The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2017

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NADPH oxidase 5 (NOX5)-induced reactive oxygen signaling modulates normoxic HIF-1α and p27, Smitha Antony, Guojian Jiang, Yongzhong Wu, Jennifer L Meitzler, Hala R Makhlouf, Diana C Haines, Donna Butcher, Dave S B Hoon, Jiuping Ji, Yiping Zhang, Agnes Juhasz, Jiamo Lu, Han Liu, Iris Dahan, Mariam Konate, Krishnendu K Roy, and James H Doroshow

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Phase 1b trial of proteasome inhibitor carfilzomib with irinotecan in lung cancer and other irinotecan-sensitive malignancies that have progressed on prior therapy (Onyx IST reference number: CAR-IST-553)., Susanne M Arnold, Kari Chansky, Markos Leggas, Michael A Thompson, John L Villano, John Hamm, Rachel E Sanborn, Glen J Weiss, Gurkamal Chatta, and Maria Q Baggstrom

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Surgical Navigation: A Systematic Review of Indications, Treatments, and Outcomes in Oral and Maxillofacial Surgery., Iman Azarmehr, Kasper Stokbro, R Bryan Bell, and Torben Thygesen

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Emergency Presentations of Colorectal Cancer., Canaan Baer, Raman Menon, Sarah Bastawrous, and Amir Bastawrous

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STING expression and response to treatment with STING ligands in premalignant and malignant disease., Jason R Baird, Zipei Feng, Hong D Xiao, David Friedman, Ben Cottam, Bernard A Fox, Gwen Kramer, Rom S Leidner, Richard Bryan Bell, Kristina H Young, Marka R Crittenden, and Michael J Gough

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Microsurgical Endoscope-Assisted Gravity-Aided Transfalcine Approach for Contralateral Metastatic Deep Medial Cortical Tumors., Garni Barkhoudarian, Daniel Farahmand, Robert G Louis, Erol Oksuz, Danjuma Sale, Pablo Villanueva, and Daniel F Kelly

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Impact of ibrutinib dose adherence on therapeutic efficacy in patients with previously treated CLL/SLL., Paul M Barr, Jennifer R Brown, Peter Hillmen, Susan O'Brien, Jacqueline C Barrientos, Nishitha M Reddy, Steven Coutre, Stephen P Mulligan, Ulrich Jaeger, Richard R Furman, Florence Cymbalista, Marco Montillo, Claire Dearden, Tadeusz Robak, Carol Moreno, John M Pagel, Jan A Burger, Samuel Suzuki, Juthamas Sukbuntherng, George Cole, Danelle F James, and John C Byrd

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Agenda for Translating Physical Activity, Nutrition, and Weight Management Interventions for Cancer Survivors into Clinical and Community Practice., Karen Basen-Engquist, Catherine M Alfano, Melissa Maitin-Shepard, Cynthia A Thomson, Kathryn H Schmitz, Bernardine M Pinto, Kevin Stein, David S Zucker, Karen L Syrjala, Elizabeth Fallon, Colleen Doyle, and Wendy Demark-Wahnefried

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Immunotherapy of head and neck cancer: Emerging clinical trials from a National Cancer Institute Head and Neck Cancer Steering Committee Planning Meeting., Julie E Bauman, Ezra Cohen, Robert L Ferris, David J Adelstein, David M Brizel, John A Ridge, Brian O'Sullivan, Barbara A Burtness, Lisa H Butterfield, William E Carson, Mary L Disis, Bernard A Fox, Thomas F Gajewski, Maura L Gillison, James W Hodge, Quynh-Thu Le, David Raben, Scott E Strome, Jean Lynn, and Shakun Malik

Oral, Head and Neck Oncology and Reconstructive Surgery, R. Bryan Bell, Peter E. Andersen, and Rui P. Fernandes

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Relationships matter in oral cancer: will single-stain immunohistochemistry become irrelevant in the age of multispectral imaging?, R Bryan Bell and Bernard A Fox

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Erratum to 'Cytoreductive surgery for head and neck squamous cell carcinoma in the new age of immunotherapy' [Oral Oncol. 61 (2016) 166-176]., R Bryan Bell, Michael J Gough, Steven K Seung, Zeljka Jutric, Andrew D Weinberg, Bernard A Fox, Marka R Crittenden, Rom S Leidner, and Brendan Curti

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Head and neck surgeons at the vanguard of immunotherapy., Richard Bryan Bell

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Immunoprofiling as a predictor of patient's response to cancer therapy-promises and challenges., Daniel Bethmann, Zipei Feng, and Bernard A Fox

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IGF2 mRNA binding protein 3 (IMP3) promotes glioma cell migration by enhancing the translation of RELA/p65., Shruti Bhargava, Abhirami Visvanathan, Vikas Patil, Anuj Kumar, Santosh Kesari, Saumitra Das, Alangar S Hegde, Arimappamagan Arivazhagan, Vani Santosh, and Kumaravel Somasundaram

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Precision Oncology: Between Vaguely Right and Precisely Wrong., Amy Brock and Sui Huang

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Robot-Assisted Total Thymectomy: How I Teach It., Lisa M Brown and Brian Louie

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Photography in Telemedicine: Improving Diagnosis of Chronic Graft-Versus-Host Disease., Brianna Busby, Shannon Campbell, Rachel Cole, Charisse DeVries, Kamille Dobbins, Mary Beth Trimble, and Mihkaila Wickline

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Genome-wide chromatin accessibility, DNA methylation and gene expression analysis of histone deacetylase inhibition in triple-negative breast cancer., Matias A Bustos, Matthew P Salomon, Nellie Nelson, Sandy C Hsu, Maggie L DiNome, Dave S B Hoon, and Diego M Marzese

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MiR-200a Regulates CDK4/6 Inhibitor Effect by Targeting CDK6 in Metastatic Melanoma., Matias Bustos, Shigeshi Ono, Diego M Marzese, Takashi Oyama, Yuuki Iida, Garrett Cheung, Nellie Nelson, Sandy C Hsu, Qiang Yu, and Dave S B Hoon

Attrition rate in community-based lung cancer screening: one and done, AS Carlson, CL Wilshire, JT Fathi, CR Gilbert, SC Blanshan, BE Louie, RW Aye, AS Farivar, E Vallières, and JA Gorden

Attrition rate in community-based lung cancer screening: one and done The International Association for the Study of Lung Cancer 18th World Conference on Lung Cancer Yokohama, Japan, AS Carlson, CL Wilshire, and See all authors in comments

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External Validation of a Prognostic Model of Survival for Resected Typical Bronchial Carcinoids., Maria Cattoni, Eric Vallieres, Lisa M Brown, Amir A Sarkeshik, Stefano Margaritora, Alessandra Siciliani, Andrea Imperatori, Nicola Rotolo, Farhood Farjah, Grace Wandell, Kimberly E Costas, Catherine Mann, Michal Hubka, Stephen Kaplan, Alexander S Farivar, Ralph W Aye, and Brian Louie

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The IASLC Lung Cancer Staging Project: External Validation of the Revision of the TNM Stage Groupings in the Eighth Edition of the TNM Classification of Lung Cancer., Kari Chansky, Frank C Detterbeck, Andrew G Nicholson, Valerie W Rusch, Eric Vallières, Patti Groome, Catherine Kennedy, Mark Krasnik, Michael Peake, Lynn Shemanski, Vanessa Bolejack, John J Crowley, Hisao Asamura, and Ramón Rami-Porta

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ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment., Chi-Fen Chen, Rolando Ruiz-Vega, Priya Vasudeva, Francisco Espitia, Tatiana B Krasieva, Sebastien de Feraudy, Bruce J Tromberg, Sharon Huang, Chad P Garner, Jie Wu, Dave S B Hoon, and Anand K Ganesan

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Cancer Rehabilitation: An Overview of Current Need, Delivery Models, and Levels of Care., Andrea L Cheville, Karen Mustian, Kerri Winters-Stone, David S Zucker, Gail L Gamble, and Catherine M Alfano

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National Estimates of Genetic Testing in Women With a History of Breast or Ovarian Cancer., Christopher P Childers, Kimberly K Childers, Melinda Maggard-Gibbons, and James Macinko

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Impact of Sequencing Targeted Therapies With High-dose Interleukin-2 Immunotherapy: An Analysis of Outcome and Survival of Patients With Metastatic Renal Cell Carcinoma From an On-going Observational IL-2 Clinical Trial: PROCLAIM, Joseph I Clark, Michael K K Wong, Howard L Kaufman, Gregory A Daniels, Michael A Morse, David F McDermott, Sanjiv S Agarwala, Lionel D Lewis, John H Stewart, Ulka Vaishampayan, Brendan Curti, René Gonzalez, Jose Lutzky, Venkatesh Rudraptna, Lee D Cranmer, Joanne M Jeter, Ralph J Hauke, Gerald Miletello, Mohammed M Milhem, Asim Amin, John M Richart, Mayer Fishman, Sigrun Hallmeyer, Sapna P Patel, Peter Van Veldhuizen, Neeraj Agarwal, Bret Taback, Jonathan S Treisman, Marc S Ernstoff, Jessica C Perritt, Hong Hua, Tharak B Rao, Janice P Dutcher, and Sandra Aung

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Results of a phase I-II study of fenretinide and rituximab for patients with indolent B-cell lymphoma and mantle cell lymphoma., Andrew J Cowan, Phillip A Stevenson, Ted A Gooley, Shani L Frayo, George R Oliveira, Stephen D Smith, Damian J Green, Jennifer E Roden, John M Pagel, Brent L Wood, Oliver W Press, and Ajay K Gopal

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Chemotherapy Safe Handling: Limiting Nursing Exposure With a Hazardous Drug Control Program., Rachael Crickman

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Improved survival and tumor control with Interleukin-2 is associated with the development of immune-related adverse events: data from the PROCLAIM, Brendan Curti, Gregory A Daniels, David F McDermott, Joseph I Clark, Howard L Kaufman, Theodore F Logan, Jatinder Singh, Meenu Kaur, Theresa L Luna, Nancy Gregory, Michael A Morse, Michael K K Wong, and Janice P Dutcher

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Phase I First-in-Human Study of Venetoclax in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma., Matthew S Davids, Andrew W Roberts, John F Seymour, John M Pagel, Brad S Kahl, William G Wierda, Soham Puvvada, Thomas J Kipps, Mary Ann Anderson, Ahmed Hamed Salem, Martin Dunbar, Ming Zhu, Franklin Peale, Jeremy A Ross, Lori Gressick, Monali Desai, Su Young Kim, Maria Verdugo, Rod A Humerickhouse, Gary B Gordon, and John F Gerecitano

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Effect of alkylaminophenols on growth inhibition and apoptosis of bone cancer cells., Phuong Doan, Tien Nguyen, Olli Yli-Harja, Nuno R Candeias, and Meenakshisundaram Kandhavelu

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Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial., Anthony B El-Khoueiry, Bruno Sangro, Thomas Yau, Todd S Crocenzi, Masatoshi Kudo, Chiun Hsu, Tae-You Kim, Su-Pin Choo, Jörg Trojan, Theodore H Welling, Tim Meyer, Yoon-Koo Kang, Winnie Yeo, Akhil Chopra, Jeffrey Anderson, Christine Dela Cruz, Lixin Lang, Jaclyn Neely, Hao Tang, Homa B Dastani, and Ignacio Melero

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Pathologists' diagnosis of invasive melanoma and melanocytic proliferations: observer accuracy and reproducibility study., Joann G Elmore, Raymond L Barnhill, David E Elder, Gary M Longton, Margaret S Pepe, Lisa M Reisch, Patricia A Carney, Linda J Titus, Heidi D Nelson, Tracy Onega, Anna N A Tosteson, Martin A Weinstock, Stevan R Knezevich, and Michael W Piepkorn

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A Randomized Study Comparing Digital Imaging to Traditional Glass Slide Microscopy for Breast Biopsy and Cancer Diagnosis., Joann G Elmore, Gary M Longton, Margaret S Pepe, Patricia A Carney, Heidi D Nelson, Kimberly H Allison, Berta M Geller, Tracy Onega, Anna N A Tosteson, Ezgi Mercan, Linda G Shapiro, Tad T Brunyé, Thomas R Morgan, and Donald L Weaver

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Cancer immunotherapy: Opportunities and challenges in the rapidly evolving clinical landscape., Leisha A Emens, Paolo A Ascierto, Phillip K Darcy, Sandra Demaria, Alexander M M Eggermont, William L. Redmond, Barbara Seliger, and Francesco M Marincola

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Hypomethylation of CNTFRα is associated with proliferation and poor prognosis in lower grade gliomas., Kun Fan, Xiaowen Wang, Jingwen Zhang, Romela Irene Ramos, Haibo Zhang, Chunjie Li, Dan Ye, Jiansheng Kang, Diego M Marzese, Dave S B Hoon, and Wei Hua

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Long-Term Survival after Complete Surgical Resection and Adjuvant Immunotherapy for Distant Melanoma Metastases., Mark Faries, Nicola Mozzillo, Mohammed Kashani-Sabet, John F Thompson, Mark C Kelley, Ronald C DeConti, Jeffrey E Lee, James F Huth, Jeffrey Wagner, Angus Dalgleish, Daniel Pertschuk, Christopher Nardo, Stacey Stern, Robert Elashoff, Guy Gammon, and Donald L Morton

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Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma., Mark Faries, John F Thompson, Alistair J Cochran, Robert H Andtbacka, Nicola Mozzillo, Jonathan S Zager, Tiina Jahkola, Tawnya L Bowles, Alessandro Testori, Peter D Beitsch, Harald J Hoekstra, Marc Moncrieff, Christian Ingvar, Michel W J M Wouters, Michael S Sabel, Edward A Levine, Doreen Agnese, Michael Henderson, Reinhard Dummer, Carlo R Rossi, Rogerio I Neves, Steven D Trocha, Frances Wright, David R Byrd, Maurice Matter, Eddy Hsueh, Alastair MacKenzie-Ross, Douglas B Johnson, Patrick Terheyden, Adam C Berger, Tara L Huston, Jeffrey D Wayne, B Mark Smithers, Heather B Neuman, Schlomo Schneebaum, Jeffrey E Gershenwald, Charlotte E Ariyan, Darius C Desai, Lisa Jacobs, Kelly M McMasters, Anja Gesierich, Peter Hersey, Steven D Bines, John M Kane, Richard J Barth, Gregory McKinnon, Jeffrey M Farma, Erwin Schultz, Sergi Vidal-Sicart, Richard A Hoefer, James M Lewis, Randall Scheri, Mark C Kelley, Omgo E Nieweg, R Dirk Noyes, Dave S B Hoon, He-Jing Wang, David A Elashoff, and Robert M Elashoff

Electronic medical record inaccuracies: a multi-center analysis of the challenges for population-based lung cancer screening The American Thoracic Society Washington DC, JT Fathi, CL Wilshire, and See all authors in comments

Integrating smoking cessation counselling and treatment in a lung cancer screening program: an effective approach to long-term smoking cessation success The American Thoracic Society Wash, AF Feczko, CL Wilshire, and See all authors in comments

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Multiparametric immune profiling in HPV- oral squamous cell cancer., Zipei Feng, Daniel Bethmann, Matthias Kappler, Carmen Ballesteros-Merino, Alexander Eckert, R Bryan Bell, Allen Cheng, Tuan Bui, Rom Leidner, Walter Urba, Kent Johnson, Clifford Hoyt, Carlo Bifulco, Juergen Bukur, Claudia Wickenhauser, Barbara Seliger, and Bernard A Fox

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Descriptive analysis of unplanned readmission and reoperation rates after intradural spinal tumor resection., Christian Fisahn, Felipe H Sanders, Marc Moisi, Jeni Page, Peter C Oakes, Mary Wingerson, Joe Dettori, R Shane Tubbs, Parthasarathi Chamiraju, Peter Nora, David Newell, Johnny Delashaw, Rod J Oskouian, and Jens R Chapman

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Human cytomegalovirus-mediated immunomodulation: Effects on glioblastoma progression., Haidn Foster, Ilya V Ulasov, and Charles Cobbs

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Frontline brentuximab vedotin in combination with dacarbazine or bendamustine in patients aged ≥60 years with HL., Jonathan W Friedberg, Andres Forero-Torres, Rodolfo E Bordoni, Vivian J M Cline, Dipti Patel Donnelly, Patrick J Flynn, Gregg Olsen, Robert Chen, Abraham Fong, Yinghui Wang, and Christopher A Yasenchak

Minority and economically disadvantaged high-risk populations are underrepresented in both centralized and decentralized lung cancer screening models, CC Fuller, CL Wilshire, and M Bretta

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Sex-Specific Differences in Colon Cancer when Quality Measures Are Adhered to: Results from International, Prospective, Multicenter Clinical Trials., Shrawan G Gaitonde, Aviram Nissan, Mladjan Protić, Alexander Stojadinovic, Zev A Wainberg, David C Chen, and Anton J Bilchik

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Efficacy and Safety of Pembrolizumab in Patients Enrolled in KEYNOTE-030 in the United States: An Expanded Access Program., Tara C Gangadhar, Wen-Jen Hwu, Michael A Postow, Omid Hamid, Adil Daud, Roxana Dronca, Richard Joseph, Steven J O'Day, F S Hodi, Anna C Pavlick, Harriet Kluger, Romina P Oxborough, Aiming Yang, Mihaela Gazdoiu, Debra A Kush, Scot Ebbinghaus, and April K S Salama

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Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines., Bradley Garman, Ioannis N Anastopoulos, Clemens Krepler, Patricia Brafford, Katrin Sproesser, Yuchao Jiang, Bradley Wubbenhorst, Ravi Amaravadi, Joseph Bennett, Marilda Beqiri, David Elder, Keith T Flaherty, Dennie T Frederick, Tara C Gangadhar, Michael Guarino, Dave S B Hoon, Giorgos Karakousis, Qin Liu, Nandita Mitra, Nicholas J Petrelli, Lynn Schuchter, Batool Shannan, Carol L Shields, Jennifer Wargo, Brandon Wenz, Melissa A Wilson, Min Xiao, Wei Xu, Xaiowei Xu, Xiangfan Yin, Nancy R Zhang, Michael A Davies, Meenhard Herlyn, and Katherine L Nathanson

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Effects of socioeconomic status on children with well-differentiated thyroid cancer., Evan F Garner, Ilan I Maizlin, Matthew B Dellinger, Kenneth W Gow, Melanie Goldfarb, Adam B Goldin, John J Doski, Monica Langer, Jed G Nuchtern, Sanjeev A Vasudevan, Mehul V Raval, and Elizabeth A Beierle

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Characteristics associated with requests by pathologists for second opinions on breast biopsies., Berta M Geller, Heidi D Nelson, Donald L Weaver, Paul D Frederick, Kimberly H Allison, Tracy Onega, Patricia A Carney, Anna N A Tosteson, and Joann G Elmore

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Low-Dose-Rate Brachytherapy Versus Cryotherapy in Low- and Intermediate-Risk Prostate Cancer., Matthew M Gestaut, Wendi Cai, Shilpa Vyas, Belur J Patel, Salman A Hasan, Yolanda MunozMaldonado, Niloyjyoti Deb, and Gregory Swanson

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A Cell-Surface Membrane Protein Signature for Glioblastoma., Dhimankrishna Ghosh, Cory C Funk, Juan Caballero, Nameeta Shah, Katherine Rouleau, John C Earls, Liliana Soroceanu, Greg Foltz, Charles Cobbs, Nathan D Price, and Leroy Hood

The financial impact of a nurse practitioner directed lung cancer screening and tobacco related disease program, CR Gilbert, JT Fathi, RE Ely, HE Modin, CL Wilshire, RW Aye, AS Farivar, BE Louie, E Vallières, and JA Gorden

FDG-PET scanning has a limited role in the management of low and intermediate, CR Gilbert, CL Wilshire, and See all authors in comments

Outcomes of radiotherapy and endoscopic airway stenting for central airway obstruction in non-small cell lung cancer International Association for the Study of Lung Cancer Multidisciplinary Symposium in Thoracic Oncology Chicago, Illinois, CR Gilbert, CL Wilshire, and See all authors in comments

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Ureteroenteric anastomotic revision as initial management of stricture after urinary diversion., Greg E Gin, Nora H Ruel, Jaspreet S Parihar, Jonathan N Warner, Bertram E Yuh, Jonathan Yamzon, Timothy G Wilson, Clayton S Lau, and Kevin G Chan

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Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence., Jian Yuan Goh, Min Feng, Wenyu Wang, Gokce Oguz, Siti Maryam J M Yatim, Puay Leng Lee, Yi Bao, Tse Hui Lim, Panpan Wang, Wai Leong Tam, Annette R Kodahl, Maria B Lyng, Suman Sarma, Selena Y Lin, Alexander Lezhava, Yoon Sim Yap, Alvin S T Lim, Dave S B Hoon, Henrik J Ditzel, Soo Chin Lee, Ern Yu Tan, and Qiang Yu

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A View from the Plateau: Is There a Role for Allogeneic Stem Cell Transplantation in the Era of Highly Effective Therapies for Multiple Myeloma?, Damian J Green and William Bensinger

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Immunotherapy biomarkers 2016: overcoming the barriers., James L Gulley, Jay A Berzofsky, Marcus O Butler, Alessandra Cesano, Bernard A Fox, Sacha Gnjatic, Sylvia Janetzki, Shyam Kalavar, Vaios Karanikas, Samir N Khleif, Ilan Kirsch, Peter P Lee, Cristina Maccalli, Holden Maecker, Jeffrey Schlom, Barbara Seliger, Janet Siebert, David F Stroncek, Magdalena Thurin, Jianda Yuan, and Lisa H Butterfield

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A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma., Gao Guo, Ke Gong, Sonia Ali, Neha Ali, Shahzad Shallwani, Kimmo J Hatanpaa, Edward Pan, Bruce Mickey, Sandeep Burma, David H Wang, Santosh Kesari, Jann N Sarkaria, Dawen Zhao, and Amyn A Habib

Outcomes of radiotherapy and endoscopic airway stenting for central airway obstruction in non-small cell lung cancer The International Association for the Study of Lung Cancer 18th World Conference on Lung Cancer Yokohama, Japan, CA Henson, CL Wilshire, and See all authors in comments

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In Reply: Refining Tumor Resection Techniques for Managing Inferior Pole Breast Malignancies., Dennis R Holmes and Melvin J Silverstein

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Intraoperative radiotherapy: Patient selection, management, and follow-up., Dennis R Holmes and Robert Zimmerman

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Intraoperative radiotherapy: Patient selection, management, and follow-up., Dennis R Holmes and Robert Zimmerman

Long-term impact of endoscopic thoracic sympathectomy on quality of life for patients with primary palmar hyperhidrosis, LC Horslen, CL Wilshire, BE Louie, RW Aye, AS Farivar, and E Vallières

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Prognostic Value of Multiple Draining Lymph Node Basins in Melanoma: A Matched-Pair Analysis Based on the John Wayne Cancer Institute Experience., J Harrison Howard, Junko J Ozao-Choy, Jason M Hiles, Myung-Shin Sim, and Mark Faries

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Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma., Yuuki Iida, Aaron Ciechanover, Diego M Marzese, Keisuke Hata, Matias Bustos, Shigeshi Ono, Jinhua Wang, Matthew P Salomon, Kevin Tran, Stella Lam, Sandy Hsu, Nellie Nelson, Yelena Kravtsova-Ivantsiv, Gordon B Mills, Michael A Davies, and Dave S B Hoon

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ANGPTL4 promotes the progression of cutaneous melanoma to brain metastasis., Sivan Izraely, Shlomit Ben-Menachem, Orit Sagi-Assif, Tsipi Meshel, Diego M Marzese, Shuichi Ohe, Inna Zubrilov, Metsada Pasmanik-Chor, Dave S B Hoon, and Isaac P Witz

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Predictors of responses to immune checkpoint blockade in advanced melanoma., N Jacquelot, M P Roberti, D P Enot, S Rusakiewicz, N Ternès, S Jegou, D M Woods, A L Sodré, M Hansen, Y Meirow, M Sade-Feldman, A Burra, S S Kwek, C Flament, M Messaoudene, C P M Duong, L Chen, B S Kwon, A C Anderson, V K Kuchroo, B Weide, F Aubin, C Borg, S Dalle, O Beatrix, M Ayyoub, B Balme, G Tomasic, A M Di Giacomo, M Maio, D Schadendorf, I Melero, B Dréno, A Khammari, R Dummer, M Levesque, Yoshinobu Koguchi, L Fong, M Lotem, M Baniyash, H Schmidt, I M Svane, G Kroemer, A Marabelle, S Michiels, A Cavalcanti, M J Smyth, J S Weber, A M Eggermont, and L Zitvogel

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Safety and Feasibility of Minimally Invasive Inguinal Lymph Node Dissection in Patients With Melanoma (SAFE-MILND): Report of a Prospective Multi-institutional Trial., James W Jakub, Alicia M Terando, Amod Sarnaik, Charlotte E Ariyan, Mark Faries, Sabino Zani, Heather B Neuman, Nabil Wasif, Jeffrey M Farma, Bruce J Averbook, Karl Y Bilimoria, Travis E Grotz, Jacob B Jake Allred, Vera J Suman, Mary Sue Brady, Douglas Tyler, Jeffrey D Wayne, and Heidi Nelson

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Does gated beam delivery impact delivery accuracy on an Elekta linac?, Mohammed Jermoumi, Roger Xie, Daliang Cao, David J Housley, and David M Shepard

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The Impact of Smoking on Sentinel Node Metastasis of Primary Cutaneous Melanoma., Maris S Jones, Peter C Jones, Stacey L Stern, David Elashoff, Dave S B Hoon, John Thompson, Nicola Mozzillo, Omgo E Nieweg, Dirk Noyes, Harald J Hoekstra, Jonathan S Zager, Daniel F Roses, Alessandro Testori, Brendon J Coventry, Mark B Smithers, Robert Andtbacka, Doreen Agnese, Erwin Schultz, Eddy C Hsueh, Mark Kelley, Schlomo Schneebaum, Lisa Jacobs, Tawnya Bowles, Mohammed Kashani-Sabet, Douglas Johnson, and Mark B Faries

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Is Pregnancy-Associated Melanoma Associated with Adverse Outcomes?, Maris S Jones, Jihey Lee, Stacey L Stern, and Mark Faries

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Analysis of 340 Patients with Solid Pseudopapillary Tumors of the Pancreas: A Closer Look at Patients with Metastatic Disease., Zeljka Jutric, Yelena Rozenfeld, Jan Grendar, Chet W Hammill, Maria A Cassera, Pippa H Newell, Paul D Hansen, and Ronald F Wolf

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Reply to "Analysis of 340 Patients with Solid Pseudopapillary Tumors of the Pancreas: A Closer Look at Patients with Metastatic Disease; Methodologic Issues," by Safiri, Saeid et al., Zeljka Jutric, Yelena Rozenfeld, Jan Grendar, and Ronald F Wolf

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Triple-negative breast cancer in the elderly: Prognosis and treatment., Henry G Kaplan, Judith A Malmgren, and Mary K Atwood

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Thin Melanoma with Nodal Involvement: Analysis of Demographic, Pathologic, and Treatment Factors with Regard to Prognosis., Giorgos Karakousis, Phyllis A Gimotty, Edmund K Bartlett, Myung-Shin Sim, Madalyn G Neuwirth, Douglas Fraker, Brian J Czerniecki, and Mark B Faries

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Astrocytes promote progression of breast cancer metastases to the brain via a KISS1-mediated autophagy., Natalya Kaverina, Anton V Borovjagin, Zaira Kadagidze, Anatoly Baryshnikov, Maria Baryshnikova, Dmitry Malin, Dhimankrishhna Ghosh, Nameeta Shah, Danny R Welch, Patrik Gabikian, Apollon Karseladze, Charles Cobbs, and Ilya V Ulasov

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Second Primary Malignant Neoplasms and Survival in Adolescent and Young Adult Cancer Survivors., Theresa H M Keegan, Archie Bleyer, Aaron S Rosenberg, Qian Li, and Melanie Goldfarb

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In Reply: Endoscopic and Gravity-Assisted Resection of Medial Temporo-occipital Lesions Through a Supracerebellar Transtentorial Approach: Technical Notes With Case Illustrations., Daniel F Kelly and Garni Barkhoudarian

Clinical Stage I vs Clinical Stage II Seminoma. Nuances and Assessing Treatment Guidelines, Mark J. Kelly

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Tumor-treating fields plus chemotherapy versus chemotherapy alone for glioblastoma at first recurrence: a post hoc analysis of the EF-14 trial., Santosh Kesari and Zvi Ram

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Brigatinib in Patients With Crizotinib-Refractory Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer: A Randomized, Multicenter Phase II Trial., Dong-Wan Kim, Marcello Tiseo, Myung-Ju Ahn, Karen L Reckamp, Karin Holmskov Hansen, Sang-We Kim, Rudolf M Huber, Howard J. West, Harry J M Groen, Maximilian J Hochmair, Natasha B Leighl, Scott N Gettinger, Corey J Langer, Luis G Paz-Ares Rodríguez, Egbert F Smit, Edward S Kim, William Reichmann, Frank G Haluska, David Kerstein, and D Ross Camidge

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CCR4 is a determinant of melanoma brain metastasis., Anat Klein, Orit Sagi-Assif, Tsipi Meshel, Alona Telerman, Sivan Izraely, Shlomit Ben-Menachem, Jagadeesh Bayry, Diego M Marzese, Shuichi Ohe, Dave S B Hoon, Neta Erez, and Isaac P Witz

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A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma., Clemens Krepler, Katrin Sproesser, Patricia Brafford, Marilda Beqiri, Bradley Garman, Min Xiao, Batool Shannan, Andrea Watters, Michela Perego, Gao Zhang, Adina Vultur, Xiangfan Yin, Qin Liu, Ioannis N Anastopoulos, Bradley Wubbenhorst, Melissa A Wilson, Wei Xu, Giorgos Karakousis, Michael Feldman, Xiaowei Xu, Ravi Amaravadi, Tara C Gangadhar, David E Elder, Lauren E Haydu, Jennifer A Wargo, Michael A Davies, Yiling Lu, Gordon B Mills, Dennie T Frederick, Michal Barzily-Rokni, Keith T Flaherty, Dave S B Hoon, Michael Guarino, Joseph J Bennett, Randall W Ryan, Nicholas J Petrelli, Carol L Shields, Mizue Terai, Takami Sato, Andrew E Aplin, Alexander Roesch, David Darr, Steve Angus, Rakesh Kumar, Ensar Halilovic, Giordano Caponigro, Sebastien Jeay, Jens Wuerthner, Annette Walter, Matthias Ocker, Matthew B Boxer, Lynn Schuchter, Katherine L Nathanson, and Meenhard Herlyn

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Restriction Spectrum Imaging Improves Risk Stratification in Patients with Glioblastoma., A P Krishnan, R Karunamuni, K M Leyden, T M Seibert, R L Delfanti, J M Kuperman, H Bartsch, P Elbe, A Srikant, A M Dale, Santosh Kesari, D E Piccioni, J A Hattangadi-Gluth, N Farid, C R McDonald, and N S White

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Virtual Surgical Planning and Intraoperative Imaging in Management of Ballistic Facial and Mandibular Condylar Injuries., Philipp Kupfer, Allen Cheng, Ashish Patel, Melissa Amundson, Eric J Dierks, and R Bryan Bell

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Mutational Landscapes of Smoking-Related Cancers in Caucasians and African Americans: Precision Oncology Perspectives at Wake Forest Baptist Comprehensive Cancer Center., Ville Kytola, Umit Topaloglu, Lance D Miller, Rhonda L Bitting, Michael M Goodman, Ralph B D Agostino, Rodwige J Desnoyers, Carol Albright, George Yacoub, Shadi A Qasem, Barry DeYoung, Vesteinn Thorsson, Ilya Shmulevich, Meng Yang, Anastasia Shcherban, Matthew Pagni, Liang Liu, Matti Nykter, Kexin Chen, Gregory A Hawkins, Stefan C Grant, W Jeffrey Petty, Angela Tatiana Alistar, Edward A Levine, Edgar D Staren, Carl D Langefeld, Vincent Miller, Gaurav Singal, Robin M Petro, Mac Robinson, William Blackstock, Bayard L Powell, Lynne I Wagner, Kristie L Foley, Edward Abraham, Boris Pasche, and Wei Zhang

Intensive care unit procedure utilization at the end of life among patients with cancer: a community hospital network experience The American Thoracic Society Washington DC, AS Laliberte, CL Wilshire, and See all authors in comments

Mycobacterium bovis Bacillus Calmette-Guérin Alters Melanoma Microenvironment Favoring Antitumor T Cell Responses and Improving M2 Macrophage Function, Ricardo D Lardone, Alfred A Chan, Agnes F Lee, Leland J Foshag, Mark B Faries, Peter A Sieling, and Delphine J Lee

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Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade., Dung T Le, Jennifer N Durham, Kellie N Smith, Hao Wang, Bjarne R Bartlett, Laveet K Aulakh, Steve Lu, Holly Kemberling, Cara Wilt, Brandon S Luber, Fay Wong, Nilofer S Azad, Agnieszka A Rucki, Dan Laheru, Ross Donehower, Atif Zaheer, George A Fisher, Todd S Crocenzi, James J Lee, Tim F Greten, Austin G Duffy, Kristen K Ciombor, Aleksandra D Eyring, Bao H Lam, Andrew Joe, S Peter Kang, Matthias Holdhoff, Ludmila Danilova, Leslie Cope, Christian Meyer, Shibin Zhou, Richard M Goldberg, Deborah K Armstrong, Katherine M Bever, Amanda N Fader, Janis Taube, Franck Housseau, David Spetzler, Nianqing Xiao, Drew M Pardoll, Nickolas Papadopoulos, Kenneth W Kinzler, James R Eshleman, Bert Vogelstein, Robert A Anders, and Luis A Diaz

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The Importance of Standardization on Analyzing Circulating RNA., Inyoul Lee, David Baxter, Min Young Lee, Kelsey Scherler, and Kai Wang

Right internal jugular access as an alternative to femoral access for CardioMEMS implantation​, Rebecca Lewis, Lian Wang, Kateri Spinelli, Joshua Remick, Jeff Paulson, Jay Chappell, and Jacob Abraham

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Emerging Utility of Urinary Cell-free Nucleic Acid Biomarkers for Prostate, Bladder, and Renal Cancers., Selena Y Lin, Jennifer A Linehan, Timothy G Wilson, and Dave S B Hoon

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Modulation of Bax and mTOR for Cancer Therapeutics., Rui Li, Chunyong Ding, Jun Zhang, Maohua Xie, Dongkyoo Park, Ye Ding, Guo Chen, Guojing Zhang, Melissa Gilbert-Ross, Wei Zhou, Adam I Marcus, Shi-Yong Sun, Zhuo G Chen, Gabriel L Sica, Suresh S Ramalingam, Andrew T Magis, Haian Fu, Fadlo R Khuri, Walter J Curran, Taofeek K Owonikoko, Dong M Shin, Jia Zhou, and Xingming Deng

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Is tissue the issue?, Brian E Louie

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A Phase II Clinical Trial of an Aromatase Inhibitor for Postmenopausal Women with Lymphangioleiomyomatosis., Calvin Lu, Hye-Seung Lee, George P Pappas, Daniel F Dilling, Charles D Burger, Adrian Shifren, Srihari Veeraraghavan, Jeffrey T Chapman, Joseph Parambil, Stephen J Ruoss, Lisa R Young, Stephen R Hammes, Elizabeth J Kopras, Tammy Roads, Jeffrey P Krischer, and Francis X McCormack

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Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours., Milan T Makale, Carrie R McDonald, Jona A Hattangadi-Gluth, and Santosh Kesari