The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2022

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Orteronel for Metastatic Hormone-Sensitive Prostate Cancer: A Multicenter, Randomized, Open-Label Phase III Trial (SWOG-1216)., Neeraj Agarwal, Catherine M Tangen, Maha H A Hussain, Shilpa Gupta, Melissa Plets, Primo N Lara, Andrea L Harzstark, Przemyslaw W Twardowski, Channing J Paller, Dylan Zylla, Matthew R Zibelman, Ellis Levine, Bruce J Roth, Amir Goldkorn, Daniel A Vaena, Manish Kohli, Tony Crispino, Nicholas J Vogelzang, Ian M Thompson, and David I Quinn

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Impact of veliparib, paclitaxel dosing regimen, and germline BRCA status on the primary treatment of serous ovarian cancer - an ancillary data analysis of the VELIA trial., Carol Aghajanian, Elizabeth M Swisher, Aikou Okamoto, Karina Dahl Steffensen, Michael A Bookman, Gini F Fleming, Michael Friedlander, Kathleen N Moore, Krishnansu S Tewari, David M O'Malley, John K Chan, Christine Ratajczak, Hideyuki Hashiba, Meijing Wu, Minh H Dinh, and Robert L Coleman

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Impact of veliparib, paclitaxel dosing regimen, and germline BRCA status on the primary treatment of serous ovarian cancer - an ancillary data analysis of the VELIA trial., Carol Aghajanian, Elizabeth M Swisher, Aikou Okamoto, Karina Dahl Steffensen, Michael A Bookman, Gini F Fleming, Michael Friedlander, Kathleen N Moore, Krishnansu S Tewari, David M O'Malley, John K Chan, Christine Ratajczak, Hideyuki Hashiba, Meijing Wu, Minh H Dinh, and Robert L Coleman

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Development and Validation of Dynamic Multivariate Prediction Models of Sexual Function Recovery in Patients with Prostate Cancer Undergoing Radical Prostatectomy: Results from the MUSIC Statewide Collaborative., Nnenaya Agochukwu-Mmonu, Adharsh Murali, Daniela Wittmann, Brian Denton, Rodney L Dunn, James Montie, James Peabody, David Miller, Karandeep Singh, and Michigan Urological Surgery Improvement Collaborative

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A phase 1 multiple-ascending dose study to evaluate the safety and tolerability of XmAb23104 (PD-1 x ICOS) in subjects with selected advanced solid tumors (DUET-3)., Mehmet Akce, Rom Leidner, and See full list of authors in comments

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Enhancement of anti-tumor efficacy of immune checkpoint blockade by alpha-tocopheryloxacetic acid-lysine, Emmanuel Akporiaye, William L. Redmond, and Melissa Kasiewicz

940 siRNA screen of upregulated genes identifies targets for a multiantigen polyepitope vaccine to prevent HNSCC, Fnu Alka, James Annis, Brady Bernard, and Sasha Stanton

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Multi-modal molecular programs regulate melanoma cell state., Miles C Andrews, Junna Oba, Chang-Jiun Wu, Haifeng Zhu, Tatiana Karpinets, Caitlin A Creasy, Marie-Andrée Forget, Xiaoxing Yu, Xingzhi Song, Xizeng Mao, A Gordon Robertson, Gabriele Romano, Peng Li, Elizabeth M Burton, Yiling Lu, Robert Szczepaniak Sloane, Khalida M Wani, Kunal Rai, Alexander J Lazar, Lauren E Haydu, Matias A Bustos, Jianjun Shen, Yueping Chen, Margaret B Morgan, Jennifer A Wargo, Lawrence N Kwong, Cara L Haymaker, Elizabeth A Grimm, Patrick Hwu, Dave S B Hoon, Jianhua Zhang, Jeffrey E Gershenwald, Michael A Davies, P Andrew Futreal, Chantale Bernatchez, and Scott E Woodman

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Resection of persistent stage IIIA-N2 NSCLC following induction therapy., Weston Garrett Andrews, Brian Louie, and Adam J Bograd

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A model for the intrinsic limit of cancer therapy: Duality of treatment-induced cell death and treatment-induced stemness., Erin Angelini, Yue Wang, Joseph X Zhou, Hong Qian, and Sui Huang

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Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 2nd - 4th, 2021, Italy)., Paolo A Ascierto, Sanjiv S Agarwala, Christian Blank, Corrado Caracò, Richard D Carvajal, Marc S Ernstoff, Soldano Ferrone, Bernard A Fox, Thomas F Gajewski, Claus Garbe, Jean-Jacques Grob, Omid Hamid, Michelle Krogsgaard, Roger S Lo, Amanda W Lund, Gabriele Madonna, Olivier Michielin, Bart Neyns, Iman Osman, Solange Peters, Poulikos I Poulikakos, Sergio A Quezada, Bradley Reinfeld, Laurence Zitvogel, Igor Puzanov, and Magdalena Thurin

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Perspectives in Immunotherapy: meeting report from the Immunotherapy Bridge, December 1st-2nd, 2021., Paolo A Ascierto, Antonio Avallone, Nina Bhardwaj, Carlo Bifulco, Sergio Bracarda, Joshua D Brody, Luigi Buonaguro, Sandra Demaria, Leisha A Emens, Robert L Ferris, Jérôme Galon, Samir N Khleif, Christopher A Klebanoff, Tamara Laskowski, Ignacio Melero, Chrystal M Paulos, Sandro Pignata, Marco Ruella, Inge Marie Svane, Janis M Taube, Bernard A Fox, Patrick Hwu, and Igor Puzanov

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The "Great Debate" at Immunotherapy Bridge 2021, December 1st-2nd, 2021., Paolo A Ascierto, Lisa H Butterfield, Olivera J Finn, Andrew Futreal, Omid Hamid, Theresa LaVallee, Michael A Postow, Igor Puzanov, Jeffrey Sosman, Bernard A Fox, and Patrick Hwu

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Co-existence of chronic lymphocytic leukemia and chronic myeloid leukemia and underlying pathogenetic mechanisms., Sujan Badal, Prakash Thapaliya, and Kirstine Oh

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Pomalidomide, dexamethasone, and daratumumab immediately after lenalidomide-based treatment in patients with multiple myeloma: updated efficacy, safety, and health-related quality of life results from the phase 2 MM-014 trial., Nizar J Bahlis, David S Siegel, Gary J Schiller, Christy Samaras, Michael Sebag, Jesus Berdeja, Siddhartha Ganguly, Jeffrey Matous, Kevin Song, Christopher S Seet, Mirelis Acosta-Rivera, Michael Bar, Donald Quick, Bertrand Anz, Gustavo Fonseca, Weiyuan Chung, Kim Lee, Jorge Mouro, Amit Agarwal, and Donna Reece

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307 - A Prospective Randomized Trial Comparing Conditioning with Either BEAM or High-Dose Melphalan Prior to Autologous Transplantation for Patients with Multiple Myeloma: An Evaluation of Interim Safety in Early Recovery Phase, Megumi Bailey, Tenzin Tsomo, Neil Bailey, Tori Braun, Chiachun Lu, Carol Dean, Shannon Williams, Gayle Funk, Joanna Fesler, Sonia Glennie, Judson Hall, Vanessa Dunleavy, Daniel N Egan, Raya Mawad, Livia Hegerova, Krish Patel, John M Pagel, and William Bensinger

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Initial Efficacy and Safety of Acalabrutinib Plus RICE in Transplant Eligible Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma, Neil Bailey, Tori Braun, Megumi Bailey, Tenzin Tsomo, Jennie Szeto, Sandra Benitez Kruidenier, Vanessa Dunleavy, Joanna Fesler, Gayle Funk, Sonia Glennie, Judson Hall, Julia Parker, Daniel N Egan, Raya Mawad, Carol A. Dean, Suzan Sullivan, Chia Lu, Heidi Hohmann, Jordan Briggs, and Krish Patel

ENPP1 limits efficacy of radiation therapy in a murine pancreatic cancer model, J Baird, A Alice, M Ball, G Kramer, T Blair, A Kaur, M Gough, and M Crittenden

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The Impact of Ineffective Esophageal Motility On Patients Undergoing Magnetic Sphincter Augmentation., George N Baison, Anee Sophia Jackson, Candice L. Wilshire, Reginald C W Bell, Veronica Lazzari, Luigi Bonavina, Shahin Ayazi, Blair A Jobe, Sebastian F Schoppmann, Colin P Dunn, John C Lipham, Christy M Dunst, Alexander S Farivar, Adam J Bograd, and Brian Louie

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Selinexor-based regimens in patients with multiple myeloma after prior anti-B-cell maturation antigen treatment., Muhamed Baljevic, Cristina Gasparetto, Gary J Schiller, Sascha A Tuchman, Natalie S Callander, Suzanne Lentzsch, Jorge Monge, Rami Kotb, Nizar J Bahlis, Darrell White, Christine I Chen, Heather J Sutherland, Sumit Madan, Richard LeBlanc, Michael Sebag, Christopher P Venner, William Bensinger, Noa Biran, Andrew DeCastro, Dane R Van Domelen, Chris Zhang, Jatin J Shah, Sharon Shacham, Michael G Kauffman, Ohad S Bentur, and Brea Lipe

“Genomic and Transcriptomic Mutational Landscapes of HER2-Low Breast Cancer Patients”, R Bansal, J McGrath, MA Bustos, E Rodriguez, SL Sammons, M Accordino, J Meisel, and See full list of authors in comments

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Safety and Feasibility of Photodynamic Therapy for Ablation of Peripheral Lung Tumors., Sandeep Bansal, Rabih I Bechara, Jiten D Patel, Hiren J Mehta, J Scott Ferguson, Benjamin L Witt, Septimiu D Murgu, Kazuhiro Yasufuku, and Roberto F Casal

Clinical actionability and therapy selection for advanced NSCLC patients tested using comprehensive genomic profiling, B Bapat, R Weerasignhe, R Meng, A Dowdell, SC Chang, B Schroeder, C Bifulco, and B Piening

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Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia., Laura Barreyro, Avery M Sampson, Chiharu Ishikawa, Kathleen M Hueneman, Kwangmin Choi, Mario A Pujato, Somchai Chutipongtanate, Michael Wyder, Wendy D Haffey, Eric O'Brien, Mark Wunderlich, Vighnesh Ramesh, Ellen M Kolb, Cem Meydan, Yaseswini Neelamraju, Lyndsey C Bolanos, Susanne Christie, Molly A Smith, Madeline Niederkorn, Tomoya Muto, Santosh Kesari, Francine E Garrett-Bakelman, Boris Bartholdy, Britta Will, Matthew T Weirauch, James C Mulloy, Zartash Gul, Stephen Medlin, Rhett A Kovall, Ari M Melnick, John P Perentesis, Kenneth D Greis, Elmar Nurmemmedov, William L Seibel, and Daniel T Starczynowski

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Single-Port Retzius-Sparing Robot-Assisted Radical Prostatectomy: Feasibility and Early Outcomes., Jeffrey C Bassett, Salpi Salibian, and Simone Crivellaro

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High-Risk Features of Esophageal Adenocarcinoma Following Neoadjuvant Chemoradiation: Patients for whom Surgery Should Not Be Delayed., Erin M Bayley, Megan L Ivy, Jitesh B Shewale, Phillip S Ge, Mara B Antonoff, Ashleigh M Francis, Wayne L Hofstetter, Reza J Mehran, Ravi Rajaram, David C Rice, Jack A Roth, Boris Sepesi, Ara A Vaporciyan, Garrett L Walsh, J Jack Lee, Brian E Louie, and Stephen G Swisher

NIRT – Not Just Neoadjuvant IO, R Bryan Bell

Cancer Patient Care Journey 2.0: Don't Get Left Behind, Carlo Bifulco

Enhancing clinical genomics datasets with multimodal EHR data and imaging, Carlo Bifulco

Genomic Models of Practice That Support the Quadruple Aim, Carlo Bifulco

Lightning talks: AI in healthcare, Carlo Bifulco

The virtual molecular tumor board as a tool for integrating omics in the delivery of precision oncology, Carlo Bifulco

Enhancing Clinical Genomics Datasets with Multimodal EHR Data and Imaging, Carlo Bifulco and Brian Piening

Value of Comprehensive Genomic Profiling on Clinical Actionability and Treatment in Advanced Cancer Patients, C Bifulco, B Bapat, R Weerasinghe, R Meng, A Dowdell, A Vita, S Chang, M Campbell, B Schroeder, and B Piening

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A Random Forest Genomic Classifier for Tumor Agnostic Prediction of Response to Anti-PD1 Immunotherapy., Emma Bigelow, Suchi Saria, Brian D. Piening, Brendan Curti, Alexa K Dowdell, Roshanthi Weerasinghe, Carlo Bifulco, Walter Urba, Noam Finkelstein, Elana J Fertig, Alex Baras, Neeha Zaidi, Elizabeth Jaffee, and Mark Yarchoan

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Autoimmune Hemolytic Anemia in Children: Laboratory Investigation, Disease Associations, and Treatment Strategies., Douglas Blackall and Lily Dolatshahi

Fluorescence tagging to monitor CD8 T cell recirculation from the tumor to the tumor-draining lymph node: the impact of focal radiation therapy on recirculation, TC Blair, Brian D. Piening, Marka R Crittenden, Michael J. Gough, and See full list of authors in comments

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ICOS is upregulated on T cells following radiation and agonism combined with radiation results in enhanced tumor control., Tiffany Blair, Jason Baird, Shelly Bambina, Gwen Kramer, Monica Gostissa, Christopher J Harvey, Michael J Gough, and Marka R Crittenden

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Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapy., Tiffany Blair, Shelly Bambina, Gwen Kramer, Alexa K Dowdell, Alejandro F Alice, Jason R Baird, Amanda W Lund, Brian D. Piening, Marka R Crittenden, and Michael J. Gough

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Praluzatamab ravtansine, a CD166-targeting antibody-drug conjugate, in patients with advanced solid tumors: an open-label phase 1/2 trial., Valentina Boni, Mary J Fidler, Hendrik-Tobias Arkenau, Alexander Spira, Funda Meric-Bernstam, Nataliya Uboha, Rachel E Sanborn, Randy F Sweis, Patricia LoRusso, Misako Nagasaka, Javier Garcia-Corbacho, Shadia Jalal, James J Harding, Stella K Kim, Iris H C Miedema, Danielle J Vugts, Marc C Huisman, Gerben J C Zwezerijnen, Guus A M S van Dongen, Catharina W Menke-van der Houven van Oordt, Song Wang, Tam Dang, Ivan A Zein, Olga Vasiljeva, Susan K Lyman, Virginia Paton, Alison Hannah, and Joyce F Liu

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Automatic Analysis of Asymmetry in Facial Paralysis Patients Using Landmark-Based Measures., Digbalay Bose, Krishna Somandepalli, Tymon Tai, Courtney Voelker, Shrikanth Narayanan, and Amit Kochhar

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Phase 2 study of AV-GBM-1 (a tumor-initiating cell targeted dendritic cell vaccine) in newly diagnosed Glioblastoma patients: safety and efficacy assessment., Daniela A Bota, Thomas H Taylor, David E Piccioni, Christopher M Duma, Renato V LaRocca, Santosh Kesari, Jose Carrillo, Mehrdad Abedi, Robert D Aiken, Frank P K Hsu, Xiao-Tang Kong, Candace Hsieh, Peter G Bota, Gabriel I Nistor, Hans S Keirstead, and Robert O Dillman

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QLTI-26. INTEGRATION OF NEURO-ONCOLOGY CLINICAL PATHWAYS IN PROVIDENCE SOUTHERN CALIFORNIA CLINICAL RESEARCH NETWORK, Brad Bott, Nanor Bozoyan, Trisha Babcock, Kristen Cushman, Akanksha Sharma, Naveed Wagle, Jose Carrillo, Tiffany Juarez, and Santosh Kesari

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On-Clamp vs. Off-Clamp Robot-Assisted Partial Nephrectomy for cT2 Renal Tumors: Retrospective Propensity-Score-Matched Multicenter Outcome Analysis., Aldo Brassetti, Giovanni E Cacciamani, Andrea Mari, Juan D Garisto, Riccardo Bertolo, Chandru P Sundaram, Ithaar Derweesh, Ahmet Bindayi, Prokar Dasgupta, James R Porter, Alexander Mottrie, Luigi Schips, Koon Ho Rah, David Y T Chen, Chao Zhang, Kenneth Jacobsohn, Umberto Anceschi, Alfredo M Bove, Manuela Costantini, Mariaconsiglia Ferriero, Riccardo Mastroianni, Leonardo Misuraca, Gabriele Tuderti, Alexander Kutikov, Wesley M White, Stephen T Ryan, Francesco Porpiglia, Jihad Kaouk, Andrea Minervini, Inderbir Gill, Riccardo Autorino, and Giuseppe Simone

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Real-World Evidence of Transcutaneous Afferent Patterned Stimulation for Essential Tremor., Salima Brillman, Kalea Colletta, Sally Borucki, Peter T Lin, Olga Waln, Melita Petrossian, Pravin Khemani, Apoorva Rajagopal, Kathryn H Rosenbluth, and Dhira Khosla

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Implementation of High-Dose-Rate, CT-Based Prostate Brachytherapy in an Academic Teaching Hospital and Residency Training Program., Daniel Brunnhoelzl, Alexander Hanania, Sam Sun, Sergio Jaramillo, Linfeng Lu, and Pavan Jhaveri

997 T cell immunotherapies trigger neutrophils to eliminates heterogenous tumors, Sadna Budha, Rebekka Duhen, Andrew Weinberg, and See all authors in comments

“Cell-Free MicroRNAs as Blood Biomarkers for Aggressive Tumors”, MA Bustos

“Molecular characterization of UBQLN4 and clinical implications”, MA Bustos

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Prognostic Utility of CpG Island Hypermethylated Phenotype in Early-Stage Invasive Primary Melanomas., Matias A Bustos and Dave Hoon

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Cell-free plasma microRNAs that identify patients with glioblastoma., Matias A Bustos, Negin Rahimzadeh, Suyeon Ryu, Rebecca Gross, Linh T Tran, Victor M Renteria-Lopez, Romela Irene Ramos, Amy Eisenberg, Parvinder Hothi, Santosh Kesari, Garni Barkhoudarian, Yuki Takasumi, Charles Cobbs, Daniel F Kelly, and Dave Hoon

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Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer., Jinyoung Byun, Younghun Han, Yafang Li, Jun Xia, Erping Long, Jiyeon Choi, Xiangjun Xiao, Meng Zhu, Wen Zhou, Ryan Sun, Yohan Bossé, Zhuoyi Song, Ann Schwartz, Christine Lusk, Thorunn Rafnar, Kari Stefansson, Tongwu Zhang, Wei Zhao, Rowland W Pettit, Yanhong Liu, Xihao Li, Hufeng Zhou, Kyle M Walsh, Ivan Gorlov, Olga Gorlova, Dakai Zhu, Susan M Rosenberg, Susan Pinney, Joan E Bailey-Wilson, Diptasri Mandal, Mariza de Andrade, Colette Gaba, James C Willey, Ming You, Marshall Anderson, John K Wiencke, Demetrius Albanes, Stephan Lam, Adonina Tardon, Chu Chen, Gary E Goodman, Stig Bojeson, Hermann Brenner, Maria Teresa Landi, Stephen J Chanock, Mattias Johansson, Thomas Muley, Angela Risch, H-Erich Wichmann, Heike Bickeböller, David C Christiani, Gad Rennert, Susanne Arnold, John K Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Angeline S Andrew, Lambertus A Kiemeney, Hongbing Shen, Shanbeh Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Angela Cox, Yun-Chul Hong, Jian-Min Yuan, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Alpa Patel, Qing Lan, Nathaniel Rothman, Fiona Taylor, Linda Kachuri, John S Witte, Lori C Sakoda, Margaret Spitz, Paul Brennan, Xihong Lin, James McKay, Rayjean J Hung, and Christopher I Amos

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Efficacy and Safety of Pacritinib vs Placebo for Patients With Severe COVID-19: A Phase 2 Randomized Clinical Trial., John Cafardi, Carole Miller, Howard Terebelo, Chad Tewell, Sadia Benzaquen, David J Park, Pamela Egan, Daniel Lebovic, Kristen Pettit, Eric Whitman, Douglas Tremblay, Jonathan Feld, Sarah Buckley, Karisse Roman-Torres, Jennifer Smith, Adam Craig, and John Mascarenhas

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DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness., Arnaud Carrier, Cécile Desjobert, Loic Ponger, Laurence Lamant, Matias A Bustos, Jorge Torres-Ferreira, Rui Henrique, Carmen Jeronimo, Luisa Lanfrancone, Audrey Delmas, Gilles Favre, Antoine Daunay, Florence Busato, Dave S B Hoon, Jorg Tost, Chantal Etievant, Joëlle Riond, and Paola B Arimondo

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QLTI-22. IMPROVING BRAIN CANCER PATIENT ACCESS TO CLINICAL TRIALS ACROSS SEVEN COMMUNITY HOSPITALS, THE PROVIDENCE SOUTHERN CALIFORNIA CLINICAL RESEARCH NETWORK, Jose Carrillo, Naveed Wagle, Akanksha Sharma, Tiffany Juarez, Minhdan Nguyen, Judy D Truong, Timothy E. Byun, Brad Bott, Nanor Bozoyan, David J Park, and Santosh Kesari

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Risk of Secondary Malignancies in Ovarian Cancer Survivors: 54,305 Patients Analyzed With 40 Years of Follow-up, A C. Casper, M W. Parsons, J Chipman, L M. Burt Jr, G Suneja, K A. Maurer, and D K. Gaffney

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Smart Consumer Wearables as Digital Diagnostic Tools: A Review., Shweta Chakrabarti, Nupur Biswas, Lawrence D Jones, Santosh Kesari, and Shashaanka Ashili

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Analysis of germline-driven ancestry-associated gene expression in cancers., Nyasha Chambwe, Rosalyn W Sayaman, Donglei Hu, Scott Huntsman, Cancer Genome Analysis Network, Anab Kemal, Samantha Caesar-Johnson, Jean C Zenklusen, Elad Ziv, Rameen Beroukhim, and Andrew D Cherniack

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Editorial: Cancer Immunotherapies: From Efficacy to Resistance Mechanisms., Janin Chandra, Morten Hansen, Nathalie Labarriere, Ilaria Marigo, Fernando Souza-Fonseca-Guimaraes, Lazar Vujanovic, Yoshinobu Koguchi, and Nicolas Jacquelot

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The clinical and prognostic significance of pre-chemotherapy serum CA-125 in high-risk early stage ovarian cancer: An NRG/GOG ancillary study., John K Chan, Chunqiao Tian, Joshua P Kesterson, Michael T Richardson, Ken Lin, Krishnansu S Tewari, Thomas Herzog, Daniel S Kapp, Bradley J Monk, Yovanni Casablanca, Parviz Hanjani, Robert M Wenham, Joan Walker, Leah McNally, Larry J Copeland, Sharon Robertson, Samuel Lentz, Nick M Spirtos, and Jeffery G Bell

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Topical therapy for regression and melanoma prevention of congenital giant nevi., Yeon Sook Choi, Tal H Erlich, Max von Franque, Inbal Rachmin, Jessica L Flesher, Erik B Schiferle, Yi Zhang, Marcello Pereira da Silva, Alva Jiang, Allison S Dobry, Mack Su, Sharon Germana, Sebastian Lacher, Orly Freund, Ezra Feder, Jose L Cortez, Suyeon Ryu, Tamar Babila Propp, Yedidyah Leo Samuels, Labib R Zakka, Marjan Azin, Christin E Burd, Norman E Sharpless, X Shirley Liu, Clifford Meyer, William Gerald Austen, Branko Bojovic, Curtis L Cetrulo, Martin C Mihm, Dave S Hoon, Shadmehr Demehri, Elena B Hawryluk, and David E Fisher

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NCMP-07. CASE SERIES OF REGULARLY SCHEDULED MANNITOL INFUSIONS SHOWING WITH PROLONGED CLINICAL BENEFIT FOR MANAGEMENT OF CEREBRAL EDEMA IN GLIOMAS, Jared Chow, Jose Carrillo, Santosh Kesari, Akanksha Sharma, Minhdan Nguyen, Judy D Truong, and Naveed Wagle

Neoadjuvant chemotherapy improves outcomes in resectable pancreatic adenocarcinoma, Wade Christopher, Sean Nassoiy, Rebecca Marcus, Jennifer Keller, Shu-Ching Chang, Trevan Fischer, Anton Bilchik, and Melanie Goldfarb

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Prognostic indicators for undifferentiated carcinoma with/without osteoclast-like giant cells of the pancreas., Wade O Christopher, Sean Nassoiy, Rebecca Marcus, Jennifer Keller, Shu-Ching Chang, Trevan Fischer, Anton J Bilchik, and Melanie Goldfarb

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Changes in T-cell subsets and clonal repertoire during chemoimmunotherapy with pembrolizumab and paclitaxel or capecitabine for metastatic triple-negative breast cancer., Brie Chun, Joanna Pucilowska, Shu-Ching Chang, Isaac Kim, Benjamin Nikitin, Yoshinobu Koguchi, William L. Redmond, Brady Bernard, Venkatesh Rajamanickam, Nathan Polaske, Paul A Fields, Valerie Conrad, Mark Schmidt, Walter Urba, Alison Conlin, Heather L McArthur, and David B Page

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Sentinel lymph node melanoma metastases: Assessment of tumor burden for clinical prediction of outcome in the first Multicenter Selective Lymphadenectomy Trial (MSLT-I)., Alistair J Cochran, Duan-Ren Wen, Rong-Rong Huang, Payam Abrishami, Chandra Smart, Scott Binder, Richard A Scolyer, John F Thompson, Stacey Stern, Lisa Van Kreuningen, David E Elashoff, Myung-Shin Sim, He-Jing Wang, Mark Faries, and MSLT-I Study Group

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CT243 / 4 - Phase 1 study of TAK-676 + pembrolizumab following radiation therapy in patients with advanced non-small-cell lung cancer (NSCLC), triple-negative breast cancer (TNBC), or squamous-cell carcinoma of the head and neck (SCCHN), Benjamin Cooper, David B Page, and See full list of authors in comments

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TAK-676 in combination with pembrolizumab after radiation therapy in patients (pts) with advanced non–small cell lung cancer (NSCLC), triple-negative breast cancer (TNBC), or squamous-cell carcinoma of the head and neck (SCCHN): Phase 1 study design., Benjamin T. Cooper and David B Page

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Phase III Randomized Trial of Maintenance Taxanes Versus Surveillance in Women With Advanced Ovarian/Tubal/Peritoneal Cancer: A Gynecologic Oncology Group 0212:NRG Oncology Study., Larry J Copeland, Mark F Brady, Robert A Burger, William H Rodgers, Helen Q Huang, David Cella, David M O'Malley, Daron G Street, Krishnansu S Tewari, David P Bender, Robert T Morris, William J Lowery, David S Miller, Summer B Dewdney, Nick M Spirtos, Shashikant B Lele, Saketh Guntupalli, Frederick R Ueland, Gretchen E Glaser, Robert S Mannel, and Philip J DiSaia

Automated Staging of Breast Cancer Histopathology Images Using Deep Learning, A Crabtree, N Naik, J Searcy, G Srinivasa, C Bifulco, K Matlock, and B Piening

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Genomic Correlates of Outcome in Tumor-Infiltrating Lymphocyte Therapy for Metastatic Melanoma., Caitlin A Creasy, Yuzhong Jeff Meng, Marie-Andrée Forget, Tatiana Karpinets, Katarzyna Tomczak, Chip Stewart, Carlos A Torres-Cabala, Shari Pilon-Thomas, Amod A Sarnaik, James J Mule, Levi Garraway, Matias A Bustos, Jianhua Zhang, Sapna P Patel, Adi Diab, Isabella C Glitza, Cassian Yee, Hussein Tawbi, Michael K Wong, Jennifer McQuade, Dave S B Hoon, Michael A Davies, Patrick Hwu, Rodabe N Amaria, Cara Haymaker, Rameen Beroukhim, and Chantale Bernatchez

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Easing the Journey-an Updated Review of Palliative Care for the Patient with High-Grade Glioma., Rita C Crooms, Margaret O Johnson, Heather Leeper, Ambereen Mehta, Michelle McWhirter, and Akanksha Sharma

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ASO Author Reflections: Oncologic Safety of Fertility Preservation., Angelena Crown and Mary L Gemignani

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ASO Author Reflections: Optimizing Breast Cancer Risk Assessment and Screening Among Black Women., Angelena Crown and Kathie-Ann Joseph

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ASO Author Reflections: Reinforcing the Safety Net: Supporting Safety-Net Hospitals in Mitigating Breast Cancer Disparities., Angelena Crown and Kathie-Ann Joseph

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Invited Editorial on Breast Surgical Oncology Epidemiological Research: A Guide and Comparison of Four National Databases., Angelena Crown and Kathie-Ann Joseph

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Fertility Preservation in Young Women with Breast Cancer: Impact on Treatment and Outcomes., Angelena Crown, Shirin Muhsen, Varadan Sevilimedu, Joanne Kelvin, Shari B Goldfarb, and Mary L Gemignani

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ASO Visual Abstract: The Role of Safety Net Hospitals in Reducing Disparities in Breast Cancer Care., Angelena Crown, Kalpana Ramiah, Bruce Siegel, and Kathie-Ann Joseph

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The Role of Safety-Net Hospitals in Reducing Disparities in Breast Cancer Care., Angelena Crown, Kalpana Ramiah, Bruce Siegel, and Kathie-Ann Joseph

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For Ethical Fundraising from Patients, Respect them as Partners., Brendan Curti

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Chapter 72: Cancer of the Skin, Brendan Curti, Sancy Leachman, and Walter Urba

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Intratumoral oncolytic virus V937 plus ipilimumab in patients with advanced melanoma: the phase 1b MITCI study., Brendan Curti, Jon Richards, John R Hyngstrom, Gregory A Daniels, Mark Faries, Lynn Feun, Kim A Margolin, Sigrun Hallmeyer, Mark Grose, Yiwei Zhang, Anlong Li, and Robert H I Andtbacka

Open-label, phase 2, multicenter study of lasofoxifene (LAS) combined with abemaciclib (Abema) for treating pre- and postmenopausal women with locally advanced or metastatic ER+/HER2− breast cancer and an ESR1 mutation after progression on prior therapies., Senthil Damodaran, Paul V. Plourde, Halle CF Moore, Ian Churchill Anderson, and David Jay Portman

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Dose escalation of davoceticept, a conditional CD28 costimulator and dual checkpoint inhibitor, in advanced malignancies (NEON-1), Diwakar Davar, Rachel E Sanborn, and See full list of authors in comments

Phase 1 study of SEA-TGT, a human, nonfucosylated monoclonal antibody directed to TIGIT with enhanced immune effector function, in patients with advanced malignancies (SGNTGT-001, trial in progress), D Davar, Rachel E Sanborn, and See full list of authors in comments

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The TP53 Database: transition from the International Agency for Research on Cancer to the US National Cancer Institute., Kelvin César de Andrade, Elaine E Lee, Elise M Tookmanian, Chimene A Kesserwan, James J Manfredi, Jessica N Hatton, Jennifer K Loukissas, Jiri Zavadil, Lei Zhou, Magali Olivier, Megan N Frone, Owais Shahzada, William J R Longabaugh, Christian P Kratz, David Malkin, Pierre Hainaut, and Sharon A Savage

PIVOT IO 001: First disclosure of efficacy and safety of bempegaldesleukin (BEMPEG) plus nivolumab (NIVO) vs NIVO monotherapy in advanced melanoma (MEL), A Diab, Brendan Curti, and See all authors in comments

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Comparison of health-care utilization and expenditures for minimally invasive vs. open colectomy for benign disease., Sarah E Diaz, Yongjin F Lee, Amir Bastawrous, I-Fan Shih, Shih-Hao Lee, Yanli Li, and Robert K Cleary

546 A phase I dose escalation study of STEMVAC, a multi-antigen, multi-epitope Th1 selective plasmid-based vaccine, targeting stem cell associated proteins in patients with advanced breast cancer, Mary Disis, Sasha Stanton, and See all authors in comments

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Automatic Patient Matching for Genome-Guided Adoptive Cell Immunotherapy Trials at a Large Health System, Alexa K Dowdell, Tucker Bower, Benjamin Cosgrove, Roshanthi Weerasinghe, Ann Vita, Brian D. Piening, Carlo Bifulco, Eric Tran, and Rom Leidner

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Latinx attitudes, barriers, and experiences with genetic counseling and testing: A systematic review., Heather A Dron, Daiana Bucio, Jennifer L Young, Holly K Tabor, and Mildred K Cho

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OX40 agonist stimulation increases and sustains humoral and cell-mediated responses to SARS-CoV-2 protein and saRNA vaccines., Rebekka Duhen, Michael Beymer, Shawn M. Jensen, Srinivas Abbina, Suraj Abraham, Nikita Jain, Anitha Thomas, Andrew J Geall, Hong-Ming Hu, Bernard A Fox, and Andrew D Weinberg

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PD-1 and ICOS co-expression identifies tumor-reactive CD4 T cells in human solid tumors., Rebekka Duhen, Olivier Fesneau, Kimberly Samson, Alexandra K Frye, Michael Beymer, Venkatesh Rajamanickam, David Ross, Eric Tran, Brady Bernard, Andrew D Weinberg, and Thomas Duhen

Aperçu de l’immunothérapie et défis de l’immuno-oncologie, T Duhen

PD-1 and ICOS co-expression identifies tumor-reactive CD4 T cells in human solid tumors, Thomas Duhen

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Prognostic significance of ethnicity and age in advanced stage epithelial ovarian cancer: An NRG oncology/gynecologic oncology group study., Nefertiti C duPont, Danielle Enserro, Mark F Brady, Katherine Moxley, Joan L Walker, Casey Cosgrove, Kristin Bixel, Krishnansu S Tewari, Premal Thaker, Andrea E Wahner Hendrickson, Stephen Rubin, Keiichi Fujiwara, A Catherine Casey, John Soper, Robert A Burger, and Bradley J Monk

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Prognostic significance of ethnicity and age in advanced stage epithelial ovarian cancer: An NRG oncology/gynecologic oncology group study., Nefertiti C duPont, Danielle Enserro, Mark F Brady, Katherine Moxley, Joan L Walker, Casey Cosgrove, Kristin Bixel, Krishnansu S Tewari, Premal Thaker, Andrea E Wahner Hendrickson, Stephen Rubin, Keiichi Fujiwara, A Catherine Casey, John Soper, Robert A Burger, and Bradley J Monk

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The Emergence of Virtual Tumor Boards in Neuro-Oncology: Opportunities and Challenges., Chukwuyem Ekhator, Santosh Kesari, Ramya Tadipatri, Ekokobe Fonkem, and Jai Grewal

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Survival and Toxicities after, Erica C Emmons, Steven Bishay, Liping Du, Henry Krebs, Ripal T Gandhi, Zachary S Collins, Ryan O'Hara, Nabeel M Akhter, Eric A Wang, Christopher Grilli, Jayson S Brower, Shannon R Peck, Michael Petroziello, Ahmed K Abdel Aal, Jafar Golzarian, Andrew S Kennedy, Lea Matsuoka, Daniel Y Sze, and Daniel B Brown

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Epigenetic Signatures Predict Pathologic Nodal Stage in Breast Cancer Patients with Estrogen Receptor-Positive, Clinically Node-Positive Disease., Miquel Ensenyat-Mendez, Dennis Rünger, Javier I Orozco, Julie Le, Jennifer L Baker, Joanne Weidhaas, Diego M Marzese, and Maggie L DiNome