The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2025

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Clinical and Multiomic Features Differentiate Young Black and White Breast Cancer Cohorts Derived by Machine Learning Approaches., Kawther Abdilleh, Boris Aguilar, and George Acquaah-Mensah

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Collaborating across sectors in service of open science, precision oncology, and patients: an overview of the AACR Project GENIE (Genomics Evidence Neoplasia Information Exchange) Biopharma Collaborative (BPC), A Acebedo, Brian D. Piening, and See full list of authors in comments

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Census Tract Rurality, Predominant Race and Ethnicity, and Distance to Lung Cancer Screening Facilities : An Ecological Study., Solmaz Amiri, Candice L. Wilshire, Clemma Jacobsen Muller, Cole Allick, Allison C Welch, Gary Ferguson, Dedra Buchwald, and Jed A Gorden

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Genomic and transcriptomic landscape of HER2-low breast cancer., Rani Bansal, Tolulope Adeyelu, Andrew Elliott, Phillip Walker, Matias A Bustos, Estelamari Rodriguez, Melissa K Accordino, Jane Meisel, Margaret E Gatti-Mays, Emily Hsu, Kate Lathrop, Virginia Kaklamani, Matthew Oberley, George Sledge, Sarah L Sammons, and Stephanie L Graff

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Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube., Ian Beddows, Svetlana Djirackor, Dalia K Omran, Euihye Jung, Natalie Nc Shih, Ritu Roy, Aaron Hechmer, Adam Olshen, Guillaume Adelmant, Ann Tom, Jacob Morrison, Marie Adams, Daniel C Rohrer, Lauren E Schwartz, Celeste Leigh Pearce, Heidi Auman, Jarrod A Marto, Charles W Drescher, Ronny Drapkin, and Hui Shen

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Amivantamab Plus Lazertinib in Patients With EGFR-Mutant NSCLC After Progression on Osimertinib and Platinum-Based Chemotherapy: Results From CHRYSALIS-2 Cohort A., Benjamin Besse, Koichi Goto, Yongsheng Wang, Se-Hoon Lee, Melina E Marmarelis, Yuichiro Ohe, Reyes Bernabe Caro, Dong-Wan Kim, Jong-Seok Lee, Sophie Cousin, Eiki Ichihara, Yongsheng Li, Luis Paz-Ares, Akira Ono, Rachel E Sanborn, Naohiro Watanabe, Maria Jose de Miguel, Carole Helissey, Catherine A Shu, Alexander I Spira, Pascale Tomasini, James Chih-Hsin Yang, Yiping Zhang, Enriqueta Felip, Frank Griesinger, Saiama N Waqar, Antonio Calles, Joel W Neal, Christina S Baik, Pasi A Jänne, S Martin Shreeve, Joshua C Curtin, Bharvin Patel, Michael Gormley, Xuesong Lyu, Jun Chen, Pei-Ling Chu, Janine Mahoney, Leonardo Trani, Joshua M Bauml, Meena Thayu, Roland E Knoblauch, and Byoung Chul Cho

Foundation Digital Pathology Models: From Computational Pathology to Spatial Biology, Carlo Bifulco

Foundation Digital Pathology Models: From Computational Pathology to Spatial Biology, Carlo Bifulco

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A multi-institutional retrospective cohort of adult-onset medulloblastoma in the modern era., Alipi V Bonm, Michael S Rutenberg, Kate E Therkelsen, John Herbst, Anurag Sanaf, Marissa A Sherwood, John Y Rhee, Tresa M McGranahan, Patrick J Cimino, L Nicolas Gonzalez Castro, Derek S Tsang, Matthias A Karajannis, Seema Nagpal, Robert J Amdur, Helen Shih, Jason Barber, and Lynne P Taylor

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Recurrence and Survival Following Robotic Resection of Thymomas Greater Than Five Centimeters., John M Campbell, Peter T White, Adam J Bograd, Alexander S Farivar, Candice L Wilshire, Eric Vallières, and Brian E Louie

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Evaluation of the Toxicity and Outcomes of the Combination of Midostaurin and CLAG-M in Patients With FLT3-Mutated Acute Myeloid Leukemia (AML): A Multicenter Retrospective Analysis., Ashley Chen, Grace Baek, Kathryn Russell, Carole Shaw, Megan Othus, Jonathan Cohen, Shannon Palmer, Jack Rasmussen, Joseph Bubalo, Tenzin Tsomo, Tenley Schwarz, Swathi Namburi, and Anna Halpern

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Society for Immunotherapy of Cancer (SITC) consensus statement on essential biomarkers for immunotherapy clinical protocols., Tricia R Cottrell, Michael T Lotze, Alaa Ali, Carlo Bifulco, Christian M Capitini, Laura Q M Chow, Anthony R Cillo, Deborah Collyar, Leslie Cope, Julie Stein Deutsch, Genia Dubrovsky, Sacha Gnjatic, Denise Goh, Susan Halabi, Gary Kohanbash, Holden T Maecker, Saman Maleki Vareki, Sarah Mullin, Barbara Seliger, Janis Taube, Wim Vos, Joe Yeong, Kristin G Anderson, Tullia C Bruno, Codruta Chiuzan, Ivan Diaz-Padilla, Elizabeth Garrett-Mayer, Isabella C Glitza Oliva, Paola Grandi, Elizabeth G Hill, Brian P Hobbs, Yana G Najjar, Phyllis Pettit Nassi, Virgil H Simons, Sumit K Subudhi, Ryan J Sullivan, and Chris H Takimoto

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Importance of Surgical Margins in Patients with Early-Stage Merkel Cell Carcinoma., Arthur W Cowman, Kristel Lourdault, Douglas Hanes, Sean Nassoiy, Paul Shin, Tyler Aguilar, Melanie Goldfarb, and Richard Essner

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Surgical Management of Thick Primary Cutaneous Melanoma in the US., Arthur W Cowman, Kristel Lourdault, Douglas Hanes, Jessica Weiss, Sean Nassoiy, Melanie Goldfarb, and Richard Essner

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Checkpoint Immunotherapy for Melanoma - Offering Hope for Cure., Brendan Curti

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A phase 1 study of the CDK9 inhibitor voruciclib in relapsed/refractory acute myeloid leukemia and B-cell malignancies., Matthew S Davids, Danielle M Brander, Yesid Alvarado-Valero, Catherine S Diefenbach, Daniel N Egan, Shira N Dinner, Nathalie Javidi-Sharifi, Monzr M Al Malki, Kebede H Begna, Vijaya Raj Bhatt, Sameem Abedin, Rachel J Cook, Mary C Collins, Carly Roleder, Edward C Dominguez, Prabhu Rajagopalan, Sandra E Wiley, Richard G Ghalie, and Alexey V Danilov

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OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma., Kinjal Desai, Siyi Wanggou, Erika Luis, Heather Whetstone, Chunying Yu, Robert J Vanner, Hayden J Selvadurai, Lilian Lee, Jinchu Vijay, Julia E Jaramillo, Jerry Fan, Paul Guilhamon, Michelle Kushida, Xuejun Li, Gregory Stein, Santosh Kesari, Benjamin D Simons, Xi Huang, and Peter B Dirks

Unravelling the complexity of the anti-tumor response in human solid tumors, Thomas Duhen

Unravelling the complexity of the anti-tumor response in human solid tumors, Thomas Duhen

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Longitudinal Genomic Analysis to Fine-Tune Targeted Therapy: Results of the Phase II LOGIC 2 Trial in Patients With BRAF V600-Mutant Metastatic Melanoma., Reinhard Dummer, Shahneen Sandhu, Wilson H Miller, Marcus O Butler, Matthew H Taylor, Lucie Heinzerling, Christian U Blank, Eva Munoz-Couselo, Howard A Burris, Michael A Postow, Bartosz Chmielowski, Mark R Middleton, Carola Berking, Jessica C Hassel, Anja Heike Gesierich, Cornelia Mauch, Joseph F Kleha, Anna Polli, Allison S Harney, Alessandra di Pietro, and Paolo A Ascierto

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Classification of non-TCGA cancer samples to TCGA molecular subtypes using compact feature sets., Kyle Ellrott, Christopher K Wong, Christina Yau, Mauro A A Castro, Jordan A Lee, Brian J Karlberg, Jasleen K Grewal, Vincenzo Lagani, Bahar Tercan, Verena Friedl, Toshinori Hinoue, Vladislav Uzunangelov, Lindsay Westlake, Xavier Loinaz, Ina Felau, Peggy I Wang, Anab Kemal, Samantha J Caesar-Johnson, Ilya Shmulevich, Alexander J Lazar, Ioannis Tsamardinos, Katherine A Hoadley, A Gordon Robertson, Theo A Knijnenburg, Christopher C Benz, Joshua M Stuart, Jean C Zenklusen, Andrew D Cherniack, and Peter W Laird

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Pembrolizumab plus chemotherapy in advanced or recurrent endometrial cancer: overall survival and exploratory analyses of the NRG GY018 phase 3 randomized trial., Ramez N Eskander, Michael W Sill, Lindsey Beffa, Richard G Moore, Joanie M Hope, Fernanda Musa, Robert S Mannel, Mark S Shahin, Guilherme H Cantuaria, Eugenia Girda, Elizabeth Lokich, Juraj Kavecansky, Charles A Leath, Lilian T Gien, Emily M Hinchcliff, Shashikant B Lele, Lisa M Landrum, Floor Backes, Roisin E O'Cearbhaill, Tareq Al Baghdadi, Emily K Hill, Premal H Thaker, Veena S John, Stephen Welch, Amanda N Fader, Matthew A Powell, and Carol Aghajanian

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Signaling and transcriptional dynamics underlying early adaptation to oncogenic BRAF inhibition., Cameron T Flower, Chunmei Liu, Hui-Yu Chuang, Xiaoyang Ye, Hanjun Cheng, James R Heath, Wei Wei, and Forest M White

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Avoidance of Major Vascular Injury in Transcranial Brain Tumor Surgery Using Real-Time Doppler Navigation: Technical Note and Case Series., R Justin Garling, Regin Jay Mallari, Davendran Kanesen, Byron Hontiveros, Walavan Sivakumar, Daniel F Kelly, and Garni Barkhoudarian

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Survival with Trastuzumab Emtansine in Residual HER2-Positive Breast Cancer., Charles E Geyer, Michael Untch, Chiun-Sheng Huang, Max S Mano, Eleftherios P Mamounas, Norman Wolmark, Priya Rastogi, Andreas Schneeweiss, Andres Redondo, Hans H Fischer, Véronique D'Hondt, Alison Conlin, Valentina Guarneri, Irene L Wapnir, Christian Jackisch, Claudia Arce-Salinas, Peter A Fasching, Michael P DiGiovanna, John P Crown, Pia Wuelfing, Zhimin Shao, Elena Rota Caremoli, Hervé R Bonnefoi, Bryan T Hennessy, Ljiljana Stamatovic, Hugo Castro-Salguero, Adam M Brufsky, Adam Knott, Asna Siddiqui, Chiara Lambertini, Thomas Boulet, Beatrice Nyawira, Eleonora Restuccia, Sibylle Loibl, and KATHERINE Study Group

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Induced pluripotent stem-cell-derived CD19-directed chimeric antigen receptor natural killer cells in B-cell lymphoma: a phase 1, first-in-human trial., Armin Ghobadi, Veronika Bachanova, Krish Patel, Jae H Park, Ian Flinn, Peter A Riedell, Carlos Bachier, Catherine S Diefenbach, Carol Wong, Cara Bickers, Lilly Wong, Deepa Patel, Jode Goodridge, Matthew Denholt, Bahram Valamehr, Rebecca L Elstrom, and Paolo Strati

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A Multisite Demonstration of Shared Access to Older Adults' Patient Portals., Kelly T Gleason, Catherine M DesRoches, Mingche M J Wu, Danielle Peereboom, Vadim Dukhanin, Timothy W Farrell, Matthew J Gonzales, Saloni Sharma, Supriya G Mohile, Sara Epstein, Mark A Supiano, Marianne C Parshley, David L Roth, Jennifer L Wolff, and Shared Access Project Team

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Pilot Study of Plasma miRNA Signature Panel for Differentiating Single vs Multiglandular Parathyroid Disease., Melanie Goldfarb, Matias A Bustos, Jamie Moon, Katherine Jackson, Frederick R Singer, and Dave S B Hoon

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Continuing De-escalation Trends: Is Adjuvant Radioactive Iodine Administration Truly Needed for Papillary Thyroid Carcinoma with Limited Cervical Disease?, Melanie Goldfarb and Nicholas Ullman

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Longitudinal retrospective study of real-world adherence to colorectal cancer screening before and after the COVID-19 pandemic in the USA., Harsh Gupta, Robyn Ann Husa, Staci J Wendt, Ann Vita, Claire Boone, Jessica B Weiss, and Anton J Bilchik

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Human Epidermal Growth Factor Receptor 2 Alterations and Prognostic Implications in All Subtypes of Breast Cancers., Arielle L Heeke, Andrew Elliott, Kaitlyn O'Keefe, Chad Livasy, James T Symanowski, Meghan R Steiner, Irene M Kang, Dave S B Hoon, Philip Walker, George W Sledge, Milan Radovich, Paula R Pohlmann, Sandra M Swain, and Antoinette R Tan

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The end of the genetic paradigm of cancer., Sui Huang, Ana M Soto, and Carlos Sonnenschein

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Real-world outcomes after discontinuation of covalent BTK inhibitor-based therapy in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma., Nitin Jain, Toby A Eyre, Katherine B Winfree, Naleen Raj Bhandari, Manoj Khanal, Tomoko Sugihara, Yongmei Chen, Paolo Abada, and Krish Patel

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Neoadjuvant clinical trials in adults with newly diagnosed high-grade glioma: A systematic review., Tiffany M Juarez, Jaya M Gill, Boris R Minev, Akanksha Sharma, and Santosh Kesari

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Neoadjuvant clinical trials in adults with newly diagnosed high-grade glioma: A systematic review., Tiffany M Juarez, Jaya M Gill, Boris R Minev, Akanksha Sharma, and Santosh Kesari

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Evaluating Tumor Tissue Modified Viral (TTMV)-HPV DNA for the Early Detection of Anal Squamous Cell Carcinoma Recurrence., Rafi Kabarriti, Shane Lloyd, James Jabalee, Catherine Del Vecchio Fitz, Randa Tao, Tyler Slater, Corbin Jacobs, Sean Inocencio, Michael Rutenberg, Chance Matthiesen, Kasha Neff, Gene-Fu Liu, Tiffany M Juarez, and Stanley L Liauw

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Commentary: Molecular responses in pig heart to human xenotransplantation unveiled by longitudinal multi-omic profiling., Brendan J Keating, Eloi Schmauch, Michael P Snyder, Jennifer D Motter, and Brian D. Piening

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Machine Learning Model Predictors of Intrapleural Tissue Plasminogen Activator and DNase Failure in Pleural Infection: A Multicenter Study., Danai Khemasuwan, Candice Wilshire, Chakravarthy Reddy, Christopher Gilbert, Jed Gorden, Akshu Balwan, Trinidad M Sanchez, Billie Bixby, Jeffrey S Sorensen, and Samira Shojaee

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Long-term oncologic outcomes and complications of robot-assisted radical cystectomy for the treatment of urothelial carcinoma of the bladder., Daniel J Lama, Oluwatimilehin Okunowo, Jonathan Yamzon, Ali-Asghar Zhumkhawala, Timothy G Wilson, Clayton S Lau, Bertram E Yuh, and Kevin G Chan

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Lessons learned in migrating from one commercial genetics clinical decision-making tool to another: Assessment of data integrity and utilization., Calvin Le, Kevin Tatunay, Wayne Liu, Haibo Lu, Nicole-Ann Rodis, Thomas Nam, Mercy Y Laurino, and Marianne E Dubard-Gault

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A Multicenter Open-Label Randomized Phase II Study of Osimertinib With and Without Ramucirumab in Tyrosine Kinase Inhibitor-Naïve, Xiuning Le, Jyoti D Patel, Elaine Shum, Christina Baik, Rachel E Sanborn, Catherine A Shu, Chul Kim, Mary Jo Fidler, Richard Hall, Yasir Y Elamin, Janet Tu, George Blumenschein, Jianjun Zhang, Don Gibbons, Carl Gay, Nisha A Mohindra, Young Chae, Yanis Boumber, Joshua Sabari, Rafael Santana-Davila, Shane Rogosin, Benjamin Herzberg, Ben Creelan, Bruna Pellini, Tawee Tanvetyanon, Simon Heeke, Mike Hernandez, Jhanelle E Gray, Andreas Saltos, and John V Heymach

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Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial., Juanita Lopez, Thomas Powles, Fadi Braiteh, Lillian L Siu, Patricia LoRusso, Claire F Friedman, Ani S Balmanoukian, Michael Gordon, Jeffrey Yachnin, Sylvie Rottey, Ioannis Karydis, George A Fisher, Marcus Schmidt, Martin Schuler, Ryan J Sullivan, Howard A Burris, Vladimir Galvao, Brian S Henick, Luc Dirix, Dirk Jaeger, Patrick A Ott, Kit Man Wong, Guy Jerusalem, Aglaia Schiza, Lawrence Fong, Neeltje Steeghs, Rom Leidner, Achim Rittmeyer, Scott A Laurie, Eelke Gort, Raid Aljumaily, Ignacio Melero, Rachel L Sabado, Ina Rhee, Michael R Mancuso, Lars Muller, Gregg D Fine, Mahesh Yadav, Leesun Kim, Vincent J P Leveque, Alberto Robert, Martine Darwish, Ting Qi, Jiawen Zhu, Jingbin Zhang, Patrick Twomey, Gautham K Rao, Donald W Low, Chris Petry, Amy A Lo, Jill M Schartner, Lélia Delamarre, Ira Mellman, Martin Löwer, Felicitas Müller, Evelyna Derhovanessian, Andrea Cortini, Luisa Manning, Daniel Maurus, Sebastian Brachtendorf, Verena Lörks, Tana Omokoko, Eva Godehardt, Dirk Becker, Christine Hawner, Christine Wallrapp, Christian Albrecht, Christoph Kröner, Arbel D Tadmor, Jan Diekmann, Mathias Vormehr, Anette Jork, Anna Paruzynski, Maren Lang, Jonathon Blake, Oliver Hennig, Andreas N Kuhn, Ugur Sahin, Özlem Türeci, and D Ross Camidge

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In Regard to Aly et al., Join Y Luh

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Implementation of a lisocabtagene maraleucel chimeric antigen receptor T-cell therapy outpatient monitoring program: Multicenter nursing/advanced practice provider perspectives., Nicole McEntee, Jacqueline Manago, ChiaChun Lu, and Lucy Holmes

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Characterization of pritumumab in murine models and primate safety study., Avani A Mody, Rajesh Mukthavaram, Pengfei Jiang, Kishore Gangangari, Nagavarakishore Pillarsetty, Pranav R Kesari, Vijay Padul, Sneha L Kesari, Elnaz Rahbarlayegh, Mark C Glassy, and Santosh Kesari

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Patterns of Clinical Trial Enrollment for Pediatric Patients With Hepatoblastoma and Wilms Tumor: A Report From the Children's Oncology Group., Pablo S Monterroso, Sarah Lucht, Jeannette M Sample, Angela D Trobaugh-Lotrario, Helen M Parsons, Lucie M Turcotte, David Van Riper, Jenny N Poynter, and Erin L Marcotte

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Long-Term Outcomes of Radiation Monotherapy Versus Combined Radiation Monotherapy + Hormone Therapy in Low-Risk Early-Stage Breast Cancer Patients 70 Years or Older After Breast-Conserving Surgery., Astrid D Morris, Douglas Hanes, and Henry G Kaplan

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Proceedings of the National Cancer Institute Workshop on combining immunotherapy with radiotherapy: challenges and opportunities for clinical translation., Zachary S Morris, Sandra Demaria, Arta M Monjazeb, Silvia C Formenti, Ralph R Weichselbaum, James Welsh, Heiko Enderling, Jonathan D Schoenfeld, Joshua D Brody, Heather M McGee, Michele Mondini, Michael S Kent, Kristina H Young, Lorenzo Galluzzi, Sana D Karam, Willemijn S M E Theelen, Joe Y Chang, Mai Anh Huynh, Adi Daib, Sean Pitroda, Caroline Chung, Raphael Serre, Clemens Grassberger, Jie Deng, Quaovi H Sodji, Anthony T Nguyen, Ravi B Patel, Simone Krebs, Anusha Kalbasi, Caroline Kerr, Claire Vanpouille-Box, Logan Vick, Todd A Aguilera, Irene M Ong, Fernanda Herrera, Hari Menon, DeeDee Smart, Jalal Ahmed, Robyn D Gartrell, Christina L Roland, Fatemeh Fekrmandi, Binita Chakraborty, Eric H Bent, Tracy J Berg, Alan Hutson, Samir Khleif, Andrew G Sikora, and Lawrence Fong

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State of the art endocrine treatments for patients diagnosed with endometrial cancer in 2025., Fernanda Musa, Kathleen N Moore, Vivek Podder, and Brian M Slomovitz

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Integrated Antigenic and Nucleic Acid Detection in Single Virions and Extracellular Vesicles with Viral Content., Kim Truc Nguyen, Xilal Y Rima, Luong T H Nguyen, Xinyu Wang, Kwang Joo Kwak, Min Jin Yoon, Hong Li, Chi-Ling Chiang, Jacob Doon-Ralls, Kelsey Scherler, Shannon Fallen, Stephanie L Godfrey, Julie A Wallick, Setty M Magaña, Andre F Palmer, Inyoul Lee, Christopher C. Nunn, Kimberly M Reeves, Henry G Kaplan, Jason D Goldman, James R Heath, Kai Wang, Preeti Pancholi, L James Lee, and Eduardo Reátegui

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Comparative microRNA signatures based on liquid biopsy to identify lymph node metastasis in T1 colorectal cancer patients undergoing upfront surgery or endoscopic resection., Kazuaki Okamoto, Hiroaki Nozawa, Tsuyoshi Ozawa, Yoko Yamamoto, Yuichiro Yokoyama, Shigenobu Emoto, Koji Murono, Kazuhito Sasaki, Mitsuhiro Fujishiro, and Soichiro Ishihara

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Analysis of Endoscope-Assisted Retrosigmoid Approach versus Modified Transjugular Approach for Microvascular Decompression of the Facial Nerve: A Comparative Cadaveric Study., Mehrdad Pahlevani, Felipe Sfeir, Fan Zhao, Kayla Lanker, Alex Corlin, Regin Jay Mallari, Gregory Lekovic, and Garni Barkhoudarian

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Improved survival at the population level for patients with advanced Merkel cell carcinoma following availability of immunotherapy., Kelly G Paulson, Song Y Park, Shailender Bhatia, Daniel S Hippe, and Paul Nghiem

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Safety and efficacy of acalabrutinib plus bendamustine and rituximab in patients with treatment-naïve or relapsed/refractory mantle cell lymphoma: phase Ib trial., Tycel Phillips, Michael Wang, Tadeusz Robak, David Gallinson, Don Stevens, Krish Patel, Safaa Ramadan, Chuan-Chuan Wun, Wojciech Jurczak, and Stephen D Smith

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Head and Neck Cancer Research Training Program Associated with Academic Success for Trainees., Aanish Puri, Andrew C Elton, Beverly R Wuertz, and Frank G Ondrey

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Trastuzumab Plus Pertuzumab Versus Cetuximab Plus Irinotecan in Patients With, Kanwal Pratap Singh Raghav, Katherine A Guthrie, Benjamin Tan, Crystal S Denlinger, Marwan Fakih, Michael J Overman, N Arvind Dasari, Larry R Corum, Lee G Hicks, Mital S Patel, Benjamin T Esparaz, Syed M Kazmi, Nitya Alluri, Sarah Colby, Sepideh Gholami, Philip J Gold, E Gabriela Chiorean, Scott Kopetz, Howard S Hochster, and Philip A Philip

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Adoption of Single-Port Robotic Partial Nephrectomy Increases Utilization of the Retroperitoneal Approach: A Report from the Single-Port Advanced Research Consortium., Michael Raver, Mutahar Ahmed, Kennedy E Okhawere, Indu Saini, Ruchir Chaturvedi, Milan Patel, Ruben Sauer Calvo, Nicolas A Soputro, Roxana Ramos, Mubashir Billah, Simone Crivellaro, Ahmed M Mansour, Jihad Kaouk, Nirmish Singla, James Porter, Ronney Abaza, Akshay Bhandari, Ashok K Hemal, Phillip M Pierorazio, Benjamin I Chung, Craig G Rogers, Reza Mehrazin, Ketan Badani, and Michael Stifelman

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American Association of Neurological Surgeons/Congress of the Neurological Surgeons Section on Tumors Guidelines: Assessing Their Impact on Brain Tumor Clinical Practice., Faith C Robertson, Brian V Nahed, Garni Barkhoudarian, Anand Veeravagu, David Berg, Steven Kalkanis, Jeffrey J Olson, and Isabelle M Germano

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Safety of Extended Pirtobrutinib Exposure in Relapsed and/or Refractory B-Cell Malignancies., Lindsey E Roeker, Catherine C Coombs, Nirav N Shah, Wojciech Jurczak, Jennifer A Woyach, Chan Y Cheah, Krish Patel, Kami Maddocks, Yucai Wang, Pier Luigi Zinzani, Talha Munir, Youngil Koh, Meghan C Thompson, Catherine E Muehlenbein, Chunxiao Wang, Richard Sizelove, Sarang Abhyankar, Safarulla Hasanabba, Donald E Tsai, Toby A Eyre, and Michael Wang

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Abstract P004: Mapping the tumor-sentinel node immune migratome demonstrates a key role for CCR7+ dendritic cells in the successful response to immunoradiotherapy, Robert Saddawi-Konefka, Shawn M. Jensen, Bernard A Fox, Richard Bryan Bell, and See full list of authors in comments

Should ADCs Replace Docetaxel in 2L NSCLC, Rachel Sanborn

Should ADCs Replace Docetaxel in 2L NSCLC, Rachel Sanborn

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Practical management of adverse events in patients receiving tarlatamab, a delta-like ligand 3-targeted bispecific T-cell engager immunotherapy, for previously treated small cell lung cancer., Jacob M Sands, Stéphane Champiat, Horst-Dieter Hummel, Kelly G Paulson, Hossein Borghaei, Jean Bustamante Alvarez, David P Carbone, Jennifer W Carlisle, Noura J Choudhury, Jeffrey M Clarke, Shirish M Gadgeel, Hiroki Izumi, Alejandro Navarro, Sally C M Lau, Philip E Lammers, Shuang Huang, Ali Hamidi, Sujoy Mukherjee, and Taofeek K Owonikoko

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Social determinants of health and variability in treatment for patients with early-stage non-small cell lung cancer., Molly Scannell Bryan, Xiaohan Hu, Monika A Izano, Hina Mohammed, Marianna Wicks, Thomas Brown, George Simon, Henry G Kaplan, and Anna Berry

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The improved prognosis of FLT3-internal tandem duplication but not tyrosine kinase domain mutations in acute myeloid leukemia in the era of targeted therapy: a real-world study using large-scale electronic health record data, Matthew Schwede, Gladys Rodriguez, Vanessa E Kennedy, Solomon Henry, Douglas Wood, Gabriel N Mannis, Ravindra Majeti, Jonathan H Chen, Eran Bendavid, and Tian Yi Zhang

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Pirtobrutinib monotherapy in Bruton tyrosine kinase inhibitor-intolerant patients with B-cell malignancies: results of the phase I/II BRUIN trial., Nirav N Shah, Michael Wang, Lindsey E Roeker, Krish Patel, Jennifer A Woyach, William G Wierda, Chaitra S Ujjani, Toby A Eyre, Pier Luigi Zinzani, Alvaro J Alencar, Paolo Ghia, Nicole Lamanna, Marc S Hoffmann, Manish R Patel, Ian Flinn, James N Gerson, Shuo Ma, Catherine C Coombs, Chan Y Cheah, Ewa Lech-Maranda, Bita Fakhri, Won Seog Kim, Minal A Barve, Jonathon B Cohen, Wojciech Jurczak, Talha Munir, Meghan C Thompson, Donald E Tsai, Katherine Bao, Nicholas A Cangemi, Jennifer F Kherani, Richard A Walgren, Hongmei Han, Amy S Ruppert, and Jennifer R Brown

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Correction: Efficacy and safety in a 4-year follow-up of the ELEVATE-TN study comparing acalabrutinib with or without obinutuzumab versus obinutuzumab plus chlorambucil in treatment-naïve chronic lymphocytic leukemia., Jeff P Sharman, Miklos Egyed, Wojciech Jurczak, Alan Skarbnik, John M Pagel, Ian W Flinn, Manali Kamdar, Talha Munir, Renata Walewska, Gillian Corbett, Laura Maria Fogliatto, Yair Herishanu, Versha Banerji, Steven Coutre, George Follows, Patricia Walker, Karin Karlsson, Paolo Ghia, Ann Janssens, Florence Cymbalista, Jennifer A Woyach, Emmanuelle Ferrant, William G Wierda, Veerendra Munugalavadla, Ting Yu, Min Hui Wang, and John C Byrd

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Consensus recommendations from the 2024 Lymphoma Research Foundation workshop on treatment selection and sequencing in CLL or SLL., Jacob D Soumerai, Jacqueline Barrientos, Inhye Ahn, Catherine Coombs, Douglas Gladstone, Marc Hoffman, Adam Kittai, Ryan Jacobs, Andrew Lipsky, Krish Patel, Joanna Rhodes, Alan Skarbnik, Meghan Thompson, Daniel Ermann, Patrick Reville, Harsh Shah, Jennifer R Brown, and Deborah M Stephens

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A Microfluidic, Multi-Antibody Cell Capture Method to Evaluate Tumor Cells in Cerebrospinal Fluid in Patients With Suspected Leptomeningeal Metastases., Nathan T Sweed, Hao-Ching Hsiao, Barbara Blouw, Tony J Pircher, Deanna Fisher, Katrina Rose Naluz, Julie Ann Mayer, Michael C Dugan, Akanksha Sharma, Jose Carrillo, and Santosh Kesari

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Development of a Diagnostic Model for Pancreatic Ductal Adenocarcinoma Using Machine Learning and Blood-Based miRNAs., Jason Y Tang, Valentina L Kouznetsova, Santosh Kesari, and Igor F Tsigelny

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Current landscape and future prospects of interleukin-2 receptor (IL-2R) agonists in cancer immunotherapy., Kengo Tanigawa and William L Redmond

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Society for Immunotherapy of Cancer: updates and best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) image analysis and data sharing., Janis M Taube, Joel C Sunshine, Michael Angelo, Guray Akturk, Margaret Eminizer, Logan L Engle, Cláudia S Ferreira, Sacha Gnjatic, Benjamin Green, Shirley Greenbaum, Noah F Greenwald, Cyrus V Hedvat, Travis J Hollmann, Daniel Jiménez-Sánchez, Konstanty Korski, Ana Lako, Edwin R Parra, Marlon C Rebelatto, David L Rimm, Scott J Rodig, Jamie Rodriguez-Canales, Jeffrey S Roskes, Kurt A Schalper, Emanuel Schenck, Keith E Steele, Michael J Surace, Alexander S Szalay, Michael T Tetzlaff, Ignacio I Wistuba, Jennifer H Yearley, and Carlo Bifulco

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Outcomes of CD19 CAR T in Transformed Indolent Lymphoma Compared to De Novo Aggressive Large B-Cell Lymphoma., Swetha Kambhampati Thiruvengadam, Reid Merryman, Yan Wang, Charles Gaulin, Evandro Bezerra, Timothy Voorhees, Madhav R Seshadri, Ayo Falade, Alma Habib, Amy A Ayers, Megumi Bailey, Annette Brown, Neil Bailey, Krish Patel, Charalambos B Andreadis, Adam S Kittai, Caron Jacobson, Joycelynne Palmer, Stephen J Forman, Loretta Nastoupil, and Lihua E Budde

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Outcomes of CD19 CAR T in Transformed Indolent Lymphoma Compared to De Novo Aggressive Large B-Cell Lymphoma., Swetha Kambhampati Thiruvengadam, Reid Merryman, Yan Wang, Charles Gaulin, Evandro Bezerra, Timothy Voorhees, Madhav R Seshadri, Ayo Falade, Alma Habib, Amy A Ayers, Megumi Bailey, Annette Brown, Neil Bailey, Krish Patel, Charalambos B Andreadis, Adam S Kittai, Caron Jacobson, Joycelynne Palmer, Stephen J Forman, Loretta Nastoupil, and Lihua E Budde

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Abemaciclib in combination with therapies for patients with metastatic breast cancer: a phase 1b study., Sara M Tolaney, Komal Jhaveri, Teresa Helsten, Shannon L Puhalla, Alison Conlin, E Claire Dees, Muralidhar Beeram, Sonya C Chapman, Andrew Lithio, Lacey M Litchfield, and Matthew P Goetz

Adoptive T-cell therapy against cancer using tumor-infiltrating lymphocytes (TIL) and gene engineered T cells, Eric Tran

Adoptive T-cell therapy against cancer using tumor-infiltrating lymphocytes (TIL) and gene engineered T cells, Eric Tran

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Characteristics of patients with liver tumors deemed ineligible for enrollment on Children's Oncology Group trial AHEP1531: An opportunity to expand inclusion criteria and improve outcome., Angela Trobaugh-Lotrario, Allison F O'Neill, Katelyn A Belmonte, Marcio H Malogolowkin, Greg M Tiao, and James I Geller

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Outcomes in patients with classic Hodgkin lymphoma refractory or intolerant to brentuximab vedotin and anti-PD-1 therapy: a real world analysis from 15 U.S. academic centers., Timothy J Voorhees, Eric M McLaughlin, Pallawi Torka, Jorge Florindez, Na Hyun Kim, Tamara K Moyo, Heather Reves, Nuttavut Sumransub, Saarang Deshpande, Ashley Rose, Cassandra Duarte, Muhammad Salman Faisal, Showkat Hamid, Suki Subbiah, Sabarish Ayyappan, Lauren Shea, Matt Cortese, Krish Patel, Ajay Major, Hayder Saeed, Jakub Svoboda, Sanjal Desai, Praveen Ramakrishnan Geethakumari, Mehdi Hamadani, Natalie Grover, and Narendranath Epperla

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The first international experience with histotripsy: a safety analysis of 230 cases., Chase J Wehrle, Kevin Burns, Evan Ong, Allison Couillard, Neehar D Parikh, Elaine Caoili, JaeKeun Kim, Federico Aucejo, Andrea Schlegel, Emily Knott, Paul Laeseke, J Philip Boudreaux, Philipp von Breitenbuch, Mikhail Silk, Mohamed Alassas, Andrew Guzowski, Brian Fuller, Erica Knavel Koepsel, Brock Hewitt, Mishal Mendiratta-Lala, and David C H Kwon

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Ego networks associated with e-cigarette use among college fraternity students: a cross-sectional study., Allison C Welch, Megan S Patterson, Candice L. Wilshire, Hasmeena Kathuria, Christopher Gilbert, and Jed A Gorden

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Durability of response of UGN-101: Longitudinal follow up of multicenter study., Solomon L Woldu, Daniel Igel, Brett Johnson, Katie S Murray, Hiroko Miyagi, Wade Sexton, Isamu Tachibana, Hristos Kaimakliotis, Joseph Jacob, Rian Dickstein, Jennifer M Linehan, Alan Nieder, Marc A Bjurlin, Daniel Heidenberg, Mitchell Humphreys, Saum Ghodoussipour, Marcus L Quek, Michael O'Donnell, Brian H Eisner, Surena F Matin, Adam S Feldman, and Yair Lotan

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APMAT analysis reveals the association between CD8 T cell receptors, cognate antigen, and T cell phenotype and persistence., Jingyi Xie, Daniel G Chen, William Chour, Rachel H Ng, Rongyu Zhang, Dan Yuan, Jongchan Choi, Michaela McKasson, Pamela Troisch, Brett Smith, Lesley Jones, Andrew Webster, Yusuf Rasheed, Sarah Li, Rick Edmark, Sunga Hong, Kim M Murray, Jennifer K Logue, Nicholas M Franko, Christopher G Lausted, Brian Piening, Heather Algren, Julie Wallick, Andrew T Magis, Kino Watanabe, Phil Mease, Philip D Greenberg, Helen Chu, Jason D Goldman, Yapeng Su, and James R Heath

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Identification and validation of a T cell receptor targeting KRAS G12V in HLA-A*11:01 pancreatic cancer patients., Xiongfei Xu, Shiwei Guo, Haihui Gu, Zhanshan Cha, Xiaohan Shi, Xiaoyi Yin, Huan Wang, Suizhi Gao, Bo Li, Lingyu Zhu, Wei Jing, Kailian Zheng, Zhuo Shao, Peng Cheng, Chunhong Zheng, Yi-Ping Shih, Yunguang Li, Baohua Qian, Dong Gao, Eric Tran, and Gang Jin

Radiation: Keep it Simple, Kim Young

Radiation: Keep it Simple, Kim Young

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Machine-learning diagnostics of breast cancer using piRNA biomarkers., Amy R Zhao, Valentina L Kouznetsova, Santosh Kesari, and Igor F Tsigelny

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Natural Killer Cell Infiltration in Prostate Cancers Predict Improved Patient Outcomes., Nicholas A Zorko, Allison Makovec, Andrew Elliott, Samuel Kellen, John R Lozada, Ali T Arafa, Martin Felices, Madison Shackelford, Pedro Barata, Yousef Zakharia, Vivek Narayan, Mark N Stein, Kevin K Zarrabi, Akash Patniak, Mehmet A Bilen, Milan Radovich, George Sledge, Wafik S El-Deiry, Elisabeth I Heath, Dave S B Hoon, Chadi Nabhan, Jeffrey S Miller, Justin H Hwang, and Emmanuel S Antonarakis

Submissions from 2024

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Type B Lactic Acidosis: A Very Rare but Fatal Complication of Gastrointestinal Solid Tumor., Fuad I Abaleka, Genanew Bedanie, Diego Olavarria Bernal, Selome F Yewedalsew, and Tasur Seen

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Clinical and Multiomic Features Differentiate Young Black and White Breast Cancer Cohorts Derived by Machine Learning Approaches., Kawther Abdilleh, Boris Aguilar, and George Acquaah-Mensah

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Combining a complex cancer vaccine with anti-PD-1 and DGK inhibitor Improves therapeutic efficacy and may augment anti-cancer memory development, E Adwani, Brian Fox, and See full list of authors in comments

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Nuclear Protein in Testis Carcinoma of the Orbit., Chip Agarwal, Anand Bhatt, and Frank P K Hsu

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PRESTO: A Phase III, Open-Label Study of Intensification of Androgen Blockade in Patients With High-Risk Biochemically Relapsed Castration-Sensitive Prostate Cancer (AFT-19)., Rahul Aggarwal, Glenn Heller, David W Hillman, Han Xiao, Joel Picus, Mary-Ellen Taplin, Tanya Dorff, Leonard Appleman, Douglas Weckstein, Akash Patnaik, Alan Bryce, Daniel Shevrin, James Mohler, Daniel Anderson, Arpit Rao, Scott Tagawa, Alan Tan, Susan Halabi, Katharine Dooley, Patrick O'Brien, Ronald Chen, Charles J Ryan, Scott E Eggener, Michael J Morris, EORTC-55994 Study Group, and Brendan Curti (EORTC-55994 Study Group)

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Neoadjuvant Trebananib plus Paclitaxel-based Chemotherapy for Stage II/III Breast Cancer in the Adaptively Randomized I-SPY2 Trial-Efficacy and Biomarker Discovery., Kathy S Albain, Christina Yau, Emanuel F Petricoin, Denise M Wolf, Julie E Lang, A Jo Chien, Tufia Haddad, Andres Forero-Torres, Anne M Wallace, Henry G Kaplan, Lajos Pusztai, David Euhus, Rita Nanda, Anthony D Elias, Amy S Clark, Constantine Godellas, Judy C Boughey, Claudine Isaacs, Debu Tripathy, Janice Lu, Rachel L Yung, Rosa I Gallagher, Julia D Wulfkuhle, Lamorna Brown-Swigart, Gregor Krings, Yunn Yi Chen, David A Potter, Erica Stringer-Reasor, Sarah Blair, Smita M Asare, Amy Wilson, Gillian L Hirst, Ruby Singhrao, Meredith Buxton, Julia L Clennell, Ashish Sanil, Scott Berry, Adam L Asare, Jeffrey B Matthews, Angela M DeMichele, Nola M Hylton, Michelle Melisko, Jane Perlmutter, Hope S Rugo, W Fraser Symmans, Laura J Van't Veer, Douglas Yee, Donald A Berry, and Laura J Esserman

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A phase 1 study of triple-targeted therapy with BRAF, MEK, and AKT inhibitors for patients with BRAF-mutated cancers., Alain P Algazi, James Moon, Christopher D Lao, Bartosz Chmielowski, Kari L Kendra, Karl D Lewis, Rene Gonzalez, Kevin Kim, John E Godwin, Brendan D. Curti, Michaella Latkovic-Taber, Shirley H Lomeli, Brandon T Gufford, Philip O Scumpia, Roger S Lo, Megan Othus, and Antoni Ribas

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Pathologic Features of Esophageal and Gastric Malignancies., Sanaa Al-Nattah, Eduard Matkovic, Michael Schwalbe, and Kristina A Matkowskyj

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The doc versus the bot: A pilot study to assess the quality and accuracy of physician and chatbot responses to clinical questions in gynecologic oncology., Mary Katherine Anastasio, Pamela Peters, Jonathan Foote, Alexander Melamed, Susan C Modesitt, Fernanda Musa, Emma Rossi, Benjamin B Albright, Laura J Havrilesky, and Haley A Moss

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Using Machine Learning and miRNA for the Diagnosis of Esophageal Cancer., Vishnu A Aravind, Valentina L Kouznetsova, Santosh Kesari, and Igor F Tsigelny

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Drug delivery in leptomeningeal disease: Navigating barriers and beyond., Numair Arshad, Nupur Biswas, Jaya Gill, Santosh Kesari, and Shashaanka Ashili

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Tumor Regression Following Engineered Polyomavirus-Specific T Cell Therapy in Immune Checkpoint Inhibitor-Refractory Merkel Cell Carcinoma., Yuta Asano, Joshua Veatch, Megan McAfee, Jakob Bakhtiari, Bo Lee, Lauren Martin, Shihong Zhang, Francesco Mazziotta, Kelly G Paulson, Thomas M Schmitt, Ariunnaa Munkbhat, Cecilia Young, Brandon Seaton, Daniel Hunter, Nick Horst, Marcus Lindberg, Natalie Miller, Matt Stone, Jason Bielas, David Koelle, Valentin Voillet, Raphael Gottardo, Ted Gooley, Shannon Oda, Philip D Greenberg, Paul Nghiem, and Aude G Chapuis