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Submissions from 2022

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The Two Sides of Siponimod: Evidence for Brain and Immune Mechanisms in Multiple Sclerosis., Stanley Cohan, Ralph H B Benedict, Bruce A C Cree, John DeLuca, Le H Hua, and Jerold Chun

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Impact of oral health integration training on children's receipt of oral assessment, fluoride varnish and dental services., Hannah Cohen-Cline, Jannate Ahmed, Megan Holtorf, Laura McKeane, and Sarah Bartelmann

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Local Housing Choice Voucher Distribution Policies Impact Healthcare Utilization: a Randomized Natural Experiment., Hannah Cohen-Cline, Kyle G Jones, and Keri B Vartanian

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CT243 / 4 - Phase 1 study of TAK-676 + pembrolizumab following radiation therapy in patients with advanced non-small-cell lung cancer (NSCLC), triple-negative breast cancer (TNBC), or squamous-cell carcinoma of the head and neck (SCCHN), Benjamin Cooper, David B Page, and See full list of authors in comments

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TAK-676 in combination with pembrolizumab after radiation therapy in patients (pts) with advanced non–small cell lung cancer (NSCLC), triple-negative breast cancer (TNBC), or squamous-cell carcinoma of the head and neck (SCCHN): Phase 1 study design., Benjamin T. Cooper and David B Page

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Correlates of 90-Day Mortality Among People Who Do and Do Not Inject Drugs With Infective Endocarditis in Seattle, Washington., Maria A Corcorran, Jenell Stewart, Kristine Lan, Ayushi Gupta, Sara N Glick, Chetan Seshadri, Kevin J Koomalsingh, Edward F Gibbons, Robert D Harrington, Shireesha Dhanireddy, and H Nina Kim

IVIG Research Project, K Couch and ST Chiu

Automated Staging of Breast Cancer Histopathology Images Using Deep Learning, A Crabtree, N Naik, J Searcy, G Srinivasa, C Bifulco, K Matlock, and B Piening

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The Economic Impact of Lower Extremity Peri-Prosthetic Fractures in a Large Hospital System., James P Crutcher, Geoffrey Tompkins, Genevieve Rollier, Katie Sypher, Rebecca Valderrama, and Paul J Duwelius

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For Ethical Fundraising from Patients, Respect them as Partners., Brendan Curti

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Chapter 72: Cancer of the Skin, Brendan Curti, Sancy Leachman, and Walter Urba

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Intratumoral oncolytic virus V937 plus ipilimumab in patients with advanced melanoma: the phase 1b MITCI study., Brendan Curti, Jon Richards, John R Hyngstrom, Gregory A Daniels, Mark Faries, Lynn Feun, Kim A Margolin, Sigrun Hallmeyer, Mark Grose, Yiwei Zhang, Anlong Li, and Robert H I Andtbacka

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Development and validation of a model to calculate anesthetic agent consumption from inspired and end-expired concentrations, minute ventilation, fresh gas flow and dead space ventilation., Louise Cuveele, Jan F A Hendrickx, Andre M De Wolf, Sofie De Cooman, Brian B. Chesebro, Jeffrey Feldman, and Jodi Sherman

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Dose escalation of davoceticept, a conditional CD28 costimulator and dual checkpoint inhibitor, in advanced malignancies (NEON-1), Diwakar Davar, Rachel E Sanborn, and See full list of authors in comments

Phase 1 study of SEA-TGT, a human, nonfucosylated monoclonal antibody directed to TIGIT with enhanced immune effector function, in patients with advanced malignancies (SGNTGT-001, trial in progress), D Davar, Rachel E Sanborn, and See full list of authors in comments

Case: Stent Thrombosis – Attacked on All Fronts, C H. Davies

Case: Stent Thrombosis – Attacked on All Fronts, CH Davies

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Examining Acute Coronary Syndrome Across Ethnicity, Sex, and Age, Kristofer De Leon and Elizabeth Winokur

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Climate Change: A Crisis for Family Medicine Educators., Monica DeMasi, Bhargavi Chekuri, Heather L Paladine, and Tina Kenyon

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Transcatheter Aortic Valve Replacement for Severe Aortic Regurgitation in Patients With a Left Ventricular Assist Device., Ashwat S Dhillon, Brandon Jones, Robert W. Hodson, and Ethan C Korngold

PIVOT IO 001: First disclosure of efficacy and safety of bempegaldesleukin (BEMPEG) plus nivolumab (NIVO) vs NIVO monotherapy in advanced melanoma (MEL), A Diab, Brendan Curti, and See all authors in comments

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ASHP Foundation Pharmacy Forecast 2022: Strategic Planning Guidance for Pharmacy Departments in Hospitals and Health Systems., Joseph T DiPiro, Jannet M Carmichael, Vivian B Johnson, Monika N Daftary, Leyner Martinez, Michelle D Wiest, Binita Patel, Tom Woller, Elva Van Devender, Rita Shane, and Francesca Cunningham

546 A phase I dose escalation study of STEMVAC, a multi-antigen, multi-epitope Th1 selective plasmid-based vaccine, targeting stem cell associated proteins in patients with advanced breast cancer, Mary Disis, Sasha Stanton, and See all authors in comments

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Automatic Patient Matching for Genome-Guided Adoptive Cell Immunotherapy Trials at a Large Health System, Alexa K Dowdell, Tucker Bower, Benjamin Cosgrove, Roshanthi Weerasinghe, Ann Vita, Brian D. Piening, Carlo Bifulco, Eric Tran, and Rom Leidner

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OX40 agonist stimulation increases and sustains humoral and cell-mediated responses to SARS-CoV-2 protein and saRNA vaccines., Rebekka Duhen, Michael Beymer, Shawn M. Jensen, Srinivas Abbina, Suraj Abraham, Nikita Jain, Anitha Thomas, Andrew J Geall, Hong-Ming Hu, Bernard A Fox, and Andrew D Weinberg

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PD-1 and ICOS co-expression identifies tumor-reactive CD4 T cells in human solid tumors., Rebekka Duhen, Olivier Fesneau, Kimberly Samson, Alexandra K Frye, Michael Beymer, Venkatesh Rajamanickam, David Ross, Eric Tran, Brady Bernard, Andrew D Weinberg, and Thomas Duhen

OX40 boosts and sustains humoral and cellular immune responses to SARS-CoV-2 spike protein and RNA vaccinations, R Duhen, Bernard A Fox, Andrew D Weinberg, and See all authors in comments

Aperçu de l’immunothérapie et défis de l’immuno-oncologie, T Duhen

PD-1 and ICOS co-expression identifies tumor-reactive CD4 T cells in human solid tumors, Thomas Duhen

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Carfilzomib-Induced Thrombotic Microangiopathy: Focus on Pathogenesis., Odianosen Eigbire-Molen, Daniela Hermelin, and Douglas Blackall

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Real-world burden of chemotherapy-induced myelosuppression in patients with small cell lung cancer: a retrospective analysis of electronic medical data from community cancer care providers., Robert S. Epstein, Roshanthi Weerasinghe, Amy S. Parrish, JoAnn Krenitsky, Rachel E Sanborn, and Tehseen Salimi

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T Cells Engineered to Express Immunoreceptors Targeting the Frequently Expressed Medullary Thyroid Cancer Antigens Calcitonin, CEA, and RET M918T., Timothy A Erickson, Yi-Ping Shih, Joseph Fass, Myungkyu Jang, and Eric Tran

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Speaking Up for Patient Safety: Will Nurses Report Errors Now a Nurse Has Been Convicted of a Criminal Act?, Cyndi Evans, Jovie Jabla, Geary A Gardner, Taranjeet Rathore, and Elizabeth Ann Scruth

Aldosterone Blocking Agent In-Hospital Prescription Based on Implementation of the ACC Patient Navigator Program: Focus MI, C Eza-Nliam, Ty Gluckman, and See all authors in comments

Chapter: High-Sensitivity C-Reactive Protein, David I. Feldman, Roger S. Blumenthal, and Ty J. Gluckman

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A Phase II, Single-arm Trial of Sunitinib and Erlotinib in Advanced Renal Cell Carcinoma., Zizhen Feng, Brendan Curti, David I Quinn, John M Strother, Zunqiu Chen, Rebecca Agnor, Tomasz M Beer, and Christopher W Ryan

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Phase II Randomized Trial of Transoral Surgery and Low-Dose Intensity Modulated Radiation Therapy in Resectable p16+ Locally Advanced Oropharynx Cancer: An ECOG-ACRIN Cancer Research Group Trial (E3311)., Robert L Ferris, Yael Flamand, Gregory S Weinstein, Shuli Li, Harry Quon, Ranee Mehra, Joaquin J Garcia, Christine H Chung, Maura L Gillison, Umamaheswar Duvvuri, Bert W O'Malley, Enver Ozer, Giovana R Thomas, Wayne M Koch, Neil D Gross, Richard Bryan Bell, Nabil F Saba, Miriam Lango, Eduardo Méndez, and Barbara Burtness

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A Review of the Clinical and Cost Effectiveness of Intravenous and Intramuscular Pharmacological Treatment on Acute Agitation in Patients Admitted to the Emergency Department, Ryan Ferris and Carol Keller

Identification of a subset of tumor-reactive CD8 TILs expressing NKG2A in HNSCC and CRC., O Fesneau, Thomas Duhen, and See full list of authors in comments

Identification of a subset of tumor-reactive CD8 TIL expressing NKG2A in HNSCC and CRC, O Fesneau, K Samson, V Rajamanickam, D Ross, and Thomas Duhen

Post-Operative Mitral Valve Intervention Hemostasis in Patients that Receive Vitamin K Supplementation, Torin P. Fitton

40 years of experiences moving science from the bench to 1st in human clinical trials of immunotherapy and gene therapy, Bernard Fox

A Vision for Personalizing Treatments to Overcome Cancer’s Escape Mechanisms and Improve Outcomes for Patients, Bernard Fox

A Vision to Cure More Patients with Cancer by Better Identifying the Impact of Treatment and Modifying Therapy Appropriately, Bernard Fox

Cancer Vaccines: A Phoenix Rising from the Ashes, Bernard Fox

Combining 10x scRNA-seq and 100 plex mIF: Too much data or complimentary technologies to examine what works, Bernard Fox

Complex Cancer Vaccines: An Approach to Induce Immunity Against Gastroesophageal Malignancies in 2022, Bernard Fox

Comprehensive Spatial Phenotyping: Mapping the Tumor Microenvironment at Scale, Bernard Fox

Immune Activating and Cancer Vaccine Technology, Bernard Fox

Overview of Immunotherapy and Challenges for Immuno-Oncology, Bernard Fox

Progress in Cellular Immunotherapy - It is not Just Mutations: A Vision into Combinations to Expect in 2023 and Beyond, Bernard Fox

Evaluation of long-term anti-Spike immune response following a novel coronavirus vaccine (CORVax): electroporation of SARS-CoV-2 Spike plasmid DNA plus plasmid IL-12, Bernard A Fox

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Recommended phase 2 dose (RP2D) of HB-200 arenavirus-based cancer immunotherapies in patients with HPV16+ cancers., Siqing Fu, Rom Leidner, and Matthew H Taylor

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Functional status at 30 and 90 days after mild ischaemic stroke., Hannah Gardener, Leo A Romano, Eric E Smith, Iszet Campo-Bustillo, Yosef Khan, Sofie Tai, Nikesha Riley, Ralph L Sacco, Pooja Khatri, Heather M Alger, Brian Mac Grory, Deepak Gulati, Navdeep S Sangha, Karin E Olds, Curtis G Benesch, Adam G Kelly, Scott S Brehaut, Amit Kansara, Lee H Schwamm, and Jose G Romano

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Management of Anorectal Malformations and Hirschsprung Disease., Colin D Gause and Sanjay Krishnaswami

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Video game rehabilitation for outpatient stroke (VIGoROUS): A multi-site randomized controlled trial of in-home, self-managed, upper-extremity therapy., Lynne V Gauthier, Deborah S Nichols-Larsen, Gitendra Uswatte, Nancy Strahl, Marie Simeo, Rachel Proffitt, Kristina Kelly, Roger Crawfis, Edward Taub, David Morris, Linda Pax Lowes, Victor Mark, and Alexandra Borstad

A Phase 1 Study of TAK-676, a Novel STING Agonist, Plus Pembrolizumab Following Radiation Therapy in Patients with Advanced Non–Small-Cell Lung Cancer (NSCLC), Triple-Negative Breast Cancer (TNBC), or Squamous-Cell Carcinoma of the Head and Neck (SCCHN), NK Gerber, DB Page, and See all authors in comments

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A phase 2 study of an off-the-shelf, multi-neoantigen vector (ADXS-503) in patients with metastatic non–small cell lung cancer either progressing on prior pembrolizumab or in the first-line setting., Gregory James Gerstner, Rachel E Sanborn, and See full list of authors in comments

Safety Analyses of NRG BR004: A Randomized, Double-blind, Phase III Trial of Taxane/Trastuzumab/Pertuzumab with Atezolizumab or Placebo in First-line HER2-Postive Metastatic Breast Cancer (MBC), CE Geyer and DB Page

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Safety of Nivolumab Added to Chemoradiation Therapy Platforms for Intermediate and High-Risk Locoregionally Advanced Head and Neck Squamous Cell Carcinoma: Radiation Therapy Oncology Group Foundation 3504., Maura L Gillison, Robert L Ferris, Jonathan Harris, A Dimitrios Colevas, Loren K Mell, Christina Kong, Richard C Jordan, Kevin L Moore, Minh-Tam Truong, Claudia Kirsch, Arnab Chakravarti, Dukagjin M Blakaj, David A Clump, James P Ohr, John F Deeken, Michael F Gensheimer, Nabil F Saba, Jennifer A Dorth, David I Rosenthal, Rom S Leidner, Randall J Kimple, Mitchell Machtay, Walter J Curran, Pedro Torres-Saavedra, and Quynh Thu Le

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Housing and Reentry: A Mixed-Method Evaluation of a Low-Cost Community-Based Intervention for Increasing Access to Housing Post-Incarceration, Monique Gill, Kyle Jones, Ritu Ghosal, James M. Scanlan, and Emily J. Cox

Accelerating Cardiovascular Outcomes/Health Services Research Within Community-Based Health Systems-Lessons Learned and Steps Moving Forward, Ty J. Gluckman

Accelerating Cardiovascular Outcomes/Health Services Research Within Community-Based Health Systems-Lessons Learned and Steps Moving Forward, Ty J. Gluckman

Acute, Near-Term, and Long-Term Cardiovascular Sequelae of COVID-19, Ty J. Gluckman

Benefit and Barriers to New Quality Measures, Ty J. Gluckman

Cardiovascular Sequelae of COVID-19, Ty J. Gluckman

Cardiovascular Sequelae of COVID-19, Ty J. Gluckman

Cardiovascular Sequelae of COVID-19 in Adults: Myocarditis, Long COVID, and Return to Play, Ty J. Gluckman

Cost of Prevention—How Much is Too Much?, Ty J. Gluckman

Diversifying Patients in Clinical Trials--Approaches to Different Trial Designs, Ty J. Gluckman

Intersection of Antiplatelet and Anticoagulant Therapy-What to Do When a Patient Needs Both, Ty J. Gluckman

Ongoing Dilemmas with Surveillance and Diagnosis of Atrial Fibrillation, Ty J. Gluckman

Prevention and Treatment of COVID-19: A Review of the Current Data, Ty J. Gluckman

Referral to Advanced Heart Failure-A Key Component in Team-Based Care, Ty J. Gluckman

Target: Aortic Stenosis—Initiative Experience, Ty J. Gluckman

Treadmill, Nuclear Myocardial Perfusion Imaging (MPI), and Cardiac PET, Ty J. Gluckman

Stakeholder Perspectives - Clinical Care, Ty J. Gluckman, J Bachmann, H Chetan, ATS Sandhu, and C Porter

Accelerating Cardiovascular Outcomes/Health Services Research Within Community-Based Health Systems-Lessons Learned and Steps Moving Forward, Tyler J Gluckman

Accelerating Cardiovascular Outcomes/Health Services Research Within Community-Based Health Systems-Lessons Learned and Steps Moving Forward, Tyler J Gluckman

Accelerating Cardiovascular Outcomes/Health Services Research Within Community-Based Health Systems-Lessons Learned and Steps Moving Forward, Tyler J Gluckman

Cardiovascular Sequelae of COVID-19, Tyler J Gluckman

Cardiovascular Sequelae of COVID-19 (Long-COVID and Post-Acute Sequelae of SARS-CoV-2 Infection) CV Sequelae of COVID-19 in Adults: Myocarditis and Other Mycoardial Involvement, PASC, Tyler J Gluckman

Cost of Prevention—How Much is Too much?, Tyler J Gluckman

Do Registries Help Us or Cost Us, Tyler J Gluckman

Incorporating the 2021 AHA/ACC Chest Pain Guidelines Into My Clinical Practice, Tyler J Gluckman

Optimizing LDL-C: Individualizing Treatment Using Statins and Nonstatin Therapy, Tyler J Gluckman

Prevention and Treatment of COVID-19: A Review of the Current Data, Tyler J Gluckman

Treadmill, Nuclear Myocardial Perfusion Imaging (MPI), and Cardiac PET, Tyler J Gluckman

ACC Expert Consensus Decision Pathway of Bleeding Management in Patients on Oral Anticoagulant and Cost Implications, Tyler J Gluckman and See full list of authors in comments

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Polyunsaturated fatty acids, omega-3 fatty acids, and eicosapentaenoic acid- mechanisms of action, Tyler J Gluckman and See full list of authors in comments

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A phase 1b, multicenter, dose-escalation study of subasumstat (TAK-981) in combination with pembrolizumab in patients (pts) with advanced solid tumors., Sanjay Goel, Rachel E Sanborn, and See full list of authors in comments

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Safety and tolerability of MEDI0562, an OX40 agonist monoclonal antibody, in combination with durvalumab or tremelimumab in adult patients with advanced solid tumors., Jonathan W Goldman, Sarina A Piha-Paul, Brendan Curti, Katrina S Pedersen, Todd M Bauer, Stefanie L Groenland, Richard D Carvajal, Vaishali Chhaya, Gray Kirby, Kelly McGlinchey, Scott A Hammond, Katie L Streicher, Danielle Townsley, Young Kwang Chae, Jens Voortman, Aurelien Marabelle, and John Powderly

The Development and Dynamics of Pre-existing immunity in tumors, Michael Gough

Fluorescence tagging to monitor CD8 T cell recirculation from the tumor to the tumor-draining lymph node: the impact of focal radiation therapy on recirculation, Michael J. Gough

Tumor resident memory CD8 T cell formation and concomitant tumor immunity is CD40L dependent and CD4 independent, Michael J. Gough

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The paradox of radiation and T cells in tumors., Michael J. Gough and Marka R Crittenden

Tumor resident memory CD8 T cell formation and concomitant tumor immunity is CD40L dependent and CD4 independent., Michael J. Gough, Thomas Duhen, Marka R Crittenden, and See all authors in comments

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Differences in access to virtual and in-person primary care by race/ethnicity and community social vulnerability among adults diagnosed with COVID-19 in a large, multi-state health system., Diana J Govier, Hannah Cohen-Cline, Katherine Marsi, and Sarah E Roth

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Leveraging Healthcare System Data to Identify High-Risk Dyslipidemia Patients., Nayrana Griffith, Grace Bigham, Aparna Sajja, and Ty J Gluckman

Reproductive Health Features Associated with SCAD: A Report of the iSCAD Registry, A Grodzinsky, L Tam, and See all authors in comments