. Gough, Kristina H Young, Anant Madabhushi, Eduardo Romero, Pallavi Tiwari, and Satish E Viswanath

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Census Tract Rurality, Predominant Race and Ethnicity, and Distance to Lung Cancer Screening Facilities : An Ecological Study., Solmaz Amiri, Candice L. Wilshire, Clemma Jacobsen Muller, Cole Allick, Allison C Welch, Gary Ferguson, Dedra Buchwald, and Jed A Gorden

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Why the BOSS Trial Falls Short of Guiding Clinical Practice in Barrett's Esophagus., Shahin Ayazi, John C Lipham, and Brian Louie

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Prognostic Features of Recurrent Midline and H3 K27M-Mutant Glioma., Stephen J Bagley, Yoshie Umemura, Joe S Mendez, Isabel Arrillaga-Romany, Kevin J Bielamowicz, Nick Butowski, Kelley Hutchins, Xiao-Tang Kong, Yazmin Odia, Akanksha Sharma, Lauren Weintraub, Carl Koschmann, Patrick Y Wen, Amanda M Saratsis, Tom Brundage, Samuel C Ramage, Rohinton S Tarapore, Truman Knowles, Dewen Yang, Joshua E Allen, and Timothy Cloughesy

Genomic and transcriptomic landscape of HER2-low breast cancer., Rani Bansal, Tolulope Adeyelu, Andrew Elliott, Phillip Walker, Matias A Bustos, Estelamari Rodriguez, Melissa K Accordino, Jane Meisel, Margaret E Gatti-Mays, Emily Hsu, Kate Lathrop, Virginia Kaklamani, Matthew Oberley, George Sledge, Sarah L Sammons, and Stephanie L Graff

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Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube., Ian Beddows, Svetlana Djirackor, Dalia K Omran, Euihye Jung, Natalie Nc Shih, Ritu Roy, Aaron Hechmer, Adam Olshen, Guillaume Adelmant, Ann Tom, Jacob Morrison, Marie Adams, Daniel C Rohrer, Lauren E Schwartz, Celeste Leigh Pearce, Heidi Auman, Jarrod A Marto, Charles W Drescher, Ronny Drapkin, and Hui Shen

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Epigenetic determinants of an immune-evasive phenotype in HER2-low triple-negative breast cancer., Andrés F Bedoya-López, Sookyung Ahn, Miquel Ensenyat-Mendez, Javier I Orozco, Sandra Iñiguez-Muñoz, Pere Llinàs-Arias, Samantha M Thomas, Jennifer L Baker, Peggy S Sullivan, Jitin Makker, Julie B Steele, Sunil M Kurian, Diego M Marzese, and Maggie L DiNome

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A multivariate cell-based liquid biopsy for lung nodule risk stratification: Analytical validation and early clinical evaluation., Jason D Berndt, Fergal J Duffy, Mark D D'Ascenzo, Leslie R Miller, Yijun Qi, G Adam Whitney, Samuel A Danziger, Anil Vachani, Pierre P Massion, Stephen A Deppen, Robert J Lipshutz, John D Aitchison, and Jennifer J Smith

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Amivantamab Plus Lazertinib in Patients With EGFR-Mutant NSCLC After Progression on Osimertinib and Platinum-Based Chemotherapy: Results From CHRYSALIS-2 Cohort A., Benjamin Besse, Koichi Goto, Yongsheng Wang, Se-Hoon Lee, Melina E Marmarelis, Yuichiro Ohe, Reyes Bernabe Caro, Dong-Wan Kim, Jong-Seok Lee, Sophie Cousin, Eiki Ichihara, Yongsheng Li, Luis Paz-Ares, Akira Ono, Rachel E Sanborn, Naohiro Watanabe, Maria Jose de Miguel, Carole Helissey, Catherine A Shu, Alexander I Spira, Pascale Tomasini, James Chih-Hsin Yang, Yiping Zhang, Enriqueta Felip, Frank Griesinger, Saiama N Waqar, Antonio Calles, Joel W Neal, Christina S Baik, Pasi A Jänne, S Martin Shreeve, Joshua C Curtin, Bharvin Patel, Michael Gormley, Xuesong Lyu, Jun Chen, Pei-Ling Chu, Janine Mahoney, Leonardo Trani, Joshua M Bauml, Meena Thayu, Roland E Knoblauch, and Byoung Chul Cho

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A Population-Level Real-World Analysis and Single-Center Validation of Melanoma Brain Metastasis Epidemiology following Dual-Agent Immunotherapy., Debarati Bhanja, Junjia Zhu, Hannah Wilding, Jorge Benavides-Vasquez, Leonardo de Macedo Filho, Ahmad Ozair, Camille Moeckel, Aarav Badani, Jinpyo Hong, Jeffrey Sivik, Joseph J Drabick, Colette R Pameijer, Kim Margolin, Manmeet Ahluwalia, and Alireza Mansouri

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Pan-cancer immune and stromal deconvolution predicts clinical outcomes and mutation profiles., Bhavneet Bhinder, Verena Friedl, Sunantha Sethuraman, Davide Risso, Kami E Chiotti, R Jay Mashl, Kyle P Ellrott, Jordan A Lee, Christopher K Wong, Kofi Gyan, Aditya Deshpande, Marcin Imielinski, Rohan Bareja, Josh Stuart, Myron Peto, Katherine A Hoadley, Alexander J Lazar, Andrew D Cherniack, Jingchun Zhu, Shaolong Cao, Mark Rubin, Wenyi Wang, Oliver F Bathe, Nicolas Robine, Li Ding, Peter W Laird, Wanding Zhou, Hui Shen, Vésteinn Thorsson, Jen Jen Yeh, Matthew H Bailey, Daniel Cui Zhou, Xianlu L Peng, Mary Goldman, Yongsheng Li, Anil Korkut, Nidhi Sahni, D Neil Hayes, Michael K A Mensah, Ina Felau, Anab Kemal, Samantha Caesar-Johnson, John A Demchok, Liming Yang, Martin L Ferguson, Roy Tarnuzzer, Zhining Wang, Jean C Zenklusen, Paul Spellman, and Olivier Elemento

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New Insights into Upper Tract Urothelial Carcinoma: Lessons Learned from the ROBUUST Collaborative Study., Arianna Biasatti, Gabriele Bignante, Francesco Ditonno, Alessandro Veccia, Riccardo Bertolo, Alessandro Antonelli, Randall Lee, Daniel D Eun, Vitaly Margulis, Firas Abdollah, Takashi Yoshida, Ithaar H Derweesh, Margaret F Meagher, Giuseppe Simone, Gabriele Tuderti, Eugenio Bologna, Reza Mehrazin, Soroush Rais-Bahrami, Chandru P Sundaram, Courtney Yong, Andrea Minervini, Andrea Mari, Luca Lambertini, Matteo Ferro, Nirmish Singla, Savio D Pandolfo, Daniele Amparore, Enrico Checcucci, Mark L Gonzalgo, James R Porter, Alireza Ghoreifi, Roberto Contieri, Sisto Perdonà, Francesco Porpiglia, Hooman Djaladat, Saum Ghodoussipour, and Riccardo Autorino

Foundation Digital Pathology Models: From Computational Pathology to Spatial Biology, Carlo Bifulco

Foundation Digital Pathology Models: From Computational Pathology to Spatial Biology, Carlo Bifulco

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Exploring the Intersection of Artificial Intelligence and Psychosocial Oncology: Enhancing Care in the Digital Age, Jennifer Bires, Elizabeth Franklin, Krista Nelson, Kyle Bonesteel, and Douglas Flora

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A multi-institutional retrospective cohort of adult-onset medulloblastoma in the modern era., Alipi V Bonm, Michael S Rutenberg, Kate E Therkelsen, John Herbst, Anurag Sanaf, Marissa A Sherwood, John Y Rhee, Tresa M McGranahan, Patrick J Cimino, L Nicolas Gonzalez Castro, Derek S Tsang, Matthias A Karajannis, Seema Nagpal, Robert J Amdur, Helen Shih, Jason Barber, and Lynne P Taylor

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Phase 2 trial of personal dendritic cell vaccines in newly diagnosed glioblastoma: 3-year follow-up and correlations with survival., Daniela A Bota, David E Piccioni, Christopher M Duma, Santosh Kesari, Jose A Carrillo, Renato V LaRocca, Robert D Aiken, Thomas H Taylor, Mehrdad Abedi, Rockelle M Robles, Krystal Godding, Hans S Keirstead, Gabriel I Nistor, and Robert O Dillman

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Reoperative Pulmonary Metastasectomy: Outcomes and Indications., Alejandro C Bribriesco, Puneet Bansal, Melanie P Subramanian, and Adam J Bograd

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Real-world outcomes of patients with aggressive B-cell lymphoma treated with epcoritamab or glofitamab., Taylor R Brooks, Emily C Zabor, Yohanna Bedelu, Xi Yang, Yasmin H Karimi, Adrienne N Nedved, Yucai Wang, Nikita K Dave, Daniel J Landsburg, Kelsey Baron, Boyu Hu, Daniel Trotier, Priyanka A Pophali, Jordan Miller, Natalie S Grover, Catherine Reinert, Ajay Major, Tenley Schwarz, Krish Patel, Kiarash Salafian, Emily C Ayers, Suchitra Sundaram, Joshua D Brody, Marshall McKenna, Yun Kyoung Ryu Tiger, Megan Sears-Smith, Nilanjan Ghosh, Chelsea Peterson, Cyrus Khan, Sean P Bliven, Mayur Narkhede, Alyssa Gibson, Justin Kline, Javier Munoz, Rodolfo Garza Morales, Carrie Ho, Stephen D Smith, Alex Niu, Francisco J Hernandez-Ilizaliturri, Fadzai Chinyengetere, Sandeep S Dave, Nayef Abdel-Razeq, Muhamad Alhaj Moustafa, Paolo Caimi, and Brian T Hill

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The need for future coronary access in older medicare beneficiaries following transcatheter aortic-valve replacement., Christopher Brown, Michael Ryan, Marcella Kelley, Christin Thompson, Candace Gunnarsson, and James Hermiller

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Transcriptomic miRNA and mRNA signatures in primary prostate cancer that are associated with lymph-node invasion., Matias A Bustos, Kelly K Chong, Yoko Koh, SooMin Kim, Eleanor Ziarnik, Romela I Ramos, Gianna Jimenez, David L Krasne, Warren M Allen, Timothy G Wilson, and Dave S B Hoon

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Long-term outcomes of diaphragmatic relaxing incisions during challenging primary and revisional hiatal reconstruction: A propensity-matched analysis., John M Campbell, Alexander S Farivar, Peter T White, Adam J Bograd, and Brian Louie

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Recurrence and Survival Following Robotic Resection of Thymomas Greater Than Five Centimeters., John M Campbell, Peter T White, Adam J Bograd, Alexander S Farivar, Candice L Wilshire, Eric Vallières, and Brian E Louie

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Large language models for detecting colorectal polyps in endoscopic images., Luca Carlini, Davide Massimi, Yuichi Mori, Giulio Antonelli, Tommy Rizkala, Marco Spadaccini, Chiara Lena, Sravanthi Parasa, Raf Bisschops, Daniel von Renteln, Susanne O'Reilly, Prateek Sharma, Douglas K Rex, Michael Bretthauer, Alessandro Repici, Elena De Momi, and Cesare Hassan

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Enhanced Recovery After Adult Brain Tumor Surgery: A Proposed Succinct Evidence-Based Protocol., Alejandro Carrasquilla, Zerubabbel K Asfaw, Lewis E Tomalin, Randy S D'Amico, Shawn L Hervey-Jumper, Michael E Ivan, Walavan Sivakumar, and Isabelle M Germano

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Appropriate use of tissue sampling and somatostatin receptor PET imaging in the diagnosis of pancreatic neuroendocrine tumors: results of an International Delphi Consensus., Megan Casey, Francesca Tozzi, Jaeyun Wang, Keon Min Park, Emily Bergsland, Thomas Hope, Hagen F Kennecke, J Bart Rose, Michele Babicky, Shayan S Irani, Kevin M El-Hayek, Mohammad Abu Hilal, Horacio J Asbun, Sean Cleary, Peter Smeets, Frederik Berrevoet, Mohamed Adam, Niki Rashidian, Adnan Alseidi, and PNET Diagnosis Research Group

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Cellular heterogeneity and therapeutic response profiling of human IDH+ glioma stem cell cultures., Nyasha Chambwe, Scott R Kennedy, Brendan F Kohrn, Pavlo Lazarchuk, Mario Leutert, Guangrong Qin, Bahar Tercan, Monica Sanchez-Contreras, Weiliang Tang, Jerome J Graber, Patrick J Paddison, Judit Villén, Ilya Shmulevich, and Raymond J Monnat

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A heterodimer of hemoglobin identifies theranostic targets on brain-metastasizing melanoma cells., Maharrish Chelladurai, Orit Sagi-Assif, Shlomit Ben-Menachem, Tsipi Meshel, Metsada Pasmanik-Chor, Sivan Izraely, Dave S B Hoon, and Isaac P Witz

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Evaluation of the Toxicity and Outcomes of the Combination of Midostaurin and CLAG-M in Patients With FLT3-Mutated Acute Myeloid Leukemia (AML): A Multicenter Retrospective Analysis., Ashley Chen, Grace Baek, Kathryn Russell, Carole Shaw, Megan Othus, Jonathan Cohen, Shannon Palmer, Jack Rasmussen, Joseph Bubalo, Tenzin Tsomo, Tenley Schwarz, Swathi Namburi, and Anna Halpern

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Detection of MRD positivity as an indicator of CNS relapse in AML and therapeutic approach., Sumasri Chennapragada, Vishal Devarkonda, and Hugo Akabane

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Monitoring the rate and variability of somatic genomic alterations using long-read sequencing., Xingyao Chen, Hagai Ligumsky, Charlie Ambrose, Denisse Sibrian, Brian Tran, Daoud Arif, Olga Castellanos, Darren Kessner, Hanyi Luo, Mukta Ubale, Abigail Coleman, Vaidhyanathan Mahaganapathy, Thomas J Jönsson, Reva K Basho, Jerry S H Lee, Naim Matasci, and David B Agus

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Thorax-encompassing multi-modality PET/CT deep learning model for resected lung cancer prognostication: A retrospective, multicenter study., Jaryd R Christie, Perrin Romine, Karen Eddy, Delphine L Chen, Omar Daher, Mohamed Abdelrazek, Richard A Malthaner, Mehdi Qiabi, Rahul Nayak, Paul Kinahan, Viswam S Nair, and Sarah A Mattonen

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Society for Immunotherapy of Cancer (SITC) consensus statement on essential biomarkers for immunotherapy clinical protocols., Tricia R Cottrell, Michael T Lotze, Alaa Ali, Carlo Bifulco, Christian M Capitini, Laura Q M Chow, Anthony R Cillo, Deborah Collyar, Leslie Cope, Julie Stein Deutsch, Genia Dubrovsky, Sacha Gnjatic, Denise Goh, Susan Halabi, Gary Kohanbash, Holden T Maecker, Saman Maleki Vareki, Sarah Mullin, Barbara Seliger, Janis Taube, Wim Vos, Joe Yeong, Kristin G Anderson, Tullia C Bruno, Codruta Chiuzan, Ivan Diaz-Padilla, Elizabeth Garrett-Mayer, Isabella C Glitza Oliva, Paola Grandi, Elizabeth G Hill, Brian P Hobbs, Yana G Najjar, Phyllis Pettit Nassi, Virgil H Simons, Sumit K Subudhi, Ryan J Sullivan, and Chris H Takimoto

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Importance of Surgical Margins in Patients with Early-Stage Merkel Cell Carcinoma., Arthur W Cowman, Kristel Lourdault, Douglas Hanes, Sean Nassoiy, Paul Shin, Tyler Aguilar, Melanie Goldfarb, and Richard Essner

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Surgical Management of Thick Primary Cutaneous Melanoma in the US., Arthur W Cowman, Kristel Lourdault, Douglas Hanes, Jessica Weiss, Sean Nassoiy, Melanie Goldfarb, and Richard Essner

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Treatment, outcomes, and resource utilization among patients with metastatic breast and advanced epithelial ovarian cancer, by BRCA1/2 and HRD status., Giovanna I Cruz, Kaitlyn L Kane, Rayna K Matsuno, Connor Sweetnam, Adrienne F O Williams, Liz M Toland, Amy Stone, Anna B Berry, Monika A Izano, Liam C Lee, Jagadeswara R Earla, Thomas D Brown, Charles W Drescher, Henry G Kaplan, Smita Kothari, Arthur Sillah, and Gieira Jones

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Checkpoint Immunotherapy for Melanoma - Offering Hope for Cure., Brendan Curti

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The responses of HNSCC patients to immunotherapy are shown by two novel co-expression patterns., Narmeen Daher-Ghanem, Shay Sharon, Derrick L Tao, Zhaoyu Sun, Wesley K Rosales, Venkatesh Rajamanickam, Ryan Meng, Lakhvir Kaur, Brady Bernard, Brian D. Piening, Marcus Couey, Michael J. Gough, and Nataly Kravchenko-Balasha

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A phase 1 study of the CDK9 inhibitor voruciclib in relapsed/refractory acute myeloid leukemia and B-cell malignancies., Matthew S Davids, Danielle M Brander, Yesid Alvarado-Valero, Catherine S Diefenbach, Daniel N Egan, Shira N Dinner, Nathalie Javidi-Sharifi, Monzr M Al Malki, Kebede H Begna, Vijaya Raj Bhatt, Sameem Abedin, Rachel J Cook, Mary C Collins, Carly Roleder, Edward C Dominguez, Prabhu Rajagopalan, Sandra E Wiley, Richard G Ghalie, and Alexey V Danilov

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ZUMA-8: a phase 1 study of brexucabtagene autoleucel in patients with relapsed/refractory chronic lymphocytic leukemia., Matthew S Davids, Saad S Kenderian, Ian Flinn, Brian T Hill, Michael Maris, Paolo Ghia, Michael Byrne, Nancy L Bartlett, John M Pagel, Yan Zheng, Justyna Kanska, Wangshu Zhang, Enrique Granados, and Javier Pinilla-Ibarz

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Sharing data from the Human Tumor Atlas Network through standards, infrastructure and community engagement., Ino de Bruijn, Milen Nikolov, Clarisse Lau, Ashley Clayton, David L Gibbs, Elvira Mitraka, Dar'ya Pozhidayeva, Alex Lash, Selcuk Onur Sumer, Jennifer Altreuter, Kristen Anton, Mialy DeFelice, Xiang Li, Aaron Lisman, William J R Longabaugh, Jeremy Muhlich, Sandro Santagata, Subhiksha Nandakumar, Peter K Sorger, Christine Suver, Xengie Doan, Justin Guinney, Nikolaus Schultz, Adam J Taylor, Vésteinn Thorsson, Ethan Cerami, and James A Eddy

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OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma., Kinjal Desai, Siyi Wanggou, Erika Luis, Heather Whetstone, Chunying Yu, Robert J Vanner, Hayden J Selvadurai, Lilian Lee, Jinchu Vijay, Julia E Jaramillo, Jerry Fan, Paul Guilhamon, Michelle Kushida, Xuejun Li, Gregory Stein, Santosh Kesari, Benjamin D Simons, Xi Huang, and Peter B Dirks

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Restricted physical activity and maternal rest improve fetal growth., Greggory R DeVore, Bardo Polanco, Wesley Lee, Jeffrey Brian Fowlkes, Emma E Peek, Manesha Putra, and John C Hobbins

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Approaches to overcome the current treatment plateau in immunotherapy., Anna Maria Di Giacomo, Renzo Canetta, John Connolly, Rom Leidner, Wei Zheng, Young Kim, Ramy Ibrahim, Michael Lahn, Michael Smith, Alexander Eggermont, Bernard A Fox, and Michele Maio

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Perspectives on the role of "-Omics" in predicting response to immunotherapy., Anna Maria Di Giacomo, Sumit Subudhi, Wim Vos, Massimo Andreatta, Santiago Carmona, Will McTavish, Barbara Seliger, Ramy Ibrahim, Michael Lahn, Michael Smith, Alexander Eggermont, Bernard A Fox, and Michele Maio

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Radical nephroureterectomy vs kidney sparing surgery for upper tract urothelial carcinoma in solitary kidney patients: a multi-institutional analysis of the ROBUUST 2.0 registry., Francesco Ditonno, Alessandro Veccia, Gabriele Bignante, Zhenjie Wu, Linhui Wang, Firas Abdollah, Alex Stephens, Giuseppe Simone, Gabriele Tuderti, Randall Lee, Daniel D Eun, Andres F Correa, Ottavio De Cobelli, Matteo Ferro, Francesco Porpiglia, Daniele Amparore, Enrico Checcucci, Antonio Tufano, Roberto Contieri, Sisto Perdonà, Raj Bhanvadia, Vitaly Margulis, Stephan Brönimann, Nirmish Singla, James R Porter, Saum Ghodoussipour, Andrea Minervini, Andrea Mari, Luca Lambertini, Alireza Ghoreifi, Omri Falik Nativ, Mark L Gonzalgo, Daniel Sidhom, Chandru P Sundaram, Reuben Ben-David, Ahmed Eraky, Reza Mehrazin, Takashi Yoshida, Hidefumi Kinoshita, Alireza Dehghanmanshadi, Soroush Rais-Bahrami, Margaret F Meagher, Dhruv Puri, Ithaar H Derweesh, Farshad S Moghaddam, Hooman Djaladat, Riccardo Bertolo, Riccardo Autorino, and Alessandro Antonelli

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Impact of neoadjuvant treatment on functional outcomes after transanal total mesorectal excision (taTME)-a case series., Katherine F Donovan, Elisa Paoluzzi Tomada, Heather Carmichael, Alison Ricardo, Natalie Berger, Antoinette Bonaccorso, Karim Alavi, Karen Zaghiyan, Alessio Pigazzi, Dana Sands, Theresa DeBeche-Adams, Sami A Chadi, Elisabeth C McLemore, John H Marks, Justin A Maykel, Sherief F Shawki, Scott R Steele, Matthew Albert, Mark Whiteford, Steven D Wexner, and Patricia Sylla

Unravelling the complexity of the anti-tumor response in human solid tumors, Thomas Duhen

Unravelling the complexity of the anti-tumor response in human solid tumors, Thomas Duhen

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Longitudinal Genomic Analysis to Fine-Tune Targeted Therapy: Results of the Phase II LOGIC 2 Trial in Patients With BRAF V600-Mutant Metastatic Melanoma., Reinhard Dummer, Shahneen Sandhu, Wilson H Miller, Marcus O Butler, Matthew H Taylor, Lucie Heinzerling, Christian U Blank, Eva Munoz-Couselo, Howard A Burris, Michael A Postow, Bartosz Chmielowski, Mark R Middleton, Carola Berking, Jessica C Hassel, Anja Heike Gesierich, Cornelia Mauch, Joseph F Kleha, Anna Polli, Allison S Harney, Alessandra di Pietro, and Paolo A Ascierto

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SLC7A5 is required for cancer cell growth under arginine-limited conditions., Kyle N Dunlap, Austin Bender, Alexis Bowles, Alex J Bott, Joshua Tay, Allie H Grossmann, Jared Rutter, and Gregory S Ducker

Cancer Survivor Integrative Therapy Program Improves Physical, Metabolic and Mental Wellbeing, Gianna Durocher and Megan Wroe

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Classification of non-TCGA cancer samples to TCGA molecular subtypes using compact feature sets., Kyle Ellrott, Christopher K Wong, Christina Yau, Mauro A A Castro, Jordan A Lee, Brian J Karlberg, Jasleen K Grewal, Vincenzo Lagani, Bahar Tercan, Verena Friedl, Toshinori Hinoue, Vladislav Uzunangelov, Lindsay Westlake, Xavier Loinaz, Ina Felau, Peggy I Wang, Anab Kemal, Samantha J Caesar-Johnson, Ilya Shmulevich, Alexander J Lazar, Ioannis Tsamardinos, Katherine A Hoadley, A Gordon Robertson, Theo A Knijnenburg, Christopher C Benz, Joshua M Stuart, Jean C Zenklusen, Andrew D Cherniack, and Peter W Laird

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SITC perspective: leveraging patient enrichment biomarkers to accelerate early phase IO drug development., Leisha A Emens, Christine Moussion, Patrick Hwu, James L Gulley, Pamela S Ohashi, Carlo B Bifulco, and David Feltquate

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Pembrolizumab plus chemotherapy in advanced or recurrent endometrial cancer: overall survival and exploratory analyses of the NRG GY018 phase 3 randomized trial., Ramez N Eskander, Michael W Sill, Lindsey Beffa, Richard G Moore, Joanie M Hope, Fernanda Musa, Robert S Mannel, Mark S Shahin, Guilherme H Cantuaria, Eugenia Girda, Elizabeth Lokich, Juraj Kavecansky, Charles A Leath, Lilian T Gien, Emily M Hinchcliff, Shashikant B Lele, Lisa M Landrum, Floor Backes, Roisin E O'Cearbhaill, Tareq Al Baghdadi, Emily K Hill, Premal H Thaker, Veena S John, Stephen Welch, Amanda N Fader, Matthew A Powell, and Carol Aghajanian

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Five-Year Survival Outcomes With Atezolizumab After Chemotherapy in Resected Stage IB-IIIA Non-Small Cell Lung Cancer (IMpower010): An Open-Label, Randomized, Phase III Trial., Enriqueta Felip, Nasser Altorki, Caicun Zhou, Eric Vallieres, Tibor Csoszi, Ihor O Vynnychenko, Oleksandr Goloborodko, Achim Rittmeyer, Martin Reck, Alex Martinez-Marti, Hirotsugu Kenmotsu, Yuh-Min Chen, Antonio Chella, Shunichi Sugawara, Chenqi Fu, Marcus Ballinger, Yu Deng, Minu K Srivastava, Elizabeth Bennett, Barbara J Gitlitz, and Heather A Wakelee

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Efficacy and safety of one-time autologous tumor-infiltrating lymphocyte cell therapy in patients with recurrent and/or metastatic head and neck squamous cell carcinoma., Robert L Ferris, Rom Leidner, Christine H Chung, Antonio Jimeno, Sylvia M Lee, Ammar Sukari, Jorge J Nieva, Juneko E Grilley-Olson, Rebecca Redman, Stuart J Wong, Victoria M Villaflor, Jamal Misleh, Friedrich Graf Finckenstein, Jeffrey Chou, Brian Gastman, Rana Fiaz, Melissa Catlett, Min Yi, and Ezra E W Cohen

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Facts and Hopes: Toward the Next Quantum Leap in Melanoma., Keith T Flaherty, Andrew E Aplin, Michael A Davies, Nir Hacohen, Meenhard Herlyn, Dave Hoon, Patrick Hwu, Michal Lotem, James Mulé, Jennifer A Wargo, and David E Fisher

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Signaling and transcriptional dynamics underlying early adaptation to oncogenic BRAF inhibition., Cameron T Flower, Chunmei Liu, Hui-Yu Chuang, Xiaoyang Ye, Hanjun Cheng, James R Heath, Wei Wei, and Forest M White

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Editorial: A year in review: discussions in human and medical genomics., Maxim B Freidin and Jared C Roach

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Avoidance of Major Vascular Injury in Transcranial Brain Tumor Surgery Using Real-Time Doppler Navigation: Technical Note and Case Series., R Justin Garling, Regin Jay Mallari, Davendran Kanesen, Byron Hontiveros, Walavan Sivakumar, Daniel F Kelly, and Garni Barkhoudarian

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Manual therapy considerations for adhesive capsulitis in the breast cancer population: a clinical perspective., Diana Garrett, Gary Kearns, and Steve Karas

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Survival with Trastuzumab Emtansine in Residual HER2-Positive Breast Cancer., Charles E Geyer, Michael Untch, Chiun-Sheng Huang, Max S Mano, Eleftherios P Mamounas, Norman Wolmark, Priya Rastogi, Andreas Schneeweiss, Andres Redondo, Hans H Fischer, Véronique D'Hondt, Alison Conlin, Valentina Guarneri, Irene L Wapnir, Christian Jackisch, Claudia Arce-Salinas, Peter A Fasching, Michael P DiGiovanna, John P Crown, Pia Wuelfing, Zhimin Shao, Elena Rota Caremoli, Hervé R Bonnefoi, Bryan T Hennessy, Ljiljana Stamatovic, Hugo Castro-Salguero, Adam M Brufsky, Adam Knott, Asna Siddiqui, Chiara Lambertini, Thomas Boulet, Beatrice Nyawira, Eleonora Restuccia, Sibylle Loibl, and KATHERINE Study Group

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Induced pluripotent stem-cell-derived CD19-directed chimeric antigen receptor natural killer cells in B-cell lymphoma: a phase 1, first-in-human trial., Armin Ghobadi, Veronika Bachanova, Krish Patel, Jae H Park, Ian Flinn, Peter A Riedell, Carlos Bachier, Catherine S Diefenbach, Carol Wong, Cara Bickers, Lilly Wong, Deepa Patel, Jode Goodridge, Matthew Denholt, Bahram Valamehr, Rebecca L Elstrom, and Paolo Strati

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A Multisite Demonstration of Shared Access to Older Adults' Patient Portals., Kelly T Gleason, Catherine M DesRoches, Mingche M J Wu, Danielle Peereboom, Vadim Dukhanin, Timothy W Farrell, Matthew J Gonzales, Saloni Sharma, Supriya G Mohile, Sara Epstein, Mark A Supiano, Marianne C Parshley, David L Roth, Jennifer L Wolff, and Shared Access Project Team

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Pilot Study of Plasma miRNA Signature Panel for Differentiating Single vs Multiglandular Parathyroid Disease., Melanie Goldfarb, Matias A Bustos, Jamie Moon, Katherine Jackson, Frederick R Singer, and Dave S B Hoon

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Continuing De-escalation Trends: Is Adjuvant Radioactive Iodine Administration Truly Needed for Papillary Thyroid Carcinoma with Limited Cervical Disease?, Melanie Goldfarb and Nicholas Ullman

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Efficacy of adjuvant therapy in patients with stage IIIA cutaneous melanoma., P Grover, S N Lo, I Li, A M J Kuijpers, F Kreidieh, A Williamson, T Amaral, F Dimitriou, J Placzke, K Olino, M G Vitale, P Saiag, R Gutzmer, C Allayous, R Olofsson Bagge, J Mattsson, N Asher, T J Carter, T M Meniawy, A R Lawless, J A Czapla, L Warburton, C Gaudy-Marqueste, J J Grob, R G Collins, E Zhang, J I Kessels, B Neyns, I Mehmi, O Hamid, M Julve, A J S Furness, K A Margolin, Shaked Lev-Ari, J M Ressler, W Haque, M A Khattak, A Wicky, R Roberts-Thomson, A Arance, G Warrier, M D Schollenberger, P Parente, E Chatziioannou, E J Lipson, O Michielin, J S Weber, C Hoeller, J Larkin, M B Atkins, R Essner, D B Johnson, R J Sullivan, P Nathan, J Schachter, C Lebbe, P A Ascierto, H Kluger, P Rutkowski, R Dummer, C Garbe, P C Lorigan, E Burton, H A Tawbi, J Haanen, M S Carlino, A M Menzies, and G V Long

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A Prospective, Multicenter Analysis of Recurrence-Free Survival After Sentinel Lymph Node Biopsy Decisions Influenced by the 31-GEP., J Michael Guenther, Andrew Ward, Brian J Martin, Mark Cripe, Timothy Beard, Oliver Wisco, Rohit Sharma, Stanley P Leong, Richard Essner, Joseph I Clark, John Hamner, Brenda Sickle-Santanello, and Maki Yamamoto

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TGFβ limits proximal CD8+ TCR signaling via PTPN22 following strong and moderate agonism., Andrew J Gunderson, Kelley R Jordan, Tomoko Yamazaki, Hans-Peter Raué, Gwen Kramer, Nathaniel E Fox, Mark K Slifka, Michael J. Gough, Marka R Crittenden, and Kristina H Young

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Longitudinal retrospective study of real-world adherence to colorectal cancer screening before and after the COVID-19 pandemic in the USA., Harsh Gupta, Robyn Ann Husa, Staci J Wendt, Ann Vita, Claire Boone, Jessica B Weiss, and Anton J Bilchik

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Dostarlimab and niraparib in primary advanced ovarian cancer., A-C Hardy-Bessard, E Pujade-Lauraine, R G Moore, F Montestruc, A Redondo, M R Mirza, D Cibula, T-E Ciuleanu, L Gilbert, R Eitan, F Zagouri, S Pignata, R Glasspool, J Pfisterer, R Phaëton, C K Anderson, M Rodrigues, L Gaba, E Bakirtzi, J M Fauci, E Kalbacher, F B Musa, S Gorman, L R Duska, L Gladieff, P Braly, F Joly, J Thomes Pepin, I Ray-Coquard, and K N Moore

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Human Epidermal Growth Factor Receptor 2 Alterations and Prognostic Implications in All Subtypes of Breast Cancers., Arielle L Heeke, Andrew Elliott, Kaitlyn O'Keefe, Chad Livasy, James T Symanowski, Meghan R Steiner, Irene M Kang, Dave S B Hoon, Philip Walker, George W Sledge, Milan Radovich, Paula R Pohlmann, Sandra M Swain, and Antoinette R Tan

Association of baseline ctDNA EGFR mutation detection with clinical outcome in the phase II RAMOSE trial assessing ramucirumab plus osimertinib versus osimertinib in EGFR mutant non-small cell lung cancer, S Heeke, Rachel Sanborn, and See full list of authors in comments

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Implementation of a Traceback Testing Program for Ovarian Cancer: Findings from the FACTS Study., Nora B Henrikson, M Cabell Jonas, Paula R Blasi, Adam H Buchanan, Pim Suwannarat, Kathleen Leppig, Aaron Scrol, Tracey Leitzel, Adrienne N Deneal, Daniela Canedo, Arvind Ramaprasan, Sundeep S Basra, Jennifer Brown, Marilyn Odums, Yirui Hu, Katrina M Romagnoli, Estella Khieu, Elsa Balton, Saumya Patel, Muki Kunnmann, Dina Hassen, Jing Hao, Meredith Lewis, Rachel Schwiter, Jessica Goehringer, Heather M Ramey, Shanshan Gustafson, Katrina Hsieh, Ilene Ladd, and Alanna K Rahm

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Outcomes of endoscopic management for upper tract urothelial carcinoma: A multi-center international cohort analysis., Jaime O Herrera-Caceres, Marian Wettstein, Surena F Matin, Craig Labbate, Aaron Potretzke, Rodrigo Rodriguez, Nirmish Singla, Maximilian Pallauf, William Huang, Shavy Nagpal, Nir Kleinmann, Asaf Shvero, Alexander Small, Benjamin Green, Jennifer Linehan, Jane Choe, Ojas Shah, Arun Rai, Hristos Kaimakliotis, Isamu Tachibana, David Canes, Aaron Perecman, and Jay D Raman

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INBRX-106: a hexavalent OX40 agonist that drives superior antitumor responses via optimized receptor clustering., Nisha Holay, Rashi Yadav, Sae Jeong Ahn, Melissa Kasiewicz, Anya Polovina, Annah S Rolig, Thi Staebler, Bryan Becklund, Noah D Simons, Yoshinobu Koguchi, Brendan P Eckelman, Yaiza Diaz de Durana, and William L. Redmond

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The end of the genetic paradigm of cancer., Sui Huang, Ana M Soto, and Carlos Sonnenschein

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Access to GLP-1s: Where Do Employers Fit in?, Mary T Imboden

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Real-world outcomes after discontinuation of covalent BTK inhibitor-based therapy in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma., Nitin Jain, Toby A Eyre, Katherine B Winfree, Naleen Raj Bhandari, Manoj Khanal, Tomoko Sugihara, Yongmei Chen, Paolo Abada, and Krish Patel

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Expert Perspectives on Controversies and Critical Knowledge Gaps in Breast Cancer Management: Proceedings of the First Bridging the Gaps in Breast Cancer Symposium., Komal Jhaveri, Carey K Anders, Aditya Bardia, Manali Bhave, A Jo Chien, Ian Krop, Tiffany A Traina, Yara Abdou, Reva Basho, Alison K Conlin, Francisco J Esteva, Kevin R Fox, Vijayakrishna Gadi, Peter A Kaufman, Anya Litvak, Cynthia X Ma, Eleftherios P Mamounas, Heather McArthur, Kelly McCann, Zahi Mitri, Rebecca Shatsky, Melinda Telli, Mylin A Torres, and Kevin Kalinsky

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Updated Overall Survival Analysis From the Phase II PHAROS Study of Encorafenib Plus Binimetinib in Patients With BRAF V600E-Mutant Metastatic Non-Small Cell Lung Cancer., Melissa L Johnson, Egbert F Smit, Enriqueta Felip, Suresh S Ramalingam, Myung-Ju Ahn, Anne Tsao, Bruce E Johnson, Michael Offin, Maen Hussein, Ibiayi Dagogo-Jack, Jonathan W Goldman, Jeffrey M Clarke, Marcelo V Negrao, Rachel E Sanborn, Daniel Morgensztern, Tiziana Usari, Keith Wilner, Linh Alejandro, Nada Rifi, Xiaosong Zhang, and Gregory J Riely

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Pre-Treatment Tumor Collagen is Associated with Triple-Negative Breast Cancer Pathological Response to Chemo-Immunotherapy., Mackenzie Jones, Zahraa W Alsafwani, Javier I J Orozco, Subodh M Lele, Mohd Wasim Nasser, Surinder K Batra, and Juan A Santamaria-Barria

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Neoadjuvant clinical trials in adults with newly diagnosed high-grade glioma: A systematic review., Tiffany M Juarez, Jaya M Gill, Boris R Minev, Akanksha Sharma, and Santosh Kesari

Neoadjuvant clinical trials in adults with newly diagnosed high-grade glioma: A systematic review., Tiffany M Juarez, Jaya M Gill, Boris R Minev, Akanksha Sharma, and Santosh Kesari

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Evaluating Tumor Tissue Modified Viral (TTMV)-HPV DNA for the Early Detection of Anal Squamous Cell Carcinoma Recurrence., Rafi Kabarriti, Shane Lloyd, James Jabalee, Catherine Del Vecchio Fitz, Randa Tao, Tyler Slater, Corbin Jacobs, Sean Inocencio, Michael Rutenberg, Chance Matthiesen, Kasha Neff, Gene-Fu Liu, Tiffany M Juarez, and Stanley L Liauw

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Epigenetic Regulation of OLIG2 in Glioblastoma: Mechanisms and Therapeutic Targets to Combat Treatment Resistance., Sanya Kapoor, Valentina L Kouznetsova, Santosh Kesari, and Igor F Tsigelny

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Commentary: Molecular responses in pig heart to human xenotransplantation unveiled by longitudinal multi-omic profiling., Brendan J Keating, Eloi Schmauch, Michael P Snyder, Jennifer D Motter, and Brian D. Piening

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Impact of Unmet Social Needs on Access to Breast Cancer Screening and Treatment: An Analysis of Barriers Faced by Patients in a Breast Cancer Navigation Program., Grace Keegan, Joseph Ravenell, Angelena Crown, Charles DiMaggio, and Kathie-Ann Joseph

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Metastatic Melanoma Outcomes and the Evolving Role of Surgery in the Immunotherapy Era., Hilary R Keller, Douglas A Hanes, Jillian K McCabe, Danny Lascano, Paul Shin, Melanie Goldfarb, and Richard Essner

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Clinical Practice Recommendations on the Role Of Allogeneic Hematopoietic Cell Transplantation and Chimeric Antigen Receptor T-Cell Therapy in Patients With Chronic Lymphocytic Leukemia on Behalf of the American Society for Transplantation and Cellular Therapy., Mohamed A Kharfan-Dabaja, Ambuj Kumar, Javier Pinilla-Ibarz, Jennifer R Brown, Mazyar Shadman, Farrukh T Awan, Saad S Kenderian, Tanya Siddiqi, Jeremy S Abramson, Taha Al-Juhaishi, Danielle M Brander, Catherine C Coombs, Richard R Furman, Nitin Jain, Nadia Khan, Nakhle S Saba, Jennifer M Collins, Amer Beitinjaneh, Deborah M Stephens, Jennifer Woyach, and Mehdi Hamadani

Machine Learning Model Predictors of Intrapleural Tissue Plasminogen Activator and DNase Failure in Pleural Infection: A Multicenter Study., Danai Khemasuwan, Candice Wilshire, Chakravarthy Reddy, Christopher Gilbert, Jed Gorden, Akshu Balwan, Trinidad M Sanchez, Billie Bixby, Jeffrey S Sorensen, and Samira Shojaee

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Tumor Microenvironment Lactate: Is It a Cancer Progression Marker, Immunosuppressant, and Therapeutic Target?, Eugene Y Kim, Joyce Abides, Chandler R Keller, Steve R Martinez, and Weimin Li

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Correction: CITEViz: interactively classify cell populations in CITE-Seq via a flow cytometry-like gating workflow using R-Shiny., Garth L Kong, Thai T Nguyen, Wesley K Rosales, Anjali D Panikar, John H W Cheney, Theresa A Lusardi, William M Yashar, Brittany M Curtiss, Sarah A Carratt, Theodore P Braun, and Julia E Maxson