The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2022

State of the Art Treatment of Rectal Cancer: Moving away from Trimodality Therapy, HF Kennecke

The NEO Trial Results: Organ Sparing Therapy in Rectal Cancer, HF Kennecke

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BETA PRIME: Phase I study of AdAPT-001 as monotherapy and combined with a checkpoint inhibitor in superficially accessible, treatment-refractory solid tumors., Santosh Kesari, Alberto Bessudo, Brian R Gastman, Anthony P Conley, Victoria M Villaflor, Lisle M Nabell, DeLisa Madere, Emma Chacon, Christina Spencer, Li Li, Christopher Larson, Tony Reid, Scott Caroen, Bryan Oronsky, Meaghan Stirn, Jeannie Williams, and Minal A Barve

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A preliminary safety assessment of vertebral augmentation with 32 P brachytherapy bone cement, Joyce H Keyak, Mando L Eijansantos, Katherine G Rosecrance, Daniel Wong, Sayeh Feizi, Aleen L Meldosian, Pranav Peddinti, Clifford M Les, Harry B Skinner, and Varun Sehgal

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Early Local Therapy for the Primary Site in De Novo Stage IV Breast Cancer: Results of a Randomized Clinical Trial (EA2108)., Seema A Khan, Fengmin Zhao, Lori J Goldstein, David Cella, Mark Basik, Mehra Golshan, Thomas B Julian, Barbara A Pockaj, Christine A Lee, Wajeeha Razaq, Joseph A Sparano, Gildy V Babiera, Irene A Dy, Sarika Jain, Paula Silverman, Carla S Fisher, Amye J Tevaarwerk, Lynne I Wagner, and George W Sledge

O006/#1066 Randomized trial of pelvic radiation with and without concurrent cisplatin in patients with a pelvic only recurrence of endometrial cancer, Ann Klopp, Christopher Darus, and See all authors in comments

“IFI16 promotes immune responses through IFN-γ pathway activation in metastatic cutaneous melanomas”, Y Kobayashi, MA Bustos, Q Yu, and DSB Hoon

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Genomic Amplification of, Yuta Kobayashi, Matias A Bustos, Yoshiaki Shoji, Ron D Jachimowicz, Yosef Shiloh, and Dave S B Hoon

Single-cell RNA-seq analysis of human tumor infiltrating T cells across multiple tumor types to discover potential targets for combination immunotherapy, Y Koguchi, T Christie, V Rajamanickam, N Simons, W Rosales, JK Kaufmann, B Bernard, and William Redmond

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A Novel Class of On-Treatment Cancer Immunotherapy Biomarker: Trough Levels of Antibody Therapeutics in Peripheral Blood., Yoshinobu Koguchi and William L Redmond

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Urine Cell-Free MicroRNAs in Localized Prostate Cancer Patients., Yoko Koh, Matias A Bustos, Jamie Moon, Rebecca Gross, Romela Irene Ramos, Suyeon Ryu, Jane Choe, Selena Y Lin, Warren M Allen, David L Krasne, Timothy G Wilson, and Dave Hoon

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Factors impacting genomic testing rates among epithelial ovarian cancer patients across a large community-based healthcare system (595), Nicole Kretzer, Christopher J. Darus, Nancy Biery, Roshanthi Weerasinghe, Hsin-Fang Li, Ann Vita, Shwetha Pindikuri, Amy Parrish, Charles Drescher, and Fernanda Musa

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Factors impacting genomic testing rates among epithelial ovarian cancer patients across a large community-based healthcare system, Nicole M. Kretzer, Christopher J. Darus, Nancy Biery, Roshanthi Weerasinghe, Grace Li, Ann Vita, Shwetha Pindikuri, Amy S. Parrish, Charles W Drescher, and Fernanda B. Musa

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Frequency of homologous recombination deficiency in a large community-based cohort of epithelial ovarian cancer cases, Nicole M. Kretzer, Fernanda B. Musa, Christopher Darus, Nancy Biery, Roshanthi Weerasinghe, Grace Li, Ann Vita, Shwetha Pindikuri, Amy S. Parrish, and Charles W Drescher

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Patterns of genomic testing for epithelial ovarian cancer across a large community-based health care network- a real world experience, Nicole M. Kretzer, Fernanda B. Musa, Christopher Darus, Nancy Biery, Roshanthi Weerasinghe, Grace Li, Ann Vita, Shwetha Pindikuri, Amy S. Parrish, and Charles W Drescher

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Frequency of homologous recombination deficiency in a large community-based cohort of epithelial ovarian cancer cases (597), Nicole Kretzer, Fernanda Musa, Christopher Darus, Nancy Biery, Roshanthi Weerasinghe, Hsin-Fang Li, Ann Vita, Shwetha Pindikuri, Amy Parrish, and Charles Drescher

Factors Impacting Genomic Testing Rates Among Epithelial Ovarian Cancer Patients ​Across a Large Community-Based Healthcare System, NM Kretzer, HF Li, and See all authors in comments

Frequency of Homologous Recombination Deficiency (HRD) in a Large Community Based Cohort of Epithelial Ovarian Cancer Cases (EOC), NM Kretzer, HF Li, and See all authors in comments

Patterns of Genomic Testing for Epithelial Ovarian Cancer (EOC) Across a Large Community-Based Health Care Network- A Real World Experience, NM Kretzer, HF Li, and See all authors in comments

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Everolimus with or without bevacizumab in advanced pNET: CALGB 80701 (Alliance)., Matthew H Kulke, Fang-Shu Ou, Donna Niedzwiecki, Lucas Huebner, Pamela Kunz, Hagen F Kennecke, Edward M Wolin, Jennifer A Chan, Eileen M O'Reilly, Jeffrey A Meyerhardt, and Alan Venook

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Sustained postoperative plasma elevations of plasminogen activator inhibitor-1 following minimally invasive colorectal cancer resection., H M C Shantha Kumara, Poppy Addison, Dasuni N Gamage, Erica Pettke, Abhinit Shah, Xiaohong Yan, Vesna Cekic, and Richard L Whelan

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The role of adjuvant chemotherapy in the management of acute promyelocytic leukemia differentiation syndrome., Dominic LaBella, Samuel Regan, Heiko Konig, Daniel N Egan, Neil Bailey, Raya Mawad, Morgan Gilbert, John M Pagel, and Jeffrey J Pu

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Safety and efficacy of HSP90 inhibitor ganetespib for neoadjuvant treatment of stage II/III breast cancer., Julie E Lang, Andres Forero-Torres, Douglas Yee, Christina Yau, Denise Wolf, John Park, Barbara A Parker, A Jo Chien, Anne M Wallace, Rashmi Murthy, Kathy S Albain, Erin D Ellis, Heather Beckwith, Barbara B Haley, Anthony D Elias, Judy C Boughey, Rachel L Yung, Claudine Isaacs, Amy S Clark, Hyo S Han, Rita Nanda, Qamar J Khan, Kristen K Edmiston, Erica Stringer-Reasor, Elissa Price, Bonnie Joe, Minetta C Liu, Lamorna Brown-Swigart, Emanuel F Petricoin, Julia D Wulfkuhle, Meredith Buxton, Julia L Clennell, Ashish Sanil, Scott Berry, Smita M Asare, Amy Wilson, Gillian L Hirst, Ruby Singhrao, Adam L Asare, Jeffrey B Matthews, Michelle Melisko, Jane Perlmutter, Hope S Rugo, W Fraser Symmans, Laura J van 't Veer, Nola M Hylton, Angela M DeMichele, Donald A Berry, and Laura J Esserman

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Epidemiology of interstitial lung disease in patients with metastatic breast cancer at baseline and after treatment with HER2-directed therapy: a real-world data analysis., Jeanna Wallenta Law, Alicyn Campbell, Colin Weller, Colden Johanson, Ronda Broome, Elisabeth Piault, Monika Izano, Andrew Schrag, Mary Tran, Thomas D Brown, and Henry G Kaplan

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Real-World Treatment Patterns and Clinical Effectiveness of Palbociclib Plus an Aromatase Inhibitor as First-Line Therapy in Advanced/Metastatic Breast Cancer: Analysis from the US Syapse Learning Health Network., Jeanna Wallenta Law, Debanjali Mitra, Henry G Kaplan, Tamuno Alfred, Adam M Brufsky, Birol Emir, Haley McCracken, Xianchen Liu, Ronda G Broome, Chenan Zhang, Caroline DiCristo, and Connie Chen

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More autopsy studies are needed to understand the pathogenesis of severe COVID-19., Scott P Layne, Kathie-Anne Walters, John C Kash, and Jeffery K Taubenberger

The Multidisciplinary Management of NET Disease: Carcinoid Heart Disease, M E. Layoun

1473 Mechanism of action of bempegaldesleukin (BEMPEG) plus nivolumab (NIVO) in patients with unresectable or metastatic melanoma from the phase 3 randomized open-label PIVOT IO-001 clinical trial, Celeste Lebbe, Brendan Curti, Matthew Taylor, and See all authors in comments

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Cediranib in combination with olaparib in patients without a germline BRCA1/2 mutation and with recurrent platinum-resistant ovarian cancer: Phase IIb CONCERTO trial., Jung-Min Lee, Richard G Moore, Sharad Ghamande, Min Park, John P Diaz, Julia Chapman, James Kendrick, Brian M Slomovitz, Krishnansu S Tewari, Elizabeth S Lowe, Tsveta Milenkova, Sanjeev Kumar, Mike Dymond, Jessica Brown, and Joyce F Liu

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P2Y1 agonist HIC in combination with androgen receptor inhibitor abiraterone acetate impairs cell growth of prostate cancer., Hien Thi Thu Le, Akshaya Murugesan, Nuno R Candeias, Thiyagarajan Ramesh, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

Preliminary immunological monitoring of first-in-human immunotherapy-trio of multivalent autophagosome vaccine, anti-GITR and anti-PD-1, Rom Leidner

A phase 2, open-label, multicenter study of INCAGN01876 (anti-GITR agonist) in combination with retifanlimab (anti–PD-1) in recurrent or metastatic head and neck squamous cell carcinoma, Rom Leidner, Robert Haddad, Nawel Bourayou, Sonia Ioannidis, Feng Zhou, Zhiwan Dong, and Ezra Cohen

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Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer., Rom Leidner, Nelson Sanjuan Silva, Huayu Huang, David Sprott, Chunhong Zheng, Yi-Ping Shih, Amy Leung, Roxanne Payne, Kim Sutcliffe, Julie Cramer, Steven A Rosenberg, Bernard A Fox, Walter Urba, and Eric Tran

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CT502 - Preliminary immunological monitoring of first-in-human immunotherapy-trio for advanced head and neck squamous cell carcinoma, Rom Leidner, Matthew H Taylor, William L. Redmond, Brady Bernard, Richard Bryan Bell, Walter Urba, Carlo Bifulco, Brian D. Piening, Bernard A Fox, and See full authors list in comments

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Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma: A Phase 3 Prospective Externally Controlled Cohort Trial., Linda M Liau, Keyoumars Ashkan, Steven Brem, Jian L Campian, John E Trusheim, Fabio M Iwamoto, David D Tran, George Ansstas, Charles S Cobbs, Jason A Heth, Michael E Salacz, Stacy D'Andre, Robert D Aiken, Yaron A Moshel, Joo Y Nam, Clement P Pillainayagam, Stephanie A Wagner, Kevin A Walter, Rekha Chaudary, Samuel A Goldlust, Ian Y Lee, Daniela A Bota, Heinrich Elinzano, Jai Grewal, Kevin Lillehei, Tom Mikkelsen, Tobias Walbert, Steven Abram, Andrew J Brenner, Matthew G Ewend, Simon Khagi, Darren S Lovick, Jana Portnow, Lyndon Kim, William G Loudon, Nina L Martinez, Reid C Thompson, David E Avigan, Karen L Fink, Francois J Geoffroy, Pierre Giglio, Oleg Gligich, Dietmar Krex, Scott M Lindhorst, Jose Lutzky, Hans-Jörg Meisel, Minou Nadji-Ohl, Lhagva Sanchin, Andrew Sloan, Lynne P Taylor, Julian K Wu, Erin M Dunbar, Arnold B Etame, Santosh Kesari, David Mathieu, David E Piccioni, David S Baskin, Michel Lacroix, Sven-Axel May, Pamela Z New, Timothy J Pluard, Steven A Toms, Victor Tse, Scott Peak, John L Villano, James D Battiste, Paul J Mulholland, Michael L Pearlman, Kevin Petrecca, Michael Schulder, Robert M Prins, Alton L Boynton, and Marnix L Bosch

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Successful endovascular treatment of abdominal aortic rupture secondary to bacillus Calmette-Guérin vaccine., Andrew E Liechty, Albert Pacifico, and Peter Brant-Zawadzki

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Correction: miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway., Wan Li, Jie Yi, Xiangjin Zheng, Shiwei Liu, Weiqi Fu, Liwen Ren, Li Li, Dave Hoon, Jinhua Wang, and Guanhua Du

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Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk., Yafang Li, Xiangjun Xiao, Jianrong Li, Jinyoung Byun, Chao Cheng, Yohan Bossé, James McKay, Demetrios Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Stig E Bojesen, Maria T Landi, Mattias Johansson, Angela Risch, Heike Bickeböller, H-Erich Wichmann, David C Christiani, Gad Rennert, Susanne Arnold, Gary E Goodman, John K Field, Michael P A Davies, Sanjay S Shete, Loic Le Marchand, Olle Melander, Hans Brunnström, Geoffrey Liu, Rayjean J Hung, Angeline S Andrew, Lambertus A Kiemeney, Hongbing Shen, Ryan Sun, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Dawn M Teare, Yun-Chul Hong, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Ann G Schwartz, Ivan Gorlov, Kristen Purrington, Ping Yang, Yanhong Liu, Younghun Han, Joan E Bailey-Wilson, Susan M Pinney, Diptasri Mandal, James C Willey, Colette Gaba, Paul Brennan, Christopher I Amos, and INTEGRAL-ILCCO lung cancer consortium

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Impact of consensus molecular subtyping (CMS) on survival in the CO.26 trial of durvalumab plus tremelimumab versus best supportive care (BSC) in metastatic colorectal cancer (mCRC), Jonathan M. Loree, Hagen F Kennecke, and See full list of authors in comments

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Commentary: The forgotten nodal station in esophageal cancer., Brian Louie

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Accuracy and agreement of a large panel of endosonographers for endomicroscopy-guided virtual biopsy of pancreatic cystic lesions., Jorge D Machicado, Bertrand Napoleon, Anne Marie Lennon, Samer El-Dika, Stephen P Pereira, Damien Tan, Rahul Pannala, Mohit Girotra, Pradermchai Kongkam, Helga Bertani, Yunlu Feng, Hao Sijie, Ning Zhong, Vincent Valantin, Sarah Leblanc, Alice Hinton, and Somashekar G Krishna

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Angiotensin receptor blockade and stereotactic body radiation therapy for early stage lung cancer ARB & SBRT for early stage lung cancer., Lauren T Maloney, Emile Latour, Yiyi Chen, Douglas Rice, Alison Grossblatt-Wait, Nima Nabavizadeh, Charles R Thomas, Kristina H Young, Joshua M Walker, John Holland, and Aaron J Grossberg

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Physical and in silico immunopeptidomic profiling of a cancer antigen prostatic acid phosphatase reveals targets enabling TCR isolation., Zhiyuan Mao, Pavlo A Nesterenko, Jami McLaughlin, Weixian Deng, Giselle Burton Sojo, Donghui Cheng, Miyako Noguchi, William Chour, Diana C DeLucia, Kathryn A Finton, Yu Qin, Matthew B Obusan, Wendy Tran, Liang Wang, Nathanael J Bangayan, Lisa Ta, Chia-Chun Chen, Christopher S Seet, Gay M Crooks, John W Phillips, James R Heath, Roland K Strong, John K Lee, James A Wohlschlegel, and Owen N Witte

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Systemic Therapy Is Associated with Improved Oncologic Outcomes in Resectable Stage II/III Intrahepatic Cholangiocarcinoma: An Examination of the National Cancer Database over the Past Decade., Rebecca Marcus, Wade Christopher, Jennifer Keller, Sean Nassoiy, Shu-Ching Chang, Melanie Goldfarb, Ronald Wolf, and Zeljka Jutric

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Precision nephrology identified tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis., Laura H Mariani, Sean Eddy, Fadhl M AlAkwaa, Phillip J McCown, Jennifer L Harder, Viji Nair, Felix Eichinger, Sebastian Martini, Adebowale D Ademola, Vincent Boima, Heather N Reich, Jamal El Saghir, Bradley Godfrey, Wenjun Ju, Emily C Tanner, Virginia Vega-Warner, Noel L Wys, Sharon G Adler, Gerald B Appel, Ambarish Athavale, Meredith A Atkinson, Serena M Bagnasco, Laura Barisoni, Elizabeth Brown, Daniel C Cattran, Gaia M Coppock, Katherine M Dell, Vimal K Derebail, Fernando C Fervenza, Alessia Fornoni, Crystal A Gadegbeku, Keisha L Gibson, Laurence A Greenbaum, Sangeeta R Hingorani, Michelle A Hladunewich, Jeffrey B Hodgin, Marie C Hogan, Lawrence B Holzman, J Ashley Jefferson, Frederick J Kaskel, Jeffrey B Kopp, Richard A Lafayette, Kevin V Lemley, John C Lieske, Jen-Jar Lin, Rajarasee Menon, Kevin E Meyers, Patrick H Nachman, Cynthia C Nast, Michelle M O'Shaughnessy, Edgar A Otto, Kimberly J Reidy, Kamalanathan K Sambandam, John R Sedor, Christine B Sethna, Pamela Singer, Tarak Srivastava, Cheryl L Tran, Katherine Tuttle, Suzanne M Vento, Chia-Shi Wang, Akinlolu O Ojo, Dwomoa Adu, Debbie S Gipson, Howard Trachtman, and Matthias Kretzler

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Drug-Eluting Bead, Irinotecan Therapy of Unresectable Intrahepatic Cholangiocarcinoma (DELTIC) with Concomitant Systemic Gemcitabine and Cisplatin., Robert C G Martin, Kerri A Simo, Paul D Hansen, Flavio Rocha, Prejesh Philips, Kelly M McMasters, Clifton M Tatum, Lawrence R Kelly, Michael Driscoll, Vivek R Sharma, Todd S Crocenzi, and Charles R Scoggins

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ASO Visual Abstract: Drug-Eluting Beads with Irinotecan Therapy of Unresectable Intrahepatic Cholangiocarcinoma (DELTIC) with Concomitant Systemic Gemcitabine and Cisplatin., Robert C G Martin, Kerri A Simo, Paul Hansen, Flavio Rocha, Prejesh Philips, Kelly M McMasters, Clifton M Tatum, Lawrence R Kelly, Michael Driscoll, Vivek R Sharma, Todd S Crocenzi, and Charles R Scoggins

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Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy., Shijun Ma, Yue Zhao, Wee Chyan Lee, Li-Teng Ong, Puay Leng Lee, Zemin Jiang, Gokce Oguz, Zhitong Niu, Min Liu, Jian Yuan Goh, Wenyu Wang, Matias A Bustos, Sidse Ehmsen, Adaikalavan Ramasamy, Dave Hoon, Henrik J Ditzel, Ern Yu Tan, Qingfeng Chen, and Qiang Yu

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ASO Visual Abstract: Timing of Presentation and Outcomes of Women with Stage IV Pregnancy-Associated Breast Cancer (PABC)., Regina Matar, Angelena Crown, Varadan Sevilimedu, Shari B Goldfarb, and Mary L Gemignani

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Reply by Authors., Surena F Matin, Phillip M Pierorazio, Nir Kleinmann, John L Gore, Ahmad Shabsigh, Brian Hu, Karim Chamie, Guilherme Godoy, Scott G Hubosky, Marcelino Rivera, Michael O'Donnell, Marcus Quek, Jay D Raman, John J Knoedler, Douglas Scherr, Christopher Weight, Alon Weizer, Michael Woods, Hristos Kaimakliotis, Angela B Smith, Jennifer M Linehan, Jonathan Coleman, Mitchell R Humphreys, Raymond Pak, David Lifshitz, Michael Verni, Ifat Klein, Marina Konorty, Dalit Strauss-Ayali, Gil Hakim, Elyse Seltzer, Mark Schoenberg, and Seth P Lerner

Neoadjuvant HER2-targeted therapy +/- immunotherapy with pembrolizumab (neoHIP): An open-label randomized phase II trial., Heather L. McArthur, David B. Page, and See all authors in comments

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A single-arm, phase 2 study of perioperative ipilimumab, nivolumab, and cryoablation in women with hormone receptor-negative, HER2-negative, early-stage/resectable breast cancer., Heather L. McArthur, David B Page, and See full list of authors in comments

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Neoadjuvant HER2-targeted therapy +/- immunotherapy with pembrolizumab (neoHIP): An open-label randomized phase II trial., Heather L. McArthur, David B Page, and See full list of authors in comments

A Single Arm Phase 2 Study of Peri-Operative Checkpoint-Mediated Immune Therapy and Cryoablation in Women with Hormone Receptor-Negative, HER2-Negative Early Stage/Resectable Breast Cancer, Heather McArthur, David B. Page, Staci Mellinger, Nicole Fredrich, Nicole Moxon, and See all authors in comments

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Recurrence and Mortality Risk of Merkel Cell Carcinoma by Cancer Stage and Time From Diagnosis., Aubriana M McEvoy, Kristina Lachance, Daniel S Hippe, Kelsey Cahill, Yasman Moshiri, Christopher W Lewis, Neha Singh, Song Y Park, Zoe Thuesmunn, Maclean M Cook, Nora A Alexander, Lauren Zawacki, Hannah Thomas, Kelly G Paulson, and Paul Nghiem

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Patient-reported tolerability of adjuvant ipilimumab (3 or 10 mg/kg) versus high-dose interferon alfa-2b for resected high-risk stage III-IV melanoma in phase III trial E1609., Laurie E McLouth, Yue Zheng, Stephanie Smith, F Stephen Hodi, Uma N Rao, Gary I Cohen, Thomas T Amatruda, Shaker R Dakhil, Brendan D Curti, Ibrahim Nakhoul, Sreenivasa R Chandana, Charles L Bane, David E Marinier, Sandra J Lee, Vernon K Sondak, John M Kirkwood, Ahmad A Tarhini, and Lynne I Wagner

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ATF6-mediated signaling contributes to PARP Inhibitor Resistance in Ovarian Cancer., Alexandra McMellen, Tomomi M Yamamoto, Lubna Qamar, Brooke E Sanders, Lily L Nguyen, Daniela Ortiz Chavez, Jaidev Bapat, Amber Berning, Miriam D Post, Joshua Johnson, Kian Behbakht, Elmar Nurmemmedov, Edward B Chuong, and Benjamin G Bitler

Lower paraspinous muscle cross-sectional area is associated with shorter survival in patients with a malignant pleural effusion The American Thoracic Society San Francisco, California, AM Meggyesy, Candice L. Wilshire, and See all authors in comments

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Utilization of palliative care resource remains low, consuming potentially avoidable hospital admissions in stage IV non-small cell lung cancer: a community-based retrospective review., Austin M Meggyesy, Kerrie E Buehler, Candice L. Wilshire, Shih-Ting Chiu, Shu-Ching Chang, Joshua R Rayburn, Christopher R Gilbert, and Jed A Gorden

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Outcomes by tobacco history in E3311, a phase II trial of transoral surgery (TOS) followed by pathology-based adjuvant treatment in HPV-associated (HPV+) oropharynx cancer (OPC): A trial of the ECOG-ACRIN Cancer Research Group., Ranee Mehra, Richard Bryan Bell, and See full list of authors in comments

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Learning from the past: a century of accuracy, aspirations, and aspersions in brachytherapy., Christopher S Melhus, Samantha J Simiele, Manik Aima, and Susan Richardson

Immunological profiling of tumor-infiltrating CD8+ T lymphocytes in primary non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), breast cancer (BCa), and renal cell cancers (RCC)., W Miller, William L. Redmond, and See full list of authors in comments

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CT041 - Monotherapy dose escalation of davoceticept (ALPN-202), a conditional CD28 costimulator and dual checkpoint inhibitor, in advanced malignancies (NEON-1), Michael Millward, Rachel E Sanborn, and See full list of authors in comments

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Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study., Bernhard Mlecnik, Toshihiko Torigoe, Gabriela Bindea, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Yoshihiko Hirohashi, Tomohisa Furuhata, Ichiro Takemasa, Prabhudas Patel, Hemangini Vora, Birva Shah, Jayendrakumar B Patel, Kruti N Rajvik, Shashank J Pandya, Shilin N Shukla, Yili Wang, Guanjun Zhang, Takayuki Yoshino, Hiroya Taniguchi, Carlo Bifulco, Alessandro Lugli, Jiun-Kae Jack Lee, Inti Zlobec, Tilman T Rau, Martin D Berger, Iris D Nagtegaal, Elisa Vink-Börger, Arndt Hartmann, Carol I Geppert, Julie Kolwelter, Susanne Merkel, Robert Grützmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Léonard, Christophe Remue, Julia Wang, Prashant Bavi, Michael H A Roehrl, Pamela S Ohashi, Linh T Nguyen, SeongJun Han, Heather L MacGregor, Sara Hafezi-Bakhtiari, Bradly G Wouters, Giuseppe V Masucci, Emilia Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Florence Marliot, Tessa Fredriksen, Bénédicte Buttard, Lucie Lafontaine, Pauline Maby, Amine Majdi, Assia Hijazi, Carine El Sissy, Amos Kirilovsky, Anne Berger, Christine Lagorce, Christopher Paustian, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn Van de Water, Shannon van Lent-van Vliet, Nikki Knijn, Ana-Maria Mușină, Dragos-Viorel Scripcariu, Francesco M Marincola, Paolo A Ascierto, Bernard A Fox, Franck Pagès, Yutaka Kawakami, and Jérôme Galon

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Synthetic lethal kinases in Ras/p53 mutant squamous cell carcinoma., Russell Moser, Kay E Gurley, Olga Nikolova, Guangrong Qin, Rashmi Joshi, Eduardo Mendez, Ilya Shmulevich, Amanda Ashley, Carla Grandori, and Christopher J Kemp

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Lenvatinib dose, efficacy, and safety in the treatment of multiple malignancies., Robert J Motzer, Matthew H Taylor, Thomas R Jeffry Evans, Takuji Okusaka, Hilary Glen, Gregory M Lubiniecki, Corina Dutcus, Alan D Smith, Chinyere E Okpara, Ziad Hussein, Seiichi Hayato, Toshiyuki Tamai, and Vicky Makker

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Radiotherapy for Plantar Fibromas (Ledderhose Disease)., John D Mozena, Eric K Hansen, and Paul Clint Jones

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Therapeutic Value of Sentinel Lymph Node Biopsy in Patients With Melanoma: A Randomized Clinical Trial., Multicenter Selective Lymphadenectomy Trials Study Group, Jessica S Crystal, John F Thompson, John Hyngstrom, Corrado Caracò, Jonathan S Zager, Tiina Jahkola, Tawnya L Bowles, Elisabetta Pennacchioli, Peter D Beitsch, Harald J Hoekstra, Marc Moncrieff, Christian Ingvar, Alexander van Akkooi, Michael S Sabel, Edward A Levine, Doreen Agnese, Michael Henderson, Reinhard Dummer, Rogerio I Neves, Carlo Riccardo Rossi, John M Kane, Steven Trocha, Frances Wright, David R Byrd, Maurice Matter, Eddy C Hsueh, Alastair MacKenzie-Ross, Mark Kelley, Patrick Terheyden, Tara L Huston, Jeffrey D Wayne, Heather Neuman, B Mark Smithers, Charlotte E Ariyan, Darius Desai, Jeffrey E Gershenwald, Shlomo Schneebaum, Anja Gesierich, Lisa K Jacobs, James M Lewis, Kelly M McMasters, Cristina O'Donoghue, Andre van der Westhuizen, Armando Sardi, Richard Barth, Robert Barone, J Greg McKinnon, Craig L Slingluff, Jeffrey M Farma, Erwin Schultz, Randall P Scheri, Sergi Vidal-Sicart, Manuel Molina, Alessandro A E Testori, Lee Foshag, Lisa Van Kreuningen, He-Jing Wang, Myung-Shin Sim, Richard A Scolyer, David E Elashoff, Alistair J Cochran, and Mark B Faries

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Trends in treatment patterns and costs of care among patients with advanced stage cervical cancer., Fernanda Musa, Elizabeth Brouwer, Jie Ting, Naomi R M Schwartz, Andy Surinach, Lisa Bloudek, and Scott D Ramsey

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CT250 / 11 - A first-in-human phase 1 study of NL-201 in patients with relapsed or refractory cancer, Aung Naing, Brendan Curti, and See full list of authors in comments

Treatment Utilization/Outcomes for Locally Advanced Rectal Cancer in Elderly Patients: Analysis of the NCDB, S Nassoiy, SC Chang, and See all authors in comments

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Treatment Utilization and Outcomes for Locally Advanced Rectal Cancer in Older Patients., Sean Nassoiy, Wade Christopher, Rebecca Marcus, Jennifer Keller, Jessica Weiss, Shu-Ching Chang, Leland Foshag, Richard Essner, Trevan Fischer, and Melanie Goldfarb

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Evolving management of early stage pancreatic adenocarcinoma in older patients., Sean Nassoiy, Wade O Christopher, Rebecca Marcus, Jennifer Keller, Jessica Weiss, Shu-Ching Chang, Richard Essner, Lee Foshag, Trevan Fischer, and Melanie Goldfarb

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Constraint-Based Reconstruction and Analyses of Metabolic Models: Open-Source Python Tools and Applications to Cancer., Rachel H Ng, Jihoon W Lee, Priyanka Baloni, Christian Diener, James R Heath, and Yapeng Su

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GPR17 Signaling Activation by CHBC Agonist Induced Cell Death via Modulation of MAPK Pathway in Glioblastoma., Phung Nguyen, Phuong Doan, Akshaya Murugesan, Thiyagarajan Ramesh, Tatu Rimpilainen, Nuno R Candeias, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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Safety and antitumor activity of dostarlimab in patients with advanced or recurrent DNA mismatch repair deficient/microsatellite instability-high (dMMR/MSI-H) or proficient/stable (MMRp/MSS) endometrial cancer: interim results from GARNET-a phase I, single-arm study., Ana Oaknin, Lucy Gilbert, Anna V Tinker, Jubilee Brown, Cara Mathews, Joshua Press, Renaud Sabatier, David M O'Malley, Vanessa Samouelian, Valentina Boni, Linda Duska, Sharad Ghamande, Prafull Ghatage, Rebecca Kristeleit, Charles Leath Iii, Wei Guo, Ellie Im, Sybil Zildjian, Xinwei Han, Tao Duan, Jennifer Veneris, and Bhavana Pothuri

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A comparison of outcomes between transperitoneal and retroperitoneal robotic assisted partial nephrectomy in patients with completely endophytic kidney tumors., Kennedy E Okhawere, Jordan Miller Rich, Burak Ucpinar, Alp Tuna Beksac, Indu Saini, Anthony Deluxe, Laura Zuluaga, Daniel D Eun, Akshay Bhandari, Ashok K Hemal, James Porter, Ronney Abaza, Ahmed Mansour, Michael D Stifelman, Simone Crivellaro, Phillip M Pierorazio, Osama Zaytoun, and Ketan K Badani

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Repeat Revascularization Post Coronary Artery Bypass Grafting: Comparing Minimally Invasive and Traditional Sternotomy Techniques in 1468 Cases., Peter Olson, Michael Cinelli, Hamfreth S Rahming, Thomas Vazzana, Jonathan Spagnola, Emad Barsoum, Marc Assaad, Frank Tamburrino, and James Lafferty

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IFI16-dependent STING signaling is a crucial regulator of anti-HER2 immune response in HER2+ breast cancer., Li-Teng Ong, Wee Chyan Lee, Shijun Ma, Gokce Oguz, Zhitong Niu, Yi Bao, Mubaraka Yusuf, Puay Leng Lee, Jian Yuan Goh, Panpan Wang, Kylie Su Mei Yong, Qingfeng Chen, Wenyu Wang, Adaikalavan Ramasamy, Dave Hoon, Henrik J Ditzel, Ern Yu Tan, Soo Chin Lee, and Qiang Yu

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A Case of Brachial Lymph Node Recurrences after the Resection of Locally Advanced Breast Cancer., Kayono Onishi, Rurina Watanuki, Takamichi Yokoe, Tsuguo Iwatani, Chisako Yamauchi, and Tatsuya Onishi

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Salpingo-oophorectomy or surveillance for ovarian endometrioma in asymptomatic premenopausal women: a cost-effectiveness analysis., Megan S Orlando, Lauren A Cadish, Jonathan P Shepherd, Tommaso Falcone, Olivia H Chang, and Rosanne M Kho

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ASO Author Reflections: Breast-Conserving Therapy: A Safe Option in Young Patients with Early-Stage Breast Cancer., Javier I Orozco, Crystal E Fancher, and Janie Grumley

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ASO Visual Abstract: Machine Learning-Based Epigenetic Classifiers for Axillary Staging of Patients with ER-Positive Early-Stage Breast Cancer., Javier I J Orozco, Julie Le, Miquel Ensenyat-Mendez, Jennifer L Baker, Joanne Weidhaas, Alexandra Klomhaus, Diego M Marzese, and Maggie L DiNome

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ASO Visual Abstract: Impact of Locoregional Treatment on Survival in Young Patients with Early-Stage Breast Cancer Undergoing Upfront Surgery., Javier I Orozco, Jennifer Keller, Shu-Ching Chang, Crystal E Fancher, and Janie Grumley

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Impact of Locoregional Treatment on Survival in Young Patients with Early-Stage Breast Cancer undergoing Upfront Surgery., Javier I Orozco, Jennifer Keller, Shu-Ching Chang, Crystal E Fancher, and Janie Grumley

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ASO Author Reflections: Molecular Signatures May Render Surgical Staging of the Axilla Obsolete., Javier I Orozco, Julie Le, Jennifer L Baker, Diego M Marzese, and Maggie L DiNome

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Machine Learning-Based Epigenetic Classifiers for Axillary Staging of Patients with ER-Positive Early-Stage Breast Cancer., Javier I Orozco, Julie Le, Miquel Ensenyat-Mendez, Jennifer L Baker, Joanne Weidhaas, Alexandra Klomhaus, Diego M Marzese, and Maggie L DiNome

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ToPP: Tumor online prognostic analysis platform for prognostic feature selection and clinical patient subgroup selection., Jian Ouyang, Guangrong Qin, Zhenhao Liu, Xingxing Jian, Tieliu Shi, and Lu Xie

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The Human Tumor Atlas Network's beginning steps toward the future of collaborative multi-omic discovery., David B Page

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Brain radiotherapy, tremelimumab-mediated CTLA-4-directed blockade +/- trastuzumab in patients with breast cancer brain metastases., David B Page, Kathryn Beal, Stefanie N Linch, Kateri Spinelli, Micaela Rodine, Darragh Halpenny, Shanu Modi, Sujata Patil, Robert J Young, Thomas Kaley, Taha Merghoub, David Redmond, Phillip Wong, Christopher A Barker, Adi Diab, Larry Norton, and Heather L McArthur

Applications of statistical regression to improve the TIL score and other immune-based biomarkers in breast cancer, DB Page

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Zandelisib with continuous or intermittent dosing as monotherapy or in combination with rituximab in patients with relapsed or refractory B-cell malignancy: a multicentre, first-in-patient, dose-escalation and dose-expansion, phase 1b trial., John M Pagel, Jacob D Soumerai, Nishitha Reddy, Deepa Jagadeesh, Anastasios Stathis, Adam Asch, Huda Salman, Vaishalee P Kenkre, Alexia Iasonos, Judith Llorin-Sangalang, Joanne Li, and Andrew D Zelenetz

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Molecular alterations associated with improved outcome in patients with glioblastoma treated with Tumor-Treating Fields., Manjari Pandey, Joanne Xiu, Sandeep Mittal, Jia Zeng, Michelle Saul, Santosh Kesari, Amir Azadi, Herbert Newton, Karina Deniz, Katherine Ladner, Ashley Sumrall, W Michael Korn, and Emil Lou

172P Phase I study of JTX-8064, a LILRB2 (ILT4) inhibitor, as monotherapy and combination with pimivalimab (pimi), a PD-1 inhibitor (PD-1i), in patients (pts) with advanced solid tumors, K Papadopoulos, Rachel Sanborn, and See all authors in comments

1296 ­Radiomics-based multi-modal prediction of treatment response to PD-1/PD-L1 immune checkpoint inhibitor (ICI) therapy in stage IV non-small cell lung carcinoma (mNSCLC), Ravi Parikh, Brendan Curti, Roshanthi Weerasinghe, and See all authors in comments

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Chemoradiation therapy alters the PD-L1 score in locoregional recurrent squamous cell carcinomas of the head and neck., Brian J Park, Austin K Mattox, Daniel Clayburgh, Mihir Patel, R Bryan Bell, Bevan Yueh, Rom Leidner, Hong Xiao, Marcus Couey, Shiting Li, Tingting Qin, Maureen A Sartor, Belinda Cairns, Tracy MacDonough, Kyle Halliwill, Daniel Deschler, Derrick T Lin, William C Faquin, Peter M Sadow, and Sara I Pai

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A single-cell based precision medicine approach using glioblastoma patient-specific models., James H Park, Abdullah H Feroze, Samuel N Emerson, Anca B Mihalas, C Dirk Keene, Patrick J Cimino, Adrian Lopez Garcia de Lomana, Kavya Kannan, Wei-Ju Wu, Serdar Turkarslan, Nitin S Baliga, and Anoop P Patel

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Posterior Ischemic Optic Neuropathy Because of Hematologic Malignancy., Ankush U Patel, Uresh S Patel, and Eugene F May

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Effect of a Community Health Worker Intervention on Acute Care Use, Advance Care Planning, and Patient-Reported Outcomes Among Adults With Advanced Stages of Cancer: A Randomized Clinical Trial., Manali I Patel, Kristopher Kapphahn, Marilyn Dewland, Veronica Aguilar, Blanca Sanchez, Etsegenet Sisay, Ariana Murillo, Kim Smith, and David J Park

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#754 A PHASE 1/2 STUDY OF ASP1570 IN PARTICIPANTS WITH LOCALLY ADVANCED OR METASTATIC SOLID TUMORS WHO HAVE PROGRESSED ON, OR ARE INELIGIBLE FOR, ALL AVAILABLE STANDARD THERAPIES, Manish Patel, David J Park, and See full list of authors in comments