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Submissions from 2021

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Tumor Microenvironment, HLA Class I and APM Expression in HPV-Negative Oral Squamous Cell Carcinoma., Claudia Wickenhauser, Daniel Bethmann, Matthias Kappler, Alexander Walter Eckert, André Steven, Jürgen Bukur, Bernard Aloysius Fox, Jana Beer, and Barbara Seliger

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Phase I/II study of nivolumab plus vorolanib in patients with thoracic malignancies: Interim efficacy of the SCLC and primary refractory NSCLC cohorts, and safety data across all cohorts., Selina K. Wong, Jennifer G. Whisenant, Rachel E Sanborn, and See list of authors in comments

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Global Chronic Total Occlusion Crossing Algorithm: JACC State-of-the-Art Review., Eugene B Wu, Emmanouil S Brilakis, Kambis Mashayekhi, Etsuo Tsuchikane, Khaldoon Alaswad, Mario Araya, Alexandre Avran, Lorenzo Azzalini, Avtandil M Babunashvili, Baktash Bayani, Michael Behnes, Ravinay Bhindi, Nicolas Boudou, Marouane Boukhris, Nenad Z Bozinovic, Leszek Bryniarski, Alexander Bufe, Christopher E Buller, M Nicholas Burke, Achim Buttner, Pedro Cardoso, Mauro Carlino, Ji-Yan Chen, Evald Hoej Christiansen, Antonio Colombo, Kevin Croce, Felix Damas de Los Santos, Tony de Martini, Joseph Dens, Carlo di Mario, Kefei Dou, Mohaned Egred, Basem Elbarouni, Ahmed M ElGuindy, Javier Escaned, Sergey Furkalo, Andrea Gagnor, Alfredo R Galassi, Roberto Garbo, Gabriele Gasparini, Junbo Ge, Lei Ge, Pravin Kumar Goel, Omer Goktekin, Nieves Gonzalo, Luca Grancini, Allison Hall, Franklin Leonardo Hanna Quesada, Colm Hanratty, Stefan Harb, Scott A Harding, Raja Hatem, Jose P S Henriques, David Hildick-Smith, Jonathan M Hill, Angela Hoye, Wissam Jaber, Farouc A Jaffer, Yangsoo Jang, Risto Jussila, Artis Kalnins, Arun Kalyanasundaram, David E Kandzari, Hsien-Li Kao, Dimitri Karmpaliotis, Hussien Heshmat Kassem, Jaikirshan Khatri, Paul Knaapen, Ran Kornowski, Oleg Krestyaninov, A V Ganesh Kumar, Pablo Manuel Lamelas, Seung-Whan Lee, Thierry Lefevre, Raymond Leung, Yu Li, Yue Li, Soo-Teik Lim, Sidney Lo, William Lombardi, Anbukarasi Maran, Margaret McEntegart, Jeffrey Moses, Muhammad Munawar, Andres Navarro, Hung M Ngo, William Nicholson, Anja Oksnes, Goran K Olivecrona, Lucio Padilla, Mitul Patel, Ashish Pershad, Marin Postu, Jie Qian, Alexandre Quadros, Nidal Abi Rafeh, Truls Råmunddal, Vithala Surya Prakasa Rao, Nicolaus Reifart, Robert F Riley, Stephane Rinfret, Meruzhan Saghatelyan, George Sianos, Elliot Smith, Anthony Spaedy, James Spratt, Gregg Stone, Julian W Strange, Khalid O Tammam, Craig A Thompson, Aurel Toma, Jennifer A Tremmel, Ricardo Santiago Trinidad, Imre Ungi, Minh Vo, Vu Hoang Vu, Simon Walsh, Gerald Werner, Jaroslaw Wojcik, Jason Wollmuth, Bo Xu, Masahisa Yamane, Luiz F Ybarra, Robert W Yeh, and Qi Zhang

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A Comparison of statistical methods for hospital performance assessment, Xiaoting Wu, Min Zhang, Ruyun Jin, Gary Grunkemeier, Charles Maynard, Ravi S. Hira, Todd Mackenzie, Morley Herbert, Chang He, Sari D. Holmes, Michael P. Thompson, and Donald S. Likosky

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Effects of radiation on tumor vasculature., Tomoko Yamazaki and Kristina H Young

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Cardiovascular Procedural Deferral and Outcomes over COVID-19 Pandemic Phases: A Multi-Center Study., Celina M Yong, Kateri J Spinelli, Shih Ting Chiu, Brandon Jones, Brian Penny, Santosh Gummidipundi, Shire Beach, Alex Perino, Mintu Turakhia, Paul Heidenreich, and Ty J Gluckman

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Six months in: COVID-19 and its impact on oncology social work practice., Brad Zebrack, Michael Grignon, Ting Guan, Donna Long, Nina Miller, Krista Nelson, Shirley Otis-Green, Makeeta Rayton, Tara Schapmire, and Lori Wiener

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Phenotyping Cardiogenic Shock., Elric Zweck, Katherine L Thayer, Ole K L Helgestad, Manreet Kanwar, Mohyee Ayouty, A Reshad Garan, Jaime Hernandez-Montfort, Claudius Mahr, Detlef Wencker, Shashank S Sinha, Esther Vorovich, Jacob Abraham, William O'Neill, Song Li, Gavin W Hickey, Jakob Josiassen, Christian Hassager, Lisette O Jensen, Lene Holmvang, Henrik Schmidt, Hanne B Ravn, Jacob E Møller, Daniel Burkhoff, and Navin K Kapur

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Compatibility of novel cardiogenic shock phenotypes from the Cardiogenic Shock Working Group (CSWG) with the SCAI staging system, E Zweck, KL Thayer, OK Helgestad, M Kanwar, M Ayouty, A Garan, J Hernandez-Montfort, C Mahr, D Wencker, S Sinha, E Vorovich, Jacob Abraham, W O'Neill, S Li, GW Hickey, J Jossiasen, C Hassager, LO Jensen, L Holmvang, H Schmidt, HB Ravn, JE Moeller, D Burkhoff, and NK Kapur

Submissions from 2020

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Management of the Patient with Heart Failure and an Implantable Pulmonary Artery Hemodynamic Sensor, Jacob Abraham, Patrick J. McCann, Maya E. Guglin, Arvind Bhimaraj, Terrie-Ann S. Benjamin, Monique R. Robinson, Orvar T. Jonsson, Scott C. Feitell, Kunjan A. Bhatt, Mosi K. Bennett, JT Heywood, and Hemodynamic Frontiers in Heart Failure (HF2) Investigators

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Characterization of a Novel Compound That Stimulates STING-Mediated Innate Immune Activity in an Allele-Specific Manner., Jinu Abraham, Sara Botto, Nobuyo Mizuno, Kara Pryke, Bryan Gall, Dylan Boehm, Tina M Sali, Haihong Jin, Aaron Nilsen, Michael J. Gough, Jason R Baird, Marita Chakhtoura, Caroline Subra, Lydie Trautmann, Elias K Haddad, and Victor R DeFilippis

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Life experiences associated with change in perpetration of domestic violence., Avanti Adhia, Vivian H Lyons, Hannah Cohen-Cline, and Ali Rowhani-Rahbar

Dangerous liaisons in pulmonary hypertension, Sophia Airhart

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Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma., Alain P Algazi, Christopher G Twitty, Katy K Tsai, Mai Le, Robert Pierce, Erica Browning, Reneta Hermiz, David A Canton, Donna Bannavong, Arielle Oglesby, Murray Francisco, Lawrence Fong, Mikael J Pittet, Sean P Arlauckas, Christopher Garris, Lauren P Levine, Carlo Bifulco, Carmen Ballesteros-Merino, Shailender Bhatia, Sharron Gargosky, Robert H I Andtbacka, Bernard A Fox, Michael D Rosenblum, and Adil I Daud

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Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma., Alain P Algazi, Christopher G Twitty, Katy K Tsai, Mai Le, Robert Pierce, Erica Browning, Reneta Hermiz, David A Canton, Donna Bannavong, Arielle Oglesby, Murray Francisco, Lawrence Fong, Mikael J Pittet, Sean P Arlauckas, Christopher Garris, Lauren P Levine, Carlos Bifulco, Carmen Ballesteros-Merino, Shailender Bhatia, Sharron Gargosky, Robert H I Andtbacka, Bernard A Fox, Michael D Rosenblum, and Adil I Daud

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Transcarotid versus transthoracic access for transcatheter aortic valve replacement: A Propensity Matched Analysis, Keith B. Allen, Adnan K. Chhatriwalla, John Saxon, James Hermiller, David Heimansohn, Sina Moainie, Raymond G. McKay, Mohiuddin Cheema, Brandon Jones, Robert W. Hodson, Ethan C Korngold, and Eric B Kirker

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Intracellular Galectin-3 Is Essential for OX40-Mediated Memory CD8, Mohammad Farhad Amani, Annah S Rolig, and William L. Redmond

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Improving Care Pathways for Acute Coronary Syndrome: Patients Undergoing Percutaneous Coronary Intervention., Amit P Amin, John A Spertus, Hemant Kulkarni, Christian McNeely, Sunil V Rao, Duane Pinto, John A House, John C Messenger, Richard G Bach, Abhinav Goyal, Adhir Shroff, Samir Pancholy, Steven M Bradley, Tyler J Gluckman, Thomas M Maddox, Jason H Wasfy, and Frederick A Masoudi

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Sgnlva-005: Open-label, phase II study of ladiratuzumab vedotin (LV) for advanced aerodigestive tract malignancies, Ian Churchill Anderson, Yinghui Wang, Zejing Wang, and Rachel E Sanborn

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Sgnlva-005: Open-label, phase II study of ladiratuzumab vedotin (LV) for advanced aerodigestive tract malignancies., Ian Churchill Anderson, Yinghui Wang, Zejing Wang, and Rachel E Sanborn

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Safety and activity of varlilumab, a novel and first-in-class agonist anti-CD27 antibody, for hematologic malignancies., Stephen M Ansell, Ian Flinn, Matthew H Taylor, Branimir I Sikic, Joshua Brody, John Nemunaitis, Andrew Feldman, Thomas R Hawthorne, Tracey Rawls, Tibor Keler, and Michael J Yellin

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Phase II Trial of Carfilzomib Plus Irinotecan in Patients with Small Cell Lung Cancer Who Have Progressed on Prior Platinum-Based Chemotherapy., Susanne M. Arnold, Kari Chansky, Maria Q. Baggstrom, Michael A. Thompson, Rachel E Sanborn, John L. Villano, Saiama N. Wagar, John Hamm, Markos Leggas, Maurice Willis, Joseph Rosales, and John J. Crowley

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The Great Debate at 'Immunotherapy Bridge', Naples, December 5, 2019., Paolo A Ascierto, Carlo Bifulco, Jerome Galon, Claus Garbe, Samir N Khleif, Jennifer McQuade, Kunle Odunsi, Hideho Okada, Chrystal M Paulos, Sergio A Quezada, Hussein A Tawbi, John Timmerman, Giorgio Trinchieri, Lisa H Butterfield, and Igor Puzanov

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Insights from immuno-oncology: The Society for Immunotherapy of Cancer statement on access to IL-6-targeting therapies for COVID-19, Paolo A. Ascierto; Bernard A Fox; Walter Urba; Ana Carrizosa Anderson; Michael Atkins; Ernest C. Borden; Julie R. Brahmer; Lisa H. Butterfield; Alessandra Cesano; Daniel S. Chen; Tanja D. De Gruijl; Robert O. Dillman; Charles G. Drake; Leisha A. Emens; Thomas F. Gajewski; James L. Gulley; F Stephen Hodi, Jr.; Patrick Hwu; David Kaufman; Howard L. Kaufman; Michael T. Lotze; Francesco M. Marincola; Kim A. Margolin; Michael J. Mastrangelo; Marcela V. Maus; Douglas G. McNeel; David R. Parkinson; Pedro J. Romero; Paul M. Sondel; Stefani Spranger; Mario Sznol; George J. Weiner; Jon M. Wigginton; and Jeffrey S. Weber

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No time to die: the consensus immunoscore for predicting survival and response to chemotherapy of locally advanced colon cancer patients in a multicenter international study., Paolo A Ascierto, Francesco M Marincola, Bernard A Fox, and Jérôme Galon

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Perspectives in melanoma: meeting report from the "Melanoma Bridge" (December 5th-7th, 2019, Naples, Italy)., Paolo A Ascierto, Igor Puzanov, Sanjiv S Agarwala, Christian Blank, Richard D Carvajal, Sandra Demaria, Reinhard Dummer, Marc Ernstoff, Soldano Ferrone, Bernard A Fox, Thomas F Gajewski, Claus Garbe, Patrick Hwu, Roger S Lo, Georgina V Long, Jason J Luke, Iman Osman, Michael A Postow, Ryan J Sullivan, Janis M Taube, Giorgio Trinchieri, Hassane M Zarour, Corrado Caracò, and Magdalena Thurin

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Contemporary Techniques in Orbital Reconstruction: A Review of the Literature and Report of a Case Combining Surgical Navigation, Computer-Aided Surgical Simulation, and a Patient-Specific Implant., Iman Azarmehr, Kasper Stokbro, R Bryan Bell, and Torben Thygesen

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Outpatient treatment with lisocabtagene maraleucel (liso-cel) across a variety of clinical sites from three ongoing clinical studies in relapsed/refractory (R/R) large B-cell lymphoma (LBCL)., Carlos R. Bachier, John E Godwin, Charalambos Andreadis, Maria Lia Palomba, Jeremy S. Abramson, Alison R. Sehgal, Gerhard Hildebrandt, Don A. Stevens, Daanish Hoda, Edward J. Licitra, Tanya Siddiqi, Thalia Andrea Farazi, Ana Kostic, Nikolaus S. Trede, Lei Wang, James Lymp, and David G. Mahoney

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Outpatient Treatment with Lisocabtagene Maraleucel (liso-cel) in 3 Ongoing Clinical Studies in Relapsed/Refractory (R/R) Large B Cell Non-Hodgkin Lymphoma (NHL), Including Second-Line Transplant Noneligible (TNE) Patients: Transcend NHL 001, Outreach, and PILOT, Carlos R. Bachier, M Lia Palomba, Jeremy S. Abramson, Charalambos Andreadis, Alison Sehgal, John E Godwin, Gerhard C. Hildebrandt, Tanya Siddiqi, Don Stevens, Thalia Farazi, Ana Kostic, Nikolaus S. Trede, Lei Wang, James Lymp, Tennille Thelen, Ken Ogasawara, and David G. Maloney

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United States Pulmonary Hypertension Scientific Registry: Baseline Characteristics., Jessica B Badlam, David B Badesch, Eric D Austin, Raymond L Benza, Wendy K Chung, Harrison W Farber, Kathy Feldkircher, Adaani E Frost, Abby D Poms, Katie A Lutz, Michael W Pauciulo, Chang Yu, William C Nichols, C Gregory Elliott, additional authors, and Sophia Airhart

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ACCEL Lite: Case Rates, Treatment, and Outcomes in AMI During the COVID-19 Pandemic, Alison Bailey, Joseph Edward Marine, Tyler J Gluckman, and Yuvraj Chowdhury

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Improved tolerability of neratinib in patients with HER2-positive early-stage breast cancer: the CONTROL trial., C H Barcenas, S A Hurvitz, J A Di Palma, R Bose, A J Chien, N Iannotti, G Marx, A Brufsky, A Litvak, E Ibrahim, R H Alvarez, M Ruiz-Borrego, N Chan, Y Manalo, A Kellum, M Trudeau, M Thirlwell, J Garcia Saenz, D Hunt, R Bryce, L McCulloch, H S Rugo, D Tripathy, A Chan, CONTROL Study Investigators, and Alison Conlin

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Feature | Thrombosis and COVID-19: FAQs For Current Practice, Geoffrey D. Barnes, Adam Cuker, Tyler J Gluckman, Gregory Piazza, and Deborah M. Siegal

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What are thrombosis risk and management considerations in COVID-19?, Geoffrey D. Barnes, Adam Cuker, Tyler J Gluckman, Gregory Piazza, and Deborah M. Siegal

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Image processing systems and methods for displaying multiple images of a biological specimen, Michael Barnes, Carlo Bifulco, Christophe Chefd'hotel, Ting Chen, and Alisa Tubbs

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Image processing systems and methods for displaying multiple images of a biological specimen, Michael Barnes, Carlo Bifulco, Christophe Chefd'hotel, Ting Chen, and Alisa Tubbs

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Abstract B01: Surgical outcomes following neoadjuvant hypofractionated radiation in combination with nivolumab: High rate of pathologic complete response in patients with p16+ head and neck squamous cell carcinoma, Richard Bryan Bell, Rom Leidner, Marcus Couey, Ashish Patel, Amber L Watters, Hong Ziao, Carlo Bifulco, Brian D. Piening, George Morris, Lessli Rushforth, Dawn Brucker, Shorin Nemeth, Kristina H Young, Michael J. Gough, and Marka R Crittenden

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Abstract B01: Surgical outcomes following neoadjuvant hypofractionated radiation in combination with nivolumab: High rate of pathologic complete response in patients with p16+ head and neck squamous cell carcinoma, Richard Bryan Bell, Rom Leidner, Marcus Couey, Ashish Patel, Amber L Watters, Hong Ziao, Carlo Bifulco, Brian D. Piening, George Morris, Lessli Rushforth, Dawn Brucker, Shorin Nemeth, Kristina H Young, Michael J. Gough, and Marka R Crittenden

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Cohort Expansion Study of Neoadjvuant Immunoradiotherapy in Locoregionally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma, Richard Bryan Bell, Rom Leidner, Kristina H Young, Brendan Curti, Marcus Couey, Ashish Patel, Amber L Watters, Hong D Xiao, George Morris, Lessli Rushforth, Michael J. Gough, and Marka R Crittenden

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Cohort Expansion Study of Neoadjvuant Immunoradiotherapy in Locoregionally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma, Richard Bryan Bell, Rom Leidner, Kristina H Young, Brendan Curti, Marcus Couey, A Patel, Amber L Watters, Hong D Xiao, G Morris, L Rushforth, Michael J. Gough, and Marka R Crittenden

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Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART Molecule., Alexey Berezhnoy, Bradley J Sumrow, Kurt Stahl, Kalpana Shah, Daorong Liu, Jonathan Li, Su-Shin Hao, Anushka De Costa, Sanjeev Kaul, Johanna Bendell, Gregory M Cote, Jason J Luke, Rachel E Sanborn, Manish R Sharma, Francine Chen, Hua Li, Gundo Diedrich, Ezio Bonvini, and Paul A Moore

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Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10., Cristina Bergamaschi, Hrishikesh Pandit, Bethany A Nagy, Dimitris Stellas, Shawn M. Jensen, Jenifer Bear, Maggie Cam, Antonio Valentin, Bernard A Fox, Barbara K Felber, and George N Pavlakis

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Transcriptional and immunohistological assessment of immune infiltration in pancreatic cancer., Brady Bernard, Venkatesh Rajamanickam, Christopher Dubay, Brian D. Piening, Emilio Alonso, Zeljka Jutric, Ephraim Tang, Pippa Newell, Paul D Hansen, Terry R Medler, Andrew J Gunderson, Kristina H Young, Carlo Bifulco, Joanna Pucilowska, Marka R Crittenden, and Michael J. Gough

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Analysis of changes in decision-making process during optical coherence tomography-guided percutaneous coronary interventions: insights from the LightLab initiative, Hiram Bezerra, Luis Augusto Palma Dallan, Gabriel Tensol Rodrgues Pereira, Jana Buccola, Richard Rapoza, Nick West, Jason R Wollmuth, John Lopez, Brian Bergmark, and Kevin Croce

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Analysis of changes in decision-making process during optical coherence tomography-guided percutaneous coronary interventions: insights from the LightLab initiative, Hiram Bezerra, Luis Dallan, Gabriel Tensol, Jana Buccola, Jason R Wollmuth, John Lopez, Richard Rapoza, Nick West, Brian Bergmark, and Kevin Croce

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When Life Gives You Lemons, Make Lemonade: The Case of Hosting the Most Successful Regional Cardiovascular Symposium during the COVID19 Pandemic –– A Tale from the Oregon Chapter of the American College of Cardiology, Castigliano M. Bhamidipati, Alan Morasch, Ben Morasch, Jayne Mitchell, Tamara Atkinson, Charles R. Cannan, Brian Gross, Pasala Ravichandran, Aly Rahimtoola, Tyler J Gluckman, and Scott Chadderdon

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Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets., Nina Bhardwaj, Philip A Friedlander, Anna C Pavlick, Marc S Ernstoff, Brian R Gastman, Brent A Hanks, Brendan Curti, Mark R Albertini, Jason J Luke, Ana B Blazquez, Sreekumar Balan, Davide Bedognetti, Joseph M Beechem, Andrea S Crocker, Leonard D'Amico, Patrick Danaher, Thomas A Davis, Thomas Hawthorne, Bruce W Hess, Tibor Keler, Lisa Lundgren, Chihiro Morishima, Nirasha Ramchurren, Darawan Rinchai, Andres M Salazar, Bob A Salim, Elad Sharon, Laura A Vitale, Ena Wang, Sarah Warren, Michael J Yellin, Mary L Disis, Martin A Cheever, and Steven P Fling

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Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets, Nina Bhardwaj, Philip A. Friedlander, Anna C. Pavlick, Marc S. Ernstoff, Brian R. Gastman, Brent A. Hanks, Brendan Curti, Mark R. Albertini, Jason J. Luke, Ana B. Blazquez, Sreekumar Balan, Davide Bedognetti, Joseph M. Beechem, Andrea S. Crocker, Leonard D'Amico, Patrick Danaher, Thomas A. Davis, Thomas Hawthorne, Bruce W. Hess, Tibor Keler, Lisa Lundgren, Chihiro Morishima, Nirasha Ramchurren, Darawan Rinchai, Andres M. Salazar, Bob A. Salim, Elad Sharon, Laura A. Vitale, Ena Wang, Sarah Warren, Michael J. Yellin, Mary L. Disis, Martin A. Cheever, and Steven P. Fling

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Integrating multiomics in the practice of diagnostic pathology, Carlo Bifulco

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72 Routine use of comprehensive genomic profiling to assess tumor mutational burden across a community health system, Carlo Bifulco, Roshanthi Weerasinghe, Bela Bapat, Alexa K Dowdell, Shwetha Pindikuri, Sheila Reynolds, Nancy Biery, David Ball, Mary Campbell, Thomas R. Ward, Alisha Stein, Brock Schroeder, David Eberhard, and Brian D. Piening

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72 Routine use of comprehensive genomic profiling to assess tumor mutational burden across a community health system, Carlo Bifulco, Roshanthi Weerasinghe, Bela Bepat, Alexa K Dowdell, Shwetha Pindikuri, Sheila Reynolds, Nancy Biery, David Ball, Mary Campbell, Thomas R. Ward, Alisha Stein, Brock Schroeder, David Eberhard, and Brian D. Piening

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COVID-19 and the CV service line: practical approaches for an unprecedented pandemic—Part 1, Jerry Blackwell, Cathie Biga, Geoffrey Rose, Tyler J Gluckman, John Rebok, and Eugene Yang

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Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors and Radiation, Tiffany C. Blair, Shelly Bambina, Alejandro F Alice, Gwen Kramer, Terry R Medler, Jason R Baird, Miranda L. Broz, Garth Tormoen, Victoria Troesch, Marka R Crittenden, and Michael J. Gough

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Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors to Radiation Therapy., Tiffany C Blair, Shelly Bambina, Alejandro F Alice, Gwen Kramer, Terry R Medler, Jason R Baird, Miranda L Broz, Garth W Tormoen, Victoria Troesch, Marka R Crittenden, and Michael J. Gough

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CX-2009, a CD166-directed probody drug conjugate (PDC): Results from the first-in-human study in patients (Pts) with advanced cancer including breast cancer (BC)., Valentina Boni, Howard A. Burris III, Joyce F. Liu, Alexandra I. Spira, Hendrik-Tobias Arkenau, Mary J. Fidler, Lee S. Rosen, Randy F. Sweis, Nataliya Volodymyrivna Uboha, Rachel E Sanborn, Bert O'Neil, James J. Harding, Patricia LoRusso, Amy M. Weise, Javier Garcia-Corbacho, Ivan Victoria, John W. Frye, Rachel Li, Mark Stroh, and Funda Meric-Bernstam

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Outcome assessment of orthodontic clear aligner vs fixed appliance treatment in a teenage population with mild malocclusions., Alissa F Borda, Judah S Garfinkle, David A Covell, Mansen Wang, Larry Doyle, and Christine M Sedgley

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PANEL DISCUSSION: Future Directions for Adoptive Cell Therapy, Adrian Bot, Andreas Bader, Christina Coughlin, and Andrew D Weinberg

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Improving Workflow and Addressing Challenges in the Device Clinic, Scott Brancato

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Chapter: Adults with Congenital Heart Disease and Heart Failure, Luke Burchill, Melissa Lee, Vidang P. Nguyen, and Karen Stout

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Digital service in a virtual era: connecting the dots to help your community and save the world without leaving your home, Andrew Burgie, Liam Elkind, Alison Grady, and Xiaoyan Huang

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A phase I/II study of HB-201, an arenavirus-based cancer immunotherapy, alone, or in combination with anti-PD-1 in patients with HPV16+ cancers., Bharat Burman, Jiaxin Niu, Rom Leidner, Ding Wang, Debra L. Richardson, Corinne Iacobucci, Andy Hwang, Xiaoping Qing, Igor Matushansky, Dmitriy Zamarin, Alan Loh Ho, David G. Pfister, and Marshall R. Posner

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Long-Term Durability of Transcatheter Valves: The Importance of Accurate Data., Eric G Butchart, John Chambers, Jeffrey S Borer, Gary Grunkemeier, and Ajit Yoganathan

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PD-1 Blockade in Anaplastic Thyroid Carcinoma., Jaume Capdevila, Lori J Wirth, Thomas Ernst, Santiago Ponce Aix, Chia-Chi Lin, Rodryg Ramlau, Marcus O Butler, Jean-Pierre Delord, Hans Gelderblom, Paolo A Ascierto, Angelica Fasolo, Dagmar Führer, Marie Luise Hütter-Krönke, Patrick M Forde, Anna Wrona, Armando Santoro, Peter M Sadow, Sebastian Szpakowski, Hongqian Wu, Geraldine Bostel, Jason Faris, Scott Cameron, Andreea Varga, and Matthew H Taylor

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Improving Primary Care Fall Risk Management: Adoption of Practice Changes After a Geriatric Mini-Fellowship, Colleen M Casey, Jamie M. Caulley, Angela F. Fox, and Marian O. Hodges

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Effect of a Health System-Sponsored Mobile App on Perinatal Health Behaviors: Retrospective Cohort Study., Caroline Cawley, Hannelore Buckenmeyer, Trina Jellison, Joseph B Rinaldi, and Keri B Vartanian

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1258O Amivantamab (JNJ-61186372), an EGFR-MET bispecific antibody, in combination with lazertinib, a 3rd-generation tyrosine kinase inhibitor (TKI), in advanced EGFR NSCLC, BC Cho, KH Lee, EK Cho, D-W Kim, J-S Lee, J-Y Han, S-W Kim, A Spira, EB Haura, EK Sabari, Rachel E Sanborn, JM Bauml, JE Gomez, P Lorenzini, JR Infante, J Xie, N Haddish-Berhane, M Thayu, RE Knoblauch, and K Park

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Impact of chemotherapy (chemo) on t-cell maturation and clonal proliferation in early-stage and metastatic breast cancer, Brie Chun, Joanna Pucilowska, Valerie Conrad, Mark Schmidt, Isaac Kim, Paul Fields, Alison Conlin, Heather McArthur, and David B Page

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Direct and indirect pathways between childhood instability and adult homelessness in a low-income population, Hannah Cohen-Cline, Kyle G Jones, and Keri B Vartanian

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976TiP SPEARHEAD-2 trial design: A phase II pilot trial of ADP-A2M4 in combination with pembrolizumab in patients with recurrent or metastatic head and neck cancer, EE Cohen, L Dunn, P Neupane, M Gibson, Rom Leidner, P Savvides, N Hyland, T Trivedi, M Dudley, S Biswas, D Williams, and E Norry

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Optical Coherence Tomography Influences Procedure and Vessel Preparation Decisions During Percutaneous Coronary Intervention– Insights from the LightLab Initiative, Kevin Croce, Hiram Bezerra, Jana Buccola, Richard Rapoza, Nick West, John Lopez, Brian Bergmark, and Jason R Wollmuth

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Effect of a Prescriptive Optical Coherence Tomography-Guided Strategy on Treatment of In-Stent Restenosis: Insights from the LightLab Initiative, Kevin Croce, Mordechai Golomb, Jana Buccola, Richard Rapoza, Nick West, John Lopez, Jason R Wollmuth, and Brian Bergmark

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Management of Zygomaticomaxillary Complex Fractures Utilizing Intraoperative 3-Dimensional Imaging: The ZYGOMAS Protocol., Karl Cuddy, Eric J Dierks, Allen Cheng, Ashish Patel, Melissa Amundson, and Richard Bryan Bell

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Randomized phase II study of stereotactic body radiotherapy and interleukin-2 versus interleukin-2 in patients with metastatic melanoma., Brendan Curti, Marka R Crittenden, Steven K Seung, Christopher B Fountain, Roxanne Payne, ShuChing Chang, Jessica Fleser, Kimberly Phillips, Ian Malkasian, Lyn B Dobrunick, and Walter Urba

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Impact of geography and travel distance on outcomes in epithelial ovarian cancer: a national cancer database analysis., Ava Daruvala, F Lee Lucas, Jesse Sammon, Christopher Darus, and Leslie Bradford

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368 REVEAL: Phase 1 dose-escalation study of NKTR-262, a novel TLR7/8 agonist, plus bempegaldesleukin: local innate immune activation and systemic adaptive immune expansion for treating solid tumors, Adi Daub, Brendan Curti, Mehmet Bilen, Andrew Brohl, Evidio Domingo-Musibay, Erkut Borazanci, Christine Fanton, Cat Haglund, Mona Vimal, Mann Muhsin, Mario Marcondes, Anh Nguyen, Mary Tagliaferri, Wei Lin, Jonathan Zalevsky, and Sandra D'Angelo

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420 Progression-free survival and biomarker correlates of response with BEMPEG plus NIVO in previously untreated patients with metastatic melanoma: results from the PIVOT-02 study, Adi Daub, Scott Tykodi, Gregory Daniels, Michele Maio, Brendan Curti, Karl Lewis, Sekwon Jang, Ewa Kalinka, Igor Puzanov, Alexander Spira, Daneil Cho, Shanhong Guan, Erika Puente, Ute Hoch, Sue Currie, Tuan Nguyen, Wei Lin, Mary Tagliaferri, Jonathan Zalevsky, Mario Sznol, and Michael Hurwitz

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368 REVEAL: Phase 1 dose-escalation study of NKTR-262, a novel TLR7/8 agonist, plus bempegaldesleukin: local innate immune activation and systemic adaptive immune expansion for treating solid tumors, Abi Diab, Brendan Curti, Mehmet Bilen, Andrew Brohl, Evidio Domingo-Musibay, Erkut Borazanci, Christine Falon, Cat Haglund, Mona Vimal, Mann Muhsin, Mario Marcondes, Anh Nguyen, Mary Tagliaferri, Wei Lin, Jonathan Zalevsky, and Sandra D'Angelo

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Bempegaldesleukin (NKTR-214) plus Nivolumab in Patients with Advanced Solid Tumors: Phase I Dose-Escalation Study of Safety, Efficacy, and Immune Activation (PIVOT-02)., Adi Diab, Nizar M Tannir, Salah-Eddine Bentebibel, Patrick Hwu, Vassiliki Papadimitrakopoulou, Cara Haymaker, Harriet M Kluger, Scott N Gettinger, Mario Sznol, Scott S Tykodi, Brendan Curti, Mary A Tagliaferri, Jonathan Zalevsky, Alison L Hannah, Ute Hoch, Sandra Aung, Christie Fanton, Ahsan Rizwan, Ernesto Iacucci, Yijie Liao, Chantale Bernatchez, Michael E Hurwitz, and Daniel C Cho

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420 Progression-free survival and biomarker correlates of response with BEMPEG plus NIVO in previously untreated patients with metastatic melanoma: results from the PIVOT-02 study, Adi Diab, Scott Tykodi, Gregory Daniels, Michele Maio, Brendan Curti, Karl Lewis, Sekwon Jang, Ewa Kalinka, Igor Puzanov, Alexander Spira, Daniel Cho, Shanhong Guan, Erika Puente, Ute Hoch, Sue Currie, Tuan Nguyen, Wei Lin, Mary Tagliaferri, Jonathan Zalevsky, Mario Sznol, and Michael Hurwitz

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420 Progression-free survival and biomarker correlates of response with BEMPEG plus NIVO in previously untreated patients with metastatic melanoma: results from the PIVOT-02 study, Adi Diab, Scott Tykodi, Gregory Daniels, Michele Maio, Brendan Curti, Karl Lewis, Sekwon Jang, Ewa Kalinka, Igor Puzanov, Alexander Spira, Daniel Cho, Shanhong Guan, Erika Puente, Ute Hoch, Sue Currie, Tuan Nguyen, Wei Lin, Mary Tagliaferri, Jonathan Zalevsky, Mario Sznol, and Michawl Hurwitz

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Genomic heterogeneity and clinical characterization of SARS-CoV-2 in Oregon, Alexa K Dowdell, Kevin Matlock, Fred L. Robinson, Roshanthi Weerasinghe, Rogan Rattray, Marina Pukay, Melvin Lathara, Anastacia Harlan, Thomas R. Ward, Mary Campbell, Walter Urba, Ganapati Srinivasa, Carlo Bifulco, and Brian D. Piening

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A phase II, open-label study of tomivosertib (eFT508) added on to continued checkpoint inhibitor therapy in patients (pts) with insufficient response to single-agent treatment., Anthony B. El-Khoueiry, Nishan Tchekmedyian, Rachel E Sanborn, Julio Antonio Peguero, Kerry Pulver, Vekas Dembla, Jacob Stephen Thomas, Gary Gene Chiang, Mark Densel, Neil Sankar, Stephen Theodore Worland, Lyon L. Gleich, and Robert S. Sikorski

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418 A phase 1, dose escalation and dose expansion study of SQZ PBMC HPV as monotherapy and in combination with atezolizumab in HLA-A*02+ Patients with HPV16+ recurrent, or metastatic solid tumors, Cathy Eng, Joaquina Baranda, Matthew H Taylor, Michael Gordon, Ursula Matulonis, Filip Janku, Martin Kornacker, Asha Kamat, Oliver Rosen, and Antonio Jimeno

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418 A phase 1, dose escalation and dose expansion study of SQZ PBMC HPV as monotherapy and in combination with atezolizumab in HLA-A*02+ Patients with HPV16+ recurrent, or metastatic solid tumors, Cathy Eng, Joaquina Baranda, Matthew H Taylor, Michael Gordon, Ursula Matulonis, Filip Janku, Martin Kornacker, Asha Kamat, Oliver Rosen, and Antonio Jimeno

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Real-world burden of myelosuppression in patients with small cell lung cancer (SCLC): Retrospective, longitudinal data analysis., Robert S. Epstein, JoAnn Krenitsky, Roshanthi Weerasinghe, Amy S. Parrish, Rachel E Sanborn, and Tehseen Salimi

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Patterns of Hospital Bypass and Interhospital Transfer Among Patients With Heart Failure., Lee W Eschenroeder, Vidang P. Nguyen, Moni B Neradilek, Song Li, and Todd F Dardas

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Longitudinal Effects of Left Ventricular Assist Device Implantation on Global and Domain-Specific Cognitive Function., Kenneth M Faulkner, Christopher V Chien, Quin E Denfeld, Jill M Gelow, Karen S Lyons, Kathleen L Grady, James O Mudd, and Christopher S Lee

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Same evidence, varying viewpoints: Three questions illustrating important differences between United States and European cholesterol guideline recommendations, David I. Feldman, Erin D. Michos, Neil J. Stone, Tyler J Gluckman, Miguel Cainzos-Achirica, Salim S. Virani, and Roger S. Blumenthal

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799 Durable responses and immune activation with intratumoral electroporation of pIL-12 plus pembrolizumab in actively progressing anti-PD-1 refractory advanced melanoma: KEYNOTE 695 interim data, Pablo Fernandez-Penas, Matteo Carlino, Katy Tsai, Victoria Atkinson, Monaster Shaheen, Sajeve Thomas, Catalin Mihalcioiu, Tom Van Hagen, Rachel Roberts-Thomson, Andrew Haydon, Andrew Mant, Marcus Butler, Gregory Daniels, Elizabeth Buchbinder, John Hyngstrom, Mecker Moller, Igor Puzanov, C Lance Cowey, Eric Whitman, Carmen Ballesteros-Merino, Shawn M. Jensen, Bernard A Fox, Emmett Schmidt, Clemens Krepler, Scott Diede, Erica Browning, Reneta Hermiz, Lauren Svenson, Jon Salazar, Jack Lee, Christopher Baker, Donna Bannavong, Jendy Sell, Kellie Malloy Foerter, David Canton, Sandra Aung, Christopher Twitty, Alain Algazi, and Adil Daud

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799 Durable responses and immune activation with intratumoral electroporation of pIL-12 plus pembrolizumab in actively progressing anti-PD-1 refractory advanced melanoma: KEYNOTE 695 interim data, Pablo Fernandez-Penas, Matteo Carlino, Katy Tsai, Victoria Atkinson, Monater Shaheen, Sajeve Thomas, Catalin Mihalcioiu, Tom Van Hagen, Rachel Roberts-Thomson, Andrew Haydon, Andrew Mant, Marcus Butler, Gregory Daniels, Elizabeth Buchbinder, John Hyngstrom, Mecker Moller, Igor Puzanov, C Lance Cowey, Eric Whitman, Carmen Ballesteros-Merino, Shawn M. Jensen, Bernard A Fox, Emmett Schmidt, Clemens Krepler, Scott Diede, Erica Browning, Reneta Hermiz, Lauren Svenson, Jon Salazar, Jack Lee, Christopher Baker, Donna Bannavong, Jendy Sell, Kellie Malloy Foerter, David Canton, Sandra Aung, Christopher Twitty, Alain Algazi, and Adil Daud

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A novel surgeon credentialing and quality assurance process using transoral surgery for oropharyngeal cancer in ECOG-ACRIN Cancer Research Group Trial E3311., Robert L Ferris, Yael Flamand, F Christopher Holsinger, Gregory S Weinstein, Harry Quon, Ranee Mehra, Joaquin J Garcia, Michael L Hinni, Neil D Gross, Erich M Sturgis, Umamaheswar Duvvuri, Eduardo Méndez, John A Ridge, J Scott Magnuson, Kerry A Higgins, Mihir R Patel, Russel B Smith, Daniel W Karakla, Michael E Kupferman, James P Malone, Benjamin L Judson, Jeremy Richmon, Jay O Boyle, Rodrigo Bayon, Bert W O'Malley, Enver Ozer, Giovana R Thomas, Wayne M Koch, Richard Bryan Bell, Nabil F Saba, Shuli Li, Elin R Sigurdson, and Barbara Burtness

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Transoral robotic surgical resection followed by randomization to low- or standard-dose IMRT in resectable p16+ locally advanced oropharynx cancer: A trial of the ECOG-ACRIN Cancer Research Group (E3311)., Robert L. Ferris, Yael Flamand, Gregory S. Weinstein, Shuli Li, Harry Quon, Ranee Mehra, Joaquin J. Garcia, Christine H. Chung, Maura L. Gillison, Umamaheswar Duvvuri, Bert W. O'Malley, Enver Ozer, Giovanna R. Thomas, Wayne Koch, Michael Elliot Kupferman, Richard Bryan Bell, Nabil F. Saba, Miriam Lango, Eduardo Mendez, and Barbara Burtness

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Cancer vaccines yesterday, today, and tomorrow: Cinderella no more?, Bernard A Fox

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Immunotherapy-induced anti-cancer responses, Bernard A Fox

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Immunotherapy-Induced Anti-Cancer Responses, Bernard A Fox

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443 An immunotherapy trio in advanced HNSCC for coordinated B and T cell antigen response, Bernard A Fox, Tarsem Moudgil, Traci Hilton, Noriko Iwamoto, Christopher Paustian, Adi Mehta, Fridtjof Lund-Johansen, Rachel E Sanborn, Richard Bryan Bell, Madeleine Laws, Glenna McDonnell, Yoshinobu Koguchi, Carlo Bifulco, Brian D. Piening, Carmen Ballesteros-Merino, Shawn M. Jensen, Takashi Shimada, Hong-Ming Hu, Walter Urba, Rom Leidner, and Marcus Couey

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443 An immunotherapy trio in advanced HNSCC for coordinated B and T cell antigen response, Bernard A Fox, Tarsem Moudgil, Traci Hilton, Noriko Iwamoto, Christopher Paustian, Adi Mehta, Fridtjof Lund-Johansen, Rachel E Sanborn, Richard Bryan Bell, Madeline Laws, Glenna McDonnell, Yoshinobu Koguchi, Carlo Bifulco, Brian D. Piening, Carmen Ballesteros-Merino, Shawn M. Jensen, Takashi Shimada, Hong-Ming Hu, Walter Urba, Rom Leidner, and Marcus Couey

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Immunoscore as a parameter predicting time to recurrence and disease-free survival in T4N0 stage II colon cancer patients., Jerome Galon, Fabienne Hermitte, Bernhard Mlecnik, Alessandro Lugli, Carlo Bifulco, Iris D. Nagtegaal, Arndt Hartmann, Florence Marliot, Marc Van Den Eynde, Michael H.A. Roehrl, Pamela S. Ohashi, Eva Zavadova, Toshihiko Torigoe, Prabhudas S. Patel, Yili Wang, Yutaka Kawakami, Francesco Marincola, Paolo Antonio Ascierto, Bernard A Fox, and Franck Pages

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Complete Hemodynamic Profiling With Pulmonary Artery Catheters in Cardiogenic Shock Is Associated With Lower In-Hospital Mortality., A Reshad Garan, Manreet Kanwar, Katherine L Thayer, Evan Whitehead, Elric Zweck, Jaime Hernandez-Montfort, Claudius Mahr, Jillian L Haywood, Neil M Harwani, Detlef Wencker, Shashank S Sinha, Esther Vorovich, Jacob Abraham, William O'Neill, Daniel Burkhoff, and Navin K Kapur

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Complete Hemodynamic Profiling With Pulmonary Artery Catheters in Cardiogenic Shock Is Associated With Lower In-Hospital Mortality., A Reshad Garan, Manreet Kanwar, Katherine L Thayer, Evan Whitehead, Elric Zweck, Jaime Hernandez-Montfort, Claudius Mahr, Jillian L Haywood, Neil M Harwani, Detlef Wencker, Shashank S Sinha, Esther Vorovich, Jacob Abraham, William O'Neill, Daniel Burkhoff, and Navin K Kapur