The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2021

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Updated report of a phase II randomized trial of transoral surgical resection followed by low-dose or standard postoperative therapy in resectable p16+ locally advanced oropharynx cancer: A trial of the ECOG-ACRIN cancer research group (E3311)., Robert L. Ferris, Yael Flammand, Richard Bryan Bell, and See list of authors in comments

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Neoadjuvant nivolumab for patients with resectable HPV-positive and HPV-negative squamous cell carcinomas of the head and neck in the CheckMate 358 trial., Robert L Ferris, William C Spanos, Rom Leidner, Anthony Gonçalves, Uwe M Martens, Chrisann Kyi, William Sharfman, Christine H Chung, Lot A Devriese, Helene Gauthier, Simon I Chiosea, Lazar Vujanovic, Janis M Taube, Julie E Stein, Jun Li, Bin Li, Tian Chen, Adam Barrows, and Suzanne L Topalian

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Associations of practical, emotional, and physical problems with psychosocial distress among cancer patients., Mark William Flanagan, Heather H Goltz, John W Henson, and Matthew Lee Smith

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Immune-related adverse events are associated with improved response, progression-free survival, and overall survival for patients with head and neck cancer receiving immune checkpoint inhibitors., Corey C Foster, Marcus Couey, Sara E Kochanny, Arun Khattri, Rajesh K Acharya, Yi-Hung Carol Tan, Ryan J Brisson, Rom S Leidner, and Tanguy Y Seiwert

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Umbralisib, a Dual PI3Kδ/CK1ε Inhibitor in Patients With Relapsed or Refractory Indolent Lymphoma., Nathan H Fowler, Felipe Samaniego, Wojciech Jurczak, Nilanjan Ghosh, Enrico Derenzini, James A Reeves, Wanda Knopińska-Posłuszny, Chan Y Cheah, Tycel Phillips, Ewa Lech-Maranda, Bruce D Cheson, Paolo F Caimi, Sebastian Grosicki, Lori A Leslie, Julio C Chavez, Gustavo Fonseca, Sunil Babu, Daniel J Hodson, Spencer H Shao, John M Burke, Jeff P Sharman, Jennie Y Law, John M Pagel, Hari P Miskin, Peter Sportelli, Owen A O'Connor, Michael S Weiss, and Pier Luigi Zinzani

Evaluating the cancer surfaceome: a possible strategy to identify targets and monitor immunity, Bernard A Fox

Exploiting Autophagy and the Ubiquitin Pathway to Educate the Immune System and Improve Cancer Immunotherapy, Bernard A Fox

Immunogenic cell death and antigen release, Bernard A Fox

Shared Immunogenic Cancer Antigens in Humans and Combination Immunotherapy Clinical Trials that Exploit Those Antigens, Bernard A Fox

Translation: An Iterative and Team Process – Our Path to the Development of Triplet Cancer Immunotherapy, Bernard A Fox

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Multicenter Evaluation of Survival and Toxicities of Hepatocellular Carcinoma following Radioembolization: Analysis of the RESiN Registry., Shelby Frantz, Lea Matsuoka, Kirubahara Vaheesan, Michael Petroziello, Jafar Golzarian, Eric Wang, Ripal Gandhi, Zach Collins, Jayson Brower, Varun M Rachakonda, Liping Du, Andrew S Kennedy, Daniel Y Sze, Justin Lee, and Daniel B Brown

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Pooled analysis of safety data from clinical trials evaluating acalabrutinib monotherapy in mature B-cell malignancies., Richard R Furman, John C Byrd, Roger G Owen, Susan M O'Brien, Jennifer R Brown, Peter Hillmen, Deborah M Stephens, Nataliya Chernyukhin, Tamara Lezhava, Ahmed M Hamdy, Raquel Izumi, Priti Patel, Marshall Baek, Beth Christian, Martin J S Dyer, Matthew J Streetly, Clare Sun, Simon Rule, Michael Wang, Paolo Ghia, Wojciech Jurczak, John M Pagel, and Jeff P Sharman

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A phase I study of the WT2725 dosing emulsion in patients with advanced malignancies., Siqing Fu, David E Piccioni, Hongtao Liu, Rimas V Lukas, Santosh Kesari, Dawit Aregawi, David S Hong, Kenichiro Yamaguchi, Kate Whicher, Yi Zhang, Yu-Luan Chen, Nagaraju Poola, John Eddy, and David Blum

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Pralsetinib for RET fusion-positive non-small-cell lung cancer (ARROW): a multi-cohort, open-label, phase 1/2 study., Justin F Gainor, Giuseppe Curigliano, Dong-Wan Kim, Dae Ho Lee, Benjamin Besse, Christina S Baik, Robert C Doebele, Philippe A Cassier, Gilberto Lopes, Daniel S W Tan, Elena Garralda, Luis G Paz-Ares, Byoung Chul Cho, Shirish M Gadgeel, Michael Thomas, Stephen V Liu, Matthew H Taylor, Aaron S Mansfield, Viola W Zhu, Corinne Clifford, Hui Zhang, Michael Palmer, Jennifer Green, Christopher D Turner, and Vivek Subbiah

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SGNTGT-001: A phase 1 study of SEA‑TGT, an effector-function enhanced monoclonal antibody (mAb), in advanced malignancies (trial in progress)., Elenda Garralda, Rachel E Sanborn, and See list of authors in comments

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Once weekly selinexor, carfilzomib and dexamethasone in carfilzomib non-refractory multiple myeloma patients., Cristina Gasparetto, Gary J Schiller, Sascha A Tuchman, Natalie S Callander, Muhamed Baljevic, Suzanne Lentzsch, Adriana C Rossi, Rami Kotb, Darrell White, Nizar J Bahlis, Christine I Chen, Heather J Sutherland, Sumit Madan, Richard LeBlanc, Michael Sebag, Christopher P Venner, William Bensinger, Noa Biran, Sonia Ammu, Osnat Ben-Shahar, Andrew DeCastro, Dane Van Domelen, Tianjun Zhou, Chris Zhang, Ohad S Bentur, Jatin Shah, Sharon Shacham, Michael Kauffman, and Brea Lipe

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Patient-Specific Cell Communication Networks Associate With Disease Progression in Cancer., David L Gibbs, Boris Aguilar, Vésteinn Thorsson, Alexander V Ratushny, and Ilya Shmulevich

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Cumulative radiation dose incurred during the management of complex pleural space infection., Christopher R Gilbert, Anee S Jackson, Candice L Wilshire, Leah C Horslen, Shu-Ching Chang, Adam J Bograd, Eric Vallieres, and Jed A Gorden

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Pleural Drainage Strategy After IPC Placement: A Focused Clinical Review., Christopher R Gilbert and Russell J Miller

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The use of intrapleural thrombolytic and/or fibrinolytic therapy via indwelling tunneled pleural catheters with or without concurrent anticoagulation usage., Christopher R Gilbert, Candice Wilshire, Shu-Ching Chang, and Jed A Gorden

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The longitudinal relationship between immune cell profiles and frailty in patients with breast cancer receiving chemotherapy., Nikesha Gilmore, Supriya Mohile, Lianlian Lei, Eva Culakova, Mostafa Mohamed, Allison Magnuson, Kah Poh Loh, Ronald Maggiore, Elizabeth Belcher, Alison Conlin, Lora Weiselberg, Mary Ontko, and Michelle Janelsins

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Identifying the miRNA Signature Association with Aging-Related Senescence in Glioblastoma., Mutharasu Gnanavel, Akshaya Murugesan, Saravanan Konda Mani, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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Outreach: Preliminary safety and efficacy results from a phase 2 study of lisocabtagene maraleucel (liso-cel) in the nonuniversity setting., John E Godwin, Bassam I. Mattar, and See list of authors in comments

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Outreach: Results from a Phase 2 Study of Lisocabtagene Maraleucel (liso-cel) Administered As Inpatient (Inpt) or Outpatient (Outpt) Treatment in the Nonuniversity Setting in Patients (Pts) with R/R Large B-Cell Lymphoma (LBCL), John E Godwin and See full list of authors in comments

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Assessing the risk of thromboembolism in cancer patients receiving immunotherapy., Abhishek Goel, Arjun Khorana, Thomas Kartika, Sonia Gowda, Derrick L Tao, Rajat Thawani, and Joseph J Shatzel

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"Young children are not the same as adolescents when it comes to treating thyroid cancer"., Melanie Goldfarb, Emily Christison-Lagay, Jeff Rastatter, and Jonathan Wasserman

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Perspectives on COVID-19 and cancer immunotherapy: a review series., Jason D Goldman and Paolo Antonio Ascierto

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COVID-19 in immunocompromised populations: implications for prognosis and repurposing of immunotherapies., Jason D Goldman, Philip C Robinson, Thomas S Uldrick, and Per Ljungman

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The chronic lymphocytic leukemia comorbidity index (CLL-CI): a three-factor comorbidity model., Max J Gordon, Andy Kaempf, Andrea Sitlinger, Geoffrey Shouse, Matthew Mei, Danielle M Brander, Tareq Salous, Brian T Hill, Hamood Alqahtani, Michael Choi, Michael C Churnetski, Jonathon B Cohen, Deborah M Stephens, Tanya Siddiqi, Xavier Rivera, Daniel Persky, Paul Wisnewski, Krish Patel, Mazyar Shadman, Byung Park, and Alexey V Danilov

The Dynamics of pre-existing T cells in tumors and the effects of radiation therapy, M Gough

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Adult pilocytic astrocytoma in the molecular era: a comprehensive review., Timothy A Gregory, Lyndon B Chumbley, John W Henson, and Brett J Theeler

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Unique Dermoscopic and Histopathologic Features of Melanoma Arising in a Patient With BAP1 Tumor Predisposition Syndrome., Eric A Grisham, Joseph Tadros, and Emily Smith

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Letter to the Editor: PET/CT in Locally Advanced Breast Cancer: Time for a Guideline Change?, David Groheux, Elif Hindié, Marc Espié, and Gary A Ulaner

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Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer., Andrew J Gunderson, Venkatesh Rajamanickam, Cynthia Bui, Brady Bernard, Joanna Pucilowska, Carmen Ballesteros-Merino, Mark Schmidt, Kayla McCarty, Michaela Philips, Brian D. Piening, Christopher Dubay, Terry R Medler, Phillipa Newell, Paul D Hansen, Eric Tran, Ephraim Tang, Carlo Bifulco, Marka R Crittenden, Michael J. Gough, and Kristina H Young

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Single-Cell Profiling of Fatty Acid Uptake Using Surface-Immobilized Dendrimers., Zhili Guo, Hanjun Cheng, Zhonghan Li, Shiqun Shao, Priyanka Sarkar, Siwen Wang, Rohit Chaudhuri, Nicole G Perkins, Fei Ji, Wei Wei, and Min Xue

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Debris-stimulated tumor growth: a Pandora's box?, Victoria M Haak, Sui Huang, and Dipak Panigrahy

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Robotic surgical management of sigmoid colon cancer in pregnancy: A case series., Edward R Hagen, Leigh Gerson, Laila Rashidi, and Amir Bastawrous

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Outcomes Among Classical Hodgkin Lymphoma Patients After an Interim PET Scan: A Real-World Experience., Muhammad Saad Hamid, Sarah C Rutherford, Hyejeong Jang, Seongho Kim, Krish Patel, Nancy L Bartlett, Mary-Kate Malecek, Marcus P Watkins, Kami J Maddocks, David A Bond, Tatyana A Feldman, Gabriela Magarelli, Ranjana H Advani, Michael A Spinner, Andrew M Evens, Mansi Shah, Sairah Ahmed, Deborah M Stephens, Pamela Allen, Michael T Tees, Reem Karmali, Bruce D Cheson, Maryam Sarraf Yazdy, Christopher Strouse, Neil Bailey, John M Pagel, and Radhakrishnan Ramchandren

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Clinical implementation of automated treatment planning for whole-brain radiotherapy., Eun Young Han, Carlos E Cardenas, Callistus Nguyen, Donald Hancock, Yao Xiao, Raymond Mumme, Laurence E Court, Dong Joo Rhee, Tucker J Netherton, Jing Li, Debra Nana Yeboa, Chenyang Wang, Tina M Briere, Peter Balter, Mary K Martel, and Zhifei Wen

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Hepatic Plexus Nerve Block for Microwave Ablation of Hepatic Tumors., Frank Hao, Navid Eghbalieh, Alexandra So, and Edward Wolfgang Lee

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LB180 - Clinical biomarker studies with two fusion-enhanced versions of oncolytic HSV (RP1 and RP2) alone and in combination with nivolumab in cancer patients indicate potent immune activation, Kevin J. Harrington, Francesca Aroldi, Joseph J. Sacco, Mohammed M. Milhem, Brendan Curti, Ari M. Vanderwalde, Scott Baum, Adel Samson, Anna C. Pavlick, Jason A. Chesney, Jiaxin Niu, Terence D. Rhodes, Tawnya L. Bowles, Robert Conry, Anna Olsson-Brown, Douglas E. Laux, Pablo Nenclares, Lavita Menezes, Alex Deterding, Victoria Roulstone, Joan Kyula, Suzanne Thomas, Praveen K. Bommareddy, Selda Samakoglu, Andrea Pirzkall, Robert S. Coffin, and Mark R. Middleton

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The frequency of medical reversals in a cross-sectional analysis of high-impact oncology journals, 2009-2018., Alyson Haslam, Jennifer Gill, Tyler Crain, Diana Herrera-Perez, Emerson Y Chen, Talal Hilal, Myung S Kim, and Vinay Prasad

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The frequency of assessment of progression in randomized oncology clinical trials., Alyson Haslam, Jennifer Gill, and Vinay Prasad

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Correction to: Physician-directed genetic screening to evaluate personal risk for medically actionable disorders: a large multi-center cohort study., Eden V Haverfield, Edward D Esplin, Sienna J Aguilar, Kathryn E Hatchell, Kelly E Ormond, Andrea Hanson-Kahn, Paldeep S Atwal, Sarah Macklin-Mantia, Stephanie Hines, Caron W-M Sak, Steven Tucker, Steven B Bleyl, Peter J Hulick, Ora K Gordon, Lea Velsher, Jessica Y J Gu, Scott M Weissman, Teresa Kruisselbrink, Christopher Abel, Michele Kettles, Anne Slavotinek, Bryce A Mendelsohn, Robert C Green, Swaroop Aradhya, and Robert L Nussbaum

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Physician-directed genetic screening to evaluate personal risk for medically actionable disorders: a large multi-center cohort study., Eden V Haverfield, Edward D Esplin, Sienna J Aguilar, Kathryn E Hatchell, Kelly E Ormond, Andrea Hanson-Kahn, Paldeep S Atwal, Sarah Macklin-Mantia, Stephanie Hines, Caron W-M Sak, Steven Tucker, Steven B Bleyl, Peter J Hulick, Ora K Gordon, Lea Velsher, Jessica Y J Gu, Scott M Weissman, Teresa Kruisselbrink, Christopher Abel, Michele Kettles, Anne Slavotinek, Bryce A Mendelsohn, Robert C Green, Swaroop Aradhya, and Robert L Nussbaum

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Receipt of Tobacco Treatment and One-Year Smoking Cessation Rates Following Lung Cancer Screening in the Veterans Health Administration., Jaimee L Heffner, Scott Coggeshall, Chelle L Wheat, Paul Krebs, Laura C Feemster, Deborah E Klein, Linda Nici, Hannah Johnson, and Steven B Zeliadt

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Digital twins for predictive oncology will be a paradigm shift for precision cancer care., Tina Hernandez-Boussard, Paul Macklin, Emily J Greenspan, Amy L Gryshuk, Eric Stahlberg, Tanveer Syeda-Mahmood, and Ilya Shmulevich

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Impact of Molecular Features of Diffuse Large B-Cell Lymphoma on Treatment Outcomes with Anti-CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy, Brian T. Hill, Neil Bailey, Krish Patel, John M Pagel, and See full list of authors in comments

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First report of the safety/tolerability and preliminary antitumor activity of HB-201 and HB-202, an arenavirus-based cancer immunotherapy, in patients with HPV16+ cancers., Alan L. Ho, Marshall R. Posner, and Rom Leidner

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Intravenous Cetirizine vs Intravenous Diphenhydramine for the Prevention of Hypersensitivity Infusion Reactions: Results of an Exploratory Phase 2 Study., Jarrod P Holmes, Julio A Peguero, R Campbell Garland, Janine North, Stacia Young, Lonnie D Brent, and Nancy Joseph-Ridge

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Intravenous Cetirizine vs Intravenous Diphenhydramine for the Prevention of Hypersensitivity Infusion Reactions: Results of an Exploratory Phase 2 Study., Jarrod P Holmes, Julio A Peguero, R Campbell Garland, Janine North, Stacia Young, Lonnie D Brent, and Nancy Joseph-Ridge

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Mogamulizumab in Combination with Nivolumab in a Phase I/II Study of Patients with Locally Advanced or Metastatic Solid Tumors., David S Hong, Olivier Rixe, Vi K Chiu, Patrick M Forde, Tomislav Dragovich, Yanyan Lou, Asha Nayak-Kapoor, Rom Leidner, James N Atkins, Agron Collaku, Floyd E Fox, Margaret A Marshall, and Anthony J Olszanski

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EpiMap: Fine-tuning integrative epigenomics maps to understand complex human regulatory genomic circuitry., Dave S B Hoon, Negin Rahimzadeh, and Matias A Bustos

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Reconciling Non-Genetic Plasticity with Somatic Evolution in Cancer., Sui Huang

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A Case of Vaccine-Preventable Back Pain, Gerald Hutfles and Tricia James

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Integrated genetic and metabolic landscapes predict vulnerabilities of temozolomide resistant glioblastoma cells., Selva Rupa Christinal Immanuel, Avinash D Ghanate, Dharmeshkumar S Parmar, Ritu Yadav, Riya Uthup, Venkateswarlu Panchagnula, and Anu Raghunathan

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In Their Voice: What Do Caregivers of Patients with Cancer Need?, Ahlam Jadalla

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The Effects of Cardiorespiratory and Motor Skill Fitness on Intrinsic Functional Connectivity of Neural Networks in Individuals with Parkinson's Disease., Behnaz Jarrahi, Sarah C McEwen, Daniel P Holschneider, Dawn M Schiehser, Andrew J Petkus, Megan E Gomez, Jack D Van Horn, Vincent Filoteo, Michael W Jakowec, and Giselle M Petzinger

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Initial results of a first-in-human, dose escalation study of a cell-based vaccine in HLA A*02+ patients (pts) with recurrent, locally advanced or metastatic HPV16+ solid tumors: SQZ-PBMC-HPV-101., Antonio Jimeno, Joaquina C. Baranda, Matthew H Taylor, and See all authors in comments

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Phase I, First-in-Human Study of the Probody Therapeutic CX-2029 in Adults with Advanced Solid Tumor Malignancies., Melissa Johnson, Anthony El-Khoueiry, Navid Hafez, Nehal Lakhani, Hirva Mamdani, Jordi Rodon, Rachel E Sanborn, Javier Garcia-Corbacho, Valentina Boni, Mark Stroh, Alison L Hannah, Song Wang, Henry Castro, and Alexander Spira

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Effect of prior therapy on tumor mutational burden in NSCLC., Sushma Jonna, Ari Vanderwalde, Jorge Nieva, Kelsey Anne Poorman, Michelle Saul, Xinyu von Buttlar, John Y Hu, and Stephen V Liu

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Toxicity After Stereotactic Body Radiation Therapy for Prostate Cancer in Patients With Inflammatory Bowel Disease: A Multi-institutional Matched Case-Control Series., Jesus E Juarez, Tahmineh Romero, Constantine A Mantz, Abigail Pepin, Nima Aghdam, Simeng Suy, Michael L Steinberg, Rebecca G Levin-Epstein, Nicholas G Nickols, Irving D Kaplan, Robert M Meier, Huong T Pham, Patrick W Linson, Robert L Hong, Mark K Buyyounouski, Hilary P Bagshaw, Donald B Fuller, Alan J Katz, Andrew Loblaw, Sean P Collins, and Amar U Kishan

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Microfluidic Single-Cell Proteomics Assay Chip: Lung Cancer Cell Line Case Study., Yugyung Jung, Minkook Son, Yu Ri Nam, Jongchan Choi, James R Heath, and Sung Yang

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Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion., Chrystian Junqueira Alves, Rafael Dariolli, Jonathan Haydak, Sangjo Kang, Theodore Hannah, Robert J Wiener, Stefanie DeFronzo, Rut Tejero, Gabriele L Gusella, Aarthi Ramakrishnan, Rodrigo Alves Dias, Alexandre Wojcinski, Santosh Kesari, Li Shen, Eric A Sobie, José Paulo Rodrigues Furtado de Mendonça, Evren U Azeloglu, Hongyan Zou, and Roland H Friedel

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Results of a randomized phase 3 study of oral sapacitabine in elderly patients with newly diagnosed acute myeloid leukemia (SEAMLESS)., Hagop M Kantarjian, Kebede H Begna, Jessica K Altman, Stuart L Goldberg, Mikkael A Sekeres, Stephen A Strickland, Martha L Arellano, David F Claxton, Maria R Baer, Marc Gautier, Ellin Berman, Karen Seiter, Scott R Solomon, Gary J Schiller, Selina M Luger, Aleksandra Butrym, Gianluca Gaidano, Xavier G Thomas, Pau Montesinos, David A Rizzieri, Donald Quick, Parameswaran Venugopal, Rakesh Gaur, Lori J Maness, Tapan M Kadia, Farhad Ravandi, Marc E Buyse, and Judy H Chiao

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Multi-omic Profiling of Simultaneous Ductal Carcinoma In Situ and Invasive Breast Cancer, Henry G. Kaplan, Anna B. Berry, Alexa Dowdell, and Brian D. Piening

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Treatment of PCM1-JAK2 fusion tyrosine kinase gene-related acute lymphoblastic leukemia with stem cell transplantation, Henry G Kaplan, Carlo Bifulco, Ruyun Jin, James M Scanlan, and David Colvin

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Risk Factors for Intravesical Recurrence after Minimally Invasive Nephroureterectomy for Upper Tract Urothelial Cancer (ROBUUST Collaboration)., Andrew B Katims, Rollin Say, Ithaar Derweesh, Robert Uzzo, Andrea Minervini, Zhenjie Wu, Firas Abdollah, Chandru Sundaram, Matteo Ferro, Koon Rha, Alex Mottrie, Giuseppe Rosiello, Giuseppe Simone, Daniel D Eun, Adam Reese, Laura C Kidd, James R Porter, Amit Satish Bhattu, Mark L Gonzalgo, Vitaly Margulis, Jamil Marcus, Alyssa Danno, Margaret Meagher, Riccardo Tellini, Andrea Mari, Alessandro Veccia, Alireza Ghoreifi, Riccardo Autorino, Hooman Djaladat, and Reza Mehrazin

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Doxorubicin in combination with cisplatin, 5-flourouracil, and vincristine is feasible and effective in unresectable hepatoblastoma: A Children's Oncology Group study., Howard M Katzenstein, Marcio H Malogolowkin, Mark D Krailo, Jin Piao, Alexander J Towbin, M Beth McCarville, Gregory M Tiao, Stephen P Dunn, Max R Langham, Eugene D McGahren, Milton J Finegold, Sarangarajan Ranganathan, Christopher B Weldon, Patrick A Thompson, Angela Trobaugh-Lotrario, Allison F O'Neill, Wayne L Furman, Nadia Chung, Jessica Randazzo, Carlos Rodriguez-Galindo, and Rebecka L Meyers

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Human Breast Extracellular Matrix Microstructures and Protein Hydrogel 3D Cultures of Mammary Epithelial Cells., Chandler R Keller, Yang Hu, Kelsey F Ruud, Anika E VanDeen, Steve R Martinez, Barry T Kahn, Zhiwu Zhang, Roland K Chen, and Weimin Li

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Treatment dependent improvements in survival of stage 2/3 rectal cancer patients treated with trimodality therapy between 2006-2016, an NCDB analysis., Hagen F Kennecke, Henry T. Bahnson, and See list of authors in comments

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CCTG CO.28 primary endpoint analysis: Neoadjuvant chemotherapy, excision and observation for early rectal cancer, the NEO trial., Hagen F Kennecke, Carl J. Brown, and See full list of authors in comments

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Mesenchymal stem cells in the treatment of severe COVID-19., Santosh Kesari, Gregory C Kasper, Lev Verkh, Terese C Hammond, Marla L Matal, Jay W Hammerling, Nikolai Tankovich, Adrianus P Lim, Kevin H Zhao, Tiffany Juarez, Roberta E Redfern, Jaya M Gill, Natsuko Nomura, Audrey Hiemer, Annie Heng, and Jessica Shoemaker

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Response to: Is there any association between a delay in surgery and nodal positivity in the ER-negative Her2 negative breast cancer subgroups?, Adam Khader and Trevan Fischer

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The regulatory saga of fedratinib., Shannon Khal, Vinay Prasad, and Alison Palumbo

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"Custom" Plate in a Day-Accurate Predictive Hole Fabrication Using Point-of-Care 3-Dimensional Printing., Baber Khatib, Marcus Couey, Ashish Patel, Allen C Cheng, and Richard Bryan Bell

Machine learning models to predict failure in administration of intrapleural tPA/DNase in patients with complicated parapneumonic effusions/empyema: A multicenter study, D Khemasuwan, S Shojaee, C Reddy, CR Gilbert, JA Gorden, A Balwan, S Trinidad, B Bixby, JS Sorensen, and CL Wilshire

Machine learning models to predict failure in administration of intrapleural tPA/DNase in patients with complicated parapneumonic effusions/empyema: A multicenter study, D Khemasuwan, S Shojaee, C Reddy, CR Gilbert, JA Gorden, A Balwan, S Trinidad, B Bixby, JS Sorensen, and CL Wilshire

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A Case Series of Metastatic Metaplastic Breast Carcinoma Treated With Anti-PD-1 Therapy., Isaac Kim, Venkatesh Rajamanickam, Brady Bernard, Brie Chun, Yaping Wu, Maritza Martel, Zhaoyu Sun, William L Redmond, Katherine Sanchez, Reva Basho, Heather McArthur, and David B Page

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Improved image reconstruction of, Julian Kirchner, Joseph A O'Donoghue, Anton S Becker, and Gary A Ulaner

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Awareness, Knowledge, and Preferences of United States (US) Patients with Chronic Lymphocytic Leukemia (CLL) and Their Caregivers Related to Finite Duration (FD) Therapy and Minimal (Measurable) Residual Disease (MRD), Brian Koffman, Neil Bailey, John M Pagel, and See all authors in comments

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Trough levels of ipilimumab in serum as a potential biomarker of clinical outcomes for patients with advanced melanoma after treatment with ipilimumab., Yoshinobu Koguchi, Noriko Iwamoto, Takashi Shimada, Shu-Ching Chang, John Cha, Brendan Curti, Walter Urba, Brian D. Piening, and William L. Redmond

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Genomic and functional characterization of a mucosal symbiont involved in early-stage colorectal cancer., Melissa C Kordahi, Ian B Stanaway, Marion Avril, Denise Chac, Marie-Pierre Blanc, Benjamin Ross, Christian Diener, Sumita Jain, Paul McCleary, Ana Parker, Vincent Friedman, Jennifer Huang, Wynn Burke, Sean M Gibbons, Amy D Willis, Richard P Darveau, William M Grady, Cynthia W Ko, and R William DePaolo

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Changes in Carcinoid Syndrome Symptoms Among Patients Receiving Telotristat Ethyl in US Clinical Practice: Findings from the TELEPRO-II Real-World Study., Matthew H Kulke, Hagen F Kennecke, Kris Murali, and Vijay N Joish

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Quality Is King: Fundamental Insights into Tumor Antigenicity from Virus-Associated Merkel Cell Carcinoma., Miranda C Lahman, Kelly G Paulson, Paul T Nghiem, and Aude G Chapuis

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An empirical antigen selection method identifies neoantigens that either elicit broad anti-tumor T cell responses or drive tumor growth., Hubert Lam, Lisa K McNeil, Hanna Starobinets, Victoria L DeVault, Roger B Cohen, Przemyslaw Twardowski, Melissa L Johnson, Maura L Gillison, Mark N Stein, Ulka N Vaishampayan, Arthur P DeCillis, James J Foti, Vijetha Vemulapalli, Emily Tjon, Kyle Ferber, Daniel B DeOliveira, Wendy Broom, Parul Agnihotri, Elizabeth M Jaffee, Kwok-Kin Wong, Charles G Drake, Pamela M Carroll, Thomas A Davis, and Jessica Baker Flechtner

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Unaltered IL-2 encapsulated in acoustically active lipid microspheres for systemic but targeted microdose delivery to tumor microenvironment., Clayton Larsen, Llew Keltner, William L. Redmond, and Rhodemann Li

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WNT Signaling as a Therapeutic Target for Glioblastoma., Michael Latour, Nam-Gu Her, Santosh Kesari, and Elmar Nurmemmedov

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Lung cancer diagnosed on pap smear: A case report and review of the literature., Marie-Claire Leaf, Diana Pearre, Fabio Cappuccini, and Krishnansu S Tewari

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Lenvatinib plus pembrolizumab in patients with either treatment-naive or previously treated metastatic renal cell carcinoma (Study 111/KEYNOTE-146): a phase 1b/2 study., Chung-Han Lee, Amishi Yogesh Shah, Drew Rasco, Arpit Rao, Matthew H Taylor, Christopher Di Simone, James J Hsieh, Alvaro Pinto, David R Shaffer, Regina Girones Sarrio, Allen Lee Cohn, Nicholas J Vogelzang, Mehmet Asim Bilen, Sara Gunnestad Ribe, Musaberk Goksel, Øyvind Krohn Tennøe, Donald Richards, Randy F Sweis, Jay Courtright, Daniel Heinrich, Sharad Jain, Jane Wu, Emmett V Schmidt, Rodolfo F Perini, Peter Kubiak, Chinyere E Okpara, Alan D Smith, and Robert J Motzer

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Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19., Jihoon W Lee, Yapeng Su, Priyanka Baloni, Daniel Chen, Ana Jimena Pavlovitch-Bedzyk, Dan Yuan, Venkata R Duvvuri, Rachel H Ng, Jongchan Choi, Jingyi Xie, Rongyu Zhang, Kim Murray, Sergey A Kornilov, Brett Smith, Andrew T Magis, Dave Hoon, Jennifer J Hadlock, Jason D Goldman, Nathan D Price, Raphael Gottardo, Mark M Davis, Leroy Hood, Philip D Greenberg, and James R Heath

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Cordycepin inhibits the proliferation of malignant peripheral nerve sheath tumor cells through the p53/Sp1/tubulin pathway., Ming-Jen Lee, Jen-Chieh Lee, Jung-Hsien Hsieh, May-Yao Lin, I-An Shih, Huey-Ling You, and Kai Wang

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Molecular interaction of HIC, an agonist of P2Y1 receptor, and its role in prostate cancer apoptosis., Hien Thi Thu Le, Akshaya Murugesan, Thiyagarajan Ramesh, Olli Yli-Harja, Saravanan Konda Mani, and Meenakshisundaram Kandhavelu

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Neoadjuvant immunoradiotherapy results in high rate of complete pathological response and clinical to pathological downstaging in locally advanced head and neck squamous cell carcinoma., Rom Leidner, Marka Crittenden, Kristina Young, Hong Xiao, Yaping Wu, Marcus A Couey, Ashish A Patel, Allen C Cheng, Amber L Watters, Carlo Bifulco, George Morris, Lessli Rushforth, Shorin Nemeth, Walter J Urba, Michael Gough, and R Bryan Bell

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Cancer microenvironment and genomics: evolution in process., Stanley P Leong, Isaac P Witz, Orit Sagi-Assif, Sivan Izraely, Jonathan Sleeman, Brian Piening, Bernard A Fox, Carlo B Bifulco, Rachel Martini, Lisa Newman, Melissa Davis, Lauren M Sanders, David Haussler, Olena M Vaske, and Marlys Witte

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Beyond Sedlis-A novel histology-specific nomogram for predicting cervical cancer recurrence risk: An NRG/GOG ancillary analysis., Kimberly Levinson, Anna L Beavis, Christopher Purdy, Anne F Rositch, Akila Viswanathan, Aaron H Wolfson, Michael G Kelly, Krishnansu S Tewari, Leah McNally, Saketh R Guntupalli, Omar Ragab, Yi-Chun Lee, David S Miller, Warner K Huh, Kelly J Wilkinson, Nicola M Spirtos, Linda Van Le, Yovanni Casablanca, Laura L Holman, Steven E Waggoner, and Amanda N Fader

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Pembrolizumab with low-dose carboplatin for recurrent platinum-resistant ovarian, fallopian tube, and primary peritoneal cancer: survival and immune correlates., John B Liao, William R Gwin, Renata R Urban, Katie M Hitchcock-Bernhardt, Andrew L Coveler, Doreen M Higgins, Jennifer S Childs, Hania N Shakalia, Ron E Swensen, Sasha E Stanton, Anna V Tinker, Tanya A Wahl, Richard G Ancheta, Kathryn F McGonigle, James Y Dai, Mary L Disis, and Barbara A Goff

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Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis., Hongjun Li, Zejun Wang, Zhaowei Chen, Tianyuan Ci, Guojun Chen, Di Wen, Ruoxin Li, Jinqiang Wang, Huan Meng, R Bryan Bell, Zhifeng Gu, Gianpietro Dotti, and Zhen Gu

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Measurements of Functional Network Connectivity Using Resting State Arterial Spin Labeling During Neurosurgery., Thomas Lindner, Hajrullah Ahmeti, Michael Helle, Olav Jansen, Jens Fiehler, Lasse Dührsen, Michael Synowitz, Santosh Kesari, and Stephan Ulmer

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Effects of yoga, cognitive behavioral therapy, and a behavioral placebo on sleep: A nationwide multicenter phase III RCT in cancer survivors., Po-Ju Lin, Charles E. Heckler, Alison Conlin, and See full list of authors in comments