The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2024

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Individualized Prediction for Risk of Recurrence in Stage I/II Melanoma Patients With Negative Sentinel Lymph Node., Shu-Ching Chang, Kristel Lourdault, Gary L Grunkemeier, Douglas Hanes, Shih-Ting Chiu, Stacey Stern, and Richard Essner

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Integrative systems biology reveals NKG2A-biased immune responses correlate with protection in infectious disease, autoimmune disease, and cancer., Daniel G Chen, Jingyi Xie, Jongchan Choi, Rachel H Ng, Rongyu Zhang, Sarah Li, Rick Edmark, Hong Zheng, Ben Solomon, Katie M Campbell, Egmidio Medina, Antoni Ribas, Purvesh Khatri, Lewis L Lanier, Philip J Mease, Jason D Goldman, Yapeng Su, and James R Heath

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MRI-derived radiomics assessing tumor-infiltrating macrophages enable prediction of immune-phenotype, immunotherapy response and survival in glioma., Di Chen, Rui Zhang, Xiaoming Huang, Chunxia Ji, Wei Xia, Ying Qi, Xinyu Yang, Lishuang Lin, Jing Wang, Haixia Cheng, Weijun Tang, Jinhua Yu, Dave S B Hoon, Jun Zhang, Xin Gao, and Yu Yao

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Acupuncture for Chronic Radiation-Induced Xerostomia in Head and Neck Cancer: A Multicenter Randomized Clinical Trial., Lorenzo Cohen, Suzanne C Danhauer, M Kay Garcia, Emily V Dressler, David I Rosenthal, Mark S Chambers, Andrew Cusimano, W Mark Brown, Jewel M Ochoa, Peiying Yang, Joseph S Chiang, Ora Gordon, Rhonda Crutcher, Jung K Kim, Michael P Russin, Joshua Lukenbill, Mercedes Porosnicu, Kathleen J Yost, Kathryn E Weaver, and Glenn J Lesser

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Preoperative immune checkpoint inhibition and cryoablation in early-stage breast cancer., Elizabeth Comen, Sadna Budhu, Yuval Elhanati, David B Page, Teresa Rasalan-Ho, Erika Ritter, Phillip Wong, George Plitas, Sujata Patil, Edi Brogi, Maxine Jochelson, Yolanda Bryce, Stephen B Solomon, Larry Norton, Taha Merghoub, and Heather L McArthur

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Phase 1b study of dazostinag plus pembrolizumab after hypofractionated radiotherapy in patients with non-small-cell lung cancer, triple-negative breast cancer, or head and neck squamous-cell carcinoma, BT Cooper, David Page, and See full list of authors in comments

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RESEARCH ACTION BRIEF: Healthcare Experiences and Perceptions as Drivers of Gaps in Mammography, CORE (Center for Outcomes Research & Education)

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Combined Germline and Mosaic SDHA Mutation Is Associated With a Multicancer Syndrome Including Neuroblastoma, Renal Cancer, and Multifocal GI Tumor., Lee D Cranmer, Eric Q Konnick, Jennifer R Yoshida, Angela L Jacobson, Bilal A Malik, Harveshp Mogal, Lucas B Sullivan, Cynthia L Handfrod, Colin C Pritchard, and Marianne E Dubard-Gault

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Making Informed Choices On Incorporating Chemoprevention into carE (MiCHOICE, SWOG 1904): Design and methods of a cluster randomized controlled trial., K D Crew, G L Anderson, K B Arnold, A P Stieb, J N Amenta, N Collins, C W Law, S Pruthi, A Sandoval-Leon, D Bertoni, M T Grosse Perdekamp, S Colonna, S Krisher, T King, L D Yee, T J Ballinger, C Braun-Inglis, D Mangino, K B Wisinski, C A DeYoung, M Ross, J Floyd, A Kaster, L Vander Walde, T Saphner, C Zarwan, S Lo, C Graham, Alison Conlin, K Yost, D Agnese, C Jernigan, D L Hershman, M L Neuhouser, B Arun, and R Kukafka

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Consensus Recommendations on the Management of Toxicity Associated with CD3xCD20 Bispecific Antibody Therapy., Jennifer L Crombie, Tara Graff, Lorenzo Falchi, Yasmin H Karimi, Rajat Bannerji, Loretta J Nastoupil, Catherine Thieblemont, Renata Ursu, Nancy L Bartlett, Victoria R Nachar, Jonathan Weiss, Jane Osterson, Krish Patel, Joshua D Brody, Jeremy S Abramson, Matthew A Lunning, Nirav N Shah, Ayed Ayed, Manali Kamdar, Benjamin M Parsons, Paolo Caimi, Ian W Flynn, Alex F Herrera, Jeff P Sharman, Marshall McKenna, Philippe Armand, Brad S Kahl, Sonali M Smith, Andrew D Zelenetz, Lihua E Budde, Martin Hutchings, Tycel J Phillips, and Michael Dickinson

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Electronic Health Record Usage Among Surgeons-The Gender Gap., Angelena Crown and Kathie-Ann Joseph

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Unveiling the disparities within: Why we need to disaggregate data for Asian women with breast cancer., Angelena Crown and Amanda L Kong

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Same day discharge colon surgery: is it financially worth it?, Karleigh R Curfman, Gabrielle E Blair, Callan L Kosnik, Sunshine A Pille, Michael E Parsons, Chirag A Shah, Christopher C Neighorn, and Laila Rashidi

Updates in Adoptive Cellular Therapy for Melanoma, Brendan Curti

Updates in Adoptive Cellular Therapy for Melanoma, Brendan Curti

Updates in Adoptive Cellular Therapy for Melanoma, Brendan Curti

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Paraneoplastic Syndrome Case Presented As Nystagmus and Ataxia., Khaled M Darwesh

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Paraneoplastic Syndrome Case Presented As Nystagmus and Ataxia., Khaled M Darwesh

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A phase 1 study of the CDK9 inhibitor voruciclib in relapsed/refractory acute myeloid leukemia and B-cell malignancies., Matthew S Davids, Danielle M Brander, Yesid Alvarado Valero, Catherine Sibyl Diefenbach, Daniel Nathan Egan, Shira Naomi Dinner, Nathalie Javidi-Sharifi, Monzr M Al Malki, Kebede Begna, Vijaya R Bhatt, Sameem Abedin, Rachel Cook, Mary C Collins, Carly Roleder, Edward C Dominguez, Prabhu Rajagopalan, Sandra E Wiley, Richard G Ghalie, and Alexey V Danilov

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Diffuse B-cell lymphoma of the testis presenting as epididymo-orchitis., Patrick Davol and Callie Davol

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Low PD-L1 expression, MAP2K2 alterations, and enriched HPV gene signatures characterize brain metastases in head and neck squamous cell carcinoma., Michael J Dennis, Dean C Pavlick, Alec Kacew, Michael Wotman, Laura E MacConaill, Stephanie M Jones, Kathleen L Pfaff, Scott J Rodig, Stephen Eacker, Maika Malig, Emily Reister, David Piccioni, Santosh Kesari, Kartik Sehgal, Robert I Haddad, Ezra Cohen, Marshall R Posner, Ida Deichaite, and Glenn J Hanna

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Experiences across a genetic screening and testing programme pathway: a qualitative study of mammogram patient perspectives., Claire Devine, Kate R Emery, Kimberly K Childers, Sandra Brown, Ora K Gordon, and Sarah E Roth

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The future of targeting cytotoxic T-lymphocyte-associated protein-4: Is there a role?, Anna Maria Di Giacomo, Michael Lahn, Alexander Mm Eggermont, Bernard Fox, Ramy Ibrahim, Padmanee Sharma, James P Allison, and Michele Maio

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Phase II trial of blood-brain barrier permeable peptide-paclitaxel conjugate ANG1005 in patients with recurrent high-grade glioma., Crismita Dmello, Andrew Brenner, David Piccioni, Patrick Y Wen, Jan Drappatz, Maciej Mrugala, Lionel D Lewis, David Schiff, Camilo E Fadul, Marc Chamberlain, Santosh Kesari, Manmeet Ahluwalia, Debora Ghosh, Adam M Sonabend, and Priya Kumthekar

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Functional Outcomes After Transanal Total Mesorectal Excision (taTME) for Rectal Cancer: Results from the Phase II North American Multicenter Prospective Observational Trial., Katherine F Donovan, Katherine C Lee, Alison Ricardo, Natalie Berger, Antoinette Bonaccorso, Karim Alavi, Karen Zaghiyan, Alessio Pigazzi, Dana Sands, Teresa DeBeche-Adams, Sami A Chadi, Elisabeth C McLemore, John H Marks, Justin A Maykel, Sherief F Shawki, Scott R Steele, Matthew Albert, Mark Whiteford, Fu-Yuan Cheng, Steven D Wexner, and Patricia Sylla

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Genomic Landscape of Fusions in Solid Tumors Detected by DNA and RNA Comprehensive Genomic Profiling at a Large Community Health System, A Dowdell, Carlo Bifulco, Brian Piening, and See full list of authors in comments

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Widespread Adoption of Precision Anticancer Therapies After Implementation of Pathologist-Directed Comprehensive Genomic Profiling Across a Large US Health System., Alexa K Dowdell, Ryan Meng, Ann Vita, Bela Bapat, Douglas Hanes, Shu-Ching Chang, Lauren Harold, Cliff Wong, Hoifung Poon, Brock Schroeder, Roshanthi Weerasignhe, Rom Leidner, Walter Urba, Carlo Bifulco, and Brian D. Piening

Developmental and functional differences between CD39+CD103+ DP CD8 T cells from normal colon and tumor in CRC patients, Thomas Duhen

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A randomized phase II trial of adjuvant pembrolizumab versus observation following curative resection for stage I non-small cell lung cancer (NSCLC) with primary tumors between 1-4 cm: Big Ten Cancer Research Consortium BTCRC-LUN18-153, GA Durm, Rachel E Sanborn, and See full list of authors in comments

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Distance to endoscopy services amplifies racial inequities in colorectal cancer mortality in Washington state., Ashley Edwards, Rachel Monroe, Ofer Amram, and Anjali Kumar

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Complexity data science: A spin-off from digital twins., Frank Emmert-Streib, Hocine Cherifi, Kimmo Kaski, Stuart Kauffman, and Olli Yli-Harja

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A metabolite-based liquid biopsy for detection of ovarian cancer., Johannes F Fahrmann, Seyyed Mahmood Ghasemi, Chae Y Han, Ranran Wu, Jennifer B Dennison, Jody Vykoukal, Joseph Celestino, Karen Lu, Zhen Lu, Charles Drescher, Kim-Anh Do, Samir Hanash, Robert C Bast, and Ehsan Irajizad

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Cumulative review of hypertension in patients with chronic lymphocytic leukemia treated with acalabrutinib., Alessandra Ferrajoli, George Follows, Yotvat Marmor, Jack Roos, Naghmana Bajwa, Venkata Madhira, Kenji Nozaki, Paulo Miranda, Dinci Pennap, and Krish Patel

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IL-12 drives the expression of the inhibitory receptor NKG2A on human tumor-reactive CD8 T cells., Olivier Fesneau, Kimberly Samson, Wesley K Rosales, Bretton Jones, Tarsem Moudgil, Bernard A Fox, Venkatesh Rajamanickam, and Thomas Duhen

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DNA repair and anti-cancer mechanisms in the long-lived bowhead whale., Denis Firsanov, Max Zacher, Xiao Tian, Todd L Sformo, Yang Zhao, Greg Tombline, J Yuyang Lu, Zhizhong Zheng, Luigi Perelli, Enrico Gurreri, Li Zhang, Jing Guo, Anatoly Korotkov, Valentin Volobaev, Seyed Ali Biashad, Zhihui Zhang, Johanna Heid, Alex Maslov, Shixiang Sun, Zhuoer Wu, Jonathan Gigas, Eric Hillpot, John Martinez, Minseon Lee, Alyssa Williams, Abbey Gilman, Nicholas Hamilton, Ena Haseljic, Avnee Patel, Maggie Straight, Nalani Miller, Julia Ablaeva, Lok Ming Tam, Chloé Couderc, Michael R Hoopmann, Robert L Moritz, Shingo Fujii, Dan J Hayman, Hongrui Liu, Yuxuan Cai, Anthony K L Leung, Mirre J P Simons, Zhengdong Zhang, C Bradley Nelson, Lisa M Abegglen, Joshua D Schiffman, Vadim N Gladyshev, Mauro Modesti, Giannicola Genovese, Jan Vijg, Andrei Seluanov, and Vera Gorbunova

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Multicenter validation of an RNA-based assay to predict anti-PD-1 disease control in patients with recurrent or metastatic head and neck squamous cell carcinoma: the PREDAPT study., Kevin C Flanagan, Jon Earls, Jeffrey Hiken, Rachel L Wellinghoff, Michelle M Ponder, Howard L McLeod, William H Westra, Vera Vavinskaya, Leisa Sutton, Ida Deichaite, Orlan K Macdonald, Karim Welaya, James Wade, Georges Azzi, Andrew W Pippas, Jennifer Slim, Bruce Bank, Xingwei Sui, Steven E Kossman, Todd D Shenkenberg, Warren L Alexander, Katharine A Price, Jessica Ley, David N Messina, Jarret I Glasscock, A Dimitrios Colevas, Ezra E W Cohen, Douglas Adkins, and Eric J Duncavage

A Historical Overview of the World Immunotherapy Council (WIC), B Fox

An Immunotherapy Doublet/Triplet for HNSCC. Fox B. Head and Neck Cancer Program Scientific Retreat; 2024 May 23; Troutdale, OR., B Fox

Cancer’s Dark Matter and Canonical Targets – a Possible Strategy for Universal Cancer Vaccines, B Fox

Developing Combination Immunotherapy Trials with Vaccines that Contain Cancer’s Dark Matter, Bernard Fox

Cancer’s Dark Matter and the Search for a Universal Cancer Vaccine, Brian Fox

Cancer’s Dark Matter: What is it and Why it Should be in Cancer Vaccines for Patients with Lung Cancer, Brian Fox

Efforts to Discover and Exploit Cancer’s Dark Matter, Brian Fox

Seromics and Dark Matter, Brian Fox

Should we do combination immunotherapy trials with drugs that lack single agent activity, Brian Fox

Why are we just discovering dark matter now?, Brian Fox

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Recommendations for Tumor Mutational Burden Assay Validation and Reporting: A Joint Consensus Recommendation of the Association for Molecular Pathology, College of American Pathologists, and Society for Immunotherapy of Cancer., Larissa V Furtado, Carlo Bifulco, Daniel Dolderer, Susan J Hsiao, Benjamin R Kipp, Neal I Lindeman, Lauren L Ritterhouse, Robyn L Temple-Smolkin, Ahmet Zehir, and Jonathan A Nowak

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Deep Learning Segmentation of Infiltrative and Enhancing Cellular Tumor at Pre- and Posttreatment Multishell Diffusion MRI of Glioblastoma., Louis Gagnon, Diviya Gupta, George Mastorakos, Nathan White, Vanessa Goodwill, Carrie R McDonald, Thomas Beaumont, Christopher Conlin, Tyler M Seibert, Uyen Nguyen, Jona Hattangadi-Gluth, Santosh Kesari, Jessica D Schulte, David Piccioni, Kathleen M Schmainda, Nikdokht Farid, Anders M Dale, and Jeffrey D Rudie

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A randomized phase III study of standard versus high-dose cytarabine with or without vorinostat for AML., Guillermo Garcia-Manero, Nikolai A Podoltsev, Megan Othus, John M Pagel, Jerald P Radich, Min Fang, David A Rizzieri, Guido Marcucci, Stephen A Strickland, Mark R Litzow, M Lynn Savoie, Bruno C Medeiros, Mikkael A Sekeres, Tara L Lin, Geoffrey L Uy, Bayard L Powell, Jonathan E Kolitz, Richard A Larson, Richard M Stone, David Claxton, James Essell, Selina M Luger, Sanjay R Mohan, Anna Moseley, Frederick R Appelbaum, and Harry P Erba

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A phase-1 dose escalation and expansion study of EP0031, a next-generation selective RET inhibitor (SRI), in patients with SRI-naïve or pretreated advanced RET-altered NSCLC and other tumors, Elena Garralda, Matthew H Taylor, and See full list of authors in comments

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CSF1R Inhibition in Patients with Advanced Solid Tumors or Tenosynovial Giant Cell Tumor: A Phase I Study of Vimseltinib., Hans Gelderblom, Albiruni A Razak, Matthew H Taylor, Todd M Bauer, Breelyn Wilky, Javier Martin-Broto, Alejandro F Gonzalez, Piotr Rutkowski, Bartlomiej Szostakowski, Thierry Alcindor, Ramy Saleh, Sofia Genta, Silvia Stacchiotti, Michiel van de Sande, Andrew J Wagner, Nicholas Bernthal, Lara E Davis, Jacqueline Vuky, Christopher Tait, Bahar Matin, Supraja Narasimhan, Maitreyi G Sharma, Rodrigo Ruiz-Soto, Matthew L Sherman, and William D Tap

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Erosive pustular dermatosis-like eruption of the scalp secondary to amivantamab: A case series., Mariya N George, Riyad N H Seervai, and Susan Y Chon

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Re: Propensity-matched Analysis of Open Versus Robotic Primary Retroperitoneal Lymph Node Dissection for Clinical Stage II Testicular Cancer., Alireza Ghoreifi, James R Porter, and Hooman Djaladat

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Oncological Outcomes Following Robotic Postchemotherapy Retroperitoneal Lymph Node Dissection for Testicular Cancer: A Worldwide Multicenter Study., Alireza Ghoreifi, Farshad Sheybaee Moghaddam, Anirban P Mitra, Ashish Khanna, Amitabh Singh, Julian Chavarriaga, Sol C Moon, Ahmed Saeed Goolam, Ryan Chuang, Jordan M Rich, Fady J Baky, Matthew Ho, Jacob Roberts, Inderbir S Gill, James R Porter, Nariman Ahmadi, Reza Mehrazin, John P Sfakianos, Soroush Rais-Bahrami, Aditya Bagrodia, Robert J Hamilton, Scott Eggener, Sudhir Rawal, John F Ward, and Hooman Djaladat

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The effect of pleural drainage on pulse oximetry in a post-operative thoracic surgery population., Christopher R Gilbert, Jason A Akulian, Candice L Wilshire, Samira Shojaee, Adam J Bograd, and Jed A Gorden

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Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity., Isabella C Glitza, Yongwoo David Seo, Christine N Spencer, Jennifer R Wortman, Elizabeth M Burton, Farah A Alayli, Christopher P Loo, Shikha Gautam, Ashish Damania, Julie Densmore, Justin Fairchild, Christopher R Cabanski, Matthew C Wong, Christine B Peterson, Brian Weiner, Nathan Hicks, John G Auniņš, Christopher McChalicher, Emily Walsh, Michael T Tetzlaff, Omid Hamid, Patrick A Ott, Genevieve M Boland, Ryan J Sullivan, Kenneth F Grossmann, Nadim J Ajami, Theresa LaVallee, Matthew R Henn, Hussein A Tawbi, and Jennifer A Wargo

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Baseline biomarkers of efficacy and on-treatment immune-profile changes associated with bempegaldesleukin plus nivolumab., Helen Gogas, Shruthi Ravimohan, Antara Datta, Aparna Chhibber, Eva Muñoz Couselo, Adi Diab, Caio Pereira, Gaëlle Quéreux, Shahneen Sandhu, Brendan Curti, Nikhil I Khushalani, Matthew H Taylor, Gregory A Daniels, Anna Spreafico, Tarek Meniawy, Alfons J M Van Den Eertwegh, Yongliang Sun, Yull Arriaga, Ming Zhou, Georgina V Long, and Céleste Lebbé

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In the Heat of the Moment: Thermal Ablation for "All Things Thyroid"., Melanie Goldfarb

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Pilot study of plasma miRNA signature panel for differentiating single vs multiglandular parathyroid disease., Melanie Goldfarb, Matias A Bustos, Jamie Moon, Katherine M Jackson, Frederick R Singer, and Dave Hoon

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Phase 1 trial of TPI 287, a microtubule stabilizing agent, in combination with bevacizumab in adults with recurrent glioblastoma., Samuel A Goldlust, Louis B Nabors, Sigmund Hsu, Nimish Mohile, Paul J Duic, Tara Benkers, Samuel Singer, Mayank Rao, Lori Cappello, Sandra L Silberman, and George Farmer

Thin and in situ melanomas of unfavorable prognosis: A retrospective observational analysis of local recurrence, metastasis, and death in early-stage disease., Joao Renato V Gontijo, Jacob H Nelson, Kyra Diehl, Veselina B Korcheva, Flavia Vasques Bittencourt, and Sancy A Leachman

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Population Screening for High-Risk Patient Identification Partnership with CARE-Comprehensive Assessment, Risk, and Education., Ora K Gordon, Brad Bott, Nanor Parseghian, Kimberly K Childers, and Sandra Brown

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Multi-Cancer Early Detection Testing (MCED), Ora K Gordon, Brad Bott, Nanor Parseghian, Paul Psychogios, Kimberly K Childers, and Sandra Brown

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Impact of Cryopreserved Placental Allografts on Biochemical Recurrence in Prostate Cancer., Josh Gottlieb, Douglas Hanes, Matias A Bustos, Jane Choe, Albert Luu, Daniel Seizer, Dave SB Hoon, and Timothy G Wilson

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Oncology social workers' involvement in palliative care: Secondary data analysis from nationwide oncology social workers survey., Ting Guan, Karlynn BrintzenhofeSzoc, Alyssa Middleton, Shirley Otis-Green, Tara Schapmire, Makeeta Rayton, Krista Nelson, Michael L Grignon, and Brad Zebrack

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Molecular analysis of primary and metastatic sites in patients with renal cell carcinoma., Shuchi Gulati, Pedro C Barata, Andrew Elliott, Mehmet Asim Bilen, Earle F Burgess, Toni K Choueiri, Sourat Darabi, Nancy Ann Dawson, Benjamin Adam Gartrell, Hans J Hammers, Elisabeth I Heath, Daniel Magee, Arpit Rao, Charles J Ryan, Przemyslaw W Twardowski, Shuanzeng Wei, James Brugarolas, Tian Zhang, Matthew R Zibelman, Chadi Nabhan, and Rana R McKay

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Characteristics and Survival Outcomes of Patients With Metastatic, Allan Hackshaw, Otto Fajardo, Urania Dafni, Hans Gelderblom, Pilar Garrido, Salvatore Siena, Matthew H Taylor, Walter Bordogna, and Christos Nikolaidis

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A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome., Terese C Hammond, Marco A Purbhoo, Sapana Kadel, Jerome Ritz, Sarah Nikiforow, Heather Daley, Kit Shaw, Koen van Besien, Alexandra Gomez-Arteaga, Don Stevens, Waldo Ortuzar, Xavier Michelet, Rachel Smith, Darrian Moskowitz, Reed Masakayan, Burcu Yigit, Shannon Boi, Kah Teong Soh, John Chamberland, Xin Song, Yu Qin, Ilya Mishchenko, Maurice Kirby, Valeriia Nasonenko, Alexa Buffa, Jennifer S Buell, Dhan Chand, Marc van Dijk, Justin Stebbing, and Mark A Exley

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A data-driven approach to improve wellness and reduce recurrence in cancer survivors., Ramkumar Hariharan, Leroy Hood, and Nathan D Price

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Top Ten Tips Palliative Care Clinicians Should Know About Caring for People with Leptomeningeal Disease., Alice Hawkins, Mariana Khawand-Azoulai, Rachel Tanenbaum, Carina Oltmann, Carolina Benjamin, Tejan Diwanji, Maria Del Pilar Guillermo Prieto Eibl, Cara Siegel, and Akanksha Sharma

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Cell-free and extracellular vesicle microRNAs with clinical utility for solid tumors., Yoshinori Hayashi, Janelle-Cheri Millen, Romela Irene Ramos, Jennifer A Linehan, Timothy G Wilson, Dave S B Hoon, and Matias A Bustos

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A Case of Kaposi's Sarcoma with Dyspnea, Claire Higgins, MD and Brinton Clark, MD, MPH

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Digital Pathology for Better Clinical Practice., Assia Hijazi, Carlo Bifulco, Pamela Baldin, and Jérôme Galon

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Upfront or delayed surgery in resectable hepatoblastoma: analysis from the children's hepatic tumors international collaboration database., Eiso Hiyama, Tomoro Hishiki, Kenichi Yoshimura, Mark Krailo, Rudolf Maibach, Beate Haeberle, Arun Rangaswami, Dolores Lopez-Terrada, Marcio H Malogolowkin, Marc Ansari, Rita Alaggio, Allison F O'Neill, Angela D Trobaugh-Lotrario, Kenichiro Watanabe, Irene Schmid, Sarangarajan Ranganathan, Yukichi Tanaka, Takeshi Inoue, Jin Piao, Jason Lin, Piotr Czauderna, Rebecka L Meyers, and Daniel C Aronson

Treatment with a novel hexavalent OX40 agonist enhances activation of circulating T cells to favor anti-tumor immunity, N Holay, Will Redmond, and See full list of authors in comments

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A Multisite Initiative to Increase Utilization of Clinical Pathways in the Selection of Systemic Cancer Treatment, Kate Hough

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Mutation burden and anti-PD-1 outcomes are not universally associated with immune cell infiltration or lymphoid activation., David Hsiehchen, Andrew Elliott, Joanne Xiu, Andreas Seeber, Wafik El-Deiry, Emmanuel S Antonarakis, Stephanie L Graff, Michael J Hall, Hossein Borghaei, Dave Hoon, Stephen V Liu, Patrick C Ma, Rana R McKay, Trisha Wise-Draper, John Marshall, George W Sledge, David Spetzler, and Hao Zhu

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Hidden secrets of the cancer genome: unlocking the impact of non-coding mutations in gene regulatory elements., Sandra Iñiguez-Muñoz, Pere Llinàs-Arias, Miquel Ensenyat-Mendez, Andrés F Bedoya-López, Javier I Orozco, Javier Cortés, Ananya Roy, Karin Forsberg-Nilsson, Maggie L DiNome, and Diego M Marzese

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ASO Author Reflections: Employment of Oncoplastic Breast Surgery for Management of Large, Multifocal, or Multicentric Breast Cancers: Another Tool in the Toolbox., Katherine M Jackson and Janie G Grumley

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Smoking Status and Survival in Patients With Early-Stage Primary Cutaneous Melanoma., Katherine M Jackson, Peter C Jones, Laura M Fluke, Trevan D Fischer, John F Thompson, Alistair J Cochran, Stacey L Stern, Mark B Faries, Dave S B Hoon, and Leland J Foshag

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Breast Conservation Project: Clinical Outcomes of Extreme Oncoplastic Breast-Conserving Therapy Versus Mastectomy for Large and Multiple Lesions., Katherine M Jackson, Janelle-Cheri Millen, Nicketti Handy, Javier I Orozco, Stacey Stern, Crystal E Fancher, and Janie Grumley

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Intratumoral radiation dose heterogeneity augments antitumor immunity in mice and primes responses to checkpoint blockade., Justin C Jagodinsky, Jessica M Vera, Won Jong Jin, Amanda G Shea, Paul A Clark, Raghava N Sriramaneni, Thomas C Havighurst, Ishan Chakravarthy, Raad H Allawi, KyungMann Kim, Paul M Harari, Paul M Sondel, Michael A Newton, Marka R Crittenden, Michael J. Gough, Jessica R Miller, Irene M Ong, and Zachary S Morris

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Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer., Chowdhury Arif Jahangir, David B Page, Glenn Broeckx, Claudia A Gonzalez, Caoimbhe Burke, Clodagh Murphy, Jorge S Reis-Filho, Amy Ly, Paul W Harms, Rajarsi R Gupta, Michael Vieth, Akira I Hida, Mohamed Kahila, Zuzana Kos, Paul J van Diest, Sara Verbandt, Jeppe Thagaard, Reena Khiroya, Khalid Abduljabbar, Gabriela Acosta Haab, Balazs Acs, Sylvia Adams, Jonas S Almeida, Isabel Alvarado-Cabrero, Farid Azmoudeh-Ardalan, Sunil Badve, Nurkhairul Bariyah Baharun, Enrique R Bellolio, Vydehi Bheemaraju, Kim Rm Blenman, Luciana Botinelly Mendonça Fujimoto, Octavio Burgues, Alexandros Chardas, Maggie Chon U Cheang, Francesco Ciompi, Lee Ad Cooper, An Coosemans, Germán Corredor, Flavio Luis Dantas Portela, Frederik Deman, Sandra Demaria, Sarah N Dudgeon, Mahmoud Elghazawy, Claudio Fernandez-Martín, Susan Fineberg, Stephen B Fox, Jennifer M Giltnane, Sacha Gnjatic, Paula I Gonzalez-Ericsson, Anita Grigoriadis, Niels Halama, Matthew G Hanna, Aparna Harbhajanka, Steven N Hart, Johan Hartman, Stephen Hewitt, Hugo M Horlings, Zaheed Husain, Sheeba Irshad, Emiel Am Janssen, Tatsuki R Kataoka, Kosuke Kawaguchi, Andrey I Khramtsov, Umay Kiraz, Pawan Kirtani, Liudmila L Kodach, Konstanty Korski, Guray Akturk, Ely Scott, Anikó Kovács, Anne-Vibeke Laenkholm, Corinna Lang-Schwarz, Denis Larsimont, Jochen K Lennerz, Marvin Lerousseau, Xiaoxian Li, Anant Madabhushi, Sai K Maley, Vidya Manur Narasimhamurthy, Douglas K Marks, Elizabeth S McDonald, Ravi Mehrotra, Stefan Michiels, Durga Kharidehal, Fayyaz Ul Amir Afsar Minhas, Shachi Mittal, David A Moore, Shamim Mushtaq, Hussain Nighat, Thomas Papathomas, Frederique Penault-Llorca, Rashindrie D Perera, Christopher J Pinard, Juan Carlos Pinto-Cardenas, Giancarlo Pruneri, Lajos Pusztai, Nasir Mahmood Rajpoot, Bernardo Leon Rapoport, Tilman T Rau, Joana M Ribeiro, David Rimm, Anne Vincent-Salomon, Joel Saltz, Shahin Sayed, Evangelos Hytopoulos, Sarah Mahon, Kalliopi P Siziopikou, Christos Sotiriou, Albrecht Stenzinger, Maher A Sughayer, Daniel Sur, Fraser Symmans, Sunao Tanaka, Timothy Taxter, Sabine Tejpar, Jonas Teuwen, E Aubrey Thompson, Trine Tramm, William T Tran, Jeroen van der Laak, Gregory E Verghese, Giuseppe Viale, Noorul Wahab, Thomas Walter, Yannick Waumans, Hannah Y Wen, Wentao Yang, Yinyin Yuan, John Bartlett, Sibylle Loibl, Carsten Denkert, Peter Savas, Sherene Loi, Elisabeth Specht Stovgaard, Roberto Salgado, William M Gallagher, and Arman Rahman

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A phase 1/2 trial in progress of MK-6070 (aka HPN328), a DLL3-targeting T cell engager, as monotherapy or combination therapy for advanced cancers associated with DLL3 expression, P Jain, Rachel Sanborn, and See full list of authors in comments

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Engineering T-cells with CD40-based chimeric receptors to enhance adoptive T-cell therapy, M Jang, Eric Tran, and See full list of authors in comments

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Vitamin A Metabolism and Resistance of Hepatic Metastases to Immunotherapy., Peter C Jones and Daniel D Von Hoff

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Tertiary Care Center Trends in Colonic Stent Placement over the Past Decade., Wassem Y Juakiem, Kelita Singh, Andrew Ofosu, Daryl Ramai, Alana Persaud, James H Tabibian, Eduardo Rodrigues-Pinto, Mohit Girotra, and Monique T Barakat

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A phase I dose-escalation study of pulsatile afatinib in patients with recurrent or progressive brain cancer., Tiffany Juarez, Jaya Mini Gill, Annie Heng, Jose Carrillo, Naveed Wagle, Natsuko Nomura, Minhdan Nguyen, Judy D Truong, Lucia Dobrawa, Walavan Sivakumar, Garni Barkhoudarian, Daniel F Kelly, and Santosh Kesari

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Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma., Tanjina Kader, Jia-Ren Lin, Clemens B Hug, Shannon Coy, Yu-An Chen, Ino de Bruijn, Natalie Shih, Euihye Jung, Roxanne J Pelletier, Mariana Lopez Leon, Gabriel Mingo, Dalia K Omran, Jong Suk Lee, Clarence Yapp, Baby A Satravada, Ritika Kundra, Yilin Xu, Sabrina Chan, Juliann B Tefft, Jeremy L Muhlich, Sarah H Kim, Stefan M Gysler, Judith Agudo, James R Heath, Nikolaus Schultz, Charles W Drescher, Peter K Sorger, Ronny Drapkin, and Sandro Santagata

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Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma., Tanjina Kader, Jia-Ren Lin, Clemens Hug, Shannon Coy, Yu-An Chen, Ino de Bruijn, Natalie Shih, Euihye Jung, Roxanne J Pelletier, Mariana Lopez Leon, Gabriel Mingo, Dalia Khaled Omran, Jong Suk Lee, Clarence Yapp, Baby Anusha Satravada, Ritika Kundra, Yilin Xu, Sabrina Chan, Juliann B Tefft, Jeremy Muhlich, Sarah Kim, Stefan M Gysler, Judith Agudo, James R Heath, Nikolaus Schultz, Charles Drescher, Peter K Sorger, Ronny Drapkin, and Sandro Santagata

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Multi-omic profiling of simultaneous ductal carcinoma in situ and invasive breast cancer., Henry G Kaplan, Alexa K Dowdell, Anna B Berry, Racheli Ben Shimol, Fred L Robinson, Christopher A Carney, and Brian D. Piening

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The Genomic, Transcriptomic, and Immunologic Landscape of, Samuel A Kareff, Asaad Trabolsi, Harris B Krause, Timothy Samec, Andrew Elliott, Estelamari Rodriguez, Coral Olazagasti, Dionysios C Watson, Matias A Bustos, Dave SB Hoon, Stephanie L Graff, Emmanuel S Antonarakis, Sanjay Goel, George Sledge, and Gilberto Lopes

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The role of family history in predicting germline pathogenic variant carriers who develop pancreatic cancer: Results of a multicenter collaboration., Eve Karloski, Beth Dudley, Brenda Diergaarde, Amie Blanco, Jessica N Everett, Elana Levinson, Tara Rangarajan, Peter P Stanich, Kimberly K Childers, Sandra Brown, Christine Drogan, Giulia Martina Cavestro, Kelly Gordon, Aparajita Singh, Diane M Simeone, Hannah Reich, Fay Kastrinos, Dana Zakalik, Heather Hampel, Rachel Pearlman, Ora K Gordon, Sonia S Kupfer, Marta Puzzono, Raffaella Alessia Zuppardo, and Randall E Brand

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The RAPID Consortium: A Platform for Clinical and Translational Pituitary Tumor Research., Michael Karsy, Varun Kshettry, Paul Gardner, Michael Chicoine, Juan C Fernandez-Miranda, James J Evans, Garni Barkhoudarian, Douglas Hardesty, Won Kim, Gabriel Zada, Tomiko Crocker, Ildiko Torok, and Andrew Little

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MRI-Linac radiation therapy outcomes in patients with prostate, breast and other advanced malignancies, Lakhvir Kaur, Marka R Crittenden, Kristina H Young, and See full list of authors in comments

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Lactate Oxidase Disrupts Lactate-Activated RAS and PI3K Oncogenic Signaling., Chandler R Keller, Steve R Martinez, Alexys Keltz, Michelle Chen, and Weimin Li

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Patient-Reported Discussions on Fertility Preservation Before Early-Onset Cancer Treatment., Samantha R Keller, Allison Rosen, Mark A Lewis, Hyo K Park, Rebecca Babyak, Jill Feldman, Fei Ye, Rajiv Agarwal, Kristen K Ciombor, Timothy M Geiger, Cathy Eng, Katherine J Hunzinger, Richard H Viskochil, Michelle K Roach, Digna R Velez Edwards, Michele L Cote, and Andreana N Holowatyj

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Pilot Study of High-Dose Pemetrexed in Patients with Progressive Chordoma., Santosh Kesari, Naveed Wagle, Jose Carrillo, Akanksha Sharma, Minhdan Nguyen, Judy D Truong, Jaya Mini Gill, Raffi Nersesian, Natsuko Nomura, Elnaz Rahbarlayegh, Garni Barkhoudarian, Walavan Sivakumar, Daniel F Kelly, Howard Krauss, Matias A Bustos, Dave Hoon, Lars Anker, Arun S Singh, Kamalesh K Sankhala, and Tiffany Juarez

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Pre-radiation Nivolumab plus ipilimumab in patients with newly diagnosed high-grade gliomas., Santosh Kesari, Alexandre Wojcinski, Sarabjot Pabla, R J Seager, Jaya Mini Gill, Jose Carrillo, Naveed Wagle, David J. Park, Minhdan Nguyen, Judy D Truong, Yuki Takasumi, Lisa Chaiken, Shu-Ching Chang, Garni Barkhoudarian, Daniel F Kelly, and Tiffany Juarez

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Management of Complications After Per Oral Endoscopic Myotomy., Francois Khazoom and Brian Louie