The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2023

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Multi-omics inference of differential breast cancer-related transcriptional regulatory network gene hubs between young Black and White patients., Boris Aguilar, Kawther Abdilleh, and George K Acquaah-Mensah

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Pertuzumab Plus Trastuzumab in Patients With Endometrial Cancer With, Eugene R Ahn, Michael Rothe, Pam K Mangat, Elizabeth Garrett-Mayer, Hussein M Ali-Ahmad, John Chan, Michael L Maitland, Sapna R Patel, Zachary Reese, Ani S Balmanoukian, Charles W Drescher, Rui Li, Apostolia M Tsimberidou, Charles A Leath, Raegan O'Lone, Gina N Grantham, Susan Halabi, and Richard L Schilsky

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AAPM BTSC Report 377: Physicist Brachytherapy Training in 2021-A survey of therapeutic medical physics residency program directors., Manik Aima, Samantha J Simiele, Susan L Richardson, and Christopher S Melhus

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Liquid biopsies and minimal residual disease in myeloid malignancies., Sabine Allam, Kristina Nasr, Farhan Khalid, Zunairah Shah, Mahammed Ziauddin Khan Suheb, Sana Mulla, Sindhu Vikash, Maroun Bou Zerdan, Faiz Anwer, and Chakra P Chaulagain

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Vemurafenib- and Cobimetinib-Associated Drug Reaction With Eosinophilia and Systemic Symptoms in a Patient With Metastatic Melanoma., Miriam Al-Saedy, Salsabeal Al-Saedy, and Chad Rieck

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Gut microbiota analyses of inflammatory bowel diseases from a representative Saudi population., Raed M Alsulaiman, Abdulaziz A Al-Quorain, Fahad A Al-Muhanna, Stanley Piotrowski, Ezzeddin A Kurdi, Chittibabu Vatte, Ahmed A Alquorain, Noorah H Alfaraj, Abdulaziz M Alrezuk, Fred L Robinson, Alexa K Dowdell, Turki A Alamri, Lauren Hamilton, Hetal Lad, Hui Gao, Divya Gandla, Brendan J Keating, Ryan Meng, Brian D. Piening, and Amein K Al-Ali

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Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 1st-3rd, 2022-Naples, Italy)., Paolo A Ascierto, Sanjiv S Agarwala, Allison Betof Warner, Marc S Ernstoff, Bernard A Fox, Thomas F Gajewski, Jérôme Galon, Claus Garbe, Brian R Gastman, Jeffrey E Gershenwald, Pawel Kalinski, Michelle Krogsgaard, Rom S Leidner, Roger S Lo, Alexander M Menzies, Olivier Michielin, Poulikos I Poulikakos, Jeffrey S Weber, Corrado Caracò, Iman Osman, Igor Puzanov, and Magdalena Thurin

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The "Great Debate" at Immunotherapy Bridge 2022, Naples, November 30th-December 1st, 2022., Paolo A Ascierto, Renier Brentjens, Samir N Khleif, Kunle Odunsi, Katayoun Rezvani, Marco Ruella, Ryan J Sullivan, Bernard A Fox, and Igor Puzanov

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Nivolumab and Relatlimab in Patients With Advanced Melanoma That Had Progressed on Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy: Results From the Phase I/IIa RELATIVITY-020 Trial., Paolo Antonio Ascierto, Evan J Lipson, Reinhard Dummer, James Larkin, Georgina V Long, Rachel E Sanborn, Vanna Chiarion-Sileni, Brigitte Dréno, Stéphane Dalle, Dirk Schadendorf, Margaret K Callahan, Marta Nyakas, Victoria Atkinson, Carlos Alberto Gomez-Roca, Naoya Yamazaki, Hussein A Tawbi, Naomey Sarkis, Deepti Warad, Sonia Dolfi, Priyam Mitra, Satyendra Suryawanshi, and Jean-Jacques Grob

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Rare presence of Charcot-Leyden crystals in acute myeloid leukemia., Sujan Badal, Mahnoosh Taheri, Peter Jiang, and Kirstine Oh

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An expanded safety/feasibility study of the EMulate Therapeutics Voyager™ System in patients with recurrent glioblastoma., Garni Barkhoudarian, Michael Badruddoja, Nicholas Blondin, Sajeel Chowdhary, Charles Cobbs, Julius Paul Duic, John Paul Flores, Ekokobe Fonkem, Edward McClay, Louis Burt Nabors, Michael Salacz, Lynn Taylor, Brian Vaillant, Jaya Gill, and Santosh Kesari

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Health-care expenditures are less for minimally invasive than open colectomy for colon cancer: A US commercial claims database analysis., Amir L Bastawrous, I-Fan Shih, Yanli Li, Marissa Khalil, Biruk Almaz, and Robert K Cleary

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A Rare Case of Demodicosis Following Treatment With Oral Fluconazole., Joshua A Bezecny, Emily Bolton, Matthew H Taylor, and Elizabeth G Berry

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Doubling down on the future of gynecologic oncology: The SGO future of the profession summit report., Stephanie V Blank, Warner K Huh, Maria Bell, Sarah Dilley, Melissa Hardesty, Ebony R Hoskins, Jason Lachance, Fernanda Musa, Emily Prendergast, B J Rimel, Mark Shahin, and Fidel Valea

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spongEffects: ceRNA modules offer patient-specific insights into the miRNA regulatory landscape., Fabio Boniolo, Markus Hoffmann, Norman Roggendorf, Bahar Tercan, Jan Baumbach, Mauro A A Castro, A Gordon Robertson, Dieter Saur, and Markus List

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ASO Visual Abstract: Changes in Surgical Management of the Axilla Over 11 Years-Report on Over 1500 Breast Cancer Patients Treated with Neoadjuvant Chemotherapy on the Prospective I-SPY2 Trial., Judy C Boughey, Hongmei Yu, Catherine Lu Dugan, Mara A Piltin, Lauren Postlewait, Jennifer D Son, Kirsten K Edmiston, Constantine Godellas, Marie C Lee, Michael J Carr, Jennifer E Tonneson, Angelena Crown, Rachel B Lancaster, Hannah E Woriax, Cheryl A Ewing, Harrison S Chau, Anne K Patterson, Jasmine M Wong, Michael D Alvarado, Rachel L Yang, Theresa W Chan, Jori B Sheade, Gretchen M Ahrendt, Kelsey E Larson, Kayla Switalla, Todd M Tuttle, Julia C Tchou, Roshni Rao, Nina Tamirisa, Puneet Singh, Rebekah E Gould, Alicia Terando, Candice Sauder, Kelly Hewitt, Akiko Chiba, Laura J Esserman, and Rita Mukhtar

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Changes in Surgical Management of the Axilla Over 11 Years - Report on More Than 1500 Breast Cancer Patients Treated with Neoadjuvant Chemotherapy on the Prospective I-SPY2 Trial., Judy C Boughey, Hongmei Yu, Catherine Lu Dugan, Mara A Piltin, Lauren Postlewait, Jennifer D Son, Kirsten K Edmiston, Constantine V Godellas, Marie C Lee, Michael J Carr, Jennifer E Tonneson, Angelena Crown, Rachel B Lancaster, Hannah E Woriax, Cheryl A Ewing, Harrison S Chau, Anne K Patterson, Jasmine M Wong, Michael D Alvarado, Rachel L Yang, Theresa W Chan, Jori B Sheade, Gretchen M Ahrendt, Kelsey E Larson, Kayla Switalla, Todd M Tuttle, Julia C Tchou, Roshni Rao, Nina Tamirisa, Puneet Singh, Rebekah E Gould, Alicia Terando, Candice Sauder, Kelly Hewitt, Akiko Chiba, Laura J Esserman, and Rita A Mukhtar

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Phase I trial of intravenous fenretinide (4-HPR) plus safingol in advanced malignancies., Alexis C Boulter, Barry J Maurer, Meredith Pogue, Min H Kang, Hwangeui Cho, Amanda Knight, C Patrick Reynolds, Donald Quick, Sanjay Awasthi, and David E Gerber

Lucchesi O, Ruete MC, Mayorga LS, and Tomes CN, MA Bustos

The 16th International Congress of the Society for Melanoma Research (SMR), November 20-23, 2019, MA Bustos

Diagnostic cell-free miRNA Signatures Found in Plasma and Urine of Sporadic Renal Cell Carcinoma Patients, MA Bustos, J Gottlieb, R Suyeon, WM Allen, DL Krasne, TG Wilson, JA Linehan, and DSB Hoon

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Incorporating radioligand therapy in clinical practice in the United States for patients with prostate cancer., Jeremie Calais, Stephen M Eulau, Linda Gardner, Ralph J Hauke, Ayse T Kendi, Neal D Shore, and Song Zhao

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Clinical Best Practices for Radiation Safety During Lutetium-177 Therapy., Derek John Cappon, Susanna Fang, Kendall Berry, Gina Capone, Gina L Carlton, Mario Chrétien, John Gough, Jacob Kamen, Anne Khoorshed, Andy Miller, Stephen Nelli, M Peter Petric, Frank Tourneur, and Josip J Zic

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CT275 / 15 - Phase 1 clinical update of allogeneic invariant natural killer T cells (iNKTs), agenT-797, alone or in combination with pembrolizumab or nivolumab in patients with advanced solid tumors, B Carneiro

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CT275 / 15 - Phase 1 clinical update of allogeneic invariant natural killer T cells (iNKTs), agenT-797, alone or in combination with pembrolizumab or nivolumab in patients with advanced solid tumors, B Carneiro, Rachel E Sanborn, and See full list of authors in comments

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New Technology for the Breast Surgeon., Michele Carpenter and Julie Le

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Partial or radical nephrectomy for complex renal mass: a comparative analysis of oncological outcomes and complications from the ROSULA (Robotic Surgery for Large Renal Mass) Collaborative Group., Clara Cerrato, Devin Patel, Riccardo Autorino, Giuseppe Simone, Bo Yang, Robert Uzzo, Francesco Porpiglia, Umberto Capitanio, James Porter, Alp Tuna Beksac, Andrea Minervini, Alessandro Antonelli, Maria Angela Cerruto, Clayton Lau, Akbar Ashrafi, Daniel Eun, Alexandre Mottrie, Carmen Mir, Margaret F Meagher, Dhruv Puri, Mimi Nguyen, Sohail Dhanji, Franklin Liu, Savio D Pandolfo, Alexander Kutikov, Francesco Montorsi, Inderbir S Gill, Chandru Sundaram, Jihad Kaouk, and Ithaar H Derweesh

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Safety and Efficacy Outcomes From a Single-Center Study of Image-Guided Percutaneous Microwave Ablation for Primary and Metastatic Lung Malignancy., Stephen M Chan, Peter J Julien, Peter Kaganjo, Robert McKenna, Charles Forscher, Ronald Natale, Robert N Wolfe, Kristi Butenschoen, Rene J Siegel, and James Mirocha

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Secondary Breast Angiosarcoma After a Primary Diagnosis of Breast Cancer: A Retrospective Analysis of the Surveillance, Epidemiology, and End Results (SEER) Database., Bonny Chau, Elizabeth T Loggers, Lee D Cranmer, Harveshp Mogal, Jeremy M Sharib, Edward Y Kim, Stephanie K Schaub, Kelly G Paulson, Hannah M Linden, Jennifer M Specht, Janice N Kim, Sara H Javid, and Michael J Wagner

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A heterodimer of α and β hemoglobin chains functions as an innate anticancer agent., Maharrish Chelladurai, Dan Xu, Sivan Izraely, Shlomit Ben-Menachem, Roman Bengaiev, Orit Sagi-Assif, Weirong Yuan, Metsada Pasmanik Chor, Dave S Hoon, Wuyuan Lu, and Isaac P Witz

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Mosaic chromosomal alterations is associated with increased lung cancer risk: insight from the INTEGRAL-ILCCO cohort analysis., Chao Cheng, Wei Hong, Yafang Li, Xiangjun Xiao, James McKay, Younghun Han, Jinyoung Byun, Bo Peng, Demetrios Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Stig E Bojesen, Maria T Landi, Mattias Johansson, Angela Risch, Heike Bickeböller, H-Erich Wichmann, David C Christiani, Gad Rennert, Susanne Arnold, Gary E Goodman, John K Field, Michael Pa Davies, Sanjay S Shete, Loic Le Marchand, Geoffrey Liu, Rayjean J Hung, Angeline S Andrew, Lambertus A Kiemeney, Meng Zhu, Hongbing Shen, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Angela Cox, Yun-Chul Hong, Jian-Min Yuan, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Paul Brennan, Yong Li, Olga Gorlova, Ivan Gorlov, and Christopher I Amos

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Amivantamab plus lazertinib in osimertinib-relapsed EGFR-mutant advanced non-small cell lung cancer: a phase 1 trial., Byoung Chul Cho, Dong-Wan Kim, Alexander I Spira, Jorge E Gomez, Eric B Haura, Sang-We Kim, Rachel E Sanborn, Eun Kyung Cho, Ki Hyeong Lee, Anna Minchom, Jong-Seok Lee, Ji-Youn Han, Misako Nagasaka, Joshua K Sabari, Sai-Hong Ignatius Ou, Patricia Lorenzini, Joshua M Bauml, Joshua C Curtin, Amy Roshak, Grace Gao, John Xie, Meena Thayu, Roland E Knoblauch, and Keunchil Park

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Consensus classification of pediatric hepatocellular tumors: A report from the Children's Hepatic tumors International Collaboration (CHIC)., Soo-Jin Cho, Sarangarajan Ranganathan, Rita Alaggio, Rudolf Maibach, Yukichi Tanaka, Takeshi Inoue, Ivo Leuschner, Ronald de Krijger, Christian Vokuhl, Mark Krailo, Marcio Malogolowkin, Rebecka Meyers, Piotr Czauderna, Eiso Hiyama, Marc Ansari, Bruce Morland, Angela Trobaugh-Lotrario, Allison F O'Neill, Arun Rangaswami, Beate Häberle, and Dolores López-Terrada

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Belzutifan plus cabozantinib for patients with advanced clear cell renal cell carcinoma previously treated with immunotherapy: an open-label, single-arm, phase 2 study., Toni K Choueiri, David F McDermott, Jaime Merchan, Todd M Bauer, Robert Figlin, Elisabeth I Heath, M Dror Michaelson, Edward Arrowsmith, Anishka D'Souza, Song Zhao, Ananya Roy, Rodolfo Perini, Donna Vickery, and Scott S Tykodi

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Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis., William Chour, Jongchan Choi, Jingyi Xie, Mary E Chaffee, Thomas M Schmitt, Kathryn Finton, Diana C DeLucia, Alexander M Xu, Yapeng Su, Daniel G Chen, Rongyu Zhang, Dan Yuan, Sunga Hong, Alphonsus H C Ng, Jonah Z Butler, Rick A Edmark, Lesley C Jones, Kim M Murray, Songming Peng, Guideng Li, Roland K Strong, John K Lee, Jason D Goldman, Philip D Greenberg, and James R Heath

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Clinician-Performed Thyroid Fine Needle Aspiration With On-Site Review Improves Diagnostic Yield., Isabelle Chu, Oliver Bellevue, Joseph C Sniezek, and Nuria Perez-Reyes

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Patterns of utilization and clinical adoption of 0.35 Tesla MR-guided radiation therapy in the United States - Understanding the transition to adaptive, ultra-hypofractionated treatments., Michael D Chuong, Mary Ann Clark, Lauren E Henke, Amar U Kishan, Lorraine Portelance, Parag J Parikh, Michael F Bassetti, Himanshu Nagar, Stephen A Rosenberg, Minesh P Mehta, Tamer Refaat, Justin M Rineer, Adam Smith, Steven Seung, Bassem I Zaki, Martin Fuss, and Raymond H Mak

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Abstract CT123: Trial in progress: First-in-human immunotherapy-trio for advanced head and neck squamous cell carcinoma, MA Couey, Matthew H Taylor, William L. Redmond, Brady Bernard, Richard Bryan Bell, Carlo Bifulco, Brian D. Piening, Walter Urba, Bernard A Fox, and Rom Leidner

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Phase 1 dose-escalation study of SEA-CD40: a non-fucosylated CD40 agonist, in advanced solid tumors and lymphomas., Andrew L Coveler, David C Smith, Tycel Phillips, Brendan D Curti, Sanjay Goel, Amitkumar N Mehta, Timothy M Kuzel, Svetomir N Markovic, Olivier Rixe, David L Bajor, Thomas F Gajewski, Martin Gutierrez, Hun Ju Lee, Ajay K Gopal, Paolo Caimi, Elisabeth I Heath, John A Thompson, Sahar Ansari, Celine Jacquemont, Ariel Topletz-Erickson, Peigen Zhou, Michael W Schmitt, and Juneko E Grilley-Olson

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Disparity in Breast Cancer Care: Current State of Access to Screening, Genetic Testing, Oncofertility, and Reconstruction., Angelena Crown, Soudabeh Fazeli, Allison W Kurian, Daniela A Ochoa, and Kathie-Ann Joseph

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Pregnancy-associated breast cancer: does timing of presentation affect outcome?, Angelena Crown, Damian McCartan, Michael A Curry, Sujata Patil, Sabrina Kamer, Shari Goldfarb, and Mary L Gemignani

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Comparison of robotic versus laparoscopic right colectomy node retrieval in the obese population., Karleigh R Curfman, Jessica M Gowing, Ruben M Lesnick, James M Scanlan, Ulrik G Wallin, John A Griffin, and Laila Rashidi

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Capicua (CIC) mutations in gliomas in association with MAPK activation for exposing a potential therapeutic target., Sourat Darabi, Joanne Xiu, Timothy Samec, Santosh Kesari, Jose Carrillo, Sonikpreet Aulakh, Kyle M Walsh, Soma Sengupta, Ashley Sumrall, David Spetzler, Michael Glantz, and Michael J Demeure

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Practical considerations when providing palliative care to patients with neuroendocrine tumors in the context of routine disease management or hospice care., Jaydira Del Rivero, Josh Mailman, Michael W Rabow, Jennifer A Chan, Sarah Creed, Hagen F Kennecke, Janice Pasieka, Jennifer Zuar, Simron Singh, and Lauren Fishbein

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Bempegaldesleukin Plus Nivolumab in Untreated Advanced Melanoma: The Open-Label, Phase III PIVOT IO 001 Trial Results., Adi Diab, Helen Gogas, Shahneen Sandhu, Georgina V Long, Paolo A Ascierto, James Larkin, Mario Sznol, Fabio Franke, Tudor E Ciuleanu, Caio Pereira, Eva Muñoz Couselo, Fernanda Bronzon Damian, Michael Schenker, Aldo Perfetti, Celeste Lebbe, Gaëlle Quéreux, Friedegund Meier, Brendan Curti, Carlos Rojas, Yull Arriaga, Haisu Yang, Ming Zhou, Shruthi Ravimohan, Paul Statkevich, Mary A Tagliaferri, and Nikhil I Khushalani

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Immunotherapy for brain metastases and primary brain tumors., Anna M Di Giacomo, Maximilian J Mair, Michele Ceccarelli, Andrea Anichini, Ramy Ibrahim, Michael Weller, Michael Lahn, Alexander M M Eggermont, Bernard Fox, and Michele Maio

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Impact of Variant Histology on Oncological Outcomes in Upper Tract Urothelial Carcinoma: Results From the ROBUUST Collaborative Group., Antoin Douglawi, Alireza Ghoreifi, Umberto Carbonara, Wesley Yip, Robert G Uzzo, Vitaly Margulis, Matteo Ferro, Ottavio De Cobelli, Zhenjie Wu, Giuseppe Simone, Riccardo Mastroianni, Koon H Rha, Daniel D Eun, Adam C Reese, James R Porter, Ithaar Derweesh, Reza Mehrazin, Giuseppe Rosiello, Riccardo Tellini, Marcus Jamil, Alexander Kenigsberg, Jason M Farrow, William P Schrock, Giovanni Cacciamani, Abhishek Srivastava, Amit S Bhattu, Alexandre Mottrie, Mark L Gonzalgo, Chandru P Sundaram, Firas Abdollah, Andrea Minervini, Riccardo Autorino, and Hooman Djaladat

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Pembrolizumab in Patients With Tumors With High Tumor Mutational Burden: Results From the Targeted Agent and Profiling Utilization Registry Study., Herbert L Duvivier, Michael Rothe, Pam K Mangat, Elizabeth Garrett-Mayer, Eugene R Ahn, Tareq Al Baghdadi, Ajjai S Alva, Stephanie A Dublis, Timothy L Cannon, Carmen J Calfa, Rui Li, Deepti Behl, Vi K Chiu, Philip J Gold, Alissa S Marr, Kathryn F Mileham, Steven Francis Powell, Jordi Rodon, Ramya Thota, Gina N Grantham, Abigail Gregory, Dominique C Hinshaw, Susan Halabi, and Richard L Schilsky

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Results from a phase 1a/1b study of botensilimab (BOT), a novel innate/adaptive immune activator, plus balstilimab (BAL; anti-PD-1 antibody) in metastatic heavily pretreated microsatellite stable colorectal cancer (MSS CRC)., Anthony B. El-Khoueiry, K A Margolin, Rachel E Sanborn, and See all authors in comments

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Clinical Activity of Combined Telomerase Vaccination and Pembrolizumab in Advanced Melanoma: Results from a Phase I Trial., Espen B Ellingsen, Steven O'Day, Artur Mezheyeuski, Agnieszka Gromadka, Trevor Clancy, Timothy S Kristedja, Mohammed Milhem, and Yousef Zakharia

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Construction and validation of a gene expression classifier to predict immunotherapy response in primary triple-negative breast cancer., Miquel Ensenyat-Mendez, Javier I J Orozco, Pere Llinàs-Arias, Sandra Íñiguez-Muñoz, Jennifer L Baker, Matthew P Salomon, Mercè Martí, Maggie L DiNome, Javier Cortés, and Diego M Marzese

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Pembrolizumab plus Chemotherapy in Advanced Endometrial Cancer., Ramez N Eskander, Michael W Sill, Lindsey Beffa, Richard G Moore, Joanie M Hope, Fernanda Musa, Robert Mannel, Mark S Shahin, Guilherme H Cantuaria, Eugenia Girda, Cara Mathews, Juraj Kavecansky, Charles A Leath, Lilian T Gien, Emily M Hinchcliff, Shashikant B Lele, Lisa M Landrum, Floor Backes, Roisin E O'Cearbhaill, Tareq Al Baghdadi, Emily K Hill, Premal H Thaker, Veena S John, Stephen Welch, Amanda N Fader, Matthew A Powell, and Carol Aghajanian

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Regarding: "Predicting Regional Lymph Node Recurrence in the Modern Age of Tumor-Positive Sentinel Node Melanoma," by Faries, Mark et al., Richard Essner and Jennifer Keller

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Objective assessment of intraoperative skills for robot-assisted partial nephrectomy (RAPN)., Rui Farinha, Alberto Breda, James Porter, Alexandre Mottrie, Ben Van Cleynenbreugel, Jozef Vander Sloten, Angelo Mottaran, and Anthony G Gallagher

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Overall survival with adjuvant atezolizumab after chemotherapy in resected stage II-IIIA non-small-cell lung cancer (IMpower010): a randomised, multicentre, open-label, phase III trial., E Felip, N Altorki, C Zhou, Eric Vallieres, A Martínez-Martí, A Rittmeyer, A Chella, M Reck, O Goloborodko, M Huang, R Belleli, V McNally, M K Srivastava, E Bennett, B J Gitlitz, and H A Wakelee

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Multidimensional biomarker predicts disease control in response to immunotherapy in recurrent or metastatic head and neck squamous-cell carcinoma., Kevin C Flanagan, Jon Earls, Ian Schillebeeckx, Jeffrey Hiken, Rachel L Wellinghoff, Natalie A LaFranzo, Zachary S Bradley, Joey Babbitt, William H Westra, Raymond Hsu, Lincoln Nadauld, Howard Mcleod, Sean D Firth, Brittany Sharp, Josh Fuller, Vera Vavinskaya, Leisa Sutton, Ida Deichaite, Samuel D Bailey, Vlad C Sandulache, Matthew J Rendo, Orlan K Macdonald, Karim Welaya, James L Wade, Andrew W Pippas, Jennifer Slim, Bruce Bank, Steven J Saccaro, Xingwei Sui, Adil Akhtar, Savitha Balaraman, Steven E Kossman, Scott A Sonnier, Todd D Shenkenberg, Warren L Alexander, Katherine A Price, Charles L Bane, Jessica Ley, David N Messina, Jarret I Glasscock, Ezra E W Cohen, Douglas R Adkins, and Eric J Duncavage

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Abstract 4876: A systems pharmacology approach to discover synergistic targeted therapy combinations, Cameron T. Flower, Chunmei Liu, James R Heath, Wei Wei, and Forest M. White

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American Society for Gastrointestinal Endoscopy guideline on endoscopic submucosal dissection for the management of early esophageal and gastric cancers: summary and recommendations., Nauzer Forbes, Sherif E Elhanafi, Mohammad A Al-Haddad, Nirav C Thosani, Peter V Draganov, Mohamed O Othman, Eugene P Ceppa, Vivek Kaul, Michael M Feely, Ilyas Sahin, James L Buxbaum, Audrey H Calderwood, Jean M Chalhoub, Nayantara Coelho-Prabhu, Madhav Desai, Larissa L Fujii-Lau, Divyanshoo R Kohli, Richard S Kwon, Jorge D Machicado, Neil B Marya, Swati Pawa, Wenly Ruan, Sunil G Sheth, Andrew C Storm, Nikhil R Thiruvengadam, and Bashar J Qumseya

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Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies., Bernard A Fox, Walter J Urba, Shawn M Jensen, David B Page, Brendan D Curti, Rachel E Sanborn, and Rom S Leidner

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Abstract 901: Monitoring of Neoantigens and Adoptively Transferred Personalized NeoTCR T Cell Populations in the Tumor and PBMCs of Patients with Solid Tumors, Susan Foy, Cliff Wang, Benjamin Yuen, Sara Said, Boi Quach, Jonathan Hoover, Saparya Nayak, Theresa Hunter, Zheng Pan, Chad Smith, Tyler Borrman, Eric Stawiski, Alphonsus H.C. Ng, Yue Lu, James R Heath, and Stefanie Mandl

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Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion., Yasunari Fukuda, Sun-Hee Kim, Matias A Bustos, Sung-Nam Cho, Jason Roszik, Jared K Burks, Hong Kim, Dave S B Hoon, Elizabeth A Grimm, and Suhendan Ekmekcioglu

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Spatial profiling of cancer-associated fibroblasts of sporadic early onset colon cancer microenvironment., Satoru Furuhashi, Matias A Bustos, Shodai Mizuno, Suyeon Ryu, Yalda Naeini, Anton J Bilchik, and Dave SB Hoon

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Pertuzumab Plus Trastuzumab in Patients With Lung Cancer With ERBB2 Mutation or Amplification: Results From the Targeted Agent and Profiling Utilization Registry Study, Apar K Ganti, Michael Rothe, Pam K Mangat, Elizabeth Garrett-Mayer, Elie G Dib, Herbert L Duvivier, Eugene R Ahn, Deepti Behl, Hossein Borghaei, Ani S Balmanoukian, Anu Gaba, Rui Li, Kwabena Osei-Boateng, Ramya Thota, Gina N Grantham, Abigail Gregory, Susan Halabi, and Richard L Schilsky

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Robot-assisted retroperitoneal lymph node dissection: a systematic review of perioperative outcomes., Harshit Garg, Ahmed M Mansour, Sarah P Psutka, Simon P Kim, James Porter, Christine S Gaspard, Furkan Dursun, Deepak K Pruthi, Hanzhang Wang, and Dharam Kaushik

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Feasibility of intraoperative injection of radioactive tracer and blue dye for sentinel lymph node biopsy in vulvar cancer., Alison A Garrett, Jason Ricciuti, Susan M Lang, Mary E Burriss, Margaret Flanigan, Emily O'Brien, Casey Hay, Jamie Lesnock, Jessica L Berger, and Sarah E Taylor

13. Long-term efficacy, safety and predictors of response to amivantamab among patients with post-platinum EGFR exon 20 insert (Ex20ins)-mutated advanced non-small cell lung cancer (aNSCLC) — CHRYSALIS (NCT02609776), P Garrido, Rachel E Sanborn, and See full list of authors in comments

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Timing and duration of bevacizumab treatment and survival in patients with recurrent ovarian, fallopian tube, and peritoneal cancer: a multi-institution study., Talayeh S Ghezelayagh, Emily S Wu, Emma L Barber, Minh D Dao, Emese Zsiros, Renata R Urban, Heidi J Gray, Barbara A Goff, Chirag A Shah, Nikki L Neubauer, James Y Dai, Janos L Tanyi, and John B Liao

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Safety and Outcomes of Outpatient Pleural Drainage in Symptomatic Postoperative Cardiac Surgery Patients., Christopher R Gilbert, Austin M Meggyesy, Adam J Bograd, Shih Ting Chiu, Candice L Wilshire, and Jed A Gorden

The presence of targetable mutations in metastatic non-small cell lung cancer patients with malignant pleural disease is not associated with improved survival The American Thoracic Society Washington, DC, CR Gilbert, CL Wilshire, and See all authors in comments

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Mammogram perceptions, communication, and gaps in care among individuals with non-English language preference in Oregon and Washington states., Monique Gill, Hannah Cohen-Cline, Megan Holtorf, and Keri Vartanian

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Characterization of Lymph Node Tumor Burden in Node-Positive Prostate Cancer Patients after Robotic-Assisted Radical Prostatectomy with Extended Pelvic Lymph Node Dissection., Josh Gottlieb, Shu-Ching Chang, Jane Choe, Gary Grunkemeier, Douglas Hanes, David L Krasne, Dave S B Hoon, and Timothy G Wilson

“Impact of Her2 Low on Survival in Patients Treated with Standard Therapies in Advanced Breast Cancer”, SL Graff, Bansal Rani, Adeyelu Tolulope, Elliott Andrew, Walker Phillip, MA Bustos, Rodriguez Estelamari, and See full list of authors in comments

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Newly Approved and Emerging Agents in HER2-Positive Metastatic Breast Cancer., Stephanie L Graff, Fengting Yan, and Yara Abdou

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Extraordinary clinical response to ibrutinib in low-grade ovarian cancer guided by organoid drug testing., Heidi J Gray, Payel Chatterjee, Rachele Rosati, Lauren R Appleyard, Grace J Durenberger, Robert L Diaz, Hallie A Swan, Danielle Peretti, Maddy Pollastro, Trevor Ainge, Katannya Kapeli, Shalini Pereira, Astrid L Margossian, Kalyan Banda, Barbara A Goff, Elizabeth M Swisher, Brady Bernard, Christopher J Kemp, and Carla Grandori

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Evidence-based procedures to improve the reliability of circulating miRNA biomarker assays., Sarah R Greytak, Kelly B Engel, Dave S B Hoon, Kevin M Elias, Christina M Lockwood, Ping Guan, and Helen M Moore

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HN-CLEAR: Head and Neck Consensus Language for Ease and Reproducibility, a Multidisciplinary Consensus Mechanism for Head and Neck Pathology., Ruta Gupta, Munita Bal, Justin A Bishop, Keith D Hunter, Kelly Magliocca, Raja R Seethala, Lester D R Thompson, Ilan Weinreb, Peter Angelos, Beth Beadle, R Bryan Bell, Jonathan R Clark, Robert Ferris, Shao Hui Huang, D Neil Hayes, Rahul Ladwa, Jean Yang, Nicole A Cipriani, Brenda L Nelson, Peter M Sadow, and James S Lewis

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A large-scale targeted proteomics of serum and tissue shows the utility of classifying high grade and low grade meningioma tumors., Ankit Halder, Deeptarup Biswas, Aparna Chauhan, Adrita Saha, Shreeman Auromahima, Deeksha Yadav, Mehar Un Nissa, Gayatri Iyer, Shashwati Parihari, Gautam Sharma, Sridhar Epari, Prakash Shetty, Aliasgar Moiyadi, Graham Roy Ball, and Sanjeeva Srivastava

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Sentinel lymphatic mapping for gynecologic malignancies., Anjali Y Hari and Krishnansu S Tewari

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Randomized phase II trial of farletuzumab plus chemotherapy versus placebo plus chemotherapy in low CA-125 platinum-sensitive ovarian cancer., Thomas J Herzog, Sandro Pignata, Sharad A Ghamande, Maria-Jesús Rubio, Keiichi Fujiwara, Christof Vulsteke, Deborah K Armstrong, Jalid Sehouli, Robert L Coleman, Hani Gabra, Giovanni Scambia, Bradley J Monk, José A Arranz, Kimio Ushijima, Rabbie Hanna, Claudio Zamagni, Robert M Wenham, Antionio González-Martín, Brian Slomovitz, Yan Jia, Lisa Ramsay, Krishnansu S Tewari, Susan C Weil, and Ignace B Vergote

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T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants., Daniel Hirschhorn, Sadna Budhu, Lukas Kraehenbuehl, Mathieu Gigoux, David Schröder, Andrew Chow, Jacob M Ricca, Billel Gasmi, Olivier De Henau, Levi Mark B Mangarin, Yanyun Li, Linda Hamadene, Anne-Laure Flamar, Hyejin Choi, Czrina A Cortez, Cailian Liu, Aliya Holland, Sara Schad, Isabell Schulze, Allison Betof Warner, Travis J Hollmann, Arshi Arora, Katherine S Panageas, Gabrielle A Rizzuto, Rebekka Duhen, Andrew D Weinberg, Christine N Spencer, David Ng, Xue-Yan He, Jean Albrengues, David Redmond, Mikala Egeblad, Jedd D Wolchok, and Taha Merghoub

Monitoring 1q21.3 amplification in circulating tumor DNA from metastatic melanoma patients receiving immune checkpoint inhibitor therapies, DSB Hoon, SY Lin, Y Kobayashi, X Zhang, Q Yu, S O’Day, and MA Bustos

“UBQLN4 triggers MRE11a and STING proteasomal degradation during cisplatin-induced DNA damage response in solid tumors, DSB Hoon, Y Shiloh, T Murakami, Y Kobayashi, R Jachimowicz, and MA Bustos

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Organotypic Models for Functional Drug Testing of Human Cancers, Yu Ling Huang, Lindsay K. Dickerson, Heidi Kenerson, Xiuyun Jiang, Venu Pillarisetty, Qiang Tian, Leroy Hood, Taranjit S. Gujral, and Raymond S. Yeung

Pan-cancer associations of B7-H3 (CD276) transcriptioinal expression across human malignancies. ASCO, Abst:2624, 6/2023., J Hwang, Dave Hoon, and See full list of authors in comments

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The Vicious Cycle of Melanoma-Microglia Crosstalk: Inter-Melanoma Variations in the Brain-Metastasis-Promoting IL-6/JAK/STAT3 Signaling Pathway., Sivan Izraely, Shlomit Ben-Menachem, Sapir Malka, Orit Sagi-Assif, Matias A Bustos, Orit Adir, Tsipi Meshel, Maharrish Chelladurai, Suyeon Ryu, Romela Irene Ramos, Metsada Pasmanik-Chor, Dave S B Hoon, and Isaac P Witz

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ASO Author Reflections: Considerations for the Contralateral Breast in Patients Undergoing Oncoplastic Breast-Conserving Surgery., Katherine M Jackson and Janie Grumley

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A Look at the Other Side: High-Risk Lesions and Occult Contralateral Malignancy in Symmetry Procedures for Patients Undergoing Oncoplastic Breast-Conserving Surgery., Katherine M Jackson, Janelle-Cheri Millen, Javier I Orozco, Stacey Stern, Crystal E Fancher, and Janie Grumley

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ASO Visual Abstract: A Look at the Other Side-High-Risk Lesions and Occult Contralateral Malignancy in Symmetry Procedures of Patients Undergoing Oncoplastic Breast-Conserving Surgery., Katherine M Jackson, Janelle-Cheri Millen, Javier I Orozco, Stacey Stern, Crystal E Fancher, and Janie Grumley

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First analysis of the safety and efficacy of UGN-101 in the treatment of ureteral tumors., Joseph M Jacob, Solomon L Woldu, Jennifer Linehan, Craig Labbate, Kyle M Rose, Wade J Sexton, Isamu Tachibana, Hristos Kaimakliotis, Alan Nieder, Marc A Bjurlin, Mitchell Humphreys, Saum Ghodoussipor, Marcus L Quek, Brett Johnson, Michael O'Donnell, Brian H Eisner, Adam S Feldman, Katie S Murray, Surena F Matin, Yair Lotan, and Rian J Dickstein

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Diagnostic Performance and Safety of, Ashesh B Jani, Gregory C Ravizzini, Benjamin A Gartrell, Barry A Siegel, Przemyslaw Twardowski, Daniel Saltzstein, Mark T Fleming, Albert Chau, Phillip Davis, Brian F Chapin, and David M Schuster

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Reply by Authors., Ashesh B Jani, Gregory C Ravizzini, Benjamin A Gartrell, Barry A Siegel, Przemyslaw Twardowski, Daniel Saltzstein, Mark T Fleming, Albert Chau, Phillip Davis, Brian F Chapin, and David M Schuster

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Diagnostic Performance and Safety of 18F-rhPSMA-7.3 Positron Emission Tomography in Men With Suspected Prostate Cancer Recurrence: Results From a Phase 3, Prospective, Multicenter Study (SPOTLIGHT), Ashesh B Jani, Gregory C Ravizzini, Benjamin A Gartrell, Barry A Siegel, Przemyslaw W Twardowski, Daniel Saltzstein, Mark T Fleming, Albert Chau, Phillip Davis, Brian F Chapin, and David M Schuster

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Phase 1 study to determine the safety and dosing of autologous PBMCs modified to present HPV16 antigens (SQZ-PBMC-HPV) in HLA-A*02+ patients with HPV16+ solid tumors., Antonio Jimeno, Joaquina Baranda, Wade T Iams, Jong Chul Park, Monica Mita, Michael S Gordon, Matthew Taylor, Neesha Dhani, Alexis D Leal, Prakash Neupane, Cathy Eng, Oladapo Yeku, Alain Mita, Justin C Moser, Marcus Butler, Scott M Loughhead, Julia Jennings, Nathan R Miselis, Rui-Ru Ji, Nitya Nair, Martin Kornacker, Ricardo F Zwirtes, Howard Bernstein, and Armon Sharei

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The ablative effect of mitomycin reverse thermal gel: Expanding the role for nephron preservation therapy in low grade upper tract urothelial carcinoma., Hristos Z Kaimakliotis, Isamu Tachibana, Solomon Woldu, Craig Labbate, Joseph Jacob, Katie Murray, Kyle Rose, Wade Sexton, Rian Dickstein, Jennifer M Linehan, Alan Nieder, Marc Bjurlin, Mitchell Humphreys, Saum Ghodoussipor, Marcus Quek, Michael O'Donnell, Brian H Eisner, Surena F Matin, Yair Lotan, and Adam S Feldman

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Prolonged Survival of NUT Midline Carcinoma and Current Approaches to Treatment., Henry G Kaplan, Somasundaram Subramaniam, Eric Vallières, and Todd Barnett

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A Practical Guide to Relugolix: Early Experience With Oral Androgen Deprivation Therapy., Saro Kasparian, Oren Wei, Ni-Chun Tsai, Joycelynne Palmer, Sumanta Pal, Yung Lyou, and Tanya Dorff

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The role of dendritic cells in radiation-induced immune responses., Aanchal Preet Kaur, Alejandro F Alice, Marka R Crittenden, and Michael J. Gough

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Ex vivo analysis of radiation effects on tumor infiltrating immune cells using tumor explants., Aanchal Preet Kaur, Gwen Kramer, Marka R Crittenden, and Michael Gough

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Abstract 6410: Deciphering the role of MyD88 signaling pathway in regulating type I IFN-mediated responses to radiation therapy in solid tumors, Aanchal Preet Kaur, Terry R. Medler, Tiffany C. Blair, Alejandro F. Alice, Megan R. Ball, Alexa K Dowdell, Brian D. Piening, Marka R Crittenden, and Michael J. Gough

3D co-culture models demonstrate radiation-mediated activation of tumor-associated macrophages, AP Kaur, Marka R Crittenden, Michael J. Gough, and See all authors in comments