The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2017

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Hypothermic Cooling Measured by Thermal Magnetic Resonance Imaging; Feasibility and Implications for Virtual Imaging in the Urogenital Pelvis., Douglas Skarecky, Hon Yu, Jennifer Linehan, Blanca Morales, Min-Ying Su, Peter Fwu, and Thomas Ahlering

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Cellular immunotherapy of cancer: an overview and future directions., Ziqi Tao, Shuang Li, Thomas E Ichim, Junbao Yang, Neil Riordan, Venkata Yenugonda, Ivan Babic, and Santosh Kesari

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Outcomes of octogenarians undergoing gastrectomy performed for malignancy., Annabelle Teng, Geoffrey Bellini, Erica Pettke, Michael Passeri, David Y Lee, Keith Rose, Anton J Bilchik, and Fadi Attiyeh

nab-paclitaxel/carboplatin induction in squamous NSCLC: longitudinal quality of life while on chemotherapy, Michael Thomas, David R Spigel, Robert M Jotte, Michael McCleod, Mark A Socinski, Ray D Page, Laurent Gressot, Jeanna Knoble, Oscar Juan, Daniel Morgensztern, Dolores Isla, Edward S Kim, Howard West, Amy Ko, Teng Jin Ong, Nataliya Trunova, and Cesare Gridelli

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The influence of tumor regression, solar elastosis, and patient age on pathologists' interpretation of melanocytic skin lesions., Linda Titus, Raymond L Barnhill, Jason P Lott, Michael W Piepkorn, David E Elder, Paul D Frederick, Heidi D Nelson, Patricia A Carney, Stevan R Knezevich, Martin A Weinstock, and Joann G Elmore

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A Milestone for CAR T Cells., Eric Tran, Dan L Longo, and Walter Urba

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Unresectable hepatoblastoma: current perspectives., Angela D Trobaugh-Lotrario, Rebecka L Meyers, Allison F O'Neill, and James H Feusner

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Early stage small cell lung cancer: very rare, but a surgical disease!, Eric Vallières

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Neurological improvement of perineural and leptomeningeal spread of squamous cell carcinoma treated with intrathecal chemotherapy and systemic EGFR inhibition., Vincent Alexander van Vugt, Marlon Garzo Saria, Andres Javier, Navin Kesari, Tiffany Turpin, and Santosh Kesari

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Proceedings of the first international state-of-the-art conference on minimally-invasive pancreatic resection (MIPR)., Charles M Vollmer, Horacio J Asbun, Jeffrey Barkun, Marc G Besselink, Ugo Boggi, Kevin C P Conlon, Ho-Seong Han, Paul D Hansen, Michael L Kendrick, Andre L Montagnini, C Palanivelu, Bård I Røsok, Shailesh V Shrikhande, Go Wakabayashi, Herbert J Zeh, and David A Kooby

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Induction and characterization of anti-tumor endothelium immunity elicited by ValloVax therapeutic cancer vaccine., Samuel C Wagner, Thomas E Ichim, Vladimir Bogin, Wei-Ping Min, Francisco Silva, Amit N Patel, and Santosh Kesari

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A phase Ib/II study of cabozantinib (XL184) with or without erlotinib in patients with non-small cell lung cancer., Heather A Wakelee, Scott Gettinger, Jeffrey Engelman, Pasi A Jänne, Howard J. West, Deepa S Subramaniam, Joseph Leach, Michael Wax, Yifah Yaron, Dale R Miles, and Primo N Lara

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P-REX1 amplification promotes progression of cutaneous melanoma via the PAK1/P38/MMP-2 pathway., Jinhua Wang, Hajime Hirose, Guanhua Du, Kelly Chong, Eiji Kiyohara, Isaac P Witz, and Dave S B Hoon

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FOXC1 is associated with estrogen receptor alpha and affects sensitivity of tamoxifen treatment in breast cancer., Jinhua Wang, Yali Xu, Li Li, Lin Wang, Ru Yao, Qiang Sun, and Guanhua Du

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Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor., Zhaoming Wang, Katherine A McGlynn, Ewa Rajpert-De Meyts, D Timothy Bishop, Charles C Chung, Marlene D Dalgaard, Mark H Greene, Ramneek Gupta, Tom Grotmol, Trine B Haugen, Robert Karlsson, Kevin Litchfield, Nandita Mitra, Kasper Nielsen, Louise C Pyle, Stephen M Schwartz, Vésteinn Thorsson, Saran Vardhanabhuti, Fredrik Wiklund, Clare Turnbull, Stephen J Chanock, Peter A Kanetsky, and Katherine L Nathanson

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Physician Aid in Dying: Caught Between the Extremes., Jeffery Ward

Variability in intensive care unit utilization at the end of life in patients with a diagnosis of cancer: a large multi-state hospital network experience The American Thoracic Society Washington DC, AC Welch, Candice L. Wilshire, and See all authors in comments

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Chemotherapy-Induced Hair Loss (Alopecia)., Howard J. West

Imaging in pleural infections: the radiation adds up European Respiratory Society International Congress 2017 Milan, Italy, Candice L. Wilshire

Pulmonary nodule malignancy risk calculators in a lung cancer screening program: performance review after positive screening results The American Thoracic Society Washington DC, Candice L. Wilshire

Imaging more frequently drives decision to increase treatment in pleural infection than clinical condition, Candice L. Wilshire, CC Fuller, CR Gilbert, BE Louie, RW Aye, AS Farivar, E Vallières, and JA Gorden

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Insights into Local Tumor Microenvironment Immune Factors Associated with Regression of Cutaneous Melanoma Metastases by, Junbao Yang, Maris S Jones, Romela Irene Ramos, Alfred A Chan, Agnes F Lee, Leland J Foshag, Peter A Sieling, Mark Faries, and Delphine J Lee

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A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma., Venkata Yenugonda, Natsuko Nomura, Valentina Kouznetsova, Igor Tsigelny, Valentina Fogal, Elmar Nurmemmedov, Santosh Kesari, and Ivan Babic

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Beyond cancer genes: colorectal cancer as robust intrinsic states formed by molecular interactions., Ruoshi Yuan, Suzhan Zhang, Jiekai Yu, Yanqin Huang, Demin Lu, Runtan Cheng, Sui Huang, Ping Ao, Shu Zheng, Leroy Hood, and Xiaomei Zhu

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A Phase I, Dose Escalation Study of Oral ASP8273 in Patients with Non-small Cell Lung Cancers with Epidermal Growth Factor Receptor Mutations., Helena A Yu, Alexander Spira, Leora Horn, Jared Weiss, Howard J. West, Giuseppe Giaccone, Tracey Evans, Ronan J Kelly, Bhardwaj Desai, Andrew Krivoshik, Diarmuid Moran, Srinivasu Poondru, Fei Jie, Kouji Aoyama, Anne Keating, and Geoffrey R Oxnard

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Early mutation bursts in colorectal tumors., Junsong Zhao, Matthew P Salomon, Darryl Shibata, Christina Curtis, Kimberly Siegmund, and Paul Marjoram

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Susceptibility loci of CNOT6 in the general mRNA degradation pathway and lung cancer risk-A re-analysis of eight GWASs., Fei Zhou, Yanru Wang, Hongliang Liu, Neal Ready, Younghun Han, Rayjean J Hung, Yonathan Brhane, John McLaughlin, Paul Brennan, Heike Bickeböller, Albert Rosenberger, Richard S Houlston, Neil Caporaso, Maria Teresa Landi, Irene Brüske, Angela Risch, Yuanqing Ye, Xifeng Wu, David C Christiani, Gary Goodman, Chu Chen, Christopher I Amos, and Qingyi Wei

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Extracting Intercellular Signaling Network of Cancer Tissues using Ligand-Receptor Expression Patterns from Whole-tumor and Single-cell Transcriptomes., Joseph X Zhou, Roberto Taramelli, Edoardo Pedrini, Theo Knijnenburg, and Sui Huang

Submissions from 2016

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Donald L. Morton, MD.... A Legendary Surgical Oncologist and Consummate Investigator., Charles M Balch and Dave S B Hoon

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Characterization of the microbiome of nipple aspirate fluid of breast cancer survivors., Alfred A Chan, Mina Bashir, Magali N Rivas, Karen Duvall, Peter A Sieling, Thomas R Pieber, Parag A Vaishampayan, Susan M Love, and Delphine J Lee

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Earle A. Chiles Research Institute 2015 Year In Review, Earle A. Chiles Research Institute

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Donald L. Morton, MD 1934-2014., Dave S B Hoon

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Preface: The Living Legacy of Donald L. Morton., Dave S B Hoon

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Logic models to predict continuous outputs based on binary inputs with an application to personalized cancer therapy., Theo A Knijnenburg, Gunnar W Klau, Francesco Iorio, Mathew J Garnett, Ultan McDermott, Ilya Shmulevich, and Lodewyk F A Wessels

Utilization of the electronic medical record to determine smoking history: a challenge for population-based lung cancer screening The American Thoracic Society International Conference San Francisco, California, SS Oswald, Candice L. Wilshire, and See all authors in comments

Early consideration of definitive pleural palliation can reduce the number and duration of serial thoracentesis European Respiratory Society International Congress 2016 London, United Kingdom, Candice L. Wilshire

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Navigating your career path in pediatric hematology/oncology: On and off the beaten track., Patrick A Zweidler-McKay, Mary-Jane Staba Hogan, Rima Jubran, Vandy Black, Jacqueline Casillas, James Harper, Suman Malempati, Judith Margolin, Judy Felgenhauer, Kathleen M Sakamoto, Janet Franklin, Mona Shah, Nita Seibel, George Buchanan, Sarah R Vaiselbuh, Caroline Hastings, Joanne Hilden, and Linda C Stork

Submissions from 2015

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Allogeneic autophagosome-enriched composition for the treatment of disease, Traci Hilton, Sandra Aung, Rieneke van de Ven, Christopher Paustian, Tarsem Moudgil, Christopher Dubay, Christopher Twitty, Hong-Ming Hu, and Bernard A Fox

Nephron Sparing Surgery vs Ablation for Hilar Renal Cell Carcinoma. Case Presentation and Literature Review, Mark J. Kelly

The Evaluation and Management of Urinary Retention in the Acute Care Setting, Mark J. Kelly

Tumor Board Presentation; Topics: 1. Current Management of Renal Angiomyolipoma 2. Update of NCCN Management of Pathological T2 Bladder Cancer, Mark J. Kelly

Submissions from 2014

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Cancer treatment and monitoring methods using OX40 agonists, Brendan Curti, Magdalena Kovacsovics-Bankowski, Ed Walker, Josh Walker, and Andy Weinberg

Active Surveillance for Men with Low-Risk Adenocarcinoma of the Prostate. “Who Is a Candidate for Surveillance, Who Is Not?”, Mark J. Kelly

Reconciling the R.E.N.A.L. Nephrometry Tool and the updated NCCN Management Guidelines for Kidney Cancer. “Upholding Oncological Principles and Avoiding Chronic Kidney Disease.”, Mark J. Kelly

Squamous Cell Carcinoma of the Penis. Natural History, Epidemiology, Diagnosis, Staging and Management, Mark J. Kelly

The use of multiparimetric MRI Imaging in the Management of Clinically Localized Prostate Cancer, Mark J. Kelly

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Ubiquitinylated proteins, Christopher Twitty, Erik LeShane, Bernard A Fox, Hong-Ming Hu, and Guangjie Yu

Submissions from 2013

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Allogeneic autophagosome-enriched composition for the treatment of disease, Traci Hilton, Sandra Aung, Rieneke van de Ven, Christopher Paustian, Tarsem Moudgil, Christopher Dubay, Christopher Twitty, Hong-Ming Hu, and Bernard A. Fox

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Methods for diagnosis, prognosis and treatment of primary and metastatic basal-like breast cancer and other cancer types, Partha S. Ray, Sanjay Bagaria, Xiaojiang Cui, and Jinhua Wang

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Method for enhancing specific immunotherapies in cancer treatment, Peter G. Traber, William L. Redmond, Eliezer Zomer, Anatole Klyosov, and Stefanie N. Linch

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Molecular malignancy in melanocytic lesions, Hui Wang, Christopher Roberts, Krishna Maddula, Zhenquiang Lu, Tom Vasicek, BJ Kerns, Bruce E. Seligmann, and Dave S B Hoon

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Elucidation of the molecular interaction between cisplatin and flavonol(s) and their effect on DNA binding., Theodore J Zwang, Kavisha Singh, Malkiat S Johal, and Cynthia R Selassie

Submissions from 2012

“A Rab-GEF cascade during human sperm exocytosis, MA Bustos, O Lucchesi, MC Ruete, LS Mayorga, Tomes and, and CN

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Utility of B-RAF DNA mutation in diagnosis and treatment of cancer, Dave S B Hoon

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Long noncoding RNA (lncRNA) as a biomarker and therapeutic marker in cancer, Dave S B Hoon and Laurent Lessard

Submissions from 2011

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Treatment of cancer and compositions, Richard Essner

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Method and apparatus for in vivo collection of circulating biological components, Dave S B Hoon, Bret Taback, and Samuel Shaolian

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Method and apparatus for in vivo surveillance of circulating biological components, Dave S B Hoon, Bret Tabeck, and Samuel Shaolian

Submissions from 2009

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Epigenetic silencing of cyclooxygenase-2 affects clinical outcome in gastric cancer, Dave S B Hoon and Michiel de Maat

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Use of ID4 for diagnosis and treatment of cancer, Dave S B Hoon and Naoyuki Umetani

Submissions from 2008

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Utility of B-RAF DNA mutation in diagnosis and treatment of cancer, Dave S B Hoon

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Epigenetic silencing of cyclooxygenase-2 affects clinical outcome in gastric cancer, Dave S B Hoon and Michiel de Maat

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Utility of RET mutant in diagnosis and treatment of melanoma, Dave S B Hoon, Norihiko Narita, and Atsushi Tanemura

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Method and apparatus for in vivo surveillance of circulating biological components, Dave S B Hoon, Bret Taback, and Samuel Shaolian

Submissions from 2007

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Methylation of estrogen receptor alpha and uses thereof, Dave S B Hoon

Submissions from 2006

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Use of ID4 for diagnosis and treatment of cancer, Dave S B Hoon and Naoyuki Umetani

Submissions from 2005

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Detection of cancer cells in body fluids, Dave S B Hoon

Submissions from 2004

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DNA markers for management of cancer, Dave S B Hoon and Bret Taback

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Method and apparatus for in vivo collection of circulating biological components, Dave S B Hoon, Bret Taback, and Samuel Shaolian

Submissions from 2003

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Molecular lymphatic mapping of sentinel lymph nodes, Dave S B Hoon and Bret Taback

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Detection of micro metastasis of melanoma and breast cancer in paraffin-embedded tumor draining lymph nodes by multimarker quantitative RT-PCR, Dave S B Hoon and Hiroya Takeuchi

Submissions from 2000

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Methods for lymph node identification, Donald L. Morton